JP2013545438A5 - - Google Patents
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- Publication number
- JP2013545438A5 JP2013545438A5 JP2013527629A JP2013527629A JP2013545438A5 JP 2013545438 A5 JP2013545438 A5 JP 2013545438A5 JP 2013527629 A JP2013527629 A JP 2013527629A JP 2013527629 A JP2013527629 A JP 2013527629A JP 2013545438 A5 JP2013545438 A5 JP 2013545438A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- antigen
- binding fragment
- seq
- bispecific construct
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38178910P | 2010-09-10 | 2010-09-10 | |
| US61/381,789 | 2010-09-10 | ||
| PCT/EP2011/065697 WO2012032181A2 (en) | 2010-09-10 | 2011-09-09 | Novel antibody derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013545438A JP2013545438A (ja) | 2013-12-26 |
| JP2013545438A5 true JP2013545438A5 (enExample) | 2014-10-23 |
| JP6173911B2 JP6173911B2 (ja) | 2017-08-09 |
Family
ID=44583080
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013527629A Expired - Fee Related JP6173911B2 (ja) | 2010-09-10 | 2011-09-09 | 抗体誘導体 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20140127209A1 (enExample) |
| EP (1) | EP2640745B1 (enExample) |
| JP (1) | JP6173911B2 (enExample) |
| CN (1) | CN103261222B (enExample) |
| WO (1) | WO2012032181A2 (enExample) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4793360A2 (en) | 2006-03-31 | 2026-08-19 | Chugai Seiyaku Kabushiki Kaisha | Methods for controlling blood pharmacokinetics of antibodies |
| CA2707840A1 (en) | 2007-08-20 | 2009-02-26 | Allozyne, Inc. | Amino acid substituted molecules |
| EP3127921A1 (en) | 2007-09-26 | 2017-02-08 | Chugai Seiyaku Kabushiki Kaisha | Method of modifying isoelectric point of antibody via amino acid substition in cdr |
| TW201920257A (zh) | 2008-04-11 | 2019-06-01 | 日商中外製藥股份有限公司 | 重複結合複數個抗原的抗原結合分子 |
| KR102049223B1 (ko) | 2010-11-04 | 2019-11-28 | 베링거 인겔하임 인터내셔날 게엠베하 | 항-il-23 항체 |
| TWI654203B (zh) | 2010-11-30 | 2019-03-21 | Chugai Seiyaku Kabushiki Kaisha | 具有鈣依存性的抗原結合能力之抗體 |
| CA2840270C (en) * | 2011-06-22 | 2023-09-26 | Apellis Pharmaceuticals, Inc. | Methods of treating chronic disorders with complement inhibitors |
| WO2013006810A1 (en) | 2011-07-06 | 2013-01-10 | Nestec Sa | Assays for detecting neutralizing autoantibodies to biologic therapy with tnf alpha |
| EP2583979B1 (en) | 2011-10-19 | 2015-12-16 | Effimune | Methods to prepare antibodies directed against p19 subunit of human IL-23 |
| CA2865158C (en) | 2012-02-24 | 2022-11-01 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule for promoting disappearance of antigen via fc.gamma.riib |
| CN109206516A (zh) | 2012-05-03 | 2019-01-15 | 勃林格殷格翰国际有限公司 | 抗IL-23p19抗体 |
| US9738724B2 (en) * | 2012-06-08 | 2017-08-22 | Sutro Biopharma, Inc. | Antibodies comprising site-specific non-natural amino acid residues, methods of their preparation and methods of their use |
| EP3135690A1 (en) | 2012-06-26 | 2017-03-01 | Sutro Biopharma, Inc. | Modified fc proteins comprising site-specific non-natural amino acid residues, conjugates of the same, methods of their preparation and methods of their use |
| TWI855488B (zh) | 2012-08-24 | 2024-09-11 | 日商中外製藥股份有限公司 | FcγRIIb特異性Fc區域變異體 |
| JP6774164B2 (ja) | 2012-08-24 | 2020-10-21 | 中外製薬株式会社 | マウスFcγRII特異的Fc抗体 |
| SI2890402T1 (sl) | 2012-08-31 | 2019-07-31 | Sutro Biopharma, Inc. | Modificirane aminokisline vsebujoče acido skupino |
| US9670521B2 (en) | 2012-09-24 | 2017-06-06 | Medimmune Limited | Amino acid derivatives |
| US10131920B2 (en) | 2013-03-15 | 2018-11-20 | Medimmune Limited | Nucleic acid molecules |
| SG11201508170TA (en) | 2013-04-02 | 2015-11-27 | Chugai Pharmaceutical Co Ltd | Fc REGION VARIANT |
| WO2015006555A2 (en) * | 2013-07-10 | 2015-01-15 | Sutro Biopharma, Inc. | Antibodies comprising multiple site-specific non-natural amino acid residues, methods of their preparation and methods of their use |
| CN105980350B (zh) | 2013-08-05 | 2018-11-27 | 米迪缪尼有限公司 | 氨基酸衍生物 |
| KR102460736B1 (ko) | 2014-05-10 | 2022-10-31 | 소렌토 쎄라퓨틱스, 인코포레이티드 | 화학적으로-로킹된 이중특이적 항체 |
| EP3172339A1 (en) | 2014-07-24 | 2017-05-31 | Boehringer Ingelheim International GmbH | Biomarkers useful in the treatment of il-23a related diseases |
| CA2959629C (en) | 2014-09-03 | 2023-10-31 | Boehringer Ingelheim International Gmbh | Compound targeting il-23a and tnf-alpha and uses thereof |
| RU2017122720A (ru) * | 2014-12-05 | 2019-01-10 | Нестек С.А. | Непрямые однородные анализы по изменению подвижности для детекции биологических препаратов в образцах пациента |
| MX2017005774A (es) | 2014-12-19 | 2017-07-28 | Chugai Pharmaceutical Co Ltd | Anticuerpos antimiostatina, polipeptidos que contienen regiones fc variantes, y metodos de uso. |
| KR20170120616A (ko) | 2015-02-04 | 2017-10-31 | 베링거 인겔하임 인터내셔날 게엠베하 | 염증성 질환의 치료 방법 |
| CN114773469B (zh) | 2015-02-05 | 2025-12-19 | 中外制药株式会社 | 包含离子浓度依赖性的抗原结合结构域的抗体,fc区变体,il-8-结合抗体及其应用 |
| US10709839B2 (en) | 2015-03-04 | 2020-07-14 | Repro-Med Systems, Inc. | Precision variable flow rate infusion system and method |
| JP6967221B2 (ja) | 2015-08-19 | 2021-11-17 | 国立研究開発法人理化学研究所 | 非天然アミノ酸導入抗体 |
| EP3394098A4 (en) | 2015-12-25 | 2019-11-13 | Chugai Seiyaku Kabushiki Kaisha | ANTI-MYOSTATIN ANTIBODIES AND METHOD OF USE |
| CN106924754B (zh) * | 2015-12-30 | 2021-11-09 | 北京大学 | 聚氨基酸偶联物 |
| AU2017212739B2 (en) | 2016-01-27 | 2024-03-21 | Sutro Biopharma, Inc. | Anti-CD74 antibody conjugates, compositions comprising anti-CD74 antibody conjugates and methods of using anti-CD74 antibody conjugates |
| CN116271014A (zh) | 2016-08-05 | 2023-06-23 | 中外制药株式会社 | 用于预防或治疗il-8相关疾病的组合物 |
| IL315727A (en) * | 2016-12-23 | 2024-11-01 | Visterra Inc | Binding polypeptides and methods for their preparation |
| KR102755136B1 (ko) * | 2017-05-09 | 2025-01-17 | 심리스 바이오로직스 게엠베하 | 변형된 마이크로시스틴 및 노둘라린 |
| KR20200086678A (ko) * | 2017-10-13 | 2020-07-17 | 어슈어, 인크. | 뉴클레오시드 리버스 트랜스크립타제 억제제 요법에 대한 준수를 모니터링하기 위한 생성물 및 방법 |
| CN110283249A (zh) * | 2018-03-19 | 2019-09-27 | 江苏莱博德医疗科技有限公司 | 一种抗白介素6的人ScFv单链抗体 |
| US20190292310A1 (en) * | 2018-03-20 | 2019-09-26 | Northeastern University | Synthesis of high density molecular dna brushes via organic-phase ring-opening metathesis (co)polymerization |
| SG11202010025YA (en) | 2018-05-31 | 2020-11-27 | Glyconex Inc | Therapeutic antibodies binding to biantennary lewis b and lewis y antigens |
| MX2021003976A (es) | 2018-10-11 | 2021-05-27 | Amgen Inc | Procesamiento posterior de constructos de anticuerpos biespecificos. |
| CN114375205A (zh) | 2019-06-20 | 2022-04-19 | 武田药品工业株式会社 | 用基于病毒的基因疗法进行治疗的方法 |
| TW202535466A (zh) | 2019-09-09 | 2025-09-16 | 德商百靈佳殷格翰國際股份有限公司 | 抗-il-23p19抗體調配物 |
| US20230192824A1 (en) * | 2020-04-02 | 2023-06-22 | United States Of America As Represented By The Secretary Of The Navy | Antigen Binding Proteins to Class 5 ETEC Adhesins |
| CN113203863B (zh) * | 2021-04-28 | 2022-01-21 | 北京美联泰科生物技术有限公司 | 一种适用于白介素-6检测的缓冲液 |
| CN113150122B (zh) * | 2021-05-19 | 2023-03-17 | 上海儒克生物科技有限公司 | 高通量全兔源单克隆抗体的制备方法 |
| KR20240035758A (ko) | 2021-05-24 | 2024-03-18 | 비르 바이오테크놀로지, 인코포레이티드 | 조작된 폴리펩타이드 |
| CN115957319B (zh) * | 2022-10-14 | 2023-06-30 | 北京东方百泰生物科技股份有限公司 | 一种抗nkg2a单克隆抗体的注射制剂 |
| WO2025010424A1 (en) | 2023-07-06 | 2025-01-09 | Vir Biotechnology, Inc. | Antibodies against staphylococcus antigens and methods of using the same |
| PL448731A1 (pl) * | 2024-05-31 | 2025-12-01 | Celon Pharma Spółka Akcyjna | Przeciwciała bispecyficzne anty–IL-17A i anty-IL-6 oraz ich zastosowanie w terapii, zwłaszcza w leczeniu chorób immunologicznych |
| CN119023961B (zh) * | 2024-08-27 | 2026-02-03 | 首都医科大学附属北京朝阳医院 | 用于检测干眼病生物标志物的试剂及其制备方法和用途 |
| WO2026102136A1 (en) | 2024-11-07 | 2026-05-15 | Glyconex Inc. | Anti-lewis y antibody and pro-antibody thereof |
| CN120329434B (zh) * | 2025-06-23 | 2025-10-21 | 杭州市第一人民医院(西湖大学附属杭州市第一人民医院) | 一种mfge8单克隆抗体及其制备方法和应用 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991016449A1 (en) | 1990-04-16 | 1991-10-31 | The Trustees Of The University Of Pennsylvania | Saccharide compositions, methods and apparatus for their synthesis |
| US5151510A (en) | 1990-04-20 | 1992-09-29 | Applied Biosystems, Inc. | Method of synethesizing sulfurized oligonucleotide analogs |
| GB9014932D0 (en) | 1990-07-05 | 1990-08-22 | Celltech Ltd | Recombinant dna product and method |
| WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
| JPH05244982A (ja) | 1991-12-06 | 1993-09-24 | Sumitomo Chem Co Ltd | 擬人化b−b10 |
| GB9915247D0 (en) | 1999-07-01 | 1999-09-01 | Amat Limited | Improvements relating to tyre degradation |
| WO2002046208A2 (en) | 2000-11-01 | 2002-06-13 | Elusys Therapeutics, Inc. | Method of producing biospecific molecules by protein trans-splicing |
| ES2464532T3 (es) | 2001-04-19 | 2014-06-03 | The Scripps Research Institute | Métodos y composiciones para la producción de pares ortogonales de ARNt-aminoacil-ARNt sintetasa |
| US20060073141A1 (en) | 2001-06-28 | 2006-04-06 | Domantis Limited | Compositions and methods for treating inflammatory disorders |
| EP2292273A3 (en) | 2001-10-10 | 2011-11-23 | BioGeneriX AG | Remodeling and glycoconjugation of peptides |
| EP1558747B1 (en) | 2002-10-16 | 2009-10-14 | The Scripps Research Institute | Glycoprotein synthesis |
| CA2511910A1 (en) * | 2002-12-27 | 2004-07-15 | Domantis Limited | Dual specific single domain antibodies specific for a ligand and for the receptor of the ligand |
| US20050287639A1 (en) | 2004-05-17 | 2005-12-29 | California Institute Of Technology | Methods of incorporating amino acid analogs into proteins |
| EP1771205B1 (en) | 2004-06-18 | 2016-10-26 | Ambrx, Inc. | Novel antigen-binding polypeptides and their uses |
| JP2008504356A (ja) * | 2004-06-30 | 2008-02-14 | ドマンティス リミテッド | 炎症性疾患を治療するための組成物及び方法 |
| TW200708792A (en) | 2005-08-24 | 2007-03-01 | Asia Optical Co Inc | Retractable lens system and turnover lens-receiving mechanism thereof |
| CA2653748A1 (en) | 2006-05-02 | 2007-11-15 | Allozyne, Inc. | Non-natural amino acid substituted polypeptides |
| CN103396489A (zh) * | 2007-02-23 | 2013-11-20 | 默沙东公司 | 工程改造的抗IL-23p19抗体 |
| MX2009009167A (es) * | 2007-02-28 | 2009-09-04 | Schering Corp | Terapia de combinacion para el tratamiento de trastornos inmunes. |
| US8188235B2 (en) * | 2008-06-18 | 2012-05-29 | Pfizer Inc. | Antibodies to IL-6 and their uses |
| WO2010027767A1 (en) * | 2008-08-27 | 2010-03-11 | Schering Corporation | Engineered anti-il-23r antibodies |
| TWI440469B (zh) * | 2008-09-26 | 2014-06-11 | Chugai Pharmaceutical Co Ltd | Improved antibody molecules |
| MX2011005672A (es) * | 2008-11-28 | 2011-06-20 | Abbott Lab | Composiciones de anticuerpo estables y metodos para estabilizar a las mismas. |
| CN102387814A (zh) * | 2009-01-29 | 2012-03-21 | 米迪缪尼有限公司 | 延长体内半衰期的人抗il-6抗体及其在治疗肿瘤、自身免疫性疾病和炎症性疾病中的应用 |
-
2011
- 2011-09-09 CN CN201180054114.9A patent/CN103261222B/zh not_active Expired - Fee Related
- 2011-09-09 EP EP11752578.2A patent/EP2640745B1/en not_active Not-in-force
- 2011-09-09 JP JP2013527629A patent/JP6173911B2/ja not_active Expired - Fee Related
- 2011-09-09 WO PCT/EP2011/065697 patent/WO2012032181A2/en not_active Ceased
-
2013
- 2013-03-08 US US13/791,312 patent/US20140127209A1/en not_active Abandoned
-
2015
- 2015-10-19 US US14/886,978 patent/US10202447B2/en not_active Expired - Fee Related
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