JP2017508461A5 - - Google Patents

Info

Publication number

JP2017508461A5

JP2017508461A5 JP2016555467A JP2016555467A JP2017508461A5 JP 2017508461 A5 JP2017508461 A5 JP 2017508461A5 JP 2016555467 A JP2016555467 A JP 2016555467A JP 2016555467 A JP2016555467 A JP 2016555467A JP 2017508461 A5 JP2017508461 A5 JP 2017508461A5

Authority

JP

Japan

Prior art keywords

seq

antibody

amino acid

pharmaceutical composition

acid sequence

Prior art date

2015-03-04

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 239000008194 pharmaceutical composition Substances 0.000 claims 31
• 125000003275 alpha amino acid group Chemical group 0.000 claims 26
• 102100024167 C-C chemokine receptor type 3 Human genes 0.000 claims 17
• 101710149862 C-C chemokine receptor type 3 Proteins 0.000 claims 17
• 102000019034 Chemokines Human genes 0.000 claims 13
• 108010012236 Chemokines Proteins 0.000 claims 13
• 108010047041 Complementarity Determining Regions Proteins 0.000 claims 12
• 201000010099 disease Diseases 0.000 claims 10
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 10
• 239000000427 antigen Substances 0.000 claims 6
• 102000036639 antigens Human genes 0.000 claims 6
• 108091007433 antigens Proteins 0.000 claims 6
• 208000012657 Atopic disease Diseases 0.000 claims 5
• 208000026935 allergic disease Diseases 0.000 claims 5
• 208000037979 autoimmune inflammatory disease Diseases 0.000 claims 5
• 210000004027 cell Anatomy 0.000 claims 5
• 230000003176 fibrotic effect Effects 0.000 claims 5
• 210000001616 monocyte Anatomy 0.000 claims 5
• 102100031172 C-C chemokine receptor type 1 Human genes 0.000 claims 4
• 101710149814 C-C chemokine receptor type 1 Proteins 0.000 claims 4
• 102100031151 C-C chemokine receptor type 2 Human genes 0.000 claims 4
• 101710149815 C-C chemokine receptor type 2 Proteins 0.000 claims 4
• 102100035875 C-C chemokine receptor type 5 Human genes 0.000 claims 4
• 101710149870 C-C chemokine receptor type 5 Proteins 0.000 claims 4
• 230000000172 allergic effect Effects 0.000 claims 4
• 125000000539 amino acid group Chemical group 0.000 claims 4
• 239000012634 fragment Substances 0.000 claims 4
• 150000007523 nucleic acids Chemical class 0.000 claims 4
• 102000039446 nucleic acids Human genes 0.000 claims 4
• 108020004707 nucleic acids Proteins 0.000 claims 4
• 238000000034 method Methods 0.000 claims 3
• 238000013508 migration Methods 0.000 claims 3
• 230000005012 migration Effects 0.000 claims 3
• 102100036849 C-C motif chemokine 24 Human genes 0.000 claims 2
• 102100032367 C-C motif chemokine 5 Human genes 0.000 claims 2
• 102100032366 C-C motif chemokine 7 Human genes 0.000 claims 2
• 101710155834 C-C motif chemokine 7 Proteins 0.000 claims 2
• 108010082548 Chemokine CCL11 Proteins 0.000 claims 2
• 108010083647 Chemokine CCL24 Proteins 0.000 claims 2
• 108010055166 Chemokine CCL5 Proteins 0.000 claims 2
• 102100023688 Eotaxin Human genes 0.000 claims 2
• 206010020751 Hypersensitivity Diseases 0.000 claims 2
• 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 208000036971 interstitial lung disease 2 Diseases 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims 2
• 206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims 2
• 201000000596 systemic lupus erythematosus Diseases 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 201000001320 Atherosclerosis Diseases 0.000 claims 1
• 206010012438 Dermatitis atopic Diseases 0.000 claims 1
• 206010016654 Fibrosis Diseases 0.000 claims 1
• 208000001145 Metabolic Syndrome Diseases 0.000 claims 1
• 201000004681 Psoriasis Diseases 0.000 claims 1
• 206010039710 Scleroderma Diseases 0.000 claims 1
• 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
• 208000024780 Urticaria Diseases 0.000 claims 1
• 206010046851 Uveitis Diseases 0.000 claims 1
• 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 1
• 230000007815 allergy Effects 0.000 claims 1
• 150000001413 amino acids Chemical class 0.000 claims 1
• 208000006673 asthma Diseases 0.000 claims 1
• 201000008937 atopic dermatitis Diseases 0.000 claims 1
• 230000007882 cirrhosis Effects 0.000 claims 1
• 208000019425 cirrhosis of liver Diseases 0.000 claims 1
• 206010009887 colitis Diseases 0.000 claims 1
• 239000013604 expression vector Substances 0.000 claims 1
• 206010061989 glomerulosclerosis Diseases 0.000 claims 1
• 230000001617 migratory effect Effects 0.000 claims 1
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• 201000006417 multiple sclerosis Diseases 0.000 claims 1
• 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
• 238000012216 screening Methods 0.000 claims 1
• 208000024891 symptom Diseases 0.000 claims 1