RU2705255C2 - Антитела против эотаксина 2, которые распознают дополнительные связывающие CCR3 хемокины - Google Patents

Антитела против эотаксина 2, которые распознают дополнительные связывающие CCR3 хемокины Download PDF

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RU2705255C2
RU2705255C2 RU2016136639A RU2016136639A RU2705255C2 RU 2705255 C2 RU2705255 C2 RU 2705255C2 RU 2016136639 A RU2016136639 A RU 2016136639A RU 2016136639 A RU2016136639 A RU 2016136639A RU 2705255 C2 RU2705255 C2 RU 2705255C2
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antibody
seq
amino acid
eotaxin
acid sequence
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RU2016136639A
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RU2016136639A3 (enExample
RU2016136639A (ru
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Ади МОР
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Хемомаб Лтд.
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Genetics & Genomics (AREA)
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  • Diabetes (AREA)
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  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
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  • Obesity (AREA)
  • Hematology (AREA)
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  • Microbiology (AREA)
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  • Epidemiology (AREA)
RU2016136639A 2014-03-04 2015-03-04 Антитела против эотаксина 2, которые распознают дополнительные связывающие CCR3 хемокины RU2705255C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461947852P 2014-03-04 2014-03-04
US61/947,852 2014-03-04
PCT/IL2015/050234 WO2015132790A2 (en) 2014-03-04 2015-03-04 Anti eotaxin-2 antibodies that recognize additional ccr3-binding chemokines

Publications (3)

Publication Number Publication Date
RU2016136639A RU2016136639A (ru) 2018-04-05
RU2016136639A3 RU2016136639A3 (enExample) 2018-05-04
RU2705255C2 true RU2705255C2 (ru) 2019-11-06

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RU2016136639A RU2705255C2 (ru) 2014-03-04 2015-03-04 Антитела против эотаксина 2, которые распознают дополнительные связывающие CCR3 хемокины

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US (2) US10246508B2 (enExample)
EP (2) EP4155317A1 (enExample)
JP (1) JP6553075B2 (enExample)
CN (1) CN106103479B (enExample)
BR (1) BR112016020366B1 (enExample)
DK (1) DK3114139T3 (enExample)
ES (1) ES2926700T3 (enExample)
IL (1) IL247219B (enExample)
PT (1) PT3114139T (enExample)
RU (1) RU2705255C2 (enExample)
WO (1) WO2015132790A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2832323C1 (ru) * 2020-04-22 2024-12-23 Кемомаб Лтд. Способ лечения с использованием антитела против CCL24

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017183028A1 (en) * 2016-04-18 2017-10-26 Chemomab Ltd. Eotaxin-2 inhibitors in the treatment of fibromyalgia
EP4252629A3 (en) 2016-12-07 2023-12-27 Biora Therapeutics, Inc. Gastrointestinal tract detection methods, devices and systems
EP3554541B1 (en) 2016-12-14 2023-06-07 Biora Therapeutics, Inc. Treatment of a disease of the gastrointestinal tract with a chemokine/chemokine receptor inhibitor
WO2018139404A1 (ja) 2017-01-24 2018-08-02 協和発酵キリン株式会社 放射線障害の治療又は予防剤並びに治療又は予防方法
GB201702500D0 (en) 2017-02-16 2017-04-05 Univ Sheffield Stable vamp reporter assay
IL251024A0 (en) * 2017-03-08 2017-06-29 Chemomab Ltd Antibodies against eutaxin 2 for use in the treatment of liver diseases
WO2020106757A1 (en) 2018-11-19 2020-05-28 Progenity, Inc. Ingestible device for delivery of therapeutic agent to the gastrointestinal tract
CN113613612B (zh) 2019-03-08 2022-08-02 奥瑞斯健康公司 用于医疗系统和应用的倾斜机构
WO2021119482A1 (en) 2019-12-13 2021-06-17 Progenity, Inc. Ingestible device for delivery of therapeutic agent to the gastrointestinal tract
US20230192836A1 (en) 2020-04-20 2023-06-22 Chemomab Ltd. Ccl24 inhibitors in the treatment of covid-19
CA3172627A1 (en) * 2020-04-22 2021-10-28 Adi Mor Method of treatment using anti-ccl24 antibody
WO2021219871A2 (en) * 2020-04-30 2021-11-04 Aduro Biotech Holdings, Europe B.V. Anti-cd103 antibodies

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000027880A2 (en) * 1998-11-11 2000-05-18 Fondazione Centro San Raffaele Del Monte Tabor Rantes-derived peptides with anti-hiv activity
WO2010086854A1 (en) * 2009-01-28 2010-08-05 The Medical Research, Infrastructure, And Health Services Fund Of The Tel Aviv Medical Center Eotaxin-2 (ccl24) inhibitors in inflammatory, autoimmune, and cardiovascular disorders
RU2009101297A (ru) * 2006-07-22 2010-08-27 Оксаген Лимитед (GB) Соединения, обладающие антагонистической активностью по отношению к crth2
WO2011025962A1 (en) * 2009-08-28 2011-03-03 Dan Allison Antikine antibodies that bind to multiple cc chemokines
RU2013140619A (ru) * 2011-03-07 2015-04-20 Атопикс Терапьютикс Лимитед Аморфная (5-фтор-2-метил-3-хинолин-2-илметилиндол-1-ил)-уксусная кислота

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000027880A2 (en) * 1998-11-11 2000-05-18 Fondazione Centro San Raffaele Del Monte Tabor Rantes-derived peptides with anti-hiv activity
RU2009101297A (ru) * 2006-07-22 2010-08-27 Оксаген Лимитед (GB) Соединения, обладающие антагонистической активностью по отношению к crth2
WO2010086854A1 (en) * 2009-01-28 2010-08-05 The Medical Research, Infrastructure, And Health Services Fund Of The Tel Aviv Medical Center Eotaxin-2 (ccl24) inhibitors in inflammatory, autoimmune, and cardiovascular disorders
WO2011025962A1 (en) * 2009-08-28 2011-03-03 Dan Allison Antikine antibodies that bind to multiple cc chemokines
RU2013140619A (ru) * 2011-03-07 2015-04-20 Атопикс Терапьютикс Лимитед Аморфная (5-фтор-2-метил-3-хинолин-2-илметилиндол-1-ил)-уксусная кислота

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2832323C1 (ru) * 2020-04-22 2024-12-23 Кемомаб Лтд. Способ лечения с использованием антитела против CCL24

Also Published As

Publication number Publication date
IL247219A0 (en) 2016-09-29
BR112016020366B1 (pt) 2024-01-02
ES2926700T3 (es) 2022-10-27
WO2015132790A3 (en) 2015-11-05
DK3114139T3 (da) 2022-09-12
EP3114139B1 (en) 2022-06-15
PT3114139T (pt) 2022-09-13
RU2016136639A3 (enExample) 2018-05-04
US10246508B2 (en) 2019-04-02
RU2016136639A (ru) 2018-04-05
IL247219B (en) 2021-09-30
WO2015132790A2 (en) 2015-09-11
CN106103479B (zh) 2019-12-24
US10479830B2 (en) 2019-11-19
JP2017508461A (ja) 2017-03-30
US20190153088A1 (en) 2019-05-23
EP4155317A1 (en) 2023-03-29
BR112016020366A2 (pt) 2018-06-05
CN106103479A (zh) 2016-11-09
EP3114139A2 (en) 2017-01-11
US20160368979A1 (en) 2016-12-22
JP6553075B2 (ja) 2019-08-07

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