JP2013541567A5 - - Google Patents

Download PDF

Info

Publication number
JP2013541567A5
JP2013541567A5 JP2013537044A JP2013537044A JP2013541567A5 JP 2013541567 A5 JP2013541567 A5 JP 2013541567A5 JP 2013537044 A JP2013537044 A JP 2013537044A JP 2013537044 A JP2013537044 A JP 2013537044A JP 2013541567 A5 JP2013541567 A5 JP 2013541567A5
Authority
JP
Japan
Prior art keywords
dose
patient
fentanyl
composition
composition according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2013537044A
Other languages
English (en)
Japanese (ja)
Other versions
JP6084571B2 (ja
JP2013541567A (ja
Filing date
Publication date
Priority claimed from EP10014972A external-priority patent/EP2450039A1/en
Application filed filed Critical
Publication of JP2013541567A publication Critical patent/JP2013541567A/ja
Publication of JP2013541567A5 publication Critical patent/JP2013541567A5/ja
Application granted granted Critical
Publication of JP6084571B2 publication Critical patent/JP6084571B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2013537044A 2010-11-08 2011-11-07 Ｃｎｓ７０５６（レミマゾラム）を用いた鎮静のための投薬レジメン Active JP6084571B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
EP10014366.8 2010-11-08
EP10014366 2010-11-08
EP10014784 2010-11-19
EP10014784.2 2010-11-19
EP10014819 2010-11-22
EP10014819.6 2010-11-22
EP10014972A EP2450039A1 (en) 2010-11-08 2010-11-25 Dosing regimen for sedation with CNS 7056 (Remimazolam)
EP10014972.3 2010-11-25
PCT/EP2011/005581 WO2012062439A1 (en) 2010-11-08 2011-11-07 Dosing regimen for sedation with cns 7056 (remimazolam)

Publications (3)

Publication Number Publication Date
JP2013541567A JP2013541567A (ja) 2013-11-14
JP2013541567A5 true JP2013541567A5 (enExample) 2014-11-06
JP6084571B2 JP6084571B2 (ja) 2017-02-22

Family

ID=44907114

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013537044A Active JP6084571B2 (ja) 2010-11-08 2011-11-07 Ｃｎｓ７０５６（レミマゾラム）を用いた鎮静のための投薬レジメン

Country Status (17)

Country Link
US (10) US9561236B2 (enExample)
EP (3) EP2450039A1 (enExample)
JP (1) JP6084571B2 (enExample)
KR (1) KR102059399B1 (enExample)
CN (1) CN103347519B (enExample)
AU (1) AU2011328497B8 (enExample)
DK (1) DK2637662T3 (enExample)
EA (1) EA024926B1 (enExample)
ES (1) ES2715179T3 (enExample)
HR (1) HRP20190447T1 (enExample)
HU (1) HUE044095T2 (enExample)
LT (1) LT2637662T (enExample)
PL (1) PL2637662T3 (enExample)
PT (1) PT2637662T (enExample)
RS (1) RS58577B1 (enExample)
SI (1) SI2637662T1 (enExample)
WO (1) WO2012062439A1 (enExample)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602007009128D1 (de) 2006-07-10 2010-10-21 Paion Uk Ltd Benzodiazepinsalze mit kurzzeitwirkung und polymorphe formen davon
EP2305647A1 (en) 2009-09-18 2011-04-06 PAION UK Limited Process for preparing 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4 H-imidazo[1,2-a][1,4]benzodiazepine-4-yl] propionic acid methyl ester or the benzene sulfonate salt thereof, and compounds useful in that process
EP2450039A1 (en) 2010-11-08 2012-05-09 PAION UK Ltd. Dosing regimen for sedation with CNS 7056 (Remimazolam)
WO2014037832A2 (en) 2012-09-06 2014-03-13 Mahesh Kandula Compositions and methods for the treatment of epilepsy and neurological diseases
WO2013167990A1 (en) 2012-05-07 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of depression
JP2015519333A (ja) 2012-05-07 2015-07-09 セリックスビオ プライヴェート リミテッド 神経疾患の治療のための組成物および方法
CN104603096A (zh) 2012-05-07 2015-05-06 塞利克斯比奥私人有限公司 用于治疗神经肌肉障碍和神经退行性疾病的组合物和方法
US9266823B2 (en) 2012-05-08 2016-02-23 Cellix Bio Private Limited Compositions and methods for the treatment of parkinson's disease
WO2013168025A1 (en) 2012-05-08 2013-11-14 Mahesh Kandula Compositions and methods for treatment of blood clotting disorders
WO2013167991A1 (en) 2012-05-08 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of metabolic disorders
WO2013167992A1 (en) 2012-05-08 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of inflammatory disorders
US9434704B2 (en) 2012-05-08 2016-09-06 Cellix Bio Private Limited Compositions and methods for the treatment of neurological degenerative disorders
WO2013168011A1 (en) 2012-05-10 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of chronic pain
US9315478B2 (en) 2012-05-10 2016-04-19 Cellix Bio Private Limited Compositions and methods for the treatment of metabolic syndrome
US9242939B2 (en) 2012-05-10 2016-01-26 Cellix Bio Private Limited Compositions and methods for the treatment of respiratory disorders
US9315461B2 (en) 2012-05-10 2016-04-19 Cellix Bio Private Limited Compositions and methods for the treatment of neurologic diseases
US9573927B2 (en) 2012-05-10 2017-02-21 Cellix Bio Private Limited Compositions and methods for the treatment of severe pain
WO2013168014A1 (en) 2012-05-10 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of familial amyloid polyneuropathy
US9339484B2 (en) 2012-05-10 2016-05-17 Cellix Bio Private Limited Compositions and methods for the treatment of restless leg syndrome and fibromyalgia
US9394288B2 (en) 2012-05-10 2016-07-19 Cellix Bio Private Limited Compositions and methods for the treatment of asthma and allergy
WO2013168033A1 (en) 2012-05-10 2013-11-14 Mahesh Kandula Compositions and methods for treatment of neurologic diseases
WO2013168002A1 (en) 2012-05-10 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of neurological conditions
US20150087674A1 (en) * 2012-05-10 2015-03-26 Mahesh Kandula Compositions and methods for the treatment of severe pain
US9403857B2 (en) 2012-05-10 2016-08-02 Cellix Bio Private Limited Compositions and methods for the treatment of metabolic syndrome
US9346742B2 (en) 2012-05-10 2016-05-24 Cellix Bio Private Limited Compositions and methods for the treatment of fibromyalgia pain
WO2013168001A1 (en) 2012-05-10 2013-11-14 Mahesh Kandula Compositions and methods for the treatment of moderate to severe pain
GEAP201813666A (en) * 2012-05-22 2018-01-25 Paion Uk Ltd Compositions comprising short-acting benzodiazepines
WO2013175376A2 (en) 2012-05-23 2013-11-28 Mahesh Kandula Compositions and methods for the treatment of local pain
JP6202287B2 (ja) 2012-05-23 2017-09-27 セリックスビオ プライヴェート リミテッド 炎症性腸疾患の治療のための組成物及び方法
WO2013175344A2 (en) 2012-05-23 2013-11-28 Mahesh Kandula Compositions and methods for the treatment of periodontitis and rheumatoid arthritis
JP2015518854A (ja) 2012-05-23 2015-07-06 セリックスビオ プライヴェート リミテッド 多発性硬化症の治療のための組成物および方法
WO2013175347A2 (en) 2012-05-23 2013-11-28 Mahesh Kandula Compositions and methods for the treatment of respiratory disorders
EP2852571A4 (en) 2012-05-23 2015-11-25 Cellix Bio Private Ltd COMPOSITIONS AND METHOD FOR THE TREATMENT OF MUCOSITIS
US9108942B1 (en) 2014-11-05 2015-08-18 Mahesh Kandula Compositions and methods for the treatment of moderate to severe pain
US9187427B2 (en) 2012-08-03 2015-11-17 Cellix Bio Private Limited N-substituted nicotinamide compounds and compositions for the treatment migraine and neurologic diseases
SI2891494T1 (sl) * 2012-08-31 2023-12-29 Paion Uk Limited Postopek za dajanje hipnotika/pomirjevala
WO2014037833A2 (en) 2012-09-06 2014-03-13 Mahesh Kandula Compositions and methods for the treatment inflammation and lipid disorders
US9670153B2 (en) 2012-09-08 2017-06-06 Cellix Bio Private Limited Compositions and methods for the treatment of inflammation and lipid disorders
AR094963A1 (es) 2013-03-04 2015-09-09 Ono Pharmaceutical Co Reacción de oxidación excelente en el índice de conversión
CN103232454A (zh) * 2013-05-05 2013-08-07 王元青 治疗精神疾病的药物
US9333187B1 (en) 2013-05-15 2016-05-10 Cellix Bio Private Limited Compositions and methods for the treatment of inflammatory bowel disease
SG11201509782TA (en) 2013-06-04 2015-12-30 Cellix Bio Private Ltd Compositions and methods for the treatment of diabetes and pre-diabetes
US9096537B1 (en) 2014-12-31 2015-08-04 Mahesh Kandula Compositions and methods for the treatment of mucositis
EP3162804B1 (en) 2014-07-23 2019-10-09 Jiangsu Nhwaluokang Pharmaceutical Research and Development Co., Ltd. New benzodiazepine derivative and use thereof
NZ736131A (en) 2014-09-26 2019-04-26 Cellix Bio Private Ltd Compositions and methods for the treatment of epilepsy and neurological disorders
JP6698643B2 (ja) 2014-09-29 2020-05-27 セリックス バイオ プライヴェート リミテッドＣｅｌｌｉｘ Ｂｉｏ Ｐｒｉｖａｔｅ Ｌｉｍｉｔｅｄ 多発性硬化症の治療のための組成物及び方法
EP3212626B1 (en) 2014-10-27 2018-11-07 Cellix Bio Private Limited Three component salts of fumaric acid monomethyl ester with piperazine or ethylene diamine for the treatment of multiple sclerosis
US9175008B1 (en) 2014-11-05 2015-11-03 Cellix Bio Private Limited Prodrugs of anti-platelet agents
US10208014B2 (en) 2014-11-05 2019-02-19 Cellix Bio Private Limited Compositions and methods for the treatment of neurological disorders
US9321716B1 (en) 2014-11-05 2016-04-26 Cellix Bio Private Limited Compositions and methods for the treatment of metabolic syndrome
US9284287B1 (en) 2014-11-05 2016-03-15 Cellix Bio Private Limited Compositions and methods for the suppression of carbonic anhydrase activity
US9290486B1 (en) 2014-11-05 2016-03-22 Cellix Bio Private Limited Compositions and methods for the treatment of epilepsy
US9173877B1 (en) 2014-11-05 2015-11-03 Cellix Bio Private Limited Compositions and methods for the treatment of local pain
US9150557B1 (en) 2014-11-05 2015-10-06 Cellix Bio Private Limited Compositions and methods for the treatment of hyperglycemia
US9932294B2 (en) 2014-12-01 2018-04-03 Cellix Bio Private Limited Compositions and methods for the treatment of multiple sclerosis
US9206111B1 (en) 2014-12-17 2015-12-08 Cellix Bio Private Limited Compositions and methods for the treatment of neurological diseases
EP3242869B1 (en) 2015-01-06 2021-10-27 Cellixbio Private Limited Compositions and methods for the treatment of inflammation and pain
EP3331509B1 (en) 2015-07-18 2020-08-19 Neon Laboratories Ltd. Stable liquid injectable solution of midazolam and pentazocine
EP3331567B1 (en) 2015-07-24 2020-09-23 Neon Laboratories Ltd. Stabilized injectable emulsion of propofol and ketamine
MX2018012498A (es) * 2016-04-14 2019-07-01 Paion Uk Ltd Benzodiazepinas inhaladas y nasales oralmente.
CN106407676A (zh) * 2016-09-12 2017-02-15 广东省农业科学院动物科学研究所 一种基于蒙特卡罗模拟的抗菌药物药效计算方法
CN108143733B (zh) * 2017-12-15 2020-12-25 宜昌人福药业有限责任公司 一种麻醉镇痛药物组合物及其制备方法
WO2019158075A1 (zh) * 2018-02-13 2019-08-22 江苏恩华络康药物研发有限公司 苯二氮卓衍生物盐酸盐与晶型、制备方法及其应用
EP3714884A1 (en) * 2019-03-27 2020-09-30 Paion UK Limited Medical uses for benzodiazepines with a particular eeg pattern
CN112462015B (zh) * 2020-11-18 2022-07-12 海南倍特药业有限公司 一种氢溴酸瑞马唑仑细菌内毒素的检测方法
CN112402428B (zh) * 2020-11-26 2022-02-25 李依泽 瑞马唑仑在制备治疗阿片类药物诱发的术后痛觉过敏的药物中的应用
CN114903904B (zh) * 2021-02-08 2024-02-09 宜昌人福药业有限责任公司 瑞马唑仑药用盐和阿片样物质的注射用药物组合物
CN116270659A (zh) * 2023-01-13 2023-06-23 上海市胸科医院 瑞马唑仑在制备治疗、减缓或处理骨癌疼痛的产品中的用途

Family Cites Families (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3520877A (en) 1967-10-02 1970-07-21 Hoffmann La Roche 3-carbonyl amino acetic acid ethyl ester substituted benzodiazepines
BR6915069D0 (pt) 1969-02-28 1973-08-16 Upjohn Co Compostos organicos e processo
NL7012813A (enExample) 1969-09-01 1971-03-03
DE2156472A1 (de) 1970-11-23 1972-05-31 Ciba-Geigy Ag, Basel (Schweiz) Verfahren zur Herstellung von neuen Diazepinderivaten
US3933794A (en) 1971-08-04 1976-01-20 The Upjohn Company 2-(2-Alkynylamino)-3H-1,4-benzodiazepines
FR2183716A1 (en) 1972-05-05 1973-12-21 Centre Etd Ind Pharma Substd-6-phenyl-4h-imidazo (1,2-a)-1,4-benzo diazepines - - tranquillisers anxiolytics,sedatives and muscle-relaxants
IE41197B1 (en) 1973-05-29 1979-11-07 Squibb & Sons Inc 4h-s-triazolo (4,3-a)(1,5)benzodiazepin-5-ones
CH608234A5 (en) 1974-08-30 1978-12-29 Crc Ricerca Chim Process for the preparation of lithium salts of 1,4-benzodiazepines
DE2900017A1 (de) 1978-01-10 1979-07-12 Clin Midy 3-alkoxycarbonyl-benzodiazepin- derivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
MC1528A1 (fr) 1982-07-21 1984-04-13 Hoffmann La Roche Imidazobenzodiazepines
IT1165588B (it) 1983-03-23 1987-04-22 Medosan Ind Biochimi 1,4 benzodiazepine terapeuticamente attive
CA1332410C (en) 1984-06-26 1994-10-11 Roger M. Freidinger Benzodiazepine analogs
US4755508A (en) 1984-06-26 1988-07-05 Merck & Co., Inc. Benzodiazepine analogs and use as antogonists of gastrin and cholecystokinin
US4820834A (en) 1984-06-26 1989-04-11 Merck & Co., Inc. Benzodiazepine analogs
US4724237A (en) 1984-06-26 1988-02-09 Merck & Co., Inc. 2-substituted-aminomethyl-1,4-benzodiazepines
DE3435973A1 (de) 1984-10-01 1986-04-10 Boehringer Ingelheim KG, 6507 Ingelheim Diazepine enthaltende pharmazeutische zusammensetzungen mit paf-antagonistischer wirkung
ES2084577T3 (es) 1986-10-24 1996-05-16 Abbott Lab Ensayo, trazadores, inmunogenos y anticuerpos para benzodiazepinas.
JP2620642B2 (ja) * 1988-04-29 1997-06-18 ベーカー ノートン ファーマシューティカルズ インコーポレイテッド 麻薬性鎮痛剤とベンゾジアゼピンとを組み合わせて非経口投与した後に観察される平均血圧の低下を拮抗させるための医薬品
US5019583A (en) 1989-02-15 1991-05-28 Glaxo Inc. N-phenyl-N-(4-piperidinyl)amides useful as analgesics
EP0411668B2 (en) 1989-08-04 1998-11-11 MERCK SHARP & DOHME LTD. Central cholecystokinin antagonists for treatment of psychiatric disorders
KR0167349B1 (ko) 1989-10-20 1999-02-18 오스카 아끼히꼬 벤조헤테로 고리 화합물
US5324726A (en) 1989-12-18 1994-06-28 Merck & Co., Inc. Benzodiazepine analogs
IL96613A0 (en) 1989-12-18 1991-09-16 Merck & Co Inc Pharmaceutical compositions containing benzodiazepine analogs
IE904560A1 (en) 1989-12-18 1991-06-19 Merck & Co Inc New benzodiazepine analogs
US5220017A (en) 1991-04-10 1993-06-15 Merck & Co., Inc. Cholecystokinin antagonists
US5185331A (en) 1991-05-14 1993-02-09 Merck & Co., Inc. Triazolobenzodiazepines
EP0523845A3 (en) 1991-06-14 1993-11-18 Merck & Co Inc New benzodiazepine analogs
GB9117852D0 (en) 1991-08-19 1991-10-09 Merck Sharp & Dohme Therapeutic agents
US5593988A (en) 1991-10-11 1997-01-14 Yoshitomi Pharmaceutical Industries, Ltd. Therapeutic agent for osteoporosis and diazepine compound
AU678503B2 (en) 1993-09-24 1997-05-29 Takeda Chemical Industries Ltd. Condensed heterocyclic compounds and their use as squalene synthetase inhibitors
CA2143246C (en) 1994-03-16 2000-08-22 Thierry Godel Imidazodiazepines
US5834464A (en) 1994-11-18 1998-11-10 Merck & Co., Inc. Imidazolinobenzodiazepines
AU4296196A (en) 1995-01-06 1996-07-24 F. Hoffmann-La Roche Ag Hydroxymethylimidazodiazepines and their esters
AU4382896A (en) 1995-02-02 1996-08-21 F. Hoffmann-La Roche Ag Acetylimidazobenzodiazepines
UA57734C2 (uk) 1996-05-07 2003-07-15 Пфайзер Інк. Комплекси включення арилгетероциклічних солей
CA2257948A1 (en) 1996-06-28 1998-01-08 Merck & Co., Inc. Antiarrhythmic combinations of selective iks antagonists with beta-adenergic blocking agents
US6635632B1 (en) 1996-12-23 2003-10-21 Athena Neurosciences, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
EP0881235A1 (fr) 1997-05-26 1998-12-02 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Nouveaux ylures de phosphore, leur préparation et leurs utilisations notamment en tant que bases fortes faiblement nucléophiles
US6440959B1 (en) 1999-04-21 2002-08-27 Hoffman-La Roche Inc. Pyrazolobenzodiazepines
US7160880B1 (en) 1999-05-14 2007-01-09 Cenes Limited Short-acting benzodiazepines
GB9911152D0 (en) 1999-05-14 1999-07-14 Glaxo Group Ltd Short-acting benzodiazepines
US7806886B2 (en) 1999-06-03 2010-10-05 Medtronic Minimed, Inc. Apparatus and method for controlling insulin infusion with state variable feedback
EP1161949A1 (en) 2000-06-09 2001-12-12 Warner-Lambert Company Use od diazepinoindoles for the treatment of chronic obstructive pulmonary disease
CN101838218A (zh) 2002-02-28 2010-09-22 日本烟草产业株式会社 酯化合物及其医药用途
HU226410B1 (en) 2003-04-22 2008-11-28 Egis Gyogyszergyar Nyilvanosan Novel polymorphous forms of olanzapine hydrochlorides, process for producing them, use thereof and pharmaceutical compositions containing them
BRPI0507594A (pt) 2004-02-11 2007-07-03 Amylin Pharmaceuticals Inc polipetìdeos hìbridos com propriedades selecionáveis
SI21850A (sl) 2004-07-28 2006-02-28 Krka, Tovarna Zdravil, D.D., Novo Mesto Soli olanzapina in njihova pretvorba v prosto bazo olanzapina
WO2006044504A1 (en) 2004-10-13 2006-04-27 Merck & Co., Inc. Cgrp receptor antagonists
WO2006078554A2 (en) 2005-01-18 2006-07-27 Merck & Co., Inc. Cgrp receptor antagonists
EA013433B1 (ru) 2005-02-15 2010-04-30 Элан Фарма Интернэшнл Лтд. Аэрозольные и впрыскиваемые рецептуры лекарственных препаратов бензодиазепина, состоящего из наночастиц
US20070040501A1 (en) 2005-08-18 2007-02-22 Aitken Bruce G Method for inhibiting oxygen and moisture degradation of a device and the resulting device
DE602007009128D1 (de) 2006-07-10 2010-10-21 Paion Uk Ltd Benzodiazepinsalze mit kurzzeitwirkung und polymorphe formen davon
GB0613692D0 (en) 2006-07-10 2006-08-16 Cenes Ltd Benzodiazepine salts
GB0613693D0 (en) 2006-07-10 2006-08-16 Cenes Ltd Benzodiazepine salts (3)
EA015529B1 (ru) 2007-05-22 2011-08-30 Кемосентрикс, Инк. 3-(имидазолил)пиразоло[3,4-b]пиридины
WO2009145323A1 (ja) 2008-05-30 2009-12-03 日産化学工業株式会社 多環式化合物を用いるアルコールの酸化方法
US20110294843A1 (en) 2008-10-16 2011-12-01 Paion Uk Limited Administration scheme of polar opioid metabolites for post-operative pain management
CA2755338C (en) 2009-03-30 2017-01-10 Nippon Paper Industries Co., Ltd. Method for recovery/reuse of n-oxyl compound
EP2305647A1 (en) 2009-09-18 2011-04-06 PAION UK Limited Process for preparing 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4 H-imidazo[1,2-a][1,4]benzodiazepine-4-yl] propionic acid methyl ester or the benzene sulfonate salt thereof, and compounds useful in that process
KR20120097508A (ko) 2009-11-05 2012-09-04 글락소스미스클라인 엘엘씨 벤조디아제핀 브로모도메인 억제제
JP5635275B2 (ja) 2010-01-28 2014-12-03 日清紡ホールディングス株式会社 アルコールの酸化方法
EP2450039A1 (en) * 2010-11-08 2012-05-09 PAION UK Ltd. Dosing regimen for sedation with CNS 7056 (Remimazolam)
CN102964349A (zh) 2011-08-31 2013-03-13 江苏恒瑞医药股份有限公司 苯并二氮杂*衍生物的托西酸盐及其多晶型、它们的制备方法和用途
JP5585597B2 (ja) 2012-01-27 2014-09-10 株式会社デンソー 車輪位置検出装置およびそれを備えたタイヤ空気圧検出装置
GEAP201813666A (en) 2012-05-22 2018-01-25 Paion Uk Ltd Compositions comprising short-acting benzodiazepines
SI2891494T1 (sl) 2012-08-31 2023-12-29 Paion Uk Limited Postopek za dajanje hipnotika/pomirjevala
CA2887728C (en) 2012-09-28 2019-07-09 Huawei Technologies Co., Ltd. Channel-state information process processing method, network device, and user equipment
AR094963A1 (es) 2013-03-04 2015-09-09 Ono Pharmaceutical Co Reacción de oxidación excelente en el índice de conversión

Similar Documents

Publication Publication Date Title
JP2013541567A5 (enExample)
US20230346796A1 (en) Dosing regimen for sedation with cns 7056 (remimazolam)
US9119848B2 (en) Morphinan derivatives for the treatment of drug overdose
JP6279547B2 (ja) オピオイド誘発性有害薬力学的応答を治療するためのシステムおよび方法
JP2011519930A5 (enExample)
WO2020055725A4 (en) Dopamine d3 receptor selective antagonists/partial agonists and uses thereof
JP6563685B2 (ja) オピオイドと組み合わせたパルミトイルエタノールアミドの使用
US20200276187A1 (en) Systems and methods for attenuating opioid-induced euphoria
JP2013510842A5 (enExample)
EP2014288A1 (en) Combination of benzyl-4, 5-dihydro-1H-imidazole derivative and an opioid receptor ligand
RU2012124063A (ru) Лекарственная комбинация с теобромином и ее использование в лечении
JP2011513278A5 (enExample)
HK1174496B (en) Morphinan derivatives for the treatment of drug overdose
HK1174496A (en) Morphinan derivatives for the treatment of drug overdose