AU2011328497B8 - Dosing regimen for sedation with CNS 7056 (remimazolam) - Google Patents

Dosing regimen for sedation with CNS 7056 (remimazolam) Download PDF

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Publication number
AU2011328497B8
AU2011328497B8 AU2011328497A AU2011328497A AU2011328497B8 AU 2011328497 B8 AU2011328497 B8 AU 2011328497B8 AU 2011328497 A AU2011328497 A AU 2011328497A AU 2011328497 A AU2011328497 A AU 2011328497A AU 2011328497 B8 AU2011328497 B8 AU 2011328497B8
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Prior art keywords
cns
dose
fentanyl
sedation
doses
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AU2011328497A
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AU2011328497A1 (en
AU2011328497B2 (en
AU2011328497A8 (en
Inventor
Keith Borkett
Gary Stuart Tilbrook
Karin Wilhelm-Ogunbiyi
Hugh Wiltshire
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Paion UK Ltd
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Paion UK Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2011328497A 2010-11-08 2011-11-07 Dosing regimen for sedation with CNS 7056 (remimazolam) Active AU2011328497B8 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
EP10014366.8 2010-11-08
EP10014366 2010-11-08
EP10014784 2010-11-19
EP10014784.2 2010-11-19
EP10014819 2010-11-22
EP10014819.6 2010-11-22
EP10014972A EP2450039A1 (en) 2010-11-08 2010-11-25 Dosing regimen for sedation with CNS 7056 (Remimazolam)
EP10014972.3 2010-11-25
PCT/EP2011/005581 WO2012062439A1 (en) 2010-11-08 2011-11-07 Dosing regimen for sedation with cns 7056 (remimazolam)

Publications (4)

Publication Number Publication Date
AU2011328497A1 AU2011328497A1 (en) 2013-04-18
AU2011328497B2 AU2011328497B2 (en) 2015-03-12
AU2011328497B8 true AU2011328497B8 (en) 2015-04-16
AU2011328497A8 AU2011328497A8 (en) 2015-04-16

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ID=44907114

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2011328497A Active AU2011328497B8 (en) 2010-11-08 2011-11-07 Dosing regimen for sedation with CNS 7056 (remimazolam)

Country Status (17)

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US (10) US9561236B2 (enExample)
EP (3) EP2450039A1 (enExample)
JP (1) JP6084571B2 (enExample)
KR (1) KR102059399B1 (enExample)
CN (1) CN103347519B (enExample)
AU (1) AU2011328497B8 (enExample)
DK (1) DK2637662T3 (enExample)
EA (1) EA024926B1 (enExample)
ES (1) ES2715179T3 (enExample)
HR (1) HRP20190447T1 (enExample)
HU (1) HUE044095T2 (enExample)
LT (1) LT2637662T (enExample)
PL (1) PL2637662T3 (enExample)
PT (1) PT2637662T (enExample)
RS (1) RS58577B1 (enExample)
SI (1) SI2637662T1 (enExample)
WO (1) WO2012062439A1 (enExample)

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