JP2013541564A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013541564A5 JP2013541564A5 JP2013537002A JP2013537002A JP2013541564A5 JP 2013541564 A5 JP2013541564 A5 JP 2013541564A5 JP 2013537002 A JP2013537002 A JP 2013537002A JP 2013537002 A JP2013537002 A JP 2013537002A JP 2013541564 A5 JP2013541564 A5 JP 2013541564A5
- Authority
- JP
- Japan
- Prior art keywords
- noroxymorphone
- mixing
- reaction
- mixture
- optionally
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 16
- 239000002253 acid Substances 0.000 claims 7
- HLMSIZPQBSYUNL-IPOQPSJVSA-N Noroxymorphone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(O)C2=C5[C@@]13CCN4 HLMSIZPQBSYUNL-IPOQPSJVSA-N 0.000 claims 6
- 238000002156 mixing Methods 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 5
- ZFPGARUNNKGOBB-UHFFFAOYSA-N 1-Ethyl-2-pyrrolidinone Chemical compound CCN1CCCC1=O ZFPGARUNNKGOBB-UHFFFAOYSA-N 0.000 claims 4
- WJBLNOPPDWQMCH-MBPVOVBZSA-N Nalmefene Chemical compound N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CCC5=C)O)CC1)O)CC1CC1 WJBLNOPPDWQMCH-MBPVOVBZSA-N 0.000 claims 4
- 238000006243 chemical reaction Methods 0.000 claims 4
- 229960003086 naltrexone Drugs 0.000 claims 4
- DQCKKXVULJGBQN-XFWGSAIBSA-N naltrexone Chemical compound N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CCC5=O)O)CC1)O)CC1CC1 DQCKKXVULJGBQN-XFWGSAIBSA-N 0.000 claims 4
- 239000002516 radical scavenger Substances 0.000 claims 4
- 239000007787 solid Substances 0.000 claims 4
- 229960005297 nalmefene Drugs 0.000 claims 3
- 239000011541 reaction mixture Substances 0.000 claims 3
- JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical group CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 claims 2
- 125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 claims 2
- -1 cyclopropylmethyl halide Chemical class 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- 238000007239 Wittig reaction Methods 0.000 claims 1
- 239000000010 aprotic solvent Substances 0.000 claims 1
- AEILLAXRDHDKDY-UHFFFAOYSA-N bromomethylcyclopropane Chemical group BrCC1CC1 AEILLAXRDHDKDY-UHFFFAOYSA-N 0.000 claims 1
- 239000003610 charcoal Substances 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 150000007529 inorganic bases Chemical group 0.000 claims 1
- 150000007530 organic bases Chemical class 0.000 claims 1
- 230000001376 precipitating effect Effects 0.000 claims 1
- 239000003586 protic polar solvent Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41040510P | 2010-11-05 | 2010-11-05 | |
| DKPA201001007 | 2010-11-05 | ||
| US61/410,405 | 2010-11-05 | ||
| DKPA201001007 | 2010-11-05 | ||
| US201161489701P | 2011-05-25 | 2011-05-25 | |
| US61/489,701 | 2011-05-25 | ||
| DKPA201100396 | 2011-05-25 | ||
| DKPA201100396 | 2011-05-25 | ||
| PCT/DK2011/000128 WO2012059103A1 (en) | 2010-11-05 | 2011-11-04 | Method for the manufacturing of naltrexone |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016125389A Division JP6215399B2 (ja) | 2010-11-05 | 2016-06-24 | ナルトレキソンの製造方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013541564A JP2013541564A (ja) | 2013-11-14 |
| JP2013541564A5 true JP2013541564A5 (enExample) | 2014-12-18 |
| JP6246589B2 JP6246589B2 (ja) | 2017-12-13 |
Family
ID=45001588
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013537002A Active JP6246589B2 (ja) | 2010-11-05 | 2011-11-04 | ナルトレキソンの製造方法 |
| JP2016125389A Active JP6215399B2 (ja) | 2010-11-05 | 2016-06-24 | ナルトレキソンの製造方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016125389A Active JP6215399B2 (ja) | 2010-11-05 | 2016-06-24 | ナルトレキソンの製造方法 |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP2635586B1 (enExample) |
| JP (2) | JP6246589B2 (enExample) |
| AP (1) | AP3415A (enExample) |
| AU (1) | AU2011325563B2 (enExample) |
| CA (1) | CA2815093C (enExample) |
| CY (1) | CY1118742T1 (enExample) |
| DK (1) | DK2635586T3 (enExample) |
| EA (1) | EA022266B1 (enExample) |
| ES (1) | ES2620660T3 (enExample) |
| HR (1) | HRP20170379T1 (enExample) |
| HU (1) | HUE033596T2 (enExample) |
| LT (1) | LT2635586T (enExample) |
| ME (1) | ME02621B (enExample) |
| MX (1) | MX2013005009A (enExample) |
| PL (1) | PL2635586T3 (enExample) |
| PT (1) | PT2635586T (enExample) |
| RS (1) | RS55777B1 (enExample) |
| SI (1) | SI2635586T1 (enExample) |
| SM (1) | SMT201700177T1 (enExample) |
| WO (1) | WO2012059103A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140005216A1 (en) | 2012-06-27 | 2014-01-02 | H. Lundbeck A/S | Nalmefene for reduction of alcohol consumption in specific target populations |
| AR096851A1 (es) | 2013-07-11 | 2016-02-03 | H Lundbeck As | Sales que no forman hidratos ni solvatos de nalmefeno |
| KR20160093025A (ko) | 2013-12-20 | 2016-08-05 | 하. 룬트벡 아크티에 셀스카브 | 멜랑코리성 특색을 갖는 우울 장애의 치료를 위한 카파-활성을 갖는 오피오이드 수용체 길항제 및 보티옥세틴의 용도 |
| JP6797691B2 (ja) | 2014-04-22 | 2020-12-09 | 大塚製薬株式会社 | ブレクスピプラゾールとナルメフェンの組み合わせ剤及び物質関連障害を治療するためのその用途 |
| US9701687B2 (en) * | 2014-05-05 | 2017-07-11 | Noramco, Inc. | Process for the preparation of opioid compounds |
| US9701688B2 (en) * | 2014-05-05 | 2017-07-11 | Noramco, Inc. | Process for the preparation of opioid compounds |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4535157A (en) | 1983-11-01 | 1985-08-13 | Key Pharmaceuticals, Inc. | Process for making 6-desoxy-6-methylenenaloxone and 6-desoxy-6-methylenenaltrexone |
| US4751307A (en) | 1985-01-17 | 1988-06-14 | Mallinckrodt, Inc. | Wittig-reaction processes |
| ATE178329T1 (de) * | 1989-10-16 | 1999-04-15 | Us Health | Totale synthese von northebain-, normorphin-, noroxymorphon-enantiomeren und -derivaten via n- nor-zwischenverbindungen |
| FR2906252B1 (fr) * | 2006-09-21 | 2008-11-28 | Sanofi Aventis Sa | Procede de preparation d'halogenures de n-aklyl naltrexone |
| WO2008138383A1 (de) | 2007-05-16 | 2008-11-20 | Cilag Ag | Verfahren zur herstellung von n-methylnaltrexonbromid |
| CN102227433B (zh) * | 2008-09-30 | 2015-01-07 | 马林克罗特有限公司 | 烷基化吗啡喃衍生物的仲胺基团的方法 |
| PL2435439T3 (pl) | 2009-05-25 | 2016-05-31 | H Lundbeck As | Wytwarzanie chlorowodorku nalmefenu z naltreksonu |
-
2011
- 2011-11-04 AU AU2011325563A patent/AU2011325563B2/en not_active Ceased
- 2011-11-04 EP EP11785301.0A patent/EP2635586B1/en active Active
- 2011-11-04 JP JP2013537002A patent/JP6246589B2/ja active Active
- 2011-11-04 AP AP2013006897A patent/AP3415A/xx active
- 2011-11-04 HU HUE11785301A patent/HUE033596T2/hu unknown
- 2011-11-04 SM SM20170177T patent/SMT201700177T1/it unknown
- 2011-11-04 CA CA2815093A patent/CA2815093C/en active Active
- 2011-11-04 DK DK11785301.0T patent/DK2635586T3/en active
- 2011-11-04 PL PL11785301T patent/PL2635586T3/pl unknown
- 2011-11-04 HR HRP20170379TT patent/HRP20170379T1/hr unknown
- 2011-11-04 PT PT117853010T patent/PT2635586T/pt unknown
- 2011-11-04 ES ES11785301.0T patent/ES2620660T3/es active Active
- 2011-11-04 RS RS20170244A patent/RS55777B1/sr unknown
- 2011-11-04 MX MX2013005009A patent/MX2013005009A/es active IP Right Grant
- 2011-11-04 SI SI201131131A patent/SI2635586T1/sl unknown
- 2011-11-04 ME MEP-2017-57A patent/ME02621B/me unknown
- 2011-11-04 LT LTEP11785301.0T patent/LT2635586T/lt unknown
- 2011-11-04 WO PCT/DK2011/000128 patent/WO2012059103A1/en not_active Ceased
- 2011-11-04 EA EA201390658A patent/EA022266B1/ru not_active IP Right Cessation
-
2016
- 2016-06-24 JP JP2016125389A patent/JP6215399B2/ja active Active
-
2017
- 2017-03-17 CY CY20171100341T patent/CY1118742T1/el unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2013541564A5 (enExample) | ||
| JP2015500335A5 (enExample) | ||
| JP2012527489A5 (enExample) | ||
| JP2009256615A5 (enExample) | ||
| JP2017522276A5 (enExample) | ||
| JP2016520038A5 (enExample) | ||
| JP2015536898A5 (enExample) | ||
| JP2011513422A5 (enExample) | ||
| JP2016515039A5 (enExample) | ||
| JP2014533285A5 (enExample) | ||
| IN2012DN03176A (enExample) | ||
| JP2018507858A5 (enExample) | ||
| ME02621B (me) | Postupak za proizvodnju naltreksona | |
| JP2017520560A5 (enExample) | ||
| CN103788069B (zh) | 埃索美拉唑镁三水合物的制备方法 | |
| JP2013100237A5 (enExample) | ||
| CN103467354B (zh) | 一种双吲哚甲烷衍生物的制备方法 | |
| WO2012002662A3 (ko) | 편광자의 제조방법 | |
| JP2015523337A5 (enExample) | ||
| JP2020502077A5 (enExample) | ||
| JP2013064130A5 (enExample) | ||
| MX2016001199A (es) | Proceso para preparar rifaximina kappa. | |
| JP2018503602A5 (enExample) | ||
| CN104151195A (zh) | 一种二叠氮基乙二肟的一锅法合成方法 | |
| JP2018521085A5 (enExample) |