JP2012527489A5 - - Google Patents
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- Publication number
- JP2012527489A5 JP2012527489A5 JP2012512208A JP2012512208A JP2012527489A5 JP 2012527489 A5 JP2012527489 A5 JP 2012527489A5 JP 2012512208 A JP2012512208 A JP 2012512208A JP 2012512208 A JP2012512208 A JP 2012512208A JP 2012527489 A5 JP2012527489 A5 JP 2012527489A5
- Authority
- JP
- Japan
- Prior art keywords
- mthf
- nalmefene
- methyltriphenylphosphonium
- naltrexone
- hcl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200900650 | 2009-05-25 | ||
| DKPA200900650 | 2009-05-25 | ||
| US18102209P | 2009-05-26 | 2009-05-26 | |
| US61/181,022 | 2009-05-26 | ||
| PCT/DK2010/050110 WO2010136039A1 (en) | 2009-05-25 | 2010-05-21 | Preparation of nalmefene hydrochloride from naltrexone |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012527489A JP2012527489A (ja) | 2012-11-08 |
| JP2012527489A5 true JP2012527489A5 (enExample) | 2013-06-27 |
| JP5794980B2 JP5794980B2 (ja) | 2015-10-14 |
Family
ID=43222172
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012512208A Active JP5794980B2 (ja) | 2009-05-25 | 2010-05-21 | ナルトレキソンからの塩酸ナルメフェンの調製 |
Country Status (35)
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2580201B1 (en) | 2010-06-11 | 2017-08-02 | Rhodes Technologies | Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof |
| DK2635586T3 (en) | 2010-11-05 | 2017-03-27 | H Lundbeck As | PROCEDURE FOR THE PREPARATION OF NALTREXON |
| CN103012416B (zh) * | 2011-09-28 | 2015-07-01 | 辽宁海思科制药有限公司 | 一种盐酸纳美芬的制备方法 |
| TWI560170B (en) | 2011-12-06 | 2016-12-01 | Lundbeck & Co As H | Process for recovery of nalmefene hydrochloride |
| CN102584840A (zh) * | 2011-12-28 | 2012-07-18 | 南京优科生物医药有限公司 | 一种制备纳美芬化合物的方法 |
| WO2013164383A1 (en) | 2012-05-03 | 2013-11-07 | H. Lundbeck A/S | Method for the manufacturing of naltrexone |
| US20140005216A1 (en) | 2012-06-27 | 2014-01-02 | H. Lundbeck A/S | Nalmefene for reduction of alcohol consumption in specific target populations |
| CN103204859B (zh) * | 2013-04-25 | 2015-12-02 | 四川海思科制药有限公司 | 一种盐酸纳美芬化合物及其制备方法 |
| AR096851A1 (es) * | 2013-07-11 | 2016-02-03 | H Lundbeck As | Sales que no forman hidratos ni solvatos de nalmefeno |
| JP6448645B2 (ja) | 2013-12-20 | 2019-01-09 | ハー・ルンドベック・アクチエゼルスカベット | メランコリアの特徴を伴う抑うつ障害を処置するための、カッパ−活性を伴うオピオイド受容体拮抗薬およびボルチオキセチンの使用 |
| AU2015250611A1 (en) | 2014-04-22 | 2016-11-24 | H. Lundbeck A/S | Combination of brexpiprazole and nalmefene and use thereof for treating substance-related disorders |
| CN104513251A (zh) * | 2014-11-28 | 2015-04-15 | 安徽悦康凯悦制药有限公司 | 一种盐酸纳美芬的制备方法 |
| US9757372B2 (en) * | 2015-03-25 | 2017-09-12 | Taiwanj Pharmaceuticals Co., Ltd. | Toll-like receptor 4 antagonists and use in autoimmune liver diseases |
| RU2712232C1 (ru) * | 2018-10-05 | 2020-01-27 | Федеральное государственное унитарное предприятие "Научно-исследовательский институт гигиены, профпатологии и экологии человека" Федерального медико-биологического агентства | Улучшенный способ получения налмефена из налтрексона |
| US10927121B1 (en) | 2019-12-20 | 2021-02-23 | Southwest Research Institute | Technologies for removing residual solvent from nalmefene hydrochloride and producing crystalline nalmefene hydrochloride monohydrate, monosolvate, or crystalline nalmefene hydrochloride dihydrate |
| JP2023548356A (ja) | 2020-11-02 | 2023-11-16 | ローズ テクノロジーズ | ノルオキシモルホンを精製するための方法 |
| WO2022165040A1 (en) | 2021-01-28 | 2022-08-04 | Rhodes Technologies | Process for crystallizing nalmefene hydrochloride |
| CN117843650A (zh) * | 2023-12-27 | 2024-04-09 | 南京海纳医药科技股份有限公司 | 一种盐酸纳美芬的精制方法 |
| CN117986261B (zh) * | 2024-04-02 | 2024-06-18 | 成都瑞尔医药科技有限公司 | 一种盐酸纳美芬母液的回收套用方法 |
| CN119080788A (zh) * | 2024-08-19 | 2024-12-06 | 南京海鲸药业股份有限公司 | 一种盐酸纳美芬杂质的去除监控系统及去除方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4341764A (en) | 1980-03-05 | 1982-07-27 | Cutter Laboratories, Inc. | Method of preparing fibronectin and antihemophilic factor |
| US4322426A (en) | 1980-04-28 | 1982-03-30 | E. I. Du Pont De Nemours And Company | 17-Substituted-6-desoxy-7,8-dihydro-6α-methylnoroxymorphone narcotic antagonists |
| US4535157A (en) * | 1983-11-01 | 1985-08-13 | Key Pharmaceuticals, Inc. | Process for making 6-desoxy-6-methylenenaloxone and 6-desoxy-6-methylenenaltrexone |
| US4751307A (en) | 1985-01-17 | 1988-06-14 | Mallinckrodt, Inc. | Wittig-reaction processes |
| US4880813A (en) * | 1988-07-22 | 1989-11-14 | Baker Cummins Pharmaceuticals, Inc. | Method of treatment for allergic rhinitis |
| US7687646B2 (en) | 2006-03-28 | 2010-03-30 | Azad Pharmaceutical Ingredients, Ag | Polymorphic forms of olopatadine hydrochloride and methods for producing olopatadine and salts thereof |
| GB2447013A (en) * | 2007-03-01 | 2008-09-03 | Reckitt Benckiser Healthcare | Analgesic composition containing buprenorphone and nalmefene |
-
2010
- 2010-05-21 ME MEP-2016-40A patent/ME02622B/me unknown
- 2010-05-21 DK DK10720257.4T patent/DK2435439T3/en active
- 2010-05-21 KR KR1020117028079A patent/KR101716522B1/ko not_active Expired - Fee Related
- 2010-05-21 CA CA2763093A patent/CA2763093C/en active Active
- 2010-05-21 AU AU2010252392A patent/AU2010252392B2/en not_active Ceased
- 2010-05-21 ES ES10720257.4T patent/ES2564006T3/es active Active
- 2010-05-21 MY MYPI2011005679A patent/MY158251A/en unknown
- 2010-05-21 GE GEAP201012510A patent/GEP20146190B/en unknown
- 2010-05-21 UA UAA201114599A patent/UA106752C2/uk unknown
- 2010-05-21 MA MA34465A patent/MA33368B1/fr unknown
- 2010-05-21 EA EA201171461A patent/EA019331B1/ru not_active IP Right Cessation
- 2010-05-21 RS RS20160137A patent/RS54599B1/sr unknown
- 2010-05-21 PL PL10720257T patent/PL2435439T3/pl unknown
- 2010-05-21 MX MX2011012502A patent/MX2011012502A/es active IP Right Grant
- 2010-05-21 SG SG2011086501A patent/SG176205A1/en unknown
- 2010-05-21 BR BRPI1010975-7A patent/BRPI1010975B1/pt not_active IP Right Cessation
- 2010-05-21 HU HUE10720257A patent/HUE026892T2/en unknown
- 2010-05-21 SI SI201031133A patent/SI2435439T1/sl unknown
- 2010-05-21 US US13/321,597 patent/US8598352B2/en not_active Expired - Fee Related
- 2010-05-21 WO PCT/DK2010/050110 patent/WO2010136039A1/en not_active Ceased
- 2010-05-21 JP JP2012512208A patent/JP5794980B2/ja active Active
- 2010-05-21 HR HRP20160110TT patent/HRP20160110T1/hr unknown
- 2010-05-21 NZ NZ596988A patent/NZ596988A/xx not_active IP Right Cessation
- 2010-05-21 CN CN201080033670.3A patent/CN102459276B/zh not_active Expired - Fee Related
- 2010-05-21 EP EP10720257.4A patent/EP2435439B8/en active Active
- 2010-05-24 TW TW99116496A patent/TWI469985B/zh not_active IP Right Cessation
- 2010-05-26 AR ARP100101818A patent/AR076891A1/es unknown
-
2011
- 2011-11-17 IL IL216422A patent/IL216422A/en not_active IP Right Cessation
- 2011-11-21 TN TNP2011000590A patent/TN2011000590A1/en unknown
- 2011-11-22 CR CR20110612A patent/CR20110612A/es unknown
- 2011-11-23 DO DO2011000362A patent/DOP2011000362A/es unknown
- 2011-11-24 CL CL2011002974A patent/CL2011002974A1/es unknown
- 2011-11-24 ZA ZA2011/08659A patent/ZA201108659B/en unknown
- 2011-11-25 CO CO11162008A patent/CO6470832A2/es active IP Right Grant
-
2016
- 2016-02-26 SM SM201600061T patent/SMT201600061B/it unknown
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