AR076891A1 - Metodo para la preparacion de clorhidrato de nalmefeno - Google Patents
Metodo para la preparacion de clorhidrato de nalmefenoInfo
- Publication number
- AR076891A1 AR076891A1 ARP100101818A ARP100101818A AR076891A1 AR 076891 A1 AR076891 A1 AR 076891A1 AR P100101818 A ARP100101818 A AR P100101818A AR P100101818 A ARP100101818 A AR P100101818A AR 076891 A1 AR076891 A1 AR 076891A1
- Authority
- AR
- Argentina
- Prior art keywords
- naltrexone
- organic phase
- optionally
- nalmefene
- solid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Addiction (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Método para la produccion de clorhidrato de nalmefeno a partir de naltrexona. Reivindicacion 1: Un método para preparar nalmefeno a partir de naltrexona en una reaccion de Wittig en la cual se utiliza 2-metiltetrahidrofurano (MTHF) tanto en la formacion de un iluro de fosforo como en la reaccion subsiguiente entre dicho iluro y naltrexona. Reivindicacion 2: El método de acuerdo con la reivindicacion 1, que comprende los siguientes pasos: a) preparacion de un iluro de fosforo mezclando una sal de metiltrifenilfosfonio con MTHF y una base adecuada y b) adicion de una mezcla que comprende naltrexona y MTHF a la mezcla obtenida en el paso a). Reivindicacion 12: Un método para aislar el nalmefeno obtenido en el paso b) de acuerdo con cualquiera de las reivindicaciones anteriores, método que comprende los siguientes pasos; c) (i) mezclar una solucion acuosa que comprende cloruro de amonio (NH4CI) con la mezcla obtenida en el paso b) o (ii) mezclar un ácido o una solucion con contenido de ácido con la mezcla obtenida en el paso b), (iii) mezclar una cetona con la mezcla obtenida en el paso b) o (iv) realizar una combinacion de los mencionados pasos (i), (ii) y (iii), y a continuacion (v) opcionalmente, diluir con agua, (d) separar la fase orgánica obtenida en el paso c), e) opcionalmente, lavar la fase orgánica obtenida en c) con agua y separar la fase orgánica, f) concentrar la fase orgánica obtenida en el paso d) o e) al vacío para eliminar los volátiles, g) diluir el residuo obtenido en el paso f) con uno o más solventes orgánicos apropiados, h) agregar cloruro de hidrogeno (HCI) a la mezcla obtenida en el paso g), i) aislar el solido así obtenido, j) opcionalmente, resuspender el solido obtenido en el paso i) en uno o más solventes apropiados y aislar el solido y k) opcionalmente, secar el solido final.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200900650 | 2009-05-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR076891A1 true AR076891A1 (es) | 2011-07-13 |
Family
ID=43222172
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP100101818A AR076891A1 (es) | 2009-05-25 | 2010-05-26 | Metodo para la preparacion de clorhidrato de nalmefeno |
Country Status (35)
Country | Link |
---|---|
US (1) | US8598352B2 (es) |
EP (1) | EP2435439B8 (es) |
JP (1) | JP5794980B2 (es) |
KR (1) | KR101716522B1 (es) |
CN (1) | CN102459276B (es) |
AR (1) | AR076891A1 (es) |
AU (1) | AU2010252392B2 (es) |
BR (1) | BRPI1010975B1 (es) |
CA (1) | CA2763093C (es) |
CL (1) | CL2011002974A1 (es) |
CO (1) | CO6470832A2 (es) |
CR (1) | CR20110612A (es) |
DK (1) | DK2435439T3 (es) |
DO (1) | DOP2011000362A (es) |
EA (1) | EA019331B1 (es) |
ES (1) | ES2564006T3 (es) |
GE (1) | GEP20146190B (es) |
HR (1) | HRP20160110T1 (es) |
HU (1) | HUE026892T2 (es) |
IL (1) | IL216422A (es) |
MA (1) | MA33368B1 (es) |
ME (1) | ME02622B (es) |
MX (1) | MX2011012502A (es) |
MY (1) | MY158251A (es) |
NZ (1) | NZ596988A (es) |
PL (1) | PL2435439T3 (es) |
RS (1) | RS54599B1 (es) |
SG (1) | SG176205A1 (es) |
SI (1) | SI2435439T1 (es) |
SM (1) | SMT201600061B (es) |
TN (1) | TN2011000590A1 (es) |
TW (1) | TWI469985B (es) |
UA (1) | UA106752C2 (es) |
WO (1) | WO2010136039A1 (es) |
ZA (1) | ZA201108659B (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2995614B8 (en) | 2010-06-11 | 2018-03-28 | Rhodes Technologies Inc. | Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof |
SI2635586T1 (sl) | 2010-11-05 | 2017-07-31 | H. Lundbeck A/S | Metoda za izdelavo naltreksona |
CN103012416B (zh) * | 2011-09-28 | 2015-07-01 | 辽宁海思科制药有限公司 | 一种盐酸纳美芬的制备方法 |
TWI560170B (en) * | 2011-12-06 | 2016-12-01 | Lundbeck & Co As H | Process for recovery of nalmefene hydrochloride |
CN102584840A (zh) * | 2011-12-28 | 2012-07-18 | 南京优科生物医药有限公司 | 一种制备纳美芬化合物的方法 |
WO2013164383A1 (en) | 2012-05-03 | 2013-11-07 | H. Lundbeck A/S | Method for the manufacturing of naltrexone |
US20140005216A1 (en) | 2012-06-27 | 2014-01-02 | H. Lundbeck A/S | Nalmefene for reduction of alcohol consumption in specific target populations |
CN103204859B (zh) * | 2013-04-25 | 2015-12-02 | 四川海思科制药有限公司 | 一种盐酸纳美芬化合物及其制备方法 |
AR096851A1 (es) * | 2013-07-11 | 2016-02-03 | H Lundbeck As | Sales que no forman hidratos ni solvatos de nalmefeno |
EP3082815B1 (en) | 2013-12-20 | 2018-10-03 | H. Lundbeck A/S | Use of an opioid receptor antagonist with kappa-activity and vortioxetine for treatment of depressive disorder with melancholic features |
RU2016145411A (ru) | 2014-04-22 | 2018-05-23 | Оцука Фармасьютикал Ко., Лтд. | Комбинация брекспипразола и налмефена, и ее применение для лечения синдрома химической зависимости |
CN104513251A (zh) * | 2014-11-28 | 2015-04-15 | 安徽悦康凯悦制药有限公司 | 一种盐酸纳美芬的制备方法 |
US9757372B2 (en) * | 2015-03-25 | 2017-09-12 | Taiwanj Pharmaceuticals Co., Ltd. | Toll-like receptor 4 antagonists and use in autoimmune liver diseases |
RU2712232C1 (ru) * | 2018-10-05 | 2020-01-27 | Федеральное государственное унитарное предприятие "Научно-исследовательский институт гигиены, профпатологии и экологии человека" Федерального медико-биологического агентства | Улучшенный способ получения налмефена из налтрексона |
US10927121B1 (en) | 2019-12-20 | 2021-02-23 | Southwest Research Institute | Technologies for removing residual solvent from nalmefene hydrochloride and producing crystalline nalmefene hydrochloride monohydrate, monosolvate, or crystalline nalmefene hydrochloride dihydrate |
JP2023548356A (ja) | 2020-11-02 | 2023-11-16 | ローズ テクノロジーズ | ノルオキシモルホンを精製するための方法 |
US20240109907A1 (en) | 2021-01-28 | 2024-04-04 | Rhodes Technologies | Process for crystallizing nalmefene hydrochloride |
CN117986261B (zh) * | 2024-04-02 | 2024-06-18 | 成都瑞尔医药科技有限公司 | 一种盐酸纳美芬母液的回收套用方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4341764A (en) | 1980-03-05 | 1982-07-27 | Cutter Laboratories, Inc. | Method of preparing fibronectin and antihemophilic factor |
US4322426A (en) * | 1980-04-28 | 1982-03-30 | E. I. Du Pont De Nemours And Company | 17-Substituted-6-desoxy-7,8-dihydro-6α-methylnoroxymorphone narcotic antagonists |
US4535157A (en) * | 1983-11-01 | 1985-08-13 | Key Pharmaceuticals, Inc. | Process for making 6-desoxy-6-methylenenaloxone and 6-desoxy-6-methylenenaltrexone |
US4751307A (en) * | 1985-01-17 | 1988-06-14 | Mallinckrodt, Inc. | Wittig-reaction processes |
US4880813A (en) * | 1988-07-22 | 1989-11-14 | Baker Cummins Pharmaceuticals, Inc. | Method of treatment for allergic rhinitis |
US7687646B2 (en) | 2006-03-28 | 2010-03-30 | Azad Pharmaceutical Ingredients, Ag | Polymorphic forms of olopatadine hydrochloride and methods for producing olopatadine and salts thereof |
GB2447013A (en) * | 2007-03-01 | 2008-09-03 | Reckitt Benckiser Healthcare | Analgesic composition containing buprenorphone and nalmefene |
-
2010
- 2010-05-21 MX MX2011012502A patent/MX2011012502A/es active IP Right Grant
- 2010-05-21 EP EP10720257.4A patent/EP2435439B8/en active Active
- 2010-05-21 WO PCT/DK2010/050110 patent/WO2010136039A1/en active Application Filing
- 2010-05-21 KR KR1020117028079A patent/KR101716522B1/ko active IP Right Grant
- 2010-05-21 CA CA2763093A patent/CA2763093C/en active Active
- 2010-05-21 DK DK10720257.4T patent/DK2435439T3/en active
- 2010-05-21 GE GEAP201012510A patent/GEP20146190B/en unknown
- 2010-05-21 AU AU2010252392A patent/AU2010252392B2/en not_active Ceased
- 2010-05-21 SG SG2011086501A patent/SG176205A1/en unknown
- 2010-05-21 US US13/321,597 patent/US8598352B2/en active Active
- 2010-05-21 CN CN201080033670.3A patent/CN102459276B/zh not_active Expired - Fee Related
- 2010-05-21 MY MYPI2011005679A patent/MY158251A/en unknown
- 2010-05-21 RS RS20160137A patent/RS54599B1/en unknown
- 2010-05-21 ME MEP-2016-40A patent/ME02622B/me unknown
- 2010-05-21 BR BRPI1010975-7A patent/BRPI1010975B1/pt not_active IP Right Cessation
- 2010-05-21 NZ NZ596988A patent/NZ596988A/xx not_active IP Right Cessation
- 2010-05-21 JP JP2012512208A patent/JP5794980B2/ja active Active
- 2010-05-21 SI SI201031133A patent/SI2435439T1/sl unknown
- 2010-05-21 PL PL10720257T patent/PL2435439T3/pl unknown
- 2010-05-21 MA MA34465A patent/MA33368B1/fr unknown
- 2010-05-21 HU HUE10720257A patent/HUE026892T2/en unknown
- 2010-05-21 EA EA201171461A patent/EA019331B1/ru not_active IP Right Cessation
- 2010-05-21 ES ES10720257.4T patent/ES2564006T3/es active Active
- 2010-05-21 UA UAA201114599A patent/UA106752C2/uk unknown
- 2010-05-24 TW TW99116496A patent/TWI469985B/zh not_active IP Right Cessation
- 2010-05-26 AR ARP100101818A patent/AR076891A1/es unknown
-
2011
- 2011-11-17 IL IL216422A patent/IL216422A/en not_active IP Right Cessation
- 2011-11-21 TN TNP2011000590A patent/TN2011000590A1/en unknown
- 2011-11-22 CR CR20110612A patent/CR20110612A/es unknown
- 2011-11-23 DO DO2011000362A patent/DOP2011000362A/es unknown
- 2011-11-24 CL CL2011002974A patent/CL2011002974A1/es unknown
- 2011-11-24 ZA ZA2011/08659A patent/ZA201108659B/en unknown
- 2011-11-25 CO CO11162008A patent/CO6470832A2/es active IP Right Grant
-
2016
- 2016-02-01 HR HRP20160110TT patent/HRP20160110T1/hr unknown
- 2016-02-26 SM SM201600061T patent/SMT201600061B/it unknown
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