EA200801963A1 - СПОСОБ ПОЛУЧЕНИЯ ПОЛИМОРФНОЙ ФОРМЫ I ГИДРОСУЛЬФАТА (S)-(+)-МЕТИЛ-α-(2-ХЛОРФЕНИЛ)-6,7-ДИГИДРОТИЕНО-[3,2-C] ПИРИДИН-5(4H)-АЦЕТАТА - Google Patents

СПОСОБ ПОЛУЧЕНИЯ ПОЛИМОРФНОЙ ФОРМЫ I ГИДРОСУЛЬФАТА (S)-(+)-МЕТИЛ-α-(2-ХЛОРФЕНИЛ)-6,7-ДИГИДРОТИЕНО-[3,2-C] ПИРИДИН-5(4H)-АЦЕТАТА

Info

Publication number
EA200801963A1
EA200801963A1 EA200801963A EA200801963A EA200801963A1 EA 200801963 A1 EA200801963 A1 EA 200801963A1 EA 200801963 A EA200801963 A EA 200801963A EA 200801963 A EA200801963 A EA 200801963A EA 200801963 A1 EA200801963 A1 EA 200801963A1
Authority
EA
Eurasian Patent Office
Prior art keywords
dihydrothieno
chlorophenyl
methyl
polymorphic form
acetet
Prior art date
Application number
EA200801963A
Other languages
English (en)
Other versions
EA013543B1 (ru
Inventor
Шандор Гараднаи
Иштван Греинер
Йожеф Неу
Original Assignee
Рихтер Гедеон Нирт.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Рихтер Гедеон Нирт. filed Critical Рихтер Гедеон Нирт.
Publication of EA200801963A1 publication Critical patent/EA200801963A1/ru
Publication of EA013543B1 publication Critical patent/EA013543B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Изобретение относится к способу получения фармацевтически применимой полиморфной формы I гидросульфата (S)-(+)-метил-α-(2-хлорофенил)-6,7-дигидротиено[3,2-с]пиридин-5(4Н)-ацетата формулы I по реакции (S)-(+)-метил-α-(2-хлорофенил)-6,7-дигидротиено[3,2-с]пиридин-5(4Н)-ацетата и серной кислоты в присутствии растворителей, который включает растворение (S)-(+)-метил-α-(2-хлорофенил)-6,7-дигидротиено[3,2-с]пиридин-5(4Н)-ацетата в простом эфире; смешивание данного раствора с раствором спирта С6-С11 и серной кислоты и извлечение полученного таким образом соединения формулы I из маточного раствора.
EA200801963A 2006-03-09 2007-03-08 СПОСОБ ПОЛУЧЕНИЯ ПОЛИМОРФНОЙ ФОРМЫ I ГИДРОСУЛЬФАТА (S)-(+)-МЕТИЛ-α-(2-ХЛОРФЕНИЛ)-6,7-ДИГИДРОТИЕНО[3,2-c]ПИРИДИН-5(4H)-АЦЕТАТА EA013543B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU0600194A HU228030B1 (en) 2006-03-09 2006-03-09 Process for producing the polymorphic i form of (s)-(+)-methyl-2-(2-chlorophenyl)-2-(6,7-dihydro-4h-thieno[3,2-c]pyridin-5- yl)-acetate
PCT/HU2007/000021 WO2007102037A2 (en) 2006-03-09 2007-03-08 A PROCESS FOR THE PREPARATION OF POLYMORPH FORM I OF (S)-(+)-METHYL-α-(2-CHLOROPHENYL)-6,7-DYHIDRO-THIENO-[3,2-c]PYRIDINE-5(4H)-ACETATE HYDROGEN SULFATE

Publications (2)

Publication Number Publication Date
EA200801963A1 true EA200801963A1 (ru) 2009-02-27
EA013543B1 EA013543B1 (ru) 2010-06-30

Family

ID=89986636

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200801963A EA013543B1 (ru) 2006-03-09 2007-03-08 СПОСОБ ПОЛУЧЕНИЯ ПОЛИМОРФНОЙ ФОРМЫ I ГИДРОСУЛЬФАТА (S)-(+)-МЕТИЛ-α-(2-ХЛОРФЕНИЛ)-6,7-ДИГИДРОТИЕНО[3,2-c]ПИРИДИН-5(4H)-АЦЕТАТА

Country Status (14)

Country Link
US (1) US20090093635A1 (ru)
EP (1) EP2010545A2 (ru)
JP (1) JP2009529521A (ru)
KR (1) KR20080110795A (ru)
CN (1) CN101600721A (ru)
AU (1) AU2007222234A1 (ru)
CA (1) CA2640242A1 (ru)
EA (1) EA013543B1 (ru)
GE (1) GEP20104957B (ru)
HU (1) HU228030B1 (ru)
IL (1) IL192825A0 (ru)
MX (1) MX2008011485A (ru)
NO (1) NO20084217L (ru)
WO (1) WO2007102037A2 (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011042804A2 (en) * 2009-10-08 2011-04-14 Jubliant Life Sciences Limited An improved process for the preparation of clopidogrel hydrogen sulfate form i
WO2011051976A2 (en) * 2009-10-30 2011-05-05 Matrix Laboratories Ltd An improved process for the preparation of clopidogrel bisulfate form i
CN103951675A (zh) * 2014-04-29 2014-07-30 浙江华海药业股份有限公司 一种硫酸氢氯吡格雷的制备方法
KR102188371B1 (ko) 2020-09-09 2020-12-08 (주)세명이앤씨 발전효율 증대 및 안전사고 예방 태양광 발전 시스템

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100839136B1 (ko) * 2001-12-18 2008-06-20 테바 파마슈티컬 인더스트리즈 리미티드 클로피도그렐 황산수소염의 다형
US6767913B2 (en) * 2001-12-18 2004-07-27 Teva Pharmaceutical Industries Ltd. Crystal forms iii, iv, v, and novel amorphous form of clopidogrel hydrogensulfate, processes for their preparation, processes for the preparation of form i, compositions containing the new forms and methods of administering the new forms
US7074928B2 (en) * 2002-01-11 2006-07-11 Teva Pharmaceutical Industries, Ltd. Polymorphs of clopidogrel hydrogensulfate
CA2676121A1 (en) * 2003-11-03 2005-07-14 Cadila Healthcare Limited Processes for preparing different forms of (s)-(+)-clopidogrel bisulfate
WO2005104663A2 (en) * 2004-03-05 2005-11-10 Ipca Laboratories Limited Industrial process for preparation of clopidogrel hydrogen sulphate
SI1740593T1 (sl) * 2004-04-19 2016-08-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Postopek za pripravo polimorfne oblike I klopidogrel hidrogen sulfata

Also Published As

Publication number Publication date
EP2010545A2 (en) 2009-01-07
WO2007102037A3 (en) 2008-11-13
WO2007102037A2 (en) 2007-09-13
AU2007222234A1 (en) 2007-09-13
MX2008011485A (es) 2009-03-05
HU0600194D0 (en) 2006-05-29
EA013543B1 (ru) 2010-06-30
HUP0600194A3 (en) 2007-12-28
JP2009529521A (ja) 2009-08-20
GEP20104957B (en) 2010-04-12
US20090093635A1 (en) 2009-04-09
HU228030B1 (en) 2012-08-28
CN101600721A (zh) 2009-12-09
KR20080110795A (ko) 2008-12-19
CA2640242A1 (en) 2007-09-13
HUP0600194A2 (en) 2007-09-28
IL192825A0 (en) 2009-08-03
NO20084217L (no) 2008-12-08

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU