HUP0401272A2 - Eljárás clopidogrel-hidrogénszulfát kristályos polimorf módosulatának előállítására - Google Patents
Eljárás clopidogrel-hidrogénszulfát kristályos polimorf módosulatának előállításáraInfo
- Publication number
- HUP0401272A2 HUP0401272A2 HU0401272A HUP0401272A HUP0401272A2 HU P0401272 A2 HUP0401272 A2 HU P0401272A2 HU 0401272 A HU0401272 A HU 0401272A HU P0401272 A HUP0401272 A HU P0401272A HU P0401272 A2 HUP0401272 A2 HU P0401272A2
- Authority
- HU
- Hungary
- Prior art keywords
- mixture
- type solvent
- clopidogrel
- sulfuric acid
- polymorph form
- Prior art date
Links
- 229950010477 clopidogrel hydrogen sulphate Drugs 0.000 title abstract 7
- FDEODCTUSIWGLK-UHFFFAOYSA-N hydrogen sulfate;hydron;methyl 2-(2-chlorophenyl)-2-(6,7-dihydro-4h-thieno[3,2-c]pyridin-5-yl)acetate Chemical compound OS(O)(=O)=O.C1CC=2SC=CC=2CN1C(C(=O)OC)C1=CC=CC=C1Cl FDEODCTUSIWGLK-UHFFFAOYSA-N 0.000 title abstract 7
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 10
- 239000000203 mixture Substances 0.000 abstract 9
- 239000002904 solvent Substances 0.000 abstract 8
- 239000005552 B01AC04 - Clopidogrel Substances 0.000 abstract 3
- 229960003009 clopidogrel Drugs 0.000 abstract 3
- GKTWGGQPFAXNFI-HNNXBMFYSA-N clopidogrel Chemical compound C1([C@H](N2CC=3C=CSC=3CC2)C(=O)OC)=CC=CC=C1Cl GKTWGGQPFAXNFI-HNNXBMFYSA-N 0.000 abstract 3
- 238000001035 drying Methods 0.000 abstract 2
- 238000001914 filtration Methods 0.000 abstract 2
- 239000002244 precipitate Substances 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- 239000000725 suspension Substances 0.000 abstract 2
- 238000005406 washing Methods 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
Landscapes
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A találmány tárgya új, javított eljárás clopidogrel-hidrogénszulfát S-(+)-(2-klór-fenil)-(6,7-di-hidro-4H-tieno[3,2-c]piridin-5-il)-ecetsav-metil-észter-hidrogénszulfát polimorf 1. módosulatának előállítására. Ó
Priority Applications (16)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU0401272A HU226773B1 (en) | 2004-06-23 | 2004-06-23 | Process for the production of clopidogrel hydrogensulfate polymorph 1 |
US10/563,133 US20070142637A1 (en) | 2003-07-02 | 2004-06-30 | Process for the preparation of crystalline polymorph of a platelet aggregation inhibitor drug |
JP2006516497A JP4681545B2 (ja) | 2003-07-02 | 2004-06-30 | 血小板凝集阻害剤の結晶多形の製法 |
EA200600138A EA010684B1 (ru) | 2003-07-02 | 2004-06-30 | Способ получения кристаллического полиморфа ингибитора агрегации тромбоцитов |
CN2004800181228A CN1812993B (zh) | 2003-07-02 | 2004-06-30 | 制备抑制血小板聚集药物的结晶性多晶型物的方法 |
SK5010-2006A SK50102006A3 (sk) | 2003-07-02 | 2004-06-30 | Spôsob prípravy kryštalického polymorfu inhibítora zrážania krvných doštičiek |
CZ20060041A CZ200641A3 (cs) | 2003-07-02 | 2004-06-30 | Zpusob prípravy krystalického polymorfu inhibitoru srázení krevních desticek |
PL378710A PL378710A1 (pl) | 2003-07-02 | 2004-06-30 | Polimorficzny lek zatrzymujący agregację płytek krwi |
PL04743729T PL1644381T3 (pl) | 2003-07-02 | 2004-06-30 | Proces wytwarzania krystalicznego polimorfu jako leku do hamowania agregacji płytek krwi |
DE602004026059T DE602004026059D1 (de) | 2003-07-02 | 2004-06-30 | Prozess zur herstellung eines kristallinen polymorphs eines die plättchen aggregation hemmenden arzneistoffs |
EP04743729A EP1644381B1 (en) | 2003-07-02 | 2004-06-30 | Process for the preparation of crystalline polymorph of a platelet aggregation inhibitor drug |
AT04743729T ATE461201T1 (de) | 2003-07-02 | 2004-06-30 | Prozess zur herstellung eines kristallinen polymorphs eines die plättchen aggregation hemmenden arzneistoffs |
CA2530449A CA2530449C (en) | 2003-07-02 | 2004-06-30 | Process for the preparation of crystalline polymorph of a platelet aggregation inhibitor drug |
KR1020067000012A KR101155679B1 (ko) | 2003-07-02 | 2004-06-30 | 혈소판 응집 억제제 약물의 결정성 다형체를 제조하는 방법 |
PCT/HU2004/000070 WO2005003139A1 (en) | 2003-07-02 | 2004-06-30 | Process for the preparation of crystalline polymorph of a platelet aggregation inhibitor drug |
BG109429A BG109429A (en) | 2003-07-02 | 2006-02-02 | A METHOD FOR OBTAINING A CRYSTAL POLYMORPHIC FORMAN FOR INHIBITING TROMBOCYTE AGGREGATION |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU0401272A HU226773B1 (en) | 2004-06-23 | 2004-06-23 | Process for the production of clopidogrel hydrogensulfate polymorph 1 |
Publications (4)
Publication Number | Publication Date |
---|---|
HU0401272D0 HU0401272D0 (en) | 2004-09-28 |
HUP0401272A2 true HUP0401272A2 (hu) | 2005-02-28 |
HUP0401272A3 HUP0401272A3 (en) | 2005-09-28 |
HU226773B1 HU226773B1 (en) | 2009-09-28 |
Family
ID=89985326
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0401272A HU226773B1 (en) | 2003-07-02 | 2004-06-23 | Process for the production of clopidogrel hydrogensulfate polymorph 1 |
Country Status (1)
Country | Link |
---|---|
HU (1) | HU226773B1 (hu) |
-
2004
- 2004-06-23 HU HU0401272A patent/HU226773B1/hu not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
HU226773B1 (en) | 2009-09-28 |
HUP0401272A3 (en) | 2005-09-28 |
HU0401272D0 (en) | 2004-09-28 |
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Legal Events
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HC9A | Change of name, address |
Owner name: EGIS GYOGYSZERGYAR NYILVANOSAN MUEKOEDOE RESZV, HU Free format text: FORMER OWNER(S): EGIS GYOGYSZERGYAR RT., HU |
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MM4A | Lapse of definitive patent protection due to non-payment of fees |