HUP0401272A2 - Eljárás clopidogrel-hidrogénszulfát kristályos polimorf módosulatának előállítására - Google Patents

Eljárás clopidogrel-hidrogénszulfát kristályos polimorf módosulatának előállítására

Info

Publication number
HUP0401272A2
HUP0401272A2 HU0401272A HUP0401272A HUP0401272A2 HU P0401272 A2 HUP0401272 A2 HU P0401272A2 HU 0401272 A HU0401272 A HU 0401272A HU P0401272 A HUP0401272 A HU P0401272A HU P0401272 A2 HUP0401272 A2 HU P0401272A2
Authority
HU
Hungary
Prior art keywords
mixture
type solvent
clopidogrel
sulfuric acid
polymorph form
Prior art date
Application number
HU0401272A
Other languages
English (en)
Inventor
Nagy Péter Kótay
Gyula Simig
József Barkóczy
Tamás Gregor
Béla Farkas
dr. Donáth Györgyi Vereczkeyné
Kálmán Nagy
Gyuláné Körtvélyessy
Zsuzsanna Szent-Királlyi
Original Assignee
EGIS Gyógyszergyár Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EGIS Gyógyszergyár Rt. filed Critical EGIS Gyógyszergyár Rt.
Priority to HU0401272A priority Critical patent/HU226773B1/hu
Priority to DE602004026059T priority patent/DE602004026059D1/de
Priority to EP04743729A priority patent/EP1644381B1/en
Priority to EA200600138A priority patent/EA010684B1/ru
Priority to CN2004800181228A priority patent/CN1812993B/zh
Priority to SK5010-2006A priority patent/SK50102006A3/sk
Priority to CZ20060041A priority patent/CZ200641A3/cs
Priority to PL378710A priority patent/PL378710A1/pl
Priority to PL04743729T priority patent/PL1644381T3/pl
Priority to US10/563,133 priority patent/US20070142637A1/en
Priority to JP2006516497A priority patent/JP4681545B2/ja
Priority to AT04743729T priority patent/ATE461201T1/de
Priority to CA2530449A priority patent/CA2530449C/en
Priority to KR1020067000012A priority patent/KR101155679B1/ko
Priority to PCT/HU2004/000070 priority patent/WO2005003139A1/en
Publication of HU0401272D0 publication Critical patent/HU0401272D0/hu
Publication of HUP0401272A2 publication Critical patent/HUP0401272A2/hu
Publication of HUP0401272A3 publication Critical patent/HUP0401272A3/hu
Priority to BG109429A priority patent/BG109429A/en
Publication of HU226773B1 publication Critical patent/HU226773B1/hu

Links

Landscapes

  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A találmány tárgya új, javított eljárás clopidogrel-hidrogénszulfát S-(+)-(2-klór-fenil)-(6,7-di-hidro-4H-tieno[3,2-c]piridin-5-il)-ecetsav-metil-észter-hidrogénszulfát polimorf 1. módosulatának előállítására. Ó
HU0401272A 2003-07-02 2004-06-23 Process for the production of clopidogrel hydrogensulfate polymorph 1 HU226773B1 (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
HU0401272A HU226773B1 (en) 2004-06-23 2004-06-23 Process for the production of clopidogrel hydrogensulfate polymorph 1
US10/563,133 US20070142637A1 (en) 2003-07-02 2004-06-30 Process for the preparation of crystalline polymorph of a platelet aggregation inhibitor drug
JP2006516497A JP4681545B2 (ja) 2003-07-02 2004-06-30 血小板凝集阻害剤の結晶多形の製法
EA200600138A EA010684B1 (ru) 2003-07-02 2004-06-30 Способ получения кристаллического полиморфа ингибитора агрегации тромбоцитов
CN2004800181228A CN1812993B (zh) 2003-07-02 2004-06-30 制备抑制血小板聚集药物的结晶性多晶型物的方法
SK5010-2006A SK50102006A3 (sk) 2003-07-02 2004-06-30 Spôsob prípravy kryštalického polymorfu inhibítora zrážania krvných doštičiek
CZ20060041A CZ200641A3 (cs) 2003-07-02 2004-06-30 Zpusob prípravy krystalického polymorfu inhibitoru srázení krevních desticek
PL378710A PL378710A1 (pl) 2003-07-02 2004-06-30 Polimorficzny lek zatrzymujący agregację płytek krwi
PL04743729T PL1644381T3 (pl) 2003-07-02 2004-06-30 Proces wytwarzania krystalicznego polimorfu jako leku do hamowania agregacji płytek krwi
DE602004026059T DE602004026059D1 (de) 2003-07-02 2004-06-30 Prozess zur herstellung eines kristallinen polymorphs eines die plättchen aggregation hemmenden arzneistoffs
EP04743729A EP1644381B1 (en) 2003-07-02 2004-06-30 Process for the preparation of crystalline polymorph of a platelet aggregation inhibitor drug
AT04743729T ATE461201T1 (de) 2003-07-02 2004-06-30 Prozess zur herstellung eines kristallinen polymorphs eines die plättchen aggregation hemmenden arzneistoffs
CA2530449A CA2530449C (en) 2003-07-02 2004-06-30 Process for the preparation of crystalline polymorph of a platelet aggregation inhibitor drug
KR1020067000012A KR101155679B1 (ko) 2003-07-02 2004-06-30 혈소판 응집 억제제 약물의 결정성 다형체를 제조하는 방법
PCT/HU2004/000070 WO2005003139A1 (en) 2003-07-02 2004-06-30 Process for the preparation of crystalline polymorph of a platelet aggregation inhibitor drug
BG109429A BG109429A (en) 2003-07-02 2006-02-02 A METHOD FOR OBTAINING A CRYSTAL POLYMORPHIC FORMAN FOR INHIBITING TROMBOCYTE AGGREGATION

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU0401272A HU226773B1 (en) 2004-06-23 2004-06-23 Process for the production of clopidogrel hydrogensulfate polymorph 1

Publications (4)

Publication Number Publication Date
HU0401272D0 HU0401272D0 (en) 2004-09-28
HUP0401272A2 true HUP0401272A2 (hu) 2005-02-28
HUP0401272A3 HUP0401272A3 (en) 2005-09-28
HU226773B1 HU226773B1 (en) 2009-09-28

Family

ID=89985326

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0401272A HU226773B1 (en) 2003-07-02 2004-06-23 Process for the production of clopidogrel hydrogensulfate polymorph 1

Country Status (1)

Country Link
HU (1) HU226773B1 (hu)

Also Published As

Publication number Publication date
HU226773B1 (en) 2009-09-28
HUP0401272A3 (en) 2005-09-28
HU0401272D0 (en) 2004-09-28

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Legal Events

Date Code Title Description
HC9A Change of name, address

Owner name: EGIS GYOGYSZERGYAR NYILVANOSAN MUEKOEDOE RESZV, HU

Free format text: FORMER OWNER(S): EGIS GYOGYSZERGYAR RT., HU

MM4A Lapse of definitive patent protection due to non-payment of fees