DE602008005461D1 - Verfahren zur herstellung von essigsäure-5-ä2-cyclopropyl-1-(2-fluorphenyl)-2-oxoethylü-4,5,6,7-tetrahydrothienoä3,2-cüpyridin-2-yl-ester (prasugrel) - Google Patents

Verfahren zur herstellung von essigsäure-5-ä2-cyclopropyl-1-(2-fluorphenyl)-2-oxoethylü-4,5,6,7-tetrahydrothienoä3,2-cüpyridin-2-yl-ester (prasugrel)

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Publication number
DE602008005461D1
DE602008005461D1 DE602008005461T DE602008005461T DE602008005461D1 DE 602008005461 D1 DE602008005461 D1 DE 602008005461D1 DE 602008005461 T DE602008005461 T DE 602008005461T DE 602008005461 T DE602008005461 T DE 602008005461T DE 602008005461 D1 DE602008005461 D1 DE 602008005461D1
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DE
Germany
Prior art keywords
formula
cyclopropyl
prasugrel
cypyridine
oxoethylene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602008005461T
Other languages
English (en)
Inventor
Hana Stepankova
Josef Hajicek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zentiva KS
Original Assignee
Zentiva KS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentiva KS filed Critical Zentiva KS
Publication of DE602008005461D1 publication Critical patent/DE602008005461D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
DE602008005461T 2007-07-09 2008-07-08 Verfahren zur herstellung von essigsäure-5-ä2-cyclopropyl-1-(2-fluorphenyl)-2-oxoethylü-4,5,6,7-tetrahydrothienoä3,2-cüpyridin-2-yl-ester (prasugrel) Active DE602008005461D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CZ20070456A CZ302135B6 (cs) 2007-07-09 2007-07-09 Zpusob výroby 5-[2-cyklopropyl-1-(2-fluorfenyl)-2-oxoethyl]-4, 5, 6, 7-tetrahydrothieno[3,2-c]pyridin-2-yl acetátu (prasugrelu)
PCT/CZ2008/000079 WO2009006859A2 (en) 2007-07-09 2008-07-08 A method of manufacturing 5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4,5,6,7- tetrahydrothieno[3,2-c]pyridin-2-yl acetate (prasugrel)

Publications (1)

Publication Number Publication Date
DE602008005461D1 true DE602008005461D1 (de) 2011-04-21

Family

ID=40229129

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602008005461T Active DE602008005461D1 (de) 2007-07-09 2008-07-08 Verfahren zur herstellung von essigsäure-5-ä2-cyclopropyl-1-(2-fluorphenyl)-2-oxoethylü-4,5,6,7-tetrahydrothienoä3,2-cüpyridin-2-yl-ester (prasugrel)

Country Status (8)

Country Link
US (1) US20100228033A1 (de)
EP (1) EP2176269B1 (de)
AT (1) ATE501152T1 (de)
CZ (1) CZ302135B6 (de)
DE (1) DE602008005461D1 (de)
EA (1) EA016207B1 (de)
PL (1) PL2176269T3 (de)
WO (1) WO2009006859A2 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ2008748A3 (cs) * 2008-11-26 2010-06-02 Zentiva, A. S Zpusob výroby vysoce cistého 5-[2-cyklopropyl-1-(2-fluorfenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c] pyridin-2-yl acetátu, prasugrelu
EP2499147A4 (de) * 2009-10-07 2013-03-06 Msn Lab Ltd Verbesserte verfahren zur herstellung von prasugrel und pharmazeutisch akzeptablen salzen davon
HU229035B1 (en) 2009-12-21 2013-07-29 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Process for producing prasurgel
HU229031B1 (en) 2009-12-21 2013-07-29 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Process for producing prasurgel and its intermediate
EP2545059A1 (de) 2010-03-09 2013-01-16 Synthon BV Herstellungsverfahren für prasugrel
HUP1000565A2 (en) 2010-10-22 2012-05-02 Egis Gyogyszergyar Nyrt Process for the preparation of pharmaceutically active compound and intermediers
CN102241612B (zh) * 2011-05-18 2013-08-21 西北师范大学 化合物2-环丙基-1-（2-氟苯基）-2-羰乙基对甲苯磺酸酯的合成方法
CN102718642B (zh) * 2012-07-09 2013-12-11 苏州立新制药有限公司 普拉格雷中间体1-环丙基-2-(2-氟苯基)-2-羟基乙酮的制备方法
CN105272993A (zh) * 2014-07-03 2016-01-27 重庆安格龙翔医药科技有限公司 一种制备普拉格雷中间体的方法
USD980074S1 (en) 2021-07-13 2023-03-07 S. C. Johnson & Son, Inc. Container

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2576901B1 (fr) * 1985-01-31 1987-03-20 Sanofi Sa Nouveaux derives de l'acide a-(oxo-2 hexahydro-2,4,5,6,7,7a thieno (3,2-c) pyridyl-5) phenyl acetique, leur procede de preparation et leur application therapeutique
FI101150B (fi) * 1991-09-09 1998-04-30 Sankyo Co Menetelmä lääkeaineina käyttökelpoisten tetrahydrotienopyridiinin johd annaisten valmistamiseksi
EP0785205B1 (de) * 1994-10-07 2002-04-17 Ube Industries, Ltd. 2-silyloxy-tetrahydrothienopyridin, sein salz und verfahren zu seiner herstellung
CA2415558C (en) * 2000-07-06 2010-09-14 Sankyo Company, Limited Acid addition salts of hydropyridine derivatives
AU2005250077B2 (en) * 2004-03-01 2011-06-09 Idorsia Pharmaceuticals Ltd Substituted 1,2,3,4-tetrahydroisoquinoline derivatives
CZ295920B6 (cs) * 2004-10-18 2005-11-16 Zentiva, A. S Způsob výroby klopidogrelu

Also Published As

Publication number Publication date
US20100228033A1 (en) 2010-09-09
EP2176269B1 (de) 2011-03-09
EP2176269A2 (de) 2010-04-21
CZ302135B6 (cs) 2010-11-10
WO2009006859A2 (en) 2009-01-15
PL2176269T3 (pl) 2011-05-31
EA201000148A1 (ru) 2010-06-30
CZ2007456A3 (cs) 2009-01-21
WO2009006859A3 (en) 2009-03-19
EA016207B1 (ru) 2012-03-30
ATE501152T1 (de) 2011-03-15

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