EA201000148A1 - Способ получения 5-[2-циклопропил-1-(2-фторфенил)-2-оксоэтил]-4,5,6,7-тетрагидротиено[3,2-с]пиридин-2-ила ацетата (прасугреля) - Google Patents

Способ получения 5-[2-циклопропил-1-(2-фторфенил)-2-оксоэтил]-4,5,6,7-тетрагидротиено[3,2-с]пиридин-2-ила ацетата (прасугреля)

Info

Publication number
EA201000148A1
EA201000148A1 EA201000148A EA201000148A EA201000148A1 EA 201000148 A1 EA201000148 A1 EA 201000148A1 EA 201000148 A EA201000148 A EA 201000148A EA 201000148 A EA201000148 A EA 201000148A EA 201000148 A1 EA201000148 A1 EA 201000148A1
Authority
EA
Eurasian Patent Office
Prior art keywords
formula
cyclopropyl
tetrahydrothieno
oxoethyl
pyridin
Prior art date
Application number
EA201000148A
Other languages
English (en)
Other versions
EA016207B1 (ru
Inventor
Гана Степанкова
Йосеф Гайицек
Original Assignee
Зентива, К.С.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Зентива, К.С. filed Critical Зентива, К.С.
Publication of EA201000148A1 publication Critical patent/EA201000148A1/ru
Publication of EA016207B1 publication Critical patent/EA016207B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Abstract

Способ получения 5-[2-циклопропил-1-(2-фторфенил)-2-оксоэтил]-4,5,6,7-тетрагидротиено[3,2-с]пиридин-2-ила ацетата, известного под МНН прасугрель, формулы (I), при котором вещество формулы (VI) подвергают взаимодействию с циклопропилмагния галогенидом с получением вещества формулы (V), которое подвергают взаимодействию с метансульфонилхлоридом с получением метансульфоната формулы (IV), который далее подвергают взаимодействию с соединением формулы (III) для преобразования в вещество формулы (II), и последнее затем преобразуют в вещество формулы (I) агентом ацетилирования.
EA201000148A 2007-07-09 2008-07-08 СПОСОБ ПОЛУЧЕНИЯ 5-[2-ЦИКЛОПРОПИЛ-1-(2-ФТОРФЕНИЛ)-2-ОКСОЭТИЛ]-4,5,6,7-ТЕТРАГИДРОТИЕНО[3,2-с]ПИРИДИН-2-ИЛА АЦЕТАТА (ПРАСУГРЕЛЯ) EA016207B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CZ20070456A CZ302135B6 (cs) 2007-07-09 2007-07-09 Zpusob výroby 5-[2-cyklopropyl-1-(2-fluorfenyl)-2-oxoethyl]-4, 5, 6, 7-tetrahydrothieno[3,2-c]pyridin-2-yl acetátu (prasugrelu)
PCT/CZ2008/000079 WO2009006859A2 (en) 2007-07-09 2008-07-08 A method of manufacturing 5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4,5,6,7- tetrahydrothieno[3,2-c]pyridin-2-yl acetate (prasugrel)

Publications (2)

Publication Number Publication Date
EA201000148A1 true EA201000148A1 (ru) 2010-06-30
EA016207B1 EA016207B1 (ru) 2012-03-30

Family

ID=40229129

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201000148A EA016207B1 (ru) 2007-07-09 2008-07-08 СПОСОБ ПОЛУЧЕНИЯ 5-[2-ЦИКЛОПРОПИЛ-1-(2-ФТОРФЕНИЛ)-2-ОКСОЭТИЛ]-4,5,6,7-ТЕТРАГИДРОТИЕНО[3,2-с]ПИРИДИН-2-ИЛА АЦЕТАТА (ПРАСУГРЕЛЯ)

Country Status (8)

Country Link
US (1) US20100228033A1 (ru)
EP (1) EP2176269B1 (ru)
AT (1) ATE501152T1 (ru)
CZ (1) CZ302135B6 (ru)
DE (1) DE602008005461D1 (ru)
EA (1) EA016207B1 (ru)
PL (1) PL2176269T3 (ru)
WO (1) WO2009006859A2 (ru)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ2008748A3 (cs) * 2008-11-26 2010-06-02 Zentiva, A. S Zpusob výroby vysoce cistého 5-[2-cyklopropyl-1-(2-fluorfenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c] pyridin-2-yl acetátu, prasugrelu
WO2011042918A2 (en) * 2009-10-07 2011-04-14 Msn Laboratories Limited Novel and improved processes for the preparation of prasugrel, its intermediates and pharmaceutically acceptable salts
HU229035B1 (en) 2009-12-21 2013-07-29 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Process for producing prasurgel
HU229031B1 (en) 2009-12-21 2013-07-29 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Process for producing prasurgel and its intermediate
WO2011110219A1 (en) 2010-03-09 2011-09-15 Synthon Bv A process for making prasugrel
HUP1000565A2 (en) 2010-10-22 2012-05-02 Egis Gyogyszergyar Nyrt Process for the preparation of pharmaceutically active compound and intermediers
CN102241612B (zh) * 2011-05-18 2013-08-21 西北师范大学 化合物2-环丙基-1-（2-氟苯基）-2-羰乙基对甲苯磺酸酯的合成方法
CN102718642B (zh) * 2012-07-09 2013-12-11 苏州立新制药有限公司 普拉格雷中间体1-环丙基-2-(2-氟苯基)-2-羟基乙酮的制备方法
CN105272993A (zh) * 2014-07-03 2016-01-27 重庆安格龙翔医药科技有限公司 一种制备普拉格雷中间体的方法
USD980074S1 (en) 2021-07-13 2023-03-07 S. C. Johnson & Son, Inc. Container

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2576901B1 (fr) * 1985-01-31 1987-03-20 Sanofi Sa Nouveaux derives de l'acide a-(oxo-2 hexahydro-2,4,5,6,7,7a thieno (3,2-c) pyridyl-5) phenyl acetique, leur procede de preparation et leur application therapeutique
FI101150B (fi) * 1991-09-09 1998-04-30 Sankyo Co Menetelmä lääkeaineina käyttökelpoisten tetrahydrotienopyridiinin johd annaisten valmistamiseksi
US5874581A (en) * 1994-10-07 1999-02-23 Ube Industries, Ltd. 2-silyloxy-tetrahydrothienopyridine, salt thereof and process for preparing the same
PT1728794E (pt) * 2000-07-06 2008-07-15 Ube Industries Sal de adição maleato de derivados de hidropiridina
SI1751111T1 (sl) * 2004-03-01 2015-04-30 Actelion Pharmaceuticals Ltd. Substituirani 1,2,3,4-tetrahidroizokinolinski derivati
CZ20041048A3 (cs) * 2004-10-18 2005-11-16 Zentiva, A. S Způsob výroby klopidogrelu

Also Published As

Publication number Publication date
CZ2007456A3 (cs) 2009-01-21
EA016207B1 (ru) 2012-03-30
EP2176269B1 (en) 2011-03-09
CZ302135B6 (cs) 2010-11-10
PL2176269T3 (pl) 2011-05-31
US20100228033A1 (en) 2010-09-09
WO2009006859A2 (en) 2009-01-15
DE602008005461D1 (de) 2011-04-21
EP2176269A2 (en) 2010-04-21
ATE501152T1 (de) 2011-03-15
WO2009006859A3 (en) 2009-03-19

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU