WO2008108742A3 - Polymorphic forms of clopidogrel hydrobromide - Google Patents

Polymorphic forms of clopidogrel hydrobromide Download PDF

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Publication number
WO2008108742A3
WO2008108742A3 PCT/SI2008/000014 SI2008000014W WO2008108742A3 WO 2008108742 A3 WO2008108742 A3 WO 2008108742A3 SI 2008000014 W SI2008000014 W SI 2008000014W WO 2008108742 A3 WO2008108742 A3 WO 2008108742A3
Authority
WO
WIPO (PCT)
Prior art keywords
forms
polymorphic forms
clopidogrel hydrobromide
dihydrothieno
chlorophenyl
Prior art date
Application number
PCT/SI2008/000014
Other languages
French (fr)
Other versions
WO2008108742A2 (en
Inventor
Miroslav Veverka
Eva Veverkova
Stefan Vodny
Janez Smodis
Matej Smrkolj
Original Assignee
Krka Tovarna Zdravil D D Novo
Miroslav Veverka
Eva Veverkova
Stefan Vodny
Janez Smodis
Matej Smrkolj
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Krka Tovarna Zdravil D D Novo, Miroslav Veverka, Eva Veverkova, Stefan Vodny, Janez Smodis, Matej Smrkolj filed Critical Krka Tovarna Zdravil D D Novo
Priority to EP08724381A priority Critical patent/EP2121704A2/en
Publication of WO2008108742A2 publication Critical patent/WO2008108742A2/en
Publication of WO2008108742A3 publication Critical patent/WO2008108742A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to amorphous form of methyl (+)-(S)-(2-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetate hydrobromide and to novel polymorphic forms alpha, beta and gama of methyl (+)-(S)-(2-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetate hydrobromide. Further, the present invention relates to the preparation of new forms, the pharmaceutical compositions comprising such forms and to the method of use such forms for inhibiting platelet aggregation.
PCT/SI2008/000014 2007-03-08 2008-03-07 Polymorphic forms of clopidogrel hydrobromide WO2008108742A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP08724381A EP2121704A2 (en) 2007-03-08 2008-03-07 Polymorphic forms of clopidogrel hydrobromide

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SI200700050A SI22492A (en) 2007-03-08 2007-03-08 Polymorphic forms of clopidogrel hydrobromide
SIP-200700050 2007-03-08

Publications (2)

Publication Number Publication Date
WO2008108742A2 WO2008108742A2 (en) 2008-09-12
WO2008108742A3 true WO2008108742A3 (en) 2009-05-14

Family

ID=39691341

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SI2008/000014 WO2008108742A2 (en) 2007-03-08 2008-03-07 Polymorphic forms of clopidogrel hydrobromide

Country Status (3)

Country Link
EP (1) EP2121704A2 (en)
SI (1) SI22492A (en)
WO (1) WO2008108742A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005103058A1 (en) * 2004-04-20 2005-11-03 Sanofi-Aventis Polymorphic forms of methyl (+) - (s) -alpha- (2-chlorophenyl) -6, 7-dihydrothieno `3,2-c!pyridine-584h) acetate hydrobromide, clopidrogel hydrobromide
EP1674468A1 (en) * 2004-12-21 2006-06-28 Ratiopharm GmbH Polymorphs of clopidogrel hydrobromide

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005103058A1 (en) * 2004-04-20 2005-11-03 Sanofi-Aventis Polymorphic forms of methyl (+) - (s) -alpha- (2-chlorophenyl) -6, 7-dihydrothieno `3,2-c!pyridine-584h) acetate hydrobromide, clopidrogel hydrobromide
EP1674468A1 (en) * 2004-12-21 2006-06-28 Ratiopharm GmbH Polymorphs of clopidogrel hydrobromide

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HANCOCK; ZOGRAFI: "CHARACTERISTICS AND SIGNIFICANCE OF THE AMORPHOUS STATE IN PHARMACEUTICAL SYSTEMS", JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 86, no. 1, 1 January 1997 (1997-01-01), pages 1 - 12, XP000929450, ISSN: 0022-3549 *
YU: "AMORPHOUS PHARMACEUTICAL SOLIDS: PREPARATION, CHARACTERIZATION AND STABILIZATION", ADVANCED DRUG DELIVERY REVIEWS, vol. 48, no. 1, 16 May 2001 (2001-05-16), pages 27 - 42, XP009065056, ISSN: 0169-409X *

Also Published As

Publication number Publication date
EP2121704A2 (en) 2009-11-25
WO2008108742A2 (en) 2008-09-12
SI22492A (en) 2008-10-31

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