ATE411998T1 - Verfahren zur herstellung der kristallform i von clopidogrel-hydrogensulphat - Google Patents
Verfahren zur herstellung der kristallform i von clopidogrel-hydrogensulphatInfo
- Publication number
- ATE411998T1 ATE411998T1 AT03750270T AT03750270T ATE411998T1 AT E411998 T1 ATE411998 T1 AT E411998T1 AT 03750270 T AT03750270 T AT 03750270T AT 03750270 T AT03750270 T AT 03750270T AT E411998 T1 ATE411998 T1 AT E411998T1
- Authority
- AT
- Austria
- Prior art keywords
- clopidogrel
- crystal form
- preparing crystal
- alpha
- formula
- Prior art date
Links
- 229950010477 clopidogrel hydrogen sulphate Drugs 0.000 title abstract 2
- FDEODCTUSIWGLK-RSAXXLAASA-N clopidogrel sulfate Chemical compound [H+].OS([O-])(=O)=O.C1([C@H](N2CC=3C=CSC=3CC2)C(=O)OC)=CC=CC=C1Cl FDEODCTUSIWGLK-RSAXXLAASA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- GKTWGGQPFAXNFI-UHFFFAOYSA-N 2-(2-chlorophenyl)-2-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetic acid methyl ester Chemical compound C1CC=2SC=CC=2CN1C(C(=O)OC)C1=CC=CC=C1Cl GKTWGGQPFAXNFI-UHFFFAOYSA-N 0.000 abstract 1
- 239000005552 B01AC04 - Clopidogrel Substances 0.000 abstract 1
- 150000001298 alcohols Chemical class 0.000 abstract 1
- 150000001735 carboxylic acids Chemical class 0.000 abstract 1
- GKTWGGQPFAXNFI-HNNXBMFYSA-N clopidogrel Chemical compound C1([C@H](N2CC=3C=CSC=3CC2)C(=O)OC)=CC=CC=C1Cl GKTWGGQPFAXNFI-HNNXBMFYSA-N 0.000 abstract 1
- 229960003009 clopidogrel Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 239000012458 free base Substances 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-M hydrogensulfate Chemical compound OS([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-M 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CZ20022906A CZ297472B6 (cs) | 2002-08-27 | 2002-08-27 | Zpusob výroby clopidogrelu hydrogensulfátu krystalické formy I |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE411998T1 true ATE411998T1 (de) | 2008-11-15 |
Family
ID=31954588
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03750270T ATE411998T1 (de) | 2002-08-27 | 2003-08-26 | Verfahren zur herstellung der kristallform i von clopidogrel-hydrogensulphat |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7714133B2 (de) |
| EP (1) | EP1554284B1 (de) |
| JP (1) | JP2006502238A (de) |
| KR (1) | KR20050058492A (de) |
| AT (1) | ATE411998T1 (de) |
| AU (1) | AU2003269673A1 (de) |
| CA (1) | CA2495823A1 (de) |
| CZ (1) | CZ297472B6 (de) |
| DE (1) | DE60324301D1 (de) |
| EA (1) | EA007977B1 (de) |
| PL (1) | PL373578A1 (de) |
| WO (1) | WO2004020443A1 (de) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1651646B1 (de) * | 2003-08-04 | 2012-05-09 | Wockhardt Limited | Neues verfahren zur herstellung von (+)-(s)-clopidogrelbisulfat form-i |
| DE10337773A1 (de) * | 2003-08-13 | 2005-03-24 | Krka Tovarna Zdravil, D.D. | Kristallisation von festen Formen von Clopidogrel-Additionssalzen |
| EP1680430B1 (de) * | 2003-11-03 | 2010-01-20 | Cadila Healthcare Ltd. | Verfahren zur herstellung form i von (s)-(+)- clopidogrelbisulfat |
| JP4550884B2 (ja) * | 2004-04-09 | 2010-09-22 | ハンミ ファーム． シーオー．， エルティーディー． | 結晶性クロピドグレルナフタレンスルホン酸塩又はその水和物、その製造方法及びそれを含む医薬組成物 |
| US7999106B2 (en) * | 2004-04-19 | 2011-08-16 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Processes for the preparation of clopidogrel hydrogen sulfate polymorphic form I |
| CN1997648A (zh) * | 2004-04-20 | 2007-07-11 | 赛诺菲-安万特 | (+)－(S)－α－(2－氯苯基)－6,7－二氢噻吩并[3,2－C]吡啶－5(4H)乙酸甲酯氢溴酸盐，即氯吡格雷氢溴酸盐的多晶型物 |
| BRPI0510008A (pt) * | 2004-04-20 | 2007-09-18 | Sanofi Aventis | sal de clopidogrel e formas polimórficas deste |
| EP1693375A1 (de) * | 2005-02-21 | 2006-08-23 | KRKA, tovarna zdravil, d.d., Novo mesto | Verfahren zur Herstellung von Clopidrogel hydrogen sulfat in Form I |
| US7772398B2 (en) * | 2005-03-11 | 2010-08-10 | Dr. Reddy's Laboratories, Inc. | Process for making crystalline form I of clopidogrel hydrogen sulphate |
| WO2007017886A1 (en) * | 2005-08-11 | 2007-02-15 | Arch Pharmalabs Limited | Novel process for preparation of clopidogrel bisulphate polymorphic form i |
| EP1926736A4 (de) | 2005-09-21 | 2010-08-25 | Chong Kun Dang Pharm Corp | Neuer resinat-komplex von s-clopidogrel und verfahren zu dessen herstellung |
| EP2114957A4 (de) * | 2007-01-29 | 2011-06-08 | Ipca Lab Ltd | Verfahren zur herstellung von kristallinem clopidogrelhydrogensulfat der form i |
| US20080188663A1 (en) * | 2007-01-29 | 2008-08-07 | Ashok Kumar | Process for the preparation of crystalline clopidogrel hydrogen sulphate Form I |
| KR20160033792A (ko) | 2007-04-27 | 2016-03-28 | 사이덱스 파마슈티칼스, 인크. | 클로피도그렐 및 설포알킬 에테르 사이클로덱스트린을 함유하는 제형 및 사용 방법 |
| EP2107061A1 (de) * | 2008-04-02 | 2009-10-07 | Krka Tovarna Zdravil, D.D., Novo Mesto | Herstellungsverfahren für optisch angereichertes Clopidogrel |
| US20110118467A1 (en) * | 2008-06-24 | 2011-05-19 | Zach System S.P.A. | Process for the preparation of clopidogrel hydrogen sulfate crystalline form i |
| US8236782B2 (en) | 2009-05-13 | 2012-08-07 | Cydex Pharmaceuticals, Inc. | Pharmaceutical compositions comprising prasugrel and cyclodextrin derivatives and methods of making and using the same |
| WO2011042804A2 (en) * | 2009-10-08 | 2011-04-14 | Jubliant Life Sciences Limited | An improved process for the preparation of clopidogrel hydrogen sulfate form i |
| KR101130445B1 (ko) * | 2009-10-29 | 2012-03-27 | 동아제약주식회사 | 클로피도그랠 황산수소염 ⅰ형 제조방법 |
| WO2011051976A2 (en) | 2009-10-30 | 2011-05-05 | Matrix Laboratories Ltd | An improved process for the preparation of clopidogrel bisulfate form i |
| US20120232274A1 (en) * | 2009-11-09 | 2012-09-13 | Pharmazell Gmbh | Process for preparation of clopiodogrel bisulfate form-1 |
| WO2011125069A1 (en) | 2010-03-22 | 2011-10-13 | Rpg Life Sciences Limited | A process for preparation of crystalline form i of clopidogrel bisulfate |
| CN102558194A (zh) * | 2010-12-11 | 2012-07-11 | 山东方明药业股份有限公司 | 一种硫酸氢氯吡格雷i型的制备方法 |
| CN102875568B (zh) * | 2012-09-06 | 2015-12-09 | 苏州晶云药物科技有限公司 | 制备(+)-(s)-氯吡格雷硫酸氢盐纯晶型i的方法 |
| KR101710922B1 (ko) | 2015-06-03 | 2017-02-28 | 경동제약 주식회사 | 클로피도그렐 황산염 결정형 i형의 제조방법 |
| CN107163060B (zh) * | 2017-05-24 | 2021-03-02 | 常州制药厂有限公司 | 一种硫酸氢氯吡格雷晶型ii制备方法 |
| CN107118221B (zh) * | 2017-05-24 | 2021-09-07 | 常州制药厂有限公司 | 一种硫酸氢氯吡格雷晶型i制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2623810B2 (fr) | 1987-02-17 | 1992-01-24 | Sanofi Sa | Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant |
| FR2779726B1 (fr) * | 1998-06-15 | 2001-05-18 | Sanofi Sa | Forme polymorphe de l'hydrogenosulfate de clopidogrel |
| GB0125708D0 (en) | 2001-10-26 | 2001-12-19 | Generics Uk Ltd | Novel compounds and processes |
| ES2316650T3 (es) * | 2001-12-18 | 2009-04-16 | Teva Pharmaceutical Industries Ltd. | Polimorfos de hidrogenosulfato de clopidogrel. |
| US6767913B2 (en) * | 2001-12-18 | 2004-07-27 | Teva Pharmaceutical Industries Ltd. | Crystal forms iii, iv, v, and novel amorphous form of clopidogrel hydrogensulfate, processes for their preparation, processes for the preparation of form i, compositions containing the new forms and methods of administering the new forms |
| US7074928B2 (en) * | 2002-01-11 | 2006-07-11 | Teva Pharmaceutical Industries, Ltd. | Polymorphs of clopidogrel hydrogensulfate |
| JP4072005B2 (ja) * | 2002-06-12 | 2008-04-02 | 日本電波工業株式会社 | 温度補償水晶発振器 |
| EP1651646B1 (de) * | 2003-08-04 | 2012-05-09 | Wockhardt Limited | Neues verfahren zur herstellung von (+)-(s)-clopidogrelbisulfat form-i |
-
2002
- 2002-08-27 CZ CZ20022906A patent/CZ297472B6/cs not_active IP Right Cessation
-
2003
- 2003-08-26 WO PCT/CZ2003/000049 patent/WO2004020443A1/en active Application Filing
- 2003-08-26 CA CA002495823A patent/CA2495823A1/en not_active Abandoned
- 2003-08-26 PL PL03373578A patent/PL373578A1/xx not_active Application Discontinuation
- 2003-08-26 EA EA200500310A patent/EA007977B1/ru not_active IP Right Cessation
- 2003-08-26 AU AU2003269673A patent/AU2003269673A1/en not_active Abandoned
- 2003-08-26 DE DE60324301T patent/DE60324301D1/de not_active Expired - Lifetime
- 2003-08-26 AT AT03750270T patent/ATE411998T1/de not_active IP Right Cessation
- 2003-08-26 EP EP03750270A patent/EP1554284B1/de not_active Revoked
- 2003-08-26 KR KR1020057003106A patent/KR20050058492A/ko not_active Application Discontinuation
- 2003-08-26 US US10/525,341 patent/US7714133B2/en not_active Expired - Fee Related
- 2003-08-26 JP JP2004569700A patent/JP2006502238A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| PL373578A1 (en) | 2005-09-05 |
| AU2003269673A1 (en) | 2004-03-19 |
| US20060041136A1 (en) | 2006-02-23 |
| CZ297472B6 (cs) | 2006-12-13 |
| EA007977B1 (ru) | 2007-02-27 |
| CA2495823A1 (en) | 2004-03-11 |
| WO2004020443A1 (en) | 2004-03-11 |
| EP1554284A1 (de) | 2005-07-20 |
| US7714133B2 (en) | 2010-05-11 |
| JP2006502238A (ja) | 2006-01-19 |
| KR20050058492A (ko) | 2005-06-16 |
| EP1554284B1 (de) | 2008-10-22 |
| DE60324301D1 (de) | 2008-12-04 |
| EA200500310A1 (ru) | 2005-08-25 |
| CZ20022906A3 (en) | 2004-05-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties | ||
| REN | Ceased due to non-payment of the annual fee |