PL373578A1 - Method for manufacturing crystalline form i of clopidogrel hydrogen sulphate - Google Patents

Method for manufacturing crystalline form i of clopidogrel hydrogen sulphate

Info

Publication number
PL373578A1
PL373578A1 PL03373578A PL37357803A PL373578A1 PL 373578 A1 PL373578 A1 PL 373578A1 PL 03373578 A PL03373578 A PL 03373578A PL 37357803 A PL37357803 A PL 37357803A PL 373578 A1 PL373578 A1 PL 373578A1
Authority
PL
Poland
Prior art keywords
hydrogen sulphate
crystalline form
clopidogrel hydrogen
clopidogrel
manufacturing crystalline
Prior art date
Application number
PL03373578A
Other languages
Polish (pl)
Inventor
Miroslav Veverka
Stefan Vodny
Eva Veverkova
Josef Hajicek
Hana Stepankova
Original Assignee
Zentiva, A.S.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=31954588&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL373578(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Zentiva, A.S. filed Critical Zentiva, A.S.
Publication of PL373578A1 publication Critical patent/PL373578A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Liquid Crystal Substances (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

A method for manufacturing hydrogen sulphate (alpha S) of the alpha-(2-chlorophenyl)-6,7dihydrothieno[3,2-c]pyridine-5(4H)-acetic acid methyl ester (clopidogrel hydrogen sulphate) of formula I, in crystalline Form I, wherein the compound of formula is separated out of a solution of clopidogrel in the form of the free base or salt in a solvent selected from the series of primary, secondary or tertiary C1-C5 alcohols, their esters with C1-C4 carboxylic acids, or optionally of mixtures thereof.
PL03373578A 2002-08-27 2003-08-26 Method for manufacturing crystalline form i of clopidogrel hydrogen sulphate PL373578A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CZ20022906A CZ297472B6 (en) 2002-08-27 2002-08-27 Process for preparing crystalline form I of clopidogrel hydrogen sulfate

Publications (1)

Publication Number Publication Date
PL373578A1 true PL373578A1 (en) 2005-09-05

Family

ID=31954588

Family Applications (1)

Application Number Title Priority Date Filing Date
PL03373578A PL373578A1 (en) 2002-08-27 2003-08-26 Method for manufacturing crystalline form i of clopidogrel hydrogen sulphate

Country Status (12)

Country Link
US (1) US7714133B2 (en)
EP (1) EP1554284B1 (en)
JP (1) JP2006502238A (en)
KR (1) KR20050058492A (en)
AT (1) ATE411998T1 (en)
AU (1) AU2003269673A1 (en)
CA (1) CA2495823A1 (en)
CZ (1) CZ297472B6 (en)
DE (1) DE60324301D1 (en)
EA (1) EA007977B1 (en)
PL (1) PL373578A1 (en)
WO (1) WO2004020443A1 (en)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2387802T3 (en) * 2003-08-04 2012-10-02 Wockhardt Limited Novel process for the manufacture of bisulfate of (+) - (S) -clopidogrel form I
DE10337773A1 (en) * 2003-08-13 2005-03-24 Krka Tovarna Zdravil, D.D. Crystallization of solid forms of clopidogrel addition salts
ATE455778T1 (en) * 2003-11-03 2010-02-15 Cadila Healthcare Ltd METHOD FOR PRODUCING FORM I OF (S)-(+)- CLOPIDOGRELBISULPHATE
BRPI0418726A (en) * 2004-04-09 2007-09-11 Hanmi Pharm Ind Co Ltd crystalline clopidogrel naphthalenesulfonate or hydrate thereof, method for their preparation and pharmaceutical composition containing the same
SI1740593T1 (en) * 2004-04-19 2016-08-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Processes for the preparation of clopidogrel hydrogen sulfate polymorphic form i
UA84335C2 (en) * 2004-04-20 2008-10-10 Санофи Авентис Clopidogrel salt and polymorphic forms thereof
JP2007533744A (en) * 2004-04-20 2007-11-22 サノフイ−アベンテイス (+)-(S) -α- (2-Chlorophenyl) -6,7-dihydrothieno [3,2-C] pyridine-5 (4H) acetic acid methyl hydrobromide, clopidrogel hydrobromic acid Polymorphic form of salt
EP1693375A1 (en) * 2005-02-21 2006-08-23 KRKA, tovarna zdravil, d.d., Novo mesto Process for preparing clopidrogel hydrogen sulfate of form I
US7772398B2 (en) 2005-03-11 2010-08-10 Dr. Reddy's Laboratories, Inc. Process for making crystalline form I of clopidogrel hydrogen sulphate
WO2007017886A1 (en) * 2005-08-11 2007-02-15 Arch Pharmalabs Limited Novel process for preparation of clopidogrel bisulphate polymorphic form i
CA2618187C (en) 2005-09-21 2011-06-21 Chong Kun Dang Pharmaceutical Corp. Novel resinate complex of s-clopidogrel and production method thereof
EP2114957A4 (en) * 2007-01-29 2011-06-08 Ipca Lab Ltd Process for preparation of crystalline clopidogrel hydrogen sulphate form i
US20080188663A1 (en) * 2007-01-29 2008-08-07 Ashok Kumar Process for the preparation of crystalline clopidogrel hydrogen sulphate Form I
NZ581362A (en) 2007-04-27 2011-07-29 Cydex Pharmaceuticals Inc Formulations containing clopidogrel and sulfoalkyl ether cyclodextrin and methods of use
EP2107061A1 (en) 2008-04-02 2009-10-07 Krka Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of optically enriched clopidogrel
CN102083837B (en) * 2008-06-24 2013-09-18 Zach系统股份公司 Process for the preparation of clopidogrel hydrogen sulfate crystalline form I
ES2769949T3 (en) 2009-05-13 2020-06-29 Cydex Pharmaceuticals Inc Pharmaceutical compositions comprising prasugrel and cyclodextrin derivatives and methods of preparing and using them
WO2011042804A2 (en) * 2009-10-08 2011-04-14 Jubliant Life Sciences Limited An improved process for the preparation of clopidogrel hydrogen sulfate form i
KR101130445B1 (en) * 2009-10-29 2012-03-27 동아제약주식회사 Process for preparing crystalline Form I Clopidogrel bisulfate
WO2011051976A2 (en) 2009-10-30 2011-05-05 Matrix Laboratories Ltd An improved process for the preparation of clopidogrel bisulfate form i
WO2011055378A1 (en) * 2009-11-09 2011-05-12 Pharmazell Gmbh Improved process for preparation of clopiodogrel bisulfate crystalline form-1
WO2011125069A1 (en) 2010-03-22 2011-10-13 Rpg Life Sciences Limited A process for preparation of crystalline form i of clopidogrel bisulfate
CN102558194A (en) * 2010-12-11 2012-07-11 山东方明药业股份有限公司 Preparation method of I-type clopidogrel hydrogen sulfate
CN102875568B (en) * 2012-09-06 2015-12-09 苏州晶云药物科技有限公司 The method of the pure crystal formation I of preparation (+)-(S)-SR-25990C
KR101710922B1 (en) 2015-06-03 2017-02-28 경동제약 주식회사 Method for preparing crystalline form I of Clopidogrel hydrogen sulfate
CN107163060B (en) * 2017-05-24 2021-03-02 常州制药厂有限公司 Preparation method of clopidogrel hydrogen sulfate crystal form II
CN107118221B (en) * 2017-05-24 2021-09-07 常州制药厂有限公司 Preparation method of clopidogrel hydrogen sulfate crystal form I

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2623810B2 (en) * 1987-02-17 1992-01-24 Sanofi Sa ALPHA SALTS- (TETRAHYDRO-4,5,6,7 THIENO (3,2-C) PYRIDYL-5) (2-CHLORO-PHENYL) -THETHYL ACETATE DEXTROGYRE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
FR2779726B1 (en) * 1998-06-15 2001-05-18 Sanofi Sa POLYMORPHIC FORM OF CLOPIDOGREL HYDROGENOSULFATE
GB0125708D0 (en) * 2001-10-26 2001-12-19 Generics Uk Ltd Novel compounds and processes
WO2003051362A2 (en) * 2001-12-18 2003-06-26 Teva Pharmaceutical Industries Ltd. Polymorphs of clopidogrel hydrogensulfate
US6767913B2 (en) * 2001-12-18 2004-07-27 Teva Pharmaceutical Industries Ltd. Crystal forms iii, iv, v, and novel amorphous form of clopidogrel hydrogensulfate, processes for their preparation, processes for the preparation of form i, compositions containing the new forms and methods of administering the new forms
US7074928B2 (en) * 2002-01-11 2006-07-11 Teva Pharmaceutical Industries, Ltd. Polymorphs of clopidogrel hydrogensulfate
JP4072005B2 (en) * 2002-06-12 2008-04-02 日本電波工業株式会社 Temperature compensated crystal oscillator
ES2387802T3 (en) * 2003-08-04 2012-10-02 Wockhardt Limited Novel process for the manufacture of bisulfate of (+) - (S) -clopidogrel form I

Also Published As

Publication number Publication date
CZ20022906A3 (en) 2004-05-12
US7714133B2 (en) 2010-05-11
CA2495823A1 (en) 2004-03-11
EP1554284B1 (en) 2008-10-22
ATE411998T1 (en) 2008-11-15
US20060041136A1 (en) 2006-02-23
EP1554284A1 (en) 2005-07-20
AU2003269673A1 (en) 2004-03-19
EA007977B1 (en) 2007-02-27
DE60324301D1 (en) 2008-12-04
KR20050058492A (en) 2005-06-16
JP2006502238A (en) 2006-01-19
WO2004020443A1 (en) 2004-03-11
CZ297472B6 (en) 2006-12-13
EA200500310A1 (en) 2005-08-25

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