GEP20104957B - A PROCESS FOR THE PREPARATION OF POLYMORPH FORM I OF (S)-(+)-METHYL-ά-(2-CHLOROPHENYL)-6,7-DYHIDRO-THIENO-[3,2-c]PYRIDINE-5(4H)-ACETATE HYDROGEN SULFATE - Google Patents

A PROCESS FOR THE PREPARATION OF POLYMORPH FORM I OF (S)-(+)-METHYL-ά-(2-CHLOROPHENYL)-6,7-DYHIDRO-THIENO-[3,2-c]PYRIDINE-5(4H)-ACETATE HYDROGEN SULFATE

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Publication number
GEP20104957B
GEP20104957B GEAP200710929A GEAP2007010929A GEP20104957B GE P20104957 B GEP20104957 B GE P20104957B GE AP200710929 A GEAP200710929 A GE AP200710929A GE AP2007010929 A GEAP2007010929 A GE AP2007010929A GE P20104957 B GEP20104957 B GE P20104957B
Authority
GE
Georgia
Prior art keywords
dyhidro
thieno
pyridine
methyl
preparation
Prior art date
Application number
GEAP200710929A
Inventor
József Neu
István Greiner
Sándor Garadnay
Original Assignee
Richter Gedeon Nyrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Nyrt filed Critical Richter Gedeon Nyrt
Publication of GEP20104957B publication Critical patent/GEP20104957B/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention relates to a process for the preparation of the pharmaceutically applicable po¬ly¬morph Form I of (S)-(+)-methyl-ά-(2-clorophe¬nyl)-6,7-dyhidro-thieno[3,2-c]-pyridine-5(4H)-ace¬tate hydrosulphate (hydrosulphate of klopidrogel).
GEAP200710929A 2006-03-09 2007-03-08 A PROCESS FOR THE PREPARATION OF POLYMORPH FORM I OF (S)-(+)-METHYL-ά-(2-CHLOROPHENYL)-6,7-DYHIDRO-THIENO-[3,2-c]PYRIDINE-5(4H)-ACETATE HYDROGEN SULFATE GEP20104957B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU0600194A HU228030B1 (en) 2006-03-09 2006-03-09 Process for producing the polymorphic i form of (s)-(+)-methyl-2-(2-chlorophenyl)-2-(6,7-dihydro-4h-thieno[3,2-c]pyridin-5- yl)-acetate

Publications (1)

Publication Number Publication Date
GEP20104957B true GEP20104957B (en) 2010-04-12

Family

ID=89986636

Family Applications (1)

Application Number Title Priority Date Filing Date
GEAP200710929A GEP20104957B (en) 2006-03-09 2007-03-08 A PROCESS FOR THE PREPARATION OF POLYMORPH FORM I OF (S)-(+)-METHYL-ά-(2-CHLOROPHENYL)-6,7-DYHIDRO-THIENO-[3,2-c]PYRIDINE-5(4H)-ACETATE HYDROGEN SULFATE

Country Status (14)

Country Link
US (1) US20090093635A1 (en)
EP (1) EP2010545A2 (en)
JP (1) JP2009529521A (en)
KR (1) KR20080110795A (en)
CN (1) CN101600721A (en)
AU (1) AU2007222234A1 (en)
CA (1) CA2640242A1 (en)
EA (1) EA013543B1 (en)
GE (1) GEP20104957B (en)
HU (1) HU228030B1 (en)
IL (1) IL192825A0 (en)
MX (1) MX2008011485A (en)
NO (1) NO20084217L (en)
WO (1) WO2007102037A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011042804A2 (en) * 2009-10-08 2011-04-14 Jubliant Life Sciences Limited An improved process for the preparation of clopidogrel hydrogen sulfate form i
WO2011051976A2 (en) * 2009-10-30 2011-05-05 Matrix Laboratories Ltd An improved process for the preparation of clopidogrel bisulfate form i
CN103951675A (en) * 2014-04-29 2014-07-30 浙江华海药业股份有限公司 Preparation method for clopidogrel hydrogen sulphate
KR102188371B1 (en) 2020-09-09 2020-12-08 (주)세명이앤씨 Increase generating efficiency and preventing accident solar power system

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6767913B2 (en) * 2001-12-18 2004-07-27 Teva Pharmaceutical Industries Ltd. Crystal forms iii, iv, v, and novel amorphous form of clopidogrel hydrogensulfate, processes for their preparation, processes for the preparation of form i, compositions containing the new forms and methods of administering the new forms
IL162461A0 (en) * 2001-12-18 2005-11-20 Teva Pharma Polymorphs of clopidogrel hydrogensulfate
US7074928B2 (en) * 2002-01-11 2006-07-11 Teva Pharmaceutical Industries, Ltd. Polymorphs of clopidogrel hydrogensulfate
EP1680430B1 (en) * 2003-11-03 2010-01-20 Cadila Healthcare Ltd. Processes for preparing form i of (s)-(+)- clopidogrel bisulfate
EP1772455A3 (en) * 2004-03-05 2007-06-27 IPCA Laboratories Limited Industrial process for preparation a polmorph of clopidogrel hydrogen sulphate
SI1740593T1 (en) * 2004-04-19 2016-08-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Processes for the preparation of clopidogrel hydrogen sulfate polymorphic form i

Also Published As

Publication number Publication date
CN101600721A (en) 2009-12-09
WO2007102037A3 (en) 2008-11-13
HU0600194D0 (en) 2006-05-29
HUP0600194A2 (en) 2007-09-28
EA200801963A1 (en) 2009-02-27
US20090093635A1 (en) 2009-04-09
IL192825A0 (en) 2009-08-03
MX2008011485A (en) 2009-03-05
CA2640242A1 (en) 2007-09-13
JP2009529521A (en) 2009-08-20
HU228030B1 (en) 2012-08-28
AU2007222234A1 (en) 2007-09-13
EP2010545A2 (en) 2009-01-07
NO20084217L (en) 2008-12-08
EA013543B1 (en) 2010-06-30
WO2007102037A2 (en) 2007-09-13
KR20080110795A (en) 2008-12-19
HUP0600194A3 (en) 2007-12-28

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