SI1740593T1 - Postopek za pripravo polimorfne oblike I klopidogrel hidrogen sulfata - Google Patents
Postopek za pripravo polimorfne oblike I klopidogrel hidrogen sulfataInfo
- Publication number
- SI1740593T1 SI1740593T1 SI200532079A SI200532079A SI1740593T1 SI 1740593 T1 SI1740593 T1 SI 1740593T1 SI 200532079 A SI200532079 A SI 200532079A SI 200532079 A SI200532079 A SI 200532079A SI 1740593 T1 SI1740593 T1 SI 1740593T1
- Authority
- SI
- Slovenia
- Prior art keywords
- processes
- preparation
- hydrogen sulfate
- polymorphic form
- clopidogrel hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 200410009028 CN1690060A (zh) | 2004-04-19 | 2004-04-19 | 一种制备i型硫酸氯吡格雷的方法 |
SI200400122A SI21749A (sl) | 2004-04-21 | 2004-04-21 | Postopek za pripravo polimorfne oblike I klopidogrel hidrogen sulfata |
EP05734224.8A EP1740593B1 (en) | 2004-04-19 | 2005-04-19 | Processes for the preparation of clopidogrel hydrogen sulfate polymorphic form i |
PCT/EP2005/004160 WO2005100364A1 (en) | 2004-04-19 | 2005-04-19 | Processes for the preparation of clopidogrel hydrogen sulfate polymorphic form i |
Publications (1)
Publication Number | Publication Date |
---|---|
SI1740593T1 true SI1740593T1 (sl) | 2016-08-31 |
Family
ID=34965241
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200532079A SI1740593T1 (sl) | 2004-04-19 | 2005-04-19 | Postopek za pripravo polimorfne oblike I klopidogrel hidrogen sulfata |
Country Status (10)
Country | Link |
---|---|
US (1) | US7999106B2 (sl) |
EP (1) | EP1740593B1 (sl) |
EA (1) | EA010198B1 (sl) |
ES (1) | ES2577303T3 (sl) |
HR (1) | HRP20160757T1 (sl) |
HU (1) | HUE029459T2 (sl) |
NO (1) | NO339878B1 (sl) |
PL (1) | PL1740593T3 (sl) |
SI (1) | SI1740593T1 (sl) |
WO (1) | WO2005100364A1 (sl) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7772398B2 (en) * | 2005-03-11 | 2010-08-10 | Dr. Reddy's Laboratories, Inc. | Process for making crystalline form I of clopidogrel hydrogen sulphate |
US20090093635A1 (en) * | 2006-03-09 | 2009-04-09 | Sandor Garadnay | PROCESS FOR MAKING POLYMORPH FROM I OF (S) - (+) -METHYL-ALPHA- (2-CHLOROPHENYL) -6, 7-DYHIDRO-THIENO- [3, 2-c] PYRIDINE-5 (4H) -ACETATE HYDROGEN SULFATE |
CA2655844A1 (en) * | 2006-08-03 | 2008-02-14 | Teva Pharmaceutical Industries Ltd. | Process for preparing clopidogrel bisulphate |
WO2008032995A1 (en) * | 2006-09-15 | 2008-03-20 | Boryung Pharmaceutical Co., Ltd | Clopidogrel(+)-camphorsulfonate salt, method of preparing the same and a pharmaceutical composition comprising the same |
SI22383A (sl) * | 2006-09-22 | 2008-04-30 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Nov postopek sinteze klopidogrela in nove oblike njegovih farmacevtsko sprejemljivih soli |
WO2008068569A2 (en) * | 2006-12-01 | 2008-06-12 | Wockhardt Research Centre | Processes for the preparation of clopidogrel hydrochloride |
WO2008093357A2 (en) * | 2007-01-29 | 2008-08-07 | Ipca Laboratories Limited | Process for preparation of crystalline clopidogrel hydrogen sulphate form i |
PL382055A1 (pl) * | 2007-03-23 | 2008-09-29 | Koźluk Tomasz Nobilus Ent | Sposób wytwarzania formy krystalicznej 1 wodorosiarczanu klopidogrelu |
EP2107061A1 (en) | 2008-04-02 | 2009-10-07 | Krka Tovarna Zdravil, D.D., Novo Mesto | Process for the preparation of optically enriched clopidogrel |
WO2011042804A2 (en) | 2009-10-08 | 2011-04-14 | Jubliant Life Sciences Limited | An improved process for the preparation of clopidogrel hydrogen sulfate form i |
WO2011051976A2 (en) * | 2009-10-30 | 2011-05-05 | Matrix Laboratories Ltd | An improved process for the preparation of clopidogrel bisulfate form i |
WO2011125069A1 (en) * | 2010-03-22 | 2011-10-13 | Rpg Life Sciences Limited | A process for preparation of crystalline form i of clopidogrel bisulfate |
CN103360406A (zh) * | 2012-03-26 | 2013-10-23 | 黑龙江福和华星制药集团股份有限公司 | 一种制备i型硫酸氢氯吡格雷的方法 |
CN102924474B (zh) * | 2012-11-08 | 2015-04-01 | 浙江海翔药业股份有限公司 | 一种氯吡格雷硫酸氢盐晶型ⅰ的制备方法 |
CN110256338A (zh) | 2013-10-22 | 2019-09-20 | 奇斯药制品公司 | 用于制备pde4抑制剂的方法 |
BR112017018954A2 (pt) | 2015-03-06 | 2018-05-15 | Beyondspring Pharmaceuticals, Inc. | uso de forma mutante de proteína ras e método para tratar câncer |
KR101710922B1 (ko) | 2015-06-03 | 2017-02-28 | 경동제약 주식회사 | 클로피도그렐 황산염 결정형 i형의 제조방법 |
CN107921021A (zh) | 2015-06-17 | 2018-04-17 | 大塚制药美国公司 | 结晶化合物 |
IL260933B2 (en) | 2016-02-08 | 2023-04-01 | Beyondspring Pharmaceuticals Inc | Preparations containing tocorsol or its analogues |
WO2018129381A1 (en) | 2017-01-06 | 2018-07-12 | Beyondspring Pharmaceuticals, Inc. | Tubulin binding compounds and therapeutic use thereof |
SG11201907023UA (en) | 2017-02-01 | 2019-08-27 | Beyondspring Pharmaceuticals Inc | Method of reducing neutropenia |
WO2018149608A1 (en) | 2017-02-16 | 2018-08-23 | Sandoz Ag | Crystalline forms of cabotegravir sodium |
KR20200112881A (ko) | 2018-01-24 | 2020-10-05 | 비욘드스프링 파마수티컬스, 인코포레이티드. | 플리나불린의 투여를 통해 혈소판감소증을 감소시키는 조성물 및 방법 |
TW202028208A (zh) | 2018-10-09 | 2020-08-01 | 瑞士商諾華公司 | N-(4-氟-3-(6-(3-甲基吡啶-2-基)-[1,2,4]三唑并[1,5-a]嘧啶-2-基)苯基)-2,4-二甲基㗁唑-5-甲醯胺固體形式 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2623810B2 (fr) | 1987-02-17 | 1992-01-24 | Sanofi Sa | Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant |
FR2779726B1 (fr) * | 1998-06-15 | 2001-05-18 | Sanofi Sa | Forme polymorphe de l'hydrogenosulfate de clopidogrel |
WO2002018357A1 (en) | 2000-08-29 | 2002-03-07 | Rpg Life Sciences Limited | A ONE-POT PROCESS FOR THE PREPARATION OF PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS OF 4, 5, 6, 7 - TETRAHYDROTHIENO (3,2-c) PYRIDINE DERIVATIVES HAVING ANTITHROMBOTIC ACTIVITY |
GB0125708D0 (en) | 2001-10-26 | 2001-12-19 | Generics Uk Ltd | Novel compounds and processes |
KR100839136B1 (ko) * | 2001-12-18 | 2008-06-20 | 테바 파마슈티컬 인더스트리즈 리미티드 | 클로피도그렐 황산수소염의 다형 |
AU2003257541A1 (en) * | 2002-08-27 | 2004-03-19 | Yamanouchi Pharmaceutical Co., Ltd. | Novel crystals |
CZ297472B6 (cs) * | 2002-08-27 | 2006-12-13 | Zentiva, A.S. | Zpusob výroby clopidogrelu hydrogensulfátu krystalické formy I |
WO2004048385A2 (en) * | 2002-11-28 | 2004-06-10 | Instytut Farmaceutyczny | A process for the preparation of crystalline form 1 or clopidogrel hydrogen sulfate |
WO2004081016A1 (en) * | 2003-03-12 | 2004-09-23 | Cadila Healthcare Limited | Polymorphs and amorphous form of (s) - (+) -clopidogrel bisulfate |
EA010684B1 (ru) * | 2003-07-02 | 2008-10-30 | Эгиш Дьёдьсердьяр Рт. | Способ получения кристаллического полиморфа ингибитора агрегации тромбоцитов |
WO2005012300A1 (en) | 2003-08-04 | 2005-02-10 | Wockhardt Limited | A novel process for the manufacture of (+)-(s)-clopidogrel bisulfate form-i |
DE10337773A1 (de) * | 2003-08-13 | 2005-03-24 | Krka Tovarna Zdravil, D.D. | Kristallisation von festen Formen von Clopidogrel-Additionssalzen |
WO2005104663A2 (en) * | 2004-03-05 | 2005-11-10 | Ipca Laboratories Limited | Industrial process for preparation of clopidogrel hydrogen sulphate |
-
2005
- 2005-04-19 SI SI200532079A patent/SI1740593T1/sl unknown
- 2005-04-19 HU HUE05734224A patent/HUE029459T2/en unknown
- 2005-04-19 EP EP05734224.8A patent/EP1740593B1/en active Active
- 2005-04-19 PL PL05734224.8T patent/PL1740593T3/pl unknown
- 2005-04-19 EA EA200601822A patent/EA010198B1/ru not_active IP Right Cessation
- 2005-04-19 US US11/568,075 patent/US7999106B2/en not_active Expired - Fee Related
- 2005-04-19 ES ES05734224.8T patent/ES2577303T3/es active Active
- 2005-04-19 WO PCT/EP2005/004160 patent/WO2005100364A1/en active Application Filing
-
2006
- 2006-11-20 NO NO20065321A patent/NO339878B1/no not_active IP Right Cessation
-
2016
- 2016-06-28 HR HRP20160757TT patent/HRP20160757T1/hr unknown
Also Published As
Publication number | Publication date |
---|---|
HUE029459T2 (en) | 2017-02-28 |
EA200601822A1 (ru) | 2007-02-27 |
EA010198B1 (ru) | 2008-06-30 |
NO20065321L (no) | 2007-01-09 |
EP1740593B1 (en) | 2016-04-06 |
US20090234123A1 (en) | 2009-09-17 |
WO2005100364A1 (en) | 2005-10-27 |
NO339878B1 (no) | 2017-02-13 |
HRP20160757T1 (hr) | 2016-08-12 |
PL1740593T3 (pl) | 2016-09-30 |
EP1740593A1 (en) | 2007-01-10 |
ES2577303T3 (es) | 2016-07-14 |
US7999106B2 (en) | 2011-08-16 |
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