EA201171461A1 - Получение налмефена гидрохлорида из налтрексона - Google Patents

Получение налмефена гидрохлорида из налтрексона

Info

Publication number
EA201171461A1
EA201171461A1 EA201171461A EA201171461A EA201171461A1 EA 201171461 A1 EA201171461 A1 EA 201171461A1 EA 201171461 A EA201171461 A EA 201171461A EA 201171461 A EA201171461 A EA 201171461A EA 201171461 A1 EA201171461 A1 EA 201171461A1
Authority
EA
Eurasian Patent Office
Prior art keywords
hydrochloride
naltrex
nalmephene
obtaining
nalmefene
Prior art date
Application number
EA201171461A
Other languages
English (en)
Other versions
EA019331B1 (ru
Inventor
Карла Де Фавери
Мауро Казарин
Микеле Брузеган
Original Assignee
Х. Лундбекк А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43222172&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201171461(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Х. Лундбекк А/С filed Critical Х. Лундбекк А/С
Publication of EA201171461A1 publication Critical patent/EA201171461A1/ru
Publication of EA019331B1 publication Critical patent/EA019331B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Addiction (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Psychiatry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Способ получения гидрохлорида налмефена из налтрексона, где способ в особенности хорошо подходит для крупномасштабного промышленного применения, и как установлено, эффективно обеспечивает высокий выход и предоставляет очень чистый налмефен в виде гидрохлоридной соли.
EA201171461A 2009-05-25 2010-05-21 Получение налмефена гидрохлорида из налтрексона EA019331B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200900650 2009-05-25
PCT/DK2010/050110 WO2010136039A1 (en) 2009-05-25 2010-05-21 Preparation of nalmefene hydrochloride from naltrexone

Publications (2)

Publication Number Publication Date
EA201171461A1 true EA201171461A1 (ru) 2012-05-30
EA019331B1 EA019331B1 (ru) 2014-02-28

Family

ID=43222172

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201171461A EA019331B1 (ru) 2009-05-25 2010-05-21 Получение налмефена гидрохлорида из налтрексона

Country Status (35)

Country Link
US (1) US8598352B2 (ru)
EP (1) EP2435439B8 (ru)
JP (1) JP5794980B2 (ru)
KR (1) KR101716522B1 (ru)
CN (1) CN102459276B (ru)
AR (1) AR076891A1 (ru)
AU (1) AU2010252392B2 (ru)
BR (1) BRPI1010975B1 (ru)
CA (1) CA2763093C (ru)
CL (1) CL2011002974A1 (ru)
CO (1) CO6470832A2 (ru)
CR (1) CR20110612A (ru)
DK (1) DK2435439T3 (ru)
DO (1) DOP2011000362A (ru)
EA (1) EA019331B1 (ru)
ES (1) ES2564006T3 (ru)
GE (1) GEP20146190B (ru)
HR (1) HRP20160110T1 (ru)
HU (1) HUE026892T2 (ru)
IL (1) IL216422A (ru)
MA (1) MA33368B1 (ru)
ME (1) ME02622B (ru)
MX (1) MX2011012502A (ru)
MY (1) MY158251A (ru)
NZ (1) NZ596988A (ru)
PL (1) PL2435439T3 (ru)
RS (1) RS54599B1 (ru)
SG (1) SG176205A1 (ru)
SI (1) SI2435439T1 (ru)
SM (1) SMT201600061B (ru)
TN (1) TN2011000590A1 (ru)
TW (1) TWI469985B (ru)
UA (1) UA106752C2 (ru)
WO (1) WO2010136039A1 (ru)
ZA (1) ZA201108659B (ru)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2995614B8 (en) 2010-06-11 2018-03-28 Rhodes Technologies Inc. Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof
SI2635586T1 (sl) 2010-11-05 2017-07-31 H. Lundbeck A/S Metoda za izdelavo naltreksona
CN103012416B (zh) * 2011-09-28 2015-07-01 辽宁海思科制药有限公司 一种盐酸纳美芬的制备方法
TWI560170B (en) * 2011-12-06 2016-12-01 Lundbeck & Co As H Process for recovery of nalmefene hydrochloride
CN102584840A (zh) * 2011-12-28 2012-07-18 南京优科生物医药有限公司 一种制备纳美芬化合物的方法
WO2013164383A1 (en) 2012-05-03 2013-11-07 H. Lundbeck A/S Method for the manufacturing of naltrexone
US20140005216A1 (en) 2012-06-27 2014-01-02 H. Lundbeck A/S Nalmefene for reduction of alcohol consumption in specific target populations
CN103204859B (zh) * 2013-04-25 2015-12-02 四川海思科制药有限公司 一种盐酸纳美芬化合物及其制备方法
AR096851A1 (es) * 2013-07-11 2016-02-03 H Lundbeck As Sales que no forman hidratos ni solvatos de nalmefeno
EP3082815B1 (en) 2013-12-20 2018-10-03 H. Lundbeck A/S Use of an opioid receptor antagonist with kappa-activity and vortioxetine for treatment of depressive disorder with melancholic features
RU2016145411A (ru) 2014-04-22 2018-05-23 Оцука Фармасьютикал Ко., Лтд. Комбинация брекспипразола и налмефена, и ее применение для лечения синдрома химической зависимости
CN104513251A (zh) * 2014-11-28 2015-04-15 安徽悦康凯悦制药有限公司 一种盐酸纳美芬的制备方法
US9757372B2 (en) * 2015-03-25 2017-09-12 Taiwanj Pharmaceuticals Co., Ltd. Toll-like receptor 4 antagonists and use in autoimmune liver diseases
RU2712232C1 (ru) * 2018-10-05 2020-01-27 Федеральное государственное унитарное предприятие "Научно-исследовательский институт гигиены, профпатологии и экологии человека" Федерального медико-биологического агентства Улучшенный способ получения налмефена из налтрексона
US10927121B1 (en) 2019-12-20 2021-02-23 Southwest Research Institute Technologies for removing residual solvent from nalmefene hydrochloride and producing crystalline nalmefene hydrochloride monohydrate, monosolvate, or crystalline nalmefene hydrochloride dihydrate
JP2023548356A (ja) 2020-11-02 2023-11-16 ローズ テクノロジーズ ノルオキシモルホンを精製するための方法
US20240109907A1 (en) 2021-01-28 2024-04-04 Rhodes Technologies Process for crystallizing nalmefene hydrochloride
CN117986261B (zh) * 2024-04-02 2024-06-18 成都瑞尔医药科技有限公司 一种盐酸纳美芬母液的回收套用方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4341764A (en) 1980-03-05 1982-07-27 Cutter Laboratories, Inc. Method of preparing fibronectin and antihemophilic factor
US4322426A (en) * 1980-04-28 1982-03-30 E. I. Du Pont De Nemours And Company 17-Substituted-6-desoxy-7,8-dihydro-6α-methylnoroxymorphone narcotic antagonists
US4535157A (en) * 1983-11-01 1985-08-13 Key Pharmaceuticals, Inc. Process for making 6-desoxy-6-methylenenaloxone and 6-desoxy-6-methylenenaltrexone
US4751307A (en) * 1985-01-17 1988-06-14 Mallinckrodt, Inc. Wittig-reaction processes
US4880813A (en) * 1988-07-22 1989-11-14 Baker Cummins Pharmaceuticals, Inc. Method of treatment for allergic rhinitis
US7687646B2 (en) 2006-03-28 2010-03-30 Azad Pharmaceutical Ingredients, Ag Polymorphic forms of olopatadine hydrochloride and methods for producing olopatadine and salts thereof
GB2447013A (en) * 2007-03-01 2008-09-03 Reckitt Benckiser Healthcare Analgesic composition containing buprenorphone and nalmefene

Also Published As

Publication number Publication date
SG176205A1 (en) 2011-12-29
ME02622B (me) 2017-06-20
WO2010136039A1 (en) 2010-12-02
US20120123123A1 (en) 2012-05-17
MX2011012502A (es) 2011-12-12
ZA201108659B (en) 2013-02-27
PL2435439T3 (pl) 2016-05-31
SMT201600061B (it) 2016-07-01
CN102459276B (zh) 2016-09-21
AU2010252392A1 (en) 2012-01-12
EP2435439A1 (en) 2012-04-04
NZ596988A (en) 2013-03-28
CL2011002974A1 (es) 2012-04-13
RS54599B1 (en) 2016-08-31
JP2012527489A (ja) 2012-11-08
MA33368B1 (fr) 2012-06-01
BRPI1010975A2 (pt) 2015-10-20
DOP2011000362A (es) 2012-07-15
CN102459276A (zh) 2012-05-16
US8598352B2 (en) 2013-12-03
CR20110612A (es) 2012-02-22
EP2435439B8 (en) 2016-05-18
HRP20160110T1 (hr) 2016-03-11
BRPI1010975B1 (pt) 2021-08-24
AR076891A1 (es) 2011-07-13
EA019331B1 (ru) 2014-02-28
IL216422A (en) 2015-06-30
IL216422A0 (en) 2012-02-29
HUE026892T2 (en) 2016-07-28
GEP20146190B (en) 2014-11-10
KR20120023704A (ko) 2012-03-13
SI2435439T1 (sl) 2016-06-30
ES2564006T3 (es) 2016-03-17
TWI469985B (zh) 2015-01-21
EP2435439B1 (en) 2016-01-06
UA106752C2 (ru) 2014-10-10
KR101716522B1 (ko) 2017-03-14
CA2763093C (en) 2017-03-07
JP5794980B2 (ja) 2015-10-14
TW201043634A (en) 2010-12-16
CA2763093A1 (en) 2010-12-02
AU2010252392B2 (en) 2014-10-23
TN2011000590A1 (en) 2013-05-24
MY158251A (en) 2016-09-30
CO6470832A2 (es) 2012-06-29
DK2435439T3 (en) 2016-02-29

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AZ BY KZ RU