CR20110612A - Metodo para la preparacion de hidrocloruro de nalmefeno - Google Patents
Metodo para la preparacion de hidrocloruro de nalmefenoInfo
- Publication number
- CR20110612A CR20110612A CR20110612A CR20110612A CR20110612A CR 20110612 A CR20110612 A CR 20110612A CR 20110612 A CR20110612 A CR 20110612A CR 20110612 A CR20110612 A CR 20110612A CR 20110612 A CR20110612 A CR 20110612A
- Authority
- CR
- Costa Rica
- Prior art keywords
- nalmefen
- hydrocloride
- preparation
- nalmefene hydrochloride
- naltrexone
- Prior art date
Links
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 title 1
- GYWMRGWFQPSQLK-OPHZJPRHSA-N (4r,4as,7as,12bs)-3-(cyclopropylmethyl)-7-methylidene-2,4,5,6,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,9-diol;hydron;chloride Chemical compound Cl.N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CCC5=C)O)CC1)O)CC1CC1 GYWMRGWFQPSQLK-OPHZJPRHSA-N 0.000 abstract 2
- 229960000677 nalmefene hydrochloride Drugs 0.000 abstract 1
- 229960003086 naltrexone Drugs 0.000 abstract 1
- DQCKKXVULJGBQN-XFWGSAIBSA-N naltrexone Chemical compound N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CCC5=O)O)CC1)O)CC1CC1 DQCKKXVULJGBQN-XFWGSAIBSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Addiction (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200900650 | 2009-05-25 | ||
| US18102209P | 2009-05-26 | 2009-05-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR20110612A true CR20110612A (es) | 2012-02-22 |
Family
ID=43222172
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR20110612A CR20110612A (es) | 2009-05-25 | 2011-11-22 | Metodo para la preparacion de hidrocloruro de nalmefeno |
Country Status (35)
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2802295C (en) | 2010-06-11 | 2016-09-20 | Rhodes Technologies | Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof |
| HRP20170379T1 (hr) | 2010-11-05 | 2017-05-05 | H. Lundbeck A/S | Postupak proizvodnje naltreksona |
| CN103012416B (zh) * | 2011-09-28 | 2015-07-01 | 辽宁海思科制药有限公司 | 一种盐酸纳美芬的制备方法 |
| TWI560170B (en) * | 2011-12-06 | 2016-12-01 | Lundbeck & Co As H | Process for recovery of nalmefene hydrochloride |
| CN102584840A (zh) * | 2011-12-28 | 2012-07-18 | 南京优科生物医药有限公司 | 一种制备纳美芬化合物的方法 |
| WO2013164383A1 (en) | 2012-05-03 | 2013-11-07 | H. Lundbeck A/S | Method for the manufacturing of naltrexone |
| US20140005216A1 (en) | 2012-06-27 | 2014-01-02 | H. Lundbeck A/S | Nalmefene for reduction of alcohol consumption in specific target populations |
| CN103204859B (zh) * | 2013-04-25 | 2015-12-02 | 四川海思科制药有限公司 | 一种盐酸纳美芬化合物及其制备方法 |
| AR096851A1 (es) | 2013-07-11 | 2016-02-03 | H Lundbeck As | Sales que no forman hidratos ni solvatos de nalmefeno |
| JP6448645B2 (ja) | 2013-12-20 | 2019-01-09 | ハー・ルンドベック・アクチエゼルスカベット | メランコリアの特徴を伴う抑うつ障害を処置するための、カッパ−活性を伴うオピオイド受容体拮抗薬およびボルチオキセチンの使用 |
| SG10201809280PA (en) | 2014-04-22 | 2018-11-29 | Otsuka Pharma Co Ltd | Combination of brexpiprazole and nalmefene and use thereof for treating substance-related disorders |
| CN104513251A (zh) * | 2014-11-28 | 2015-04-15 | 安徽悦康凯悦制药有限公司 | 一种盐酸纳美芬的制备方法 |
| US9757372B2 (en) * | 2015-03-25 | 2017-09-12 | Taiwanj Pharmaceuticals Co., Ltd. | Toll-like receptor 4 antagonists and use in autoimmune liver diseases |
| RU2712232C1 (ru) * | 2018-10-05 | 2020-01-27 | Федеральное государственное унитарное предприятие "Научно-исследовательский институт гигиены, профпатологии и экологии человека" Федерального медико-биологического агентства | Улучшенный способ получения налмефена из налтрексона |
| US10927121B1 (en) | 2019-12-20 | 2021-02-23 | Southwest Research Institute | Technologies for removing residual solvent from nalmefene hydrochloride and producing crystalline nalmefene hydrochloride monohydrate, monosolvate, or crystalline nalmefene hydrochloride dihydrate |
| CA3196369A1 (en) | 2020-11-02 | 2022-05-05 | C. Frederick M. Huntley | Process for purifying noroxymorphone |
| US20240109907A1 (en) | 2021-01-28 | 2024-04-04 | Rhodes Technologies | Process for crystallizing nalmefene hydrochloride |
| CN117843650A (zh) * | 2023-12-27 | 2024-04-09 | 南京海纳医药科技股份有限公司 | 一种盐酸纳美芬的精制方法 |
| CN117986261B (zh) * | 2024-04-02 | 2024-06-18 | 成都瑞尔医药科技有限公司 | 一种盐酸纳美芬母液的回收套用方法 |
| CN119080788A (zh) * | 2024-08-19 | 2024-12-06 | 南京海鲸药业股份有限公司 | 一种盐酸纳美芬杂质的去除监控系统及去除方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4341764A (en) | 1980-03-05 | 1982-07-27 | Cutter Laboratories, Inc. | Method of preparing fibronectin and antihemophilic factor |
| US4322426A (en) | 1980-04-28 | 1982-03-30 | E. I. Du Pont De Nemours And Company | 17-Substituted-6-desoxy-7,8-dihydro-6α-methylnoroxymorphone narcotic antagonists |
| US4535157A (en) * | 1983-11-01 | 1985-08-13 | Key Pharmaceuticals, Inc. | Process for making 6-desoxy-6-methylenenaloxone and 6-desoxy-6-methylenenaltrexone |
| US4751307A (en) * | 1985-01-17 | 1988-06-14 | Mallinckrodt, Inc. | Wittig-reaction processes |
| US4880813A (en) * | 1988-07-22 | 1989-11-14 | Baker Cummins Pharmaceuticals, Inc. | Method of treatment for allergic rhinitis |
| US7687646B2 (en) | 2006-03-28 | 2010-03-30 | Azad Pharmaceutical Ingredients, Ag | Polymorphic forms of olopatadine hydrochloride and methods for producing olopatadine and salts thereof |
| GB2447013A (en) * | 2007-03-01 | 2008-09-03 | Reckitt Benckiser Healthcare | Analgesic composition containing buprenorphone and nalmefene |
-
2010
- 2010-05-21 HR HRP20160110TT patent/HRP20160110T1/hr unknown
- 2010-05-21 BR BRPI1010975-7A patent/BRPI1010975B1/pt not_active IP Right Cessation
- 2010-05-21 KR KR1020117028079A patent/KR101716522B1/ko not_active Expired - Fee Related
- 2010-05-21 MY MYPI2011005679A patent/MY158251A/en unknown
- 2010-05-21 UA UAA201114599A patent/UA106752C2/uk unknown
- 2010-05-21 ES ES10720257.4T patent/ES2564006T3/es active Active
- 2010-05-21 SI SI201031133A patent/SI2435439T1/sl unknown
- 2010-05-21 MX MX2011012502A patent/MX2011012502A/es active IP Right Grant
- 2010-05-21 ME MEP-2016-40A patent/ME02622B/me unknown
- 2010-05-21 GE GEAP201012510A patent/GEP20146190B/en unknown
- 2010-05-21 JP JP2012512208A patent/JP5794980B2/ja active Active
- 2010-05-21 CN CN201080033670.3A patent/CN102459276B/zh not_active Expired - Fee Related
- 2010-05-21 DK DK10720257.4T patent/DK2435439T3/en active
- 2010-05-21 RS RS20160137A patent/RS54599B1/sr unknown
- 2010-05-21 SG SG2011086501A patent/SG176205A1/en unknown
- 2010-05-21 PL PL10720257T patent/PL2435439T3/pl unknown
- 2010-05-21 MA MA34465A patent/MA33368B1/fr unknown
- 2010-05-21 CA CA2763093A patent/CA2763093C/en active Active
- 2010-05-21 EP EP10720257.4A patent/EP2435439B8/en active Active
- 2010-05-21 HU HUE10720257A patent/HUE026892T2/en unknown
- 2010-05-21 US US13/321,597 patent/US8598352B2/en active Active
- 2010-05-21 EA EA201171461A patent/EA019331B1/ru not_active IP Right Cessation
- 2010-05-21 AU AU2010252392A patent/AU2010252392B2/en not_active Ceased
- 2010-05-21 NZ NZ596988A patent/NZ596988A/xx not_active IP Right Cessation
- 2010-05-21 WO PCT/DK2010/050110 patent/WO2010136039A1/en not_active Ceased
- 2010-05-24 TW TW99116496A patent/TWI469985B/zh not_active IP Right Cessation
- 2010-05-26 AR ARP100101818A patent/AR076891A1/es unknown
-
2011
- 2011-11-17 IL IL216422A patent/IL216422A/en not_active IP Right Cessation
- 2011-11-21 TN TNP2011000590A patent/TN2011000590A1/en unknown
- 2011-11-22 CR CR20110612A patent/CR20110612A/es unknown
- 2011-11-23 DO DO2011000362A patent/DOP2011000362A/es unknown
- 2011-11-24 ZA ZA2011/08659A patent/ZA201108659B/en unknown
- 2011-11-24 CL CL2011002974A patent/CL2011002974A1/es unknown
- 2011-11-25 CO CO11162008A patent/CO6470832A2/es active IP Right Grant
-
2016
- 2016-02-26 SM SM201600061T patent/SMT201600061B/it unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CR20110612A (es) | Metodo para la preparacion de hidrocloruro de nalmefeno | |
| PH12013502126A1 (en) | Branched 3-phenylpropionic acid derivatives and the use thereof | |
| EP2433311A4 (en) | METHOD FOR IMPROVED PRODUCTION OF PHOTOVOLTAIC PRODUCTS | |
| BRPI0812362A2 (pt) | Métodos para produção de hidrogênio a partir de borano de am^nia | |
| CL2011000797A1 (es) | Metodo para producir anticuerpos a partir de celulas plasmaticas que comprende el cultivo de celulas plasmaticas en cantidades limitadas. | |
| EP2248906A4 (en) | PROCESS FOR THE PREPARATION OF L-AMINO ACID | |
| EP2407457A4 (en) | PROCESS FOR THE PREPARATION OF A DIAMIN DERIVATIVE | |
| EP2113570A4 (en) | PROCESS FOR PRODUCTION OF L-AMINO ACID | |
| IT1395068B1 (it) | Processo per la produzione di galatto-oligosaccaridi ultrapuri | |
| MX2012007717A (es) | Cepas y metodo para la produccion de metionina. | |
| UA111142C2 (uk) | Одержання заміщених похідних 2-фторакрилової кислоти | |
| EP2500451A4 (en) | METHOD FOR PRODUCING A LAMINATE | |
| PL2129786T3 (pl) | Sposób wytwarzania L-aminokwasów z zastosowaniem szczepów z rodziny Enterobacteriaceae | |
| BR112012019006A2 (pt) | processo para a produção de ácidos carboxilícos com 1 a 3 átomos de carbono a partir de fontes renováveis | |
| EP2371830A4 (en) | PROCESS FOR THE PREPARATION OF A DIAMIN DERIVATIVE | |
| EP2474517A4 (en) | PROCESS FOR THE PREPARATION OF 1,1,3-TRICHLOR-1-PROPENE | |
| EA201300647A1 (ru) | Оптимизированный синтез чистых неполиморфных кристаллических жёлчных кислот с заданным размером частиц | |
| BR112012004482A2 (pt) | "método para produzir um l-aminoácido" | |
| MX2010003213A (es) | Nuevo procedimiento de sintesis de la ivabradina y de sus sales de adicion a un acido farmaceuticamente aceptable. | |
| UA106886C2 (uk) | Спосіб одержання 1-бензил-3-гідроксиметил-1h-індазолу і його похідних та проміжні сполуки магнію | |
| UA106386C2 (ru) | Способ синтеза ивабрадина и его аддитивных солей с фармацевтически приемлемой кислотой | |
| BRPI1016111A2 (pt) | "método de produzir aço" | |
| CL2012003371A1 (es) | Compuestos intermediarios de la síntesis de agomelatina; y el procedimiento de obtención de agomelatina a partir de dichos compuestos intermediarios | |
| MX337997B (es) | Nuevo procedimiento de sintesis de la ivabradina y de sus sales de adicion a un acido farmaceuticamente aceptable. | |
| MX354331B (es) | Proceso de recuperación de clorhidrato de nalmefeno. |