MX354331B - Proceso de recuperación de clorhidrato de nalmefeno. - Google Patents

Proceso de recuperación de clorhidrato de nalmefeno.

Info

Publication number
MX354331B
MX354331B MX2014006705A MX2014006705A MX354331B MX 354331 B MX354331 B MX 354331B MX 2014006705 A MX2014006705 A MX 2014006705A MX 2014006705 A MX2014006705 A MX 2014006705A MX 354331 B MX354331 B MX 354331B
Authority
MX
Mexico
Prior art keywords
recovery
nalmefene hydrochloride
nalmefene
hydrochloride
methylenemorphinan
Prior art date
Application number
MX2014006705A
Other languages
English (en)
Other versions
MX2014006705A (es
Inventor
De Faveri Carla
Stivanello Mariano
Original Assignee
H Lundbeck As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48573602&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX354331(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by H Lundbeck As filed Critical H Lundbeck As
Publication of MX2014006705A publication Critical patent/MX2014006705A/es
Publication of MX354331B publication Critical patent/MX354331B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Abstract

La presente invención se refiere a un proceso mejorado para la recuperación de clorhidrato de nalmefeno [17-(ciclopropilmetil)-4, 5-alfa-epoxi-6-metilenmorfinan-3,14-diol clorhidrato] a partir de una composición acuosa que contiene nalmefeno y ciertas impurezas.
MX2014006705A 2011-12-06 2012-12-06 Proceso de recuperación de clorhidrato de nalmefeno. MX354331B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161567148P 2011-12-06 2011-12-06
DKPA201100948 2011-12-06
PCT/EP2012/074623 WO2013083685A1 (en) 2011-12-06 2012-12-06 Process for recovery of nalmefene hydrochloride

Publications (2)

Publication Number Publication Date
MX2014006705A MX2014006705A (es) 2014-07-09
MX354331B true MX354331B (es) 2018-02-27

Family

ID=48573602

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014006705A MX354331B (es) 2011-12-06 2012-12-06 Proceso de recuperación de clorhidrato de nalmefeno.

Country Status (32)

Country Link
US (1) US8841452B1 (es)
EP (1) EP2788357B1 (es)
JP (1) JP6086925B2 (es)
KR (1) KR20140103288A (es)
CN (1) CN104093721B (es)
AR (1) AR089080A1 (es)
AU (1) AU2012347261B2 (es)
BR (1) BR112014013541B1 (es)
CA (1) CA2857096C (es)
CL (1) CL2014001454A1 (es)
CO (1) CO6970605A2 (es)
CY (1) CY1118785T1 (es)
DK (1) DK2788357T3 (es)
ES (1) ES2622156T3 (es)
HK (1) HK1202874A1 (es)
HR (1) HRP20170497T1 (es)
HU (1) HUE033717T2 (es)
IL (1) IL232826A (es)
IN (1) IN2014KN01211A (es)
JO (1) JO3251B1 (es)
LT (1) LT2788357T (es)
ME (1) ME02668B (es)
MX (1) MX354331B (es)
PL (1) PL2788357T3 (es)
PT (1) PT2788357T (es)
RS (1) RS55817B1 (es)
RU (1) RU2631652C2 (es)
SG (1) SG11201402956UA (es)
SI (1) SI2788357T1 (es)
TW (1) TWI560170B (es)
WO (1) WO2013083685A1 (es)
ZA (1) ZA201404100B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105646508B (zh) * 2016-02-17 2018-02-27 南京卓康医药科技有限公司 一种盐酸纳美芬一水合物的制备方法
US10927121B1 (en) 2019-12-20 2021-02-23 Southwest Research Institute Technologies for removing residual solvent from nalmefene hydrochloride and producing crystalline nalmefene hydrochloride monohydrate, monosolvate, or crystalline nalmefene hydrochloride dihydrate
US20240109907A1 (en) 2021-01-28 2024-04-04 Rhodes Technologies Process for crystallizing nalmefene hydrochloride

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2577947A (en) * 1951-12-11 Manufacture of dihydrocodeinone
US3896226A (en) * 1971-11-26 1975-07-22 Lewinstein Evalina 6-methylene-6-desoxy dihydro morphine and codeine derivatives and pharmaceutically acceptable salts thereof, and use of the same as a narcotic antagonist
US3814768A (en) * 1971-11-26 1974-06-04 Lewenstein E 6-methylene-6-desoxy dihydro morphine and codeine derivatives and pharmaceutically acceptable salts
US4535157A (en) 1983-11-01 1985-08-13 Key Pharmaceuticals, Inc. Process for making 6-desoxy-6-methylenenaloxone and 6-desoxy-6-methylenenaltrexone
US4751307A (en) 1985-01-17 1988-06-14 Mallinckrodt, Inc. Wittig-reaction processes
US5869669A (en) * 1996-07-26 1999-02-09 Penick Corporation Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates
JP4886953B2 (ja) * 1999-11-09 2012-02-29 アボット・ラボラトリーズ ヒドロモルフィノン及びヒドロコデイノン組成物、並びに、それらの合成方法
CN1652752A (zh) * 2002-03-14 2005-08-10 欧罗赛铁克股份有限公司 盐酸纳曲酮组合物
EP1994034B1 (en) * 2006-03-02 2009-11-11 Mallinckrodt, Inc. Processes for preparing morphinan-6-one products with low levels of alpha, beta-unsaturated ketone compounds
WO2008070658A1 (en) * 2006-12-04 2008-06-12 Noramco, Inc. Process for preparing oxycodone having reduced levels of 14-hydroxycodeinone
EP2121669A2 (en) 2007-01-30 2009-11-25 Biogen Idec MA, Inc. Furanone compounds and methods of making and using the same
UA102128C2 (en) * 2008-12-05 2013-06-10 Х. Луннбек А/С Nalmefene hydrochloride dihydrate
EP2435439B8 (en) 2009-05-25 2016-05-18 H. Lundbeck A/S Preparation of nalmefene hydrochloride from naltrexone
CN101768164B (zh) * 2010-01-25 2011-09-14 海南数尔药物研究有限公司 一种高纯度的盐酸纳洛酮化合物

Also Published As

Publication number Publication date
HK1202874A1 (en) 2015-10-09
BR112014013541A2 (pt) 2017-06-13
PL2788357T3 (pl) 2017-07-31
CN104093721A (zh) 2014-10-08
CL2014001454A1 (es) 2014-10-03
SI2788357T1 (sl) 2017-06-30
MX2014006705A (es) 2014-07-09
IL232826A0 (en) 2014-08-03
JO3251B1 (ar) 2018-09-16
ZA201404100B (en) 2015-11-25
IL232826A (en) 2016-10-31
RU2014126489A (ru) 2016-01-27
ES2622156T3 (es) 2017-07-05
HRP20170497T1 (hr) 2017-06-02
TW201335110A (zh) 2013-09-01
US20140296525A1 (en) 2014-10-02
EP2788357B1 (en) 2017-03-01
PT2788357T (pt) 2017-04-24
AU2012347261A1 (en) 2014-06-19
CA2857096C (en) 2021-01-19
ME02668B (me) 2017-06-20
CY1118785T1 (el) 2017-07-12
US8841452B1 (en) 2014-09-23
JP2015504856A (ja) 2015-02-16
IN2014KN01211A (es) 2015-10-16
RS55817B1 (sr) 2017-08-31
RU2631652C2 (ru) 2017-09-26
TWI560170B (en) 2016-12-01
CA2857096A1 (en) 2013-06-13
BR112014013541B1 (pt) 2022-02-15
AR089080A1 (es) 2014-07-30
JP6086925B2 (ja) 2017-03-01
DK2788357T3 (en) 2017-04-24
CN104093721B (zh) 2016-05-18
AU2012347261B2 (en) 2016-12-01
LT2788357T (lt) 2017-04-25
HUE033717T2 (en) 2017-12-28
KR20140103288A (ko) 2014-08-26
CO6970605A2 (es) 2014-06-13
EP2788357A1 (en) 2014-10-15
WO2013083685A1 (en) 2013-06-13
SG11201402956UA (en) 2014-07-30

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