IN2014KN01211A - - Google Patents

Info

Publication number
IN2014KN01211A
IN2014KN01211A IN1211KON2014A IN2014KN01211A IN 2014KN01211 A IN2014KN01211 A IN 2014KN01211A IN 1211KON2014 A IN1211KON2014 A IN 1211KON2014A IN 2014KN01211 A IN2014KN01211 A IN 2014KN01211A
Authority
IN
India
Prior art keywords
nalmefene
hydrochloride
methylenemorphinan
cyclopropylmethyl
recovery
Prior art date
Application number
Inventor
Faveri Carla De
Mariano Stivanello
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48573602&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IN2014KN01211(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of IN2014KN01211A publication Critical patent/IN2014KN01211A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Abstract

The present invention relates to an improved process for recovery of nalmefene hydrochloride [17 (cyclopropylmethyl) 4 5 alpha epoxy 6 methylenemorphinan 3 14 diol hydrochloride] from an aqueous composition containing nalmefene and certain impurities.
IN1211KON2014 2011-12-06 2012-12-06 IN2014KN01211A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161567148P 2011-12-06 2011-12-06
DKPA201100948 2011-12-06
PCT/EP2012/074623 WO2013083685A1 (en) 2011-12-06 2012-12-06 Process for recovery of nalmefene hydrochloride

Publications (1)

Publication Number Publication Date
IN2014KN01211A true IN2014KN01211A (en) 2015-10-16

Family

ID=48573602

Family Applications (1)

Application Number Title Priority Date Filing Date
IN1211KON2014 IN2014KN01211A (en) 2011-12-06 2012-12-06

Country Status (32)

Country Link
US (1) US8841452B1 (en)
EP (1) EP2788357B1 (en)
JP (1) JP6086925B2 (en)
KR (1) KR20140103288A (en)
CN (1) CN104093721B (en)
AR (1) AR089080A1 (en)
AU (1) AU2012347261B2 (en)
BR (1) BR112014013541B1 (en)
CA (1) CA2857096C (en)
CL (1) CL2014001454A1 (en)
CO (1) CO6970605A2 (en)
CY (1) CY1118785T1 (en)
DK (1) DK2788357T3 (en)
ES (1) ES2622156T3 (en)
HK (1) HK1202874A1 (en)
HR (1) HRP20170497T1 (en)
HU (1) HUE033717T2 (en)
IL (1) IL232826A (en)
IN (1) IN2014KN01211A (en)
JO (1) JO3251B1 (en)
LT (1) LT2788357T (en)
ME (1) ME02668B (en)
MX (1) MX354331B (en)
PL (1) PL2788357T3 (en)
PT (1) PT2788357T (en)
RS (1) RS55817B1 (en)
RU (1) RU2631652C2 (en)
SG (1) SG11201402956UA (en)
SI (1) SI2788357T1 (en)
TW (1) TWI560170B (en)
WO (1) WO2013083685A1 (en)
ZA (1) ZA201404100B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105646508B (en) * 2016-02-17 2018-02-27 南京卓康医药科技有限公司 A kind of preparation method of nalmefene hydrochloride monohydrate
US10927121B1 (en) 2019-12-20 2021-02-23 Southwest Research Institute Technologies for removing residual solvent from nalmefene hydrochloride and producing crystalline nalmefene hydrochloride monohydrate, monosolvate, or crystalline nalmefene hydrochloride dihydrate
WO2022165040A1 (en) 2021-01-28 2022-08-04 Rhodes Technologies Process for crystallizing nalmefene hydrochloride

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2577947A (en) * 1951-12-11 Manufacture of dihydrocodeinone
US3814768A (en) * 1971-11-26 1974-06-04 Lewenstein E 6-methylene-6-desoxy dihydro morphine and codeine derivatives and pharmaceutically acceptable salts
US3896226A (en) 1971-11-26 1975-07-22 Lewinstein Evalina 6-methylene-6-desoxy dihydro morphine and codeine derivatives and pharmaceutically acceptable salts thereof, and use of the same as a narcotic antagonist
US4535157A (en) 1983-11-01 1985-08-13 Key Pharmaceuticals, Inc. Process for making 6-desoxy-6-methylenenaloxone and 6-desoxy-6-methylenenaltrexone
US4751307A (en) 1985-01-17 1988-06-14 Mallinckrodt, Inc. Wittig-reaction processes
US5869669A (en) * 1996-07-26 1999-02-09 Penick Corporation Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates
ES2309001T5 (en) * 1999-11-09 2011-12-28 Abbott Laboratories COMPOSITIONS OF HYDROMORFINONE AND HYDROCODEINONE, SYNTHESIS PROCEDURES OF THESE LAST.
CN1652752A (en) * 2002-03-14 2005-08-10 欧罗赛铁克股份有限公司 Naltrexone hydrochloride compositions
CN101395159A (en) * 2006-03-02 2009-03-25 马林克罗特公司 Processes for preparing morphinan-6-one products with low levels of alpha, beta-unsaturated ketone compounds
CA2671518C (en) * 2006-12-04 2016-06-07 Noramco, Inc. Process for preparing oxycodone having reduced levels of 14-hydroxycodeinone
US20100105714A1 (en) 2007-01-30 2010-04-29 Biogen Idec Ma Inc. Furanone Compounds and Methods of Making and Using The Same
UA102128C2 (en) * 2008-12-05 2013-06-10 Х. Луннбек А/С Nalmefene hydrochloride dihydrate
DK2435439T3 (en) * 2009-05-25 2016-02-29 Lundbeck & Co As H PREPARATION OF nalmefene HYDROCHLORIDE FROM naltrexone
CN101768164B (en) * 2010-01-25 2011-09-14 海南数尔药物研究有限公司 Naloxone hydrochloride compound with high purity

Also Published As

Publication number Publication date
JP2015504856A (en) 2015-02-16
KR20140103288A (en) 2014-08-26
CY1118785T1 (en) 2017-07-12
IL232826A (en) 2016-10-31
HUE033717T2 (en) 2017-12-28
PL2788357T3 (en) 2017-07-31
US8841452B1 (en) 2014-09-23
CO6970605A2 (en) 2014-06-13
SG11201402956UA (en) 2014-07-30
MX354331B (en) 2018-02-27
WO2013083685A1 (en) 2013-06-13
DK2788357T3 (en) 2017-04-24
PT2788357T (en) 2017-04-24
CA2857096C (en) 2021-01-19
ZA201404100B (en) 2015-11-25
CL2014001454A1 (en) 2014-10-03
JP6086925B2 (en) 2017-03-01
CN104093721B (en) 2016-05-18
RS55817B1 (en) 2017-08-31
CA2857096A1 (en) 2013-06-13
US20140296525A1 (en) 2014-10-02
BR112014013541A2 (en) 2017-06-13
IL232826A0 (en) 2014-08-03
EP2788357A1 (en) 2014-10-15
TW201335110A (en) 2013-09-01
CN104093721A (en) 2014-10-08
EP2788357B1 (en) 2017-03-01
RU2631652C2 (en) 2017-09-26
SI2788357T1 (en) 2017-06-30
HRP20170497T1 (en) 2017-06-02
RU2014126489A (en) 2016-01-27
AR089080A1 (en) 2014-07-30
JO3251B1 (en) 2018-09-16
AU2012347261A1 (en) 2014-06-19
LT2788357T (en) 2017-04-25
ES2622156T3 (en) 2017-07-05
AU2012347261B2 (en) 2016-12-01
MX2014006705A (en) 2014-07-09
BR112014013541B1 (en) 2022-02-15
ME02668B (en) 2017-06-20
HK1202874A1 (en) 2015-10-09
TWI560170B (en) 2016-12-01

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