JO3251B1 - عملية لاستخلاص هيدروكلوريد النالميفين - Google Patents

عملية لاستخلاص هيدروكلوريد النالميفين

Info

Publication number
JO3251B1
JO3251B1 JOP/2012/0364A JOP20120364A JO3251B1 JO 3251 B1 JO3251 B1 JO 3251B1 JO P20120364 A JOP20120364 A JO P20120364A JO 3251 B1 JO3251 B1 JO 3251B1
Authority
JO
Jordan
Prior art keywords
recovery
nalmefene hydrochloride
nalmefene
hydrochloride
methylenemorphinan
Prior art date
Application number
JOP/2012/0364A
Other languages
English (en)
Inventor
De Faveri Carla
Stivanello Mariano
Original Assignee
H Lundbeck As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48573602&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JO3251(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by H Lundbeck As filed Critical H Lundbeck As
Application granted granted Critical
Publication of JO3251B1 publication Critical patent/JO3251B1/ar

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/485Morphinan derivatives, e.g. morphine, codeine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D489/00Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08Oxygen atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

يتعلق الاختراع الحالي بعملية محسنة لاستخلاص هيدروكلوريد النالميفين [17-(سيكلو بروبيل ميثيل) - 4,5 - ألفا - إيبوكسي -6- ميثيلين مورفينان – 3,14 – دايول هيدروكلوريد] من تركيبة مائية تحتوي على نالميفين وشوائب معينة.
JOP/2012/0364A 2011-12-06 2012-12-04 عملية لاستخلاص هيدروكلوريد النالميفين JO3251B1 (ar)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA201100948 2011-12-06

Publications (1)

Publication Number Publication Date
JO3251B1 true JO3251B1 (ar) 2018-09-16

Family

ID=48573602

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2012/0364A JO3251B1 (ar) 2011-12-06 2012-12-04 عملية لاستخلاص هيدروكلوريد النالميفين

Country Status (32)

Country Link
US (1) US8841452B1 (ar)
EP (1) EP2788357B1 (ar)
JP (1) JP6086925B2 (ar)
KR (1) KR20140103288A (ar)
CN (1) CN104093721B (ar)
AR (1) AR089080A1 (ar)
AU (1) AU2012347261B2 (ar)
BR (1) BR112014013541B1 (ar)
CA (1) CA2857096C (ar)
CL (1) CL2014001454A1 (ar)
CO (1) CO6970605A2 (ar)
CY (1) CY1118785T1 (ar)
DK (1) DK2788357T3 (ar)
ES (1) ES2622156T3 (ar)
HK (1) HK1202874A1 (ar)
HR (1) HRP20170497T1 (ar)
HU (1) HUE033717T2 (ar)
IL (1) IL232826A (ar)
IN (1) IN2014KN01211A (ar)
JO (1) JO3251B1 (ar)
LT (1) LT2788357T (ar)
ME (1) ME02668B (ar)
MX (1) MX354331B (ar)
PL (1) PL2788357T3 (ar)
PT (1) PT2788357T (ar)
RS (1) RS55817B1 (ar)
RU (1) RU2631652C2 (ar)
SG (1) SG11201402956UA (ar)
SI (1) SI2788357T1 (ar)
TW (1) TWI560170B (ar)
WO (1) WO2013083685A1 (ar)
ZA (1) ZA201404100B (ar)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105646508B (zh) * 2016-02-17 2018-02-27 南京卓康医药科技有限公司 一种盐酸纳美芬一水合物的制备方法
US10927121B1 (en) 2019-12-20 2021-02-23 Southwest Research Institute Technologies for removing residual solvent from nalmefene hydrochloride and producing crystalline nalmefene hydrochloride monohydrate, monosolvate, or crystalline nalmefene hydrochloride dihydrate
US20240109907A1 (en) 2021-01-28 2024-04-04 Rhodes Technologies Process for crystallizing nalmefene hydrochloride

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2577947A (en) * 1951-12-11 Manufacture of dihydrocodeinone
US3896226A (en) * 1971-11-26 1975-07-22 Lewinstein Evalina 6-methylene-6-desoxy dihydro morphine and codeine derivatives and pharmaceutically acceptable salts thereof, and use of the same as a narcotic antagonist
US3814768A (en) * 1971-11-26 1974-06-04 Lewenstein E 6-methylene-6-desoxy dihydro morphine and codeine derivatives and pharmaceutically acceptable salts
US4535157A (en) 1983-11-01 1985-08-13 Key Pharmaceuticals, Inc. Process for making 6-desoxy-6-methylenenaloxone and 6-desoxy-6-methylenenaltrexone
US4751307A (en) 1985-01-17 1988-06-14 Mallinckrodt, Inc. Wittig-reaction processes
US5869669A (en) * 1996-07-26 1999-02-09 Penick Corporation Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates
ATE402937T1 (de) * 1999-11-09 2008-08-15 Abbott Lab Hydromorphinone and hydrocodeinone compositions and methods for their synthesis
CA2478558C (en) * 2002-03-14 2012-09-11 Euro-Celtique, S.A. Naltrexone hydrochloride compositions
DE602007003197D1 (de) * 2006-03-02 2009-12-24 Mallinckrodt Inc Verfahren zur herstellung von morphinan-6-on-produkten mit geringen konzentrationen von alpha-, beta-ungesättigten ketonverbindungen
CN101652370A (zh) * 2006-12-04 2010-02-17 诺拉姆科有限公司 制备14-羟基可待因酮水平减少的羟考酮的方法
EP2121669A2 (en) 2007-01-30 2009-11-25 Biogen Idec MA, Inc. Furanone compounds and methods of making and using the same
UA102128C2 (en) * 2008-12-05 2013-06-10 Х. Луннбек А/С Nalmefene hydrochloride dihydrate
SI2435439T1 (sl) 2009-05-25 2016-06-30 H. Lundbeck A/S Priprava nalmefen hidroklorida iz naltreksona
CN101768164B (zh) * 2010-01-25 2011-09-14 海南数尔药物研究有限公司 一种高纯度的盐酸纳洛酮化合物

Also Published As

Publication number Publication date
IL232826A0 (en) 2014-08-03
KR20140103288A (ko) 2014-08-26
ME02668B (me) 2017-06-20
BR112014013541B1 (pt) 2022-02-15
HRP20170497T1 (hr) 2017-06-02
RU2631652C2 (ru) 2017-09-26
BR112014013541A2 (pt) 2017-06-13
CN104093721B (zh) 2016-05-18
SG11201402956UA (en) 2014-07-30
JP2015504856A (ja) 2015-02-16
MX354331B (es) 2018-02-27
LT2788357T (lt) 2017-04-25
DK2788357T3 (en) 2017-04-24
PT2788357T (pt) 2017-04-24
RS55817B1 (sr) 2017-08-31
AU2012347261B2 (en) 2016-12-01
PL2788357T3 (pl) 2017-07-31
AU2012347261A1 (en) 2014-06-19
CY1118785T1 (el) 2017-07-12
IL232826A (en) 2016-10-31
CL2014001454A1 (es) 2014-10-03
SI2788357T1 (sl) 2017-06-30
CN104093721A (zh) 2014-10-08
IN2014KN01211A (ar) 2015-10-16
HK1202874A1 (en) 2015-10-09
RU2014126489A (ru) 2016-01-27
ZA201404100B (en) 2015-11-25
CA2857096A1 (en) 2013-06-13
CA2857096C (en) 2021-01-19
TWI560170B (en) 2016-12-01
US8841452B1 (en) 2014-09-23
MX2014006705A (es) 2014-07-09
EP2788357B1 (en) 2017-03-01
ES2622156T3 (es) 2017-07-05
WO2013083685A1 (en) 2013-06-13
CO6970605A2 (es) 2014-06-13
JP6086925B2 (ja) 2017-03-01
TW201335110A (zh) 2013-09-01
HUE033717T2 (en) 2017-12-28
EP2788357A1 (en) 2014-10-15
US20140296525A1 (en) 2014-10-02
AR089080A1 (es) 2014-07-30

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