MX2016001199A - Proceso para preparar rifaximina kappa. - Google Patents
Proceso para preparar rifaximina kappa.Info
- Publication number
- MX2016001199A MX2016001199A MX2016001199A MX2016001199A MX2016001199A MX 2016001199 A MX2016001199 A MX 2016001199A MX 2016001199 A MX2016001199 A MX 2016001199A MX 2016001199 A MX2016001199 A MX 2016001199A MX 2016001199 A MX2016001199 A MX 2016001199A
- Authority
- MX
- Mexico
- Prior art keywords
- rifaximin
- obtaining
- ethylacetate
- solvent
- solution
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La presente invención se refiere a un proceso para obtener la rifaximina kappa, que comprende los siguientes pasos: a) hacer reaccionar la rifamicina-O con 2-amino-4-picolina en presencia de una mezcla de solventes que comprende agua y un solvente seleccionado de metilisobutilcetona, acetato de etilo y un solvente soluble en agua; b) obtener una solución de rifaximina mediante la eliminación de la fase acuosa; c) obtener la rifaximina kappa a partir de la solución de rifaximina, en donde, cuando el solvente es un solvente soluble en agua, la metilisobutilcetona o bien el acetato de etilo es adicionalmente agregado en el paso a) . En otro aspecto más, el proceso de la invención se refiere a un proceso para obtener la forma cristalina kappa de la rifaximina, que comprende los siguientes pasos: i) poner en contacto la rifaximina o una solución de rifaximina exclusivamente con acetato de etilo, ii) obtener la rifaximina en forma cristalina kappa mediante la eliminación del acetato de etilo.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT001307A ITMI20131307A1 (it) | 2013-08-02 | 2013-08-02 | Processo per la preparazione di refaximina k |
| PCT/EP2014/066592 WO2015014984A1 (en) | 2013-08-02 | 2014-08-01 | A process for preparing rifaximin k |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2016001199A true MX2016001199A (es) | 2016-12-16 |
Family
ID=49304117
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016001199A MX2016001199A (es) | 2013-08-02 | 2014-08-01 | Proceso para preparar rifaximina kappa. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9708343B2 (es) |
| EP (1) | EP3027626A1 (es) |
| KR (1) | KR20160045068A (es) |
| CN (1) | CN105518009A (es) |
| CA (1) | CA2920080A1 (es) |
| IT (1) | ITMI20131307A1 (es) |
| MX (1) | MX2016001199A (es) |
| RU (1) | RU2016107486A (es) |
| WO (1) | WO2015014984A1 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI1698630T1 (sl) | 2005-03-03 | 2015-01-30 | Alfa Wassermann S.P.A. | Nove polimorfne oblike rifaksimina, postopki za njihovo pripravo in njihova uporaba v medicinskih pripravkih |
| IT1398550B1 (it) | 2010-03-05 | 2013-03-01 | Alfa Wassermann Spa | Formulazioni comprendenti rifaximina utili per ottenere un effetto prolungato nel tempo |
| ITBO20120368A1 (it) | 2012-07-06 | 2014-01-07 | Alfa Wassermann Spa | Composizioni comprendenti rifaximina e amminoacidi, cristalli di rifaximina derivanti da tali composizioni e loro uso. |
| ES2621557T3 (es) | 2014-03-31 | 2017-07-04 | Euticals S.P.A. | Mezcla polimórfica de rifaximina y su uso para la preparación de formulaciones sólidas |
| PL3546464T3 (pl) | 2014-05-12 | 2020-11-02 | Alfasigma S.P.A. | Sposób wytwarzania i zastosowanie postaci krystalicznej Tau rifaksyminy solwatowanej z DEGME |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1199374B (it) | 1984-05-15 | 1988-12-30 | Alfa Farmaceutici Spa | Processo per la preparazione di pirido-imidazo-rifamicine |
| US7709634B2 (en) * | 2007-09-20 | 2010-05-04 | Apotex Pharmachem Inc. | Amorphous form of rifaximin and processes for its preparation |
| BRPI0908864A2 (pt) * | 2008-02-25 | 2018-09-18 | Salix Pharmaceuticals Ltd | formas da rifaximina e usos das mesmas |
| MX2012013945A (es) * | 2010-06-03 | 2013-05-06 | Salix Pharmaceuticals Ltd | Nuevas formas de rifaximina y usos de las mismas. |
| CA2802874A1 (en) * | 2010-06-16 | 2011-12-22 | Apotex Pharmachem Inc. | Polymorphic forms of rifaximin |
| ITMI20110890A1 (it) * | 2011-05-19 | 2012-11-20 | A M S A Anonima Materie Sint & Affini S P A | Polimorfo di rifaximina e processo per la sua preparazione |
| WO2013027227A1 (en) * | 2011-07-20 | 2013-02-28 | Ind-Swift Laboratories Limited | Novel polymorphic form i of rifaximin |
-
2013
- 2013-08-02 IT IT001307A patent/ITMI20131307A1/it unknown
-
2014
- 2014-08-01 US US14/908,777 patent/US9708343B2/en active Active
- 2014-08-01 MX MX2016001199A patent/MX2016001199A/es active IP Right Grant
- 2014-08-01 CN CN201480043374.XA patent/CN105518009A/zh active Pending
- 2014-08-01 CA CA2920080A patent/CA2920080A1/en not_active Abandoned
- 2014-08-01 RU RU2016107486A patent/RU2016107486A/ru not_active Application Discontinuation
- 2014-08-01 EP EP14757857.9A patent/EP3027626A1/en not_active Ceased
- 2014-08-01 KR KR1020167004474A patent/KR20160045068A/ko not_active Application Discontinuation
- 2014-08-01 WO PCT/EP2014/066592 patent/WO2015014984A1/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| ITMI20131307A1 (it) | 2015-02-02 |
| US9708343B2 (en) | 2017-07-18 |
| KR20160045068A (ko) | 2016-04-26 |
| CA2920080A1 (en) | 2015-02-05 |
| RU2016107486A (ru) | 2017-09-07 |
| US20160168166A1 (en) | 2016-06-16 |
| CN105518009A (zh) | 2016-04-20 |
| WO2015014984A1 (en) | 2015-02-05 |
| RU2016107486A3 (es) | 2018-03-30 |
| EP3027626A1 (en) | 2016-06-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |