NZ727066A - Preparation of a solid form of gadobenate dimeglumine - Google Patents
Preparation of a solid form of gadobenate dimeglumineInfo
- Publication number
- NZ727066A NZ727066A NZ727066A NZ72706615A NZ727066A NZ 727066 A NZ727066 A NZ 727066A NZ 727066 A NZ727066 A NZ 727066A NZ 72706615 A NZ72706615 A NZ 72706615A NZ 727066 A NZ727066 A NZ 727066A
- Authority
- NZ
- New Zealand
- Prior art keywords
- solid form
- gadobenate dimeglumine
- preparation
- solution
- compound
- Prior art date
Links
- 229940096814 gadobenate dimeglumine Drugs 0.000 title abstract 4
- OCDAWJYGVOLXGZ-VPVMAENOSA-K gadobenate dimeglumine Chemical compound [Gd+3].CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.OC(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CCN(CC(O)=O)C(C([O-])=O)COCC1=CC=CC=C1 OCDAWJYGVOLXGZ-VPVMAENOSA-K 0.000 title abstract 3
- 239000007787 solid Substances 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 2
- 239000012296 anti-solvent Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- -1 gadobenate dimeglumine compound Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic Table without C-Metal linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/38—Separation; Purification; Stabilisation; Use of additives
- C07C227/40—Separation; Purification
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Radiology & Medical Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Nanotechnology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Crystallography & Structural Chemistry (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
Abstract
The present invention relates to a process for the preparation of a solid form of the gadobenate dimeglumine compound that comprises obtaining a solution of the said compound in a suitable solvent A wherein the amount by weight of the water optionally present in the solution is at most equal to or lower than the amount by weight of the gadobenate dimeglumine comprised in the solution and adding the obtained solution to an organic solvent B, acting as an appropriate antisolvent and favoring the formation of a solid form of the gadobenate dimeglumine that can be collected by filtration.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14178283.9A EP2977369A1 (en) | 2014-07-24 | 2014-07-24 | Preparation of a solid form of gadobenate dimeglumine |
PCT/EP2015/066512 WO2016012386A1 (en) | 2014-07-24 | 2015-07-20 | Preparation of a solid form of gadobenate dimeglumine |
Publications (1)
Publication Number | Publication Date |
---|---|
NZ727066A true NZ727066A (en) | 2020-04-24 |
Family
ID=51260603
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NZ727066A NZ727066A (en) | 2014-07-24 | 2015-07-20 | Preparation of a solid form of gadobenate dimeglumine |
Country Status (23)
Country | Link |
---|---|
US (2) | US10519171B2 (en) |
EP (2) | EP2977369A1 (en) |
JP (1) | JP6625605B2 (en) |
KR (1) | KR102445718B1 (en) |
CN (2) | CN111233684B (en) |
AU (1) | AU2015294042B2 (en) |
BR (1) | BR112016030362A2 (en) |
CA (1) | CA2950831C (en) |
CY (1) | CY1122739T1 (en) |
DK (1) | DK3172186T3 (en) |
ES (1) | ES2701099T3 (en) |
HR (1) | HRP20182018T1 (en) |
IL (1) | IL250248B (en) |
LT (1) | LT3172186T (en) |
MX (1) | MX2017000955A (en) |
NZ (1) | NZ727066A (en) |
PL (1) | PL3172186T3 (en) |
PT (1) | PT3172186T (en) |
RS (1) | RS58085B1 (en) |
RU (1) | RU2693625C2 (en) |
SG (1) | SG11201610655WA (en) |
SI (1) | SI3172186T1 (en) |
WO (1) | WO2016012386A1 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114845990A (en) | 2019-12-20 | 2022-08-02 | 伯拉考成像股份公司 | Calcium BOPTA complex |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3520066A (en) * | 1966-05-26 | 1970-07-14 | Pillsbury Co | Spray drying method |
IT1213029B (en) * | 1986-01-30 | 1989-12-07 | Bracco Ind Chimica Spa | PARAMAGNETIC METAL ION CHELATES. |
ITMI981583A1 (en) | 1998-07-10 | 2000-01-10 | Bracco Spa | PROCESS FOR THE PREPARATION OF THE ACID 4-CARBOX-5,8,11-TRIS (CARBOXIMETHYL) -1-PHENYL-2-OXA-5,8,11-TRIAZATRIDECAN-13-OICO |
EP2327395A1 (en) | 2009-11-23 | 2011-06-01 | Bracco Imaging S.p.A | Process for the preparation of gadobenate dimeglumine complex in a solid form |
EP2338874A1 (en) | 2009-12-16 | 2011-06-29 | Bracco Imaging S.p.A | Process for the preparation of chelated compounds |
CN102408348A (en) | 2011-07-26 | 2012-04-11 | 天津市海文普宁科技发展有限公司 | New preparation method of gadobenate dimeglumine |
-
2014
- 2014-07-24 EP EP14178283.9A patent/EP2977369A1/en not_active Withdrawn
-
2015
- 2015-07-20 CN CN202010122232.XA patent/CN111233684B/en active Active
- 2015-07-20 JP JP2017503862A patent/JP6625605B2/en active Active
- 2015-07-20 SI SI201530506T patent/SI3172186T1/en unknown
- 2015-07-20 CN CN201580039408.2A patent/CN106573875B/en active Active
- 2015-07-20 BR BR112016030362-8A patent/BR112016030362A2/en not_active Application Discontinuation
- 2015-07-20 SG SG11201610655WA patent/SG11201610655WA/en unknown
- 2015-07-20 US US15/321,176 patent/US10519171B2/en active Active
- 2015-07-20 DK DK15738381.1T patent/DK3172186T3/en active
- 2015-07-20 NZ NZ727066A patent/NZ727066A/en unknown
- 2015-07-20 ES ES15738381T patent/ES2701099T3/en active Active
- 2015-07-20 WO PCT/EP2015/066512 patent/WO2016012386A1/en active Application Filing
- 2015-07-20 PT PT15738381T patent/PT3172186T/en unknown
- 2015-07-20 LT LTEP15738381.1T patent/LT3172186T/en unknown
- 2015-07-20 AU AU2015294042A patent/AU2015294042B2/en active Active
- 2015-07-20 KR KR1020177001272A patent/KR102445718B1/en active IP Right Grant
- 2015-07-20 RS RS20181457A patent/RS58085B1/en unknown
- 2015-07-20 MX MX2017000955A patent/MX2017000955A/en active IP Right Grant
- 2015-07-20 EP EP15738381.1A patent/EP3172186B1/en active Active
- 2015-07-20 RU RU2017105846A patent/RU2693625C2/en active
- 2015-07-20 CA CA2950831A patent/CA2950831C/en active Active
- 2015-07-20 PL PL15738381T patent/PL3172186T3/en unknown
-
2017
- 2017-01-23 IL IL25024817A patent/IL250248B/en active IP Right Grant
-
2018
- 2018-11-29 HR HRP20182018TT patent/HRP20182018T1/en unknown
- 2018-12-04 CY CY20181101289T patent/CY1122739T1/en unknown
-
2019
- 2019-11-08 US US16/678,082 patent/US11014942B2/en active Active
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Legal Events
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PSEA | Patent sealed | ||
RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 20 JUL 2022 BY COMPUTER PACKAGES INC Effective date: 20210630 |
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RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 20 JUL 2023 BY COMPUTER PACKAGES INC Effective date: 20220630 |
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RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 20 JUL 2024 BY COMPUTER PACKAGES INC Effective date: 20230630 |