EA022266B1 - Способ получения налтрексона - Google Patents
Способ получения налтрексона Download PDFInfo
- Publication number
- EA022266B1 EA022266B1 EA201390658A EA201390658A EA022266B1 EA 022266 B1 EA022266 B1 EA 022266B1 EA 201390658 A EA201390658 A EA 201390658A EA 201390658 A EA201390658 A EA 201390658A EA 022266 B1 EA022266 B1 EA 022266B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- noroxymorphone
- naltrexone
- mixture
- mixing
- cyclopropylmethyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41040510P | 2010-11-05 | 2010-11-05 | |
| DKPA201001007 | 2010-11-05 | ||
| US201161489701P | 2011-05-25 | 2011-05-25 | |
| DKPA201100396 | 2011-05-25 | ||
| PCT/DK2011/000128 WO2012059103A1 (en) | 2010-11-05 | 2011-11-04 | Method for the manufacturing of naltrexone |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201390658A1 EA201390658A1 (ru) | 2013-11-29 |
| EA022266B1 true EA022266B1 (ru) | 2015-11-30 |
Family
ID=45001588
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201390658A EA022266B1 (ru) | 2010-11-05 | 2011-11-04 | Способ получения налтрексона |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP2635586B1 (enExample) |
| JP (2) | JP6246589B2 (enExample) |
| AP (1) | AP3415A (enExample) |
| AU (1) | AU2011325563B2 (enExample) |
| CA (1) | CA2815093C (enExample) |
| CY (1) | CY1118742T1 (enExample) |
| DK (1) | DK2635586T3 (enExample) |
| EA (1) | EA022266B1 (enExample) |
| ES (1) | ES2620660T3 (enExample) |
| HR (1) | HRP20170379T1 (enExample) |
| HU (1) | HUE033596T2 (enExample) |
| LT (1) | LT2635586T (enExample) |
| ME (1) | ME02621B (enExample) |
| MX (1) | MX2013005009A (enExample) |
| PL (1) | PL2635586T3 (enExample) |
| PT (1) | PT2635586T (enExample) |
| RS (1) | RS55777B1 (enExample) |
| SI (1) | SI2635586T1 (enExample) |
| SM (1) | SMT201700177T1 (enExample) |
| WO (1) | WO2012059103A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140005216A1 (en) | 2012-06-27 | 2014-01-02 | H. Lundbeck A/S | Nalmefene for reduction of alcohol consumption in specific target populations |
| AR096851A1 (es) | 2013-07-11 | 2016-02-03 | H Lundbeck As | Sales que no forman hidratos ni solvatos de nalmefeno |
| JP6448645B2 (ja) | 2013-12-20 | 2019-01-09 | ハー・ルンドベック・アクチエゼルスカベット | メランコリアの特徴を伴う抑うつ障害を処置するための、カッパ−活性を伴うオピオイド受容体拮抗薬およびボルチオキセチンの使用 |
| SG10201809280PA (en) | 2014-04-22 | 2018-11-29 | Otsuka Pharma Co Ltd | Combination of brexpiprazole and nalmefene and use thereof for treating substance-related disorders |
| US9701688B2 (en) * | 2014-05-05 | 2017-07-11 | Noramco, Inc. | Process for the preparation of opioid compounds |
| US9701687B2 (en) * | 2014-05-05 | 2017-07-11 | Noramco, Inc. | Process for the preparation of opioid compounds |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991005768A1 (en) * | 1989-10-16 | 1991-05-02 | The United States Of America, Represented By The Secretary, United States Department Of Commerce | Total synthesis of northebaine, normorphine, noroxymorphone enantiomers and derivatives via n-nor intermediates |
| WO2010039209A2 (en) * | 2008-09-30 | 2010-04-08 | Mallinckrodt Inc. | Processes for the synthesis of tertiary amines |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4535157A (en) * | 1983-11-01 | 1985-08-13 | Key Pharmaceuticals, Inc. | Process for making 6-desoxy-6-methylenenaloxone and 6-desoxy-6-methylenenaltrexone |
| US4751307A (en) | 1985-01-17 | 1988-06-14 | Mallinckrodt, Inc. | Wittig-reaction processes |
| FR2906252B1 (fr) * | 2006-09-21 | 2008-11-28 | Sanofi Aventis Sa | Procede de preparation d'halogenures de n-aklyl naltrexone |
| WO2008138383A1 (de) | 2007-05-16 | 2008-11-20 | Cilag Ag | Verfahren zur herstellung von n-methylnaltrexonbromid |
| HRP20160110T1 (hr) | 2009-05-25 | 2016-03-11 | H. Lundbeck A/S | Priprema nalmefen hidroklorida iz naltreksona |
-
2011
- 2011-11-04 HR HRP20170379TT patent/HRP20170379T1/hr unknown
- 2011-11-04 HU HUE11785301A patent/HUE033596T2/hu unknown
- 2011-11-04 MX MX2013005009A patent/MX2013005009A/es active IP Right Grant
- 2011-11-04 DK DK11785301.0T patent/DK2635586T3/en active
- 2011-11-04 AP AP2013006897A patent/AP3415A/xx active
- 2011-11-04 PT PT117853010T patent/PT2635586T/pt unknown
- 2011-11-04 RS RS20170244A patent/RS55777B1/sr unknown
- 2011-11-04 AU AU2011325563A patent/AU2011325563B2/en not_active Ceased
- 2011-11-04 EA EA201390658A patent/EA022266B1/ru not_active IP Right Cessation
- 2011-11-04 LT LTEP11785301.0T patent/LT2635586T/lt unknown
- 2011-11-04 PL PL11785301T patent/PL2635586T3/pl unknown
- 2011-11-04 SI SI201131131A patent/SI2635586T1/sl unknown
- 2011-11-04 ME MEP-2017-57A patent/ME02621B/me unknown
- 2011-11-04 WO PCT/DK2011/000128 patent/WO2012059103A1/en not_active Ceased
- 2011-11-04 ES ES11785301.0T patent/ES2620660T3/es active Active
- 2011-11-04 JP JP2013537002A patent/JP6246589B2/ja active Active
- 2011-11-04 CA CA2815093A patent/CA2815093C/en active Active
- 2011-11-04 SM SM20170177T patent/SMT201700177T1/it unknown
- 2011-11-04 EP EP11785301.0A patent/EP2635586B1/en active Active
-
2016
- 2016-06-24 JP JP2016125389A patent/JP6215399B2/ja active Active
-
2017
- 2017-03-17 CY CY20171100341T patent/CY1118742T1/el unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991005768A1 (en) * | 1989-10-16 | 1991-05-02 | The United States Of America, Represented By The Secretary, United States Department Of Commerce | Total synthesis of northebaine, normorphine, noroxymorphone enantiomers and derivatives via n-nor intermediates |
| WO2010039209A2 (en) * | 2008-09-30 | 2010-04-08 | Mallinckrodt Inc. | Processes for the synthesis of tertiary amines |
Also Published As
| Publication number | Publication date |
|---|---|
| AP2013006897A0 (en) | 2013-05-31 |
| AU2011325563B2 (en) | 2015-08-20 |
| SI2635586T1 (sl) | 2017-07-31 |
| MX2013005009A (es) | 2013-08-01 |
| EA201390658A1 (ru) | 2013-11-29 |
| ES2620660T3 (es) | 2017-06-29 |
| DK2635586T3 (en) | 2017-03-27 |
| AU2011325563A1 (en) | 2013-05-02 |
| ME02621B (me) | 2017-06-20 |
| LT2635586T (lt) | 2017-04-10 |
| JP2013541564A (ja) | 2013-11-14 |
| RS55777B1 (sr) | 2017-07-31 |
| JP6215399B2 (ja) | 2017-10-18 |
| CA2815093A1 (en) | 2012-05-10 |
| PT2635586T (pt) | 2017-03-30 |
| EP2635586A1 (en) | 2013-09-11 |
| CY1118742T1 (el) | 2017-07-12 |
| SMT201700177T1 (it) | 2017-05-08 |
| CA2815093C (en) | 2019-08-06 |
| EP2635586B1 (en) | 2017-02-08 |
| JP6246589B2 (ja) | 2017-12-13 |
| WO2012059103A1 (en) | 2012-05-10 |
| HUE033596T2 (hu) | 2017-12-28 |
| JP2016199566A (ja) | 2016-12-01 |
| AP3415A (en) | 2015-09-30 |
| PL2635586T3 (pl) | 2017-06-30 |
| HRP20170379T1 (hr) | 2017-05-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM KG MD TJ TM |
|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AZ KZ RU |
|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): BY |