|
US4032637A
(en)
|
1972-09-26 |
1977-06-28 |
Sandoz Ltd. |
Method of promoting sleep
|
|
GB8608335D0
(en)
|
1986-04-04 |
1986-05-08 |
Pfizer Ltd |
Pharmaceutically acceptable salts
|
|
US5453510A
(en)
|
1990-07-13 |
1995-09-26 |
Burroughs Wellcome Co. |
Neuromuscular blocking agents
|
|
JPH0741461A
(ja)
|
1993-05-27 |
1995-02-10 |
Eisai Co Ltd |
スルホン酸エステル誘導体
|
|
DK0813525T3
(da)
|
1995-03-10 |
2004-02-16 |
Berlex Lab |
Benzamidinderivater, deres fremstilling og anvendelse som antikoagulanter
|
|
GB9523675D0
(en)
|
1995-11-20 |
1996-01-24 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
GB9619284D0
(en)
|
1996-09-16 |
1996-10-30 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
GB9622363D0
(en)
|
1996-10-28 |
1997-01-08 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
JP4135318B2
(ja)
|
1997-12-15 |
2008-08-20 |
アステラス製薬株式会社 |
新規なピリミジン−5−カルボキサミド誘導体
|
|
US6303652B1
(en)
|
1998-08-21 |
2001-10-16 |
Hughes Institute |
BTK inhibitors and methods for their identification and use
|
|
AU5438299A
(en)
|
1998-08-29 |
2000-03-21 |
Astrazeneca Ab |
Pyrimidine compounds
|
|
AU762523C
(en)
|
1998-11-10 |
2004-02-12 |
Janssen Pharmaceutica N.V. |
HIV replication inhibiting pyrimidines
|
|
US6262088B1
(en)
|
1998-11-19 |
2001-07-17 |
Berlex Laboratories, Inc. |
Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants
|
|
US6127376A
(en)
|
1998-12-04 |
2000-10-03 |
Berlex Laboratories, Inc. |
Aryl and heterocyclyl substituted pyrimidine derivatives as anti-coagulants
|
|
GB9828511D0
(en)
|
1998-12-24 |
1999-02-17 |
Zeneca Ltd |
Chemical compounds
|
|
US6495558B1
(en)
|
1999-01-22 |
2002-12-17 |
Amgen Inc. |
Kinase inhibitors
|
|
WO2000046203A2
(en)
|
1999-02-04 |
2000-08-10 |
Millennium Pharmaceuticals, Inc. |
G-protein coupled heptahelical receptor binding compounds and methods of use thereof
|
|
GB9914258D0
(en)
|
1999-06-18 |
1999-08-18 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
ATE247645T1
(de)
|
1999-06-29 |
2003-09-15 |
Egyt Gyogyszervegyeszeti Gyar |
Neue piperazinylalkylthiopyrimidine derivate, diese enthaltende pharmazeutische zusammenstellungen und verfahren zu deren herstellung
|
|
DE60043397D1
(de)
|
1999-12-28 |
2010-01-07 |
Pharmacopeia Inc |
Cytokine, insbesondere tnf-alpha, hemmer
|
|
AU2001237041B9
(en)
|
2000-02-17 |
2005-07-28 |
Amgen Inc. |
Kinase inhibitors
|
|
GB0004890D0
(en)
|
2000-03-01 |
2000-04-19 |
Astrazeneca Uk Ltd |
Chemical compounds
|
|
GB0004888D0
(en)
|
2000-03-01 |
2000-04-19 |
Astrazeneca Uk Ltd |
Chemical compounds
|
|
GB0004887D0
(en)
|
2000-03-01 |
2000-04-19 |
Astrazeneca Uk Ltd |
Chemical compounds
|
|
US7034019B2
(en)
|
2000-05-08 |
2006-04-25 |
Janssen Pharmaceutica N.V. |
Prodrugs of HIV replication inhibiting pyrimidines
|
|
GB0016877D0
(en)
|
2000-07-11 |
2000-08-30 |
Astrazeneca Ab |
Chemical compounds
|
|
CA2417500C
(en)
|
2000-07-28 |
2008-11-18 |
Georgetown University Medical Center |
Erbb-2 selective small molecule kinase inhibitors
|
|
US6881737B2
(en)
|
2001-04-11 |
2005-04-19 |
Amgen Inc. |
Substituted triazinyl acrylamide derivatives and methods of use
|
|
JO3429B1
(ar)
|
2001-08-13 |
2019-10-20 |
Janssen Pharmaceutica Nv |
مشتقات برميدينات مثبطة فيروس الايدز
|
|
US6939874B2
(en)
|
2001-08-22 |
2005-09-06 |
Amgen Inc. |
Substituted pyrimidinyl derivatives and methods of use
|
|
WO2003030909A1
(en)
|
2001-09-25 |
2003-04-17 |
Bayer Pharmaceuticals Corporation |
2- and 4-aminopyrimidines n-substtituded by a bicyclic ring for use as kinase inhibitors in the treatment of cancer
|
|
CA2463822A1
(en)
|
2001-11-01 |
2003-05-08 |
Janssen Pharmaceutica N.V. |
Heteroaryl amines as glycogen synthase kinase 3beta inhibitors (gsk3 inhibitors)
|
|
TWI329105B
(en)
|
2002-02-01 |
2010-08-21 |
Rigel Pharmaceuticals Inc |
2,4-pyrimidinediamine compounds and their uses
|
|
WO2003066601A1
(en)
|
2002-02-08 |
2003-08-14 |
Smithkline Beecham Corporation |
Pyrimidine compounds
|
|
GB0206215D0
(en)
|
2002-03-15 |
2002-05-01 |
Novartis Ag |
Organic compounds
|
|
WO2003081210A2
(en)
|
2002-03-21 |
2003-10-02 |
Sunesis Pharmaceuticals, Inc. |
Identification of kinase inhibitors
|
|
US20040002395A1
(en)
|
2002-06-27 |
2004-01-01 |
Poynor Raymond L. |
Bridge weight for metal wood golf club
|
|
CN103169708B
(zh)
|
2002-07-29 |
2018-02-02 |
里格尔药品股份有限公司 |
用2,4‑嘧啶二胺化合物治疗或者预防自体免疫性疾病的方法
|
|
CA2439440A1
(en)
|
2002-09-05 |
2004-03-05 |
Emory University |
Treatment of tuberous sclerosis associated neoplasms
|
|
AU2002951853A0
(en)
|
2002-10-04 |
2002-10-24 |
Commonwealth Scientific And Industrial Research Organisation |
Crystal structure of erbb2 and uses thereof
|
|
WO2004050068A1
(en)
|
2002-11-29 |
2004-06-17 |
Janssen Pharmaceutica N.V. |
Pharmaceutical compositions comprising a basic respectively acidic drug compound, a surfactant and a physiologically tolerable water-soluble acid respectively base
|
|
UA80767C2
(en)
|
2002-12-20 |
2007-10-25 |
Pfizer Prod Inc |
Pyrimidine derivatives for the treatment of abnormal cell growth
|
|
EA011164B1
(ru)
|
2003-02-07 |
2009-02-27 |
Янссен Фармацевтика Н. В. |
Производные пиримидина для профилактики вич-инфекции
|
|
DE602004021472D1
(en)
|
2003-02-20 |
2009-07-23 |
Smithkline Beecham Corp |
Pyrimiidinverbindungen
|
|
GB0305929D0
(en)
|
2003-03-14 |
2003-04-23 |
Novartis Ag |
Organic compounds
|
|
US20050014753A1
(en)
|
2003-04-04 |
2005-01-20 |
Irm Llc |
Novel compounds and compositions as protein kinase inhibitors
|
|
US20050043233A1
(en)
|
2003-04-29 |
2005-02-24 |
Boehringer Ingelheim International Gmbh |
Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis
|
|
US7504396B2
(en)
|
2003-06-24 |
2009-03-17 |
Amgen Inc. |
Substituted heterocyclic compounds and methods of use
|
|
US7122542B2
(en)
|
2003-07-30 |
2006-10-17 |
Rigel Pharmaceuticals, Inc. |
Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds
|
|
DK1663242T3
(da)
|
2003-08-07 |
2011-08-01 |
Rigel Pharmaceuticals Inc |
2,4-Pyrimidindiamin-forbindelser og anvendelse som antiproliferative midler
|
|
JP4607879B2
(ja)
|
2003-08-15 |
2011-01-05 |
ノバルティス アーゲー |
新生物疾患、炎症および免疫障害の処置に有用な2,4−ピリミジンジアミン
|
|
GB0321710D0
(en)
|
2003-09-16 |
2003-10-15 |
Novartis Ag |
Organic compounds
|
|
CA2538413A1
(en)
|
2003-09-18 |
2005-03-24 |
Novartis Ag |
2,4-di (phenylamino) pyrimidines useful in the treatment of proliferative disorders
|
|
US7511137B2
(en)
|
2003-12-19 |
2009-03-31 |
Rigel Pharmaceuticals, Inc. |
Stereoisomers and stereoisomeric mixtures of 1-(2,4-pyrimidinediamino)-2-cyclopentanecarboxamide synthetic intermediates
|
|
GB2432834A
(en)
|
2004-01-12 |
2007-06-06 |
Cytopia Res Pty Ltd |
Selective Kinase Inhibitors
|
|
CN1930128A
(zh)
|
2004-01-16 |
2007-03-14 |
惠氏公司 |
受体酪氨酸激酶抑制剂的喹啉中间体及其合成
|
|
ATE545413T1
(de)
|
2004-03-15 |
2012-03-15 |
Lilly Co Eli |
Antagonisten des opioidrezeptors
|
|
US7558717B2
(en)
|
2004-04-28 |
2009-07-07 |
Vertex Pharmaceuticals Incorporated |
Crystal structure of human JAK3 kinase domain complex and binding pockets thereof
|
|
JP4812763B2
(ja)
|
2004-05-18 |
2011-11-09 |
ライジェル ファーマシューティカルズ, インコーポレイテッド |
シクロアルキル置換ピリミジンジアミン化合物およびそれらの用途
|
|
EP1598343A1
(de)
|
2004-05-19 |
2005-11-23 |
Boehringer Ingelheim International GmbH |
2-Arylaminopyrimidine als PLK Inhibitoren
|
|
EP2592155B2
(en)
|
2004-06-04 |
2019-09-11 |
Genentech, Inc. |
EGFR mutations
|
|
US7521457B2
(en)
|
2004-08-20 |
2009-04-21 |
Boehringer Ingelheim International Gmbh |
Pyrimidines as PLK inhibitors
|
|
GB0419161D0
(en)
|
2004-08-27 |
2004-09-29 |
Novartis Ag |
Organic compounds
|
|
CA2581454A1
(en)
|
2004-09-23 |
2006-03-30 |
Reddy Us Therapeutics, Inc. |
Novel pyrimidine compounds, process for their preparation and compositions containing them
|
|
AU2005288865B2
(en)
|
2004-09-30 |
2012-07-19 |
Janssen Sciences Ireland Uc |
HIV inhibiting 5-carbo- or heterocyclic substituted pyrimidines
|
|
MX2007004488A
(es)
|
2004-10-13 |
2007-09-11 |
Wyeth Corp |
Analogos de anilino-pirimidina n-bencenosulfonilo sustituidos.
|
|
EP1805208A2
(en)
|
2004-10-20 |
2007-07-11 |
Proteolix, Inc. |
Labeled compounds for proteasome inhibition
|
|
TW200628463A
(en)
|
2004-11-10 |
2006-08-16 |
Synta Pharmaceuticals Corp |
Heteroaryl compounds
|
|
GB2420559B
(en)
|
2004-11-15 |
2008-08-06 |
Rigel Pharmaceuticals Inc |
Stereoisomerically enriched 3-aminocarbonyl bicycloheptene pyrimidinediamine compounds and their uses
|
|
ATE540035T1
(de)
|
2004-11-24 |
2012-01-15 |
Rigel Pharmaceuticals Inc |
Spiro-2,4-pyrimidindiamin-verbindungen und ihre verwendungen
|
|
MY169441A
(en)
|
2004-12-08 |
2019-04-11 |
Janssen Pharmaceutica Nv |
2,4, (4,6) pyrimidine derivatives
|
|
US8211929B2
(en)
|
2004-12-30 |
2012-07-03 |
Exelixis, Inc. |
Pyrimidine derivatives as kinase modulators and method of use
|
|
WO2006076706A1
(en)
|
2005-01-14 |
2006-07-20 |
Millennium Pharmaceuticals, Inc. |
Cinnamide and hydrocinnamide derivatives with raf-kinase inhibitory activity
|
|
US7449458B2
(en)
|
2005-01-19 |
2008-11-11 |
Rigel Pharmaceuticals, Inc. |
Prodrugs of 2,4-pyrimidinediamine compounds and their uses
|
|
WO2006086777A2
(en)
|
2005-02-11 |
2006-08-17 |
Memorial Sloan Kettering Cancer Center |
Methods and compositions for detecting a drug resistant egfr mutant
|
|
CN101155799A
(zh)
|
2005-03-16 |
2008-04-02 |
塔格根公司 |
嘧啶化合物和使用方法
|
|
DE102005016634A1
(de)
|
2005-04-12 |
2006-10-19 |
Merck Patent Gmbh |
Neuartige Aza-Hetercyclen als Kinase-Inhibitoren
|
|
US20060270694A1
(en)
|
2005-05-03 |
2006-11-30 |
Rigel Pharmaceuticals, Inc. |
JAK kinase inhibitors and their uses
|
|
WO2006124874A2
(en)
|
2005-05-12 |
2006-11-23 |
Kalypsys, Inc. |
Inhibitors of b-raf kinase
|
|
WO2006128129A2
(en)
|
2005-05-26 |
2006-11-30 |
Synta Pharmaceuticals Corp. |
Method for treating cancer
|
|
WO2006128172A2
(en)
|
2005-05-26 |
2006-11-30 |
Synta Pharmaceuticals Corp. |
Method for treating b cell regulated autoimmune disorders
|
|
WO2006129100A1
(en)
|
2005-06-03 |
2006-12-07 |
Glaxo Group Limited |
Novel compounds
|
|
RU2485106C2
(ru)
|
2005-06-08 |
2013-06-20 |
Райджел Фамэсьютикэлз, Инк. |
Соединения, проявляющие активность в отношении jak-киназы (варианты), способ лечения заболеваний, опосредованных jak-киназой, способ ингибирования активности jak-киназы (варианты), фармацевтическая композиция на основе указанных соединений
|
|
US20070203161A1
(en)
|
2006-02-24 |
2007-08-30 |
Rigel Pharmaceuticals, Inc. |
Compositions and methods for inhibition of the jak pathway
|
|
WO2007023768A1
(ja)
*
|
2005-08-24 |
2007-03-01 |
Eisai R & D Management Co., Ltd. |
新規ピリジン誘導体およびピリミジン誘導体(3)
|
|
EP1948663B1
(en)
|
2005-10-21 |
2011-09-14 |
Exelixis, Inc. |
Pyrazolo-pyrimidines as casein kinase ii (ck2) modulators
|
|
MY167260A
(en)
|
2005-11-01 |
2018-08-14 |
Targegen Inc |
Bi-aryl meta-pyrimidine inhibitors of kinases
|
|
KR20080053954A
(ko)
|
2005-11-03 |
2008-06-16 |
아이알엠 엘엘씨 |
단백질 키나제 억제제
|
|
US7713987B2
(en)
|
2005-12-06 |
2010-05-11 |
Rigel Pharmaceuticals, Inc. |
Pyrimidine-2,4-diamines and their uses
|
|
WO2007120339A1
(en)
|
2005-12-19 |
2007-10-25 |
Genentech, Inc. |
Pyrimidine kinase inhibitors
|
|
TW200736232A
(en)
|
2006-01-26 |
2007-10-01 |
Astrazeneca Ab |
Pyrimidine derivatives
|
|
EP1979329A2
(en)
|
2006-01-30 |
2008-10-15 |
Exelixis, Inc. |
4-aryl-2-amino-pyrimidines or 4-aryl-2-aminoalkyl-pyrimidines as jak-2 modulators and methods of use
|
|
CA2642211C
(en)
|
2006-02-17 |
2012-01-24 |
Rigel Pharmaceuticals, Inc. |
2,4-pyrimidinediamine compounds for treating or preventing autoimmune diseases
|
|
US8962643B2
(en)
|
2006-02-24 |
2015-02-24 |
Rigel Pharmaceuticals, Inc. |
Compositions and methods for inhibition of the JAK pathway
|
|
WO2007113254A1
(en)
|
2006-03-30 |
2007-10-11 |
Tibotec Pharmaceuticals Ltd. |
Hiv inhibiting 5-amido substituted pyrimidines
|
|
AU2007233739B2
(en)
|
2006-03-30 |
2013-01-17 |
Janssen Sciences Ireland Uc |
HIV inhibiting 5-(hydroxymethylene and aminomethylene) substituted pyrimidines
|
|
GB0608386D0
(en)
|
2006-04-27 |
2006-06-07 |
Senexis Ltd |
Compounds
|
|
CA2650035C
(en)
|
2006-04-27 |
2015-02-03 |
Intezyne Technologies, Inc. |
Poly (ethylene glycol) containing chemically disparate endgroups
|
|
CA2651732C
(en)
|
2006-05-18 |
2014-10-14 |
Mannkind Corporation |
Intracellular kinase inhibitors
|
|
DE102006027156A1
(de)
|
2006-06-08 |
2007-12-13 |
Bayer Schering Pharma Ag |
Sulfimide als Proteinkinaseinhibitoren
|
|
CA2656290A1
(en)
|
2006-07-05 |
2008-01-10 |
Exelixis, Inc. |
Methods of using igf1r and abl kinase modulators
|
|
EP2046759A1
(en)
|
2006-07-21 |
2009-04-15 |
Novartis AG |
2, 4 -di (arylaminio) -pyrimidine-5-carboxamide compounds as jak kinases inhibitors
|
|
DE102006041382A1
(de)
|
2006-08-29 |
2008-03-20 |
Bayer Schering Pharma Ag |
Carbamoyl-Sulfoximide als Proteinkinaseinhibitoren
|
|
EP2526934B1
(en)
|
2006-09-22 |
2015-12-09 |
Pharmacyclics LLC |
Inhibitors of bruton's tyrosine kinase
|
|
CA2673125C
(en)
|
2006-10-19 |
2015-04-21 |
Rigel Pharmaceuticals, Inc. |
Compositions and methods for inhibition of the jak pathway
|
|
EP2089391B1
(en)
|
2006-11-03 |
2013-01-16 |
Pharmacyclics, Inc. |
Bruton's tyrosine kinase activity probe and method of using
|
|
US8163902B2
(en)
|
2006-11-21 |
2012-04-24 |
Rigel Pharmaceuticals, Inc. |
Prodrugs of 2,4-pyrimidinediamine compounds and their uses
|
|
BRPI0720264B1
(pt)
|
2006-12-08 |
2022-03-03 |
Novartis Ag |
Compostos e composições como inibidores de proteína cinase
|
|
EP2099771A1
(en)
|
2006-12-19 |
2009-09-16 |
Genentech, Inc. |
Pyrimidine kinase inhibitors
|
|
EP1939185A1
(de)
|
2006-12-20 |
2008-07-02 |
Bayer Schering Pharma Aktiengesellschaft |
Neuartige Hetaryl-Phenylendiamin-Pyrimidine als Proteinkinaseinhibitoren zur Behandlung von Krebs
|
|
WO2008080965A2
(en)
|
2006-12-29 |
2008-07-10 |
Tibotec Pharmaceuticals Ltd. |
Hiv inhibiting 5,6-substituted pyrimidines
|
|
JP5185283B2
(ja)
|
2006-12-29 |
2013-04-17 |
テイボテク・フアーマシユーチカルズ |
Hiv阻害6−置換ピリミジン
|
|
TW200902010A
(en)
|
2007-01-26 |
2009-01-16 |
Smithkline Beecham Corp |
Anthranilamide inhibitors of aurora kinase
|
|
AU2008210266B2
(en)
|
2007-01-31 |
2013-09-05 |
Ym Biosciences Australia Pty Ltd |
Thiopyrimidine-based compounds and uses thereof
|
|
DE102007010801A1
(de)
|
2007-03-02 |
2008-09-04 |
Bayer Cropscience Ag |
Diaminopyrimidine als Fungizide
|
|
CA2681250A1
(en)
|
2007-03-20 |
2008-09-25 |
Smithkline Beecham Corporation |
Chemical compounds
|
|
JP2010522186A
(ja)
|
2007-03-20 |
2010-07-01 |
スミスクライン ビーチャム コーポレーション |
化合物
|
|
WO2008118822A1
(en)
|
2007-03-23 |
2008-10-02 |
Rigel Pharmaceuticals, Inc. |
Compositions and methods for inhibition of the jak pathway
|
|
US7834024B2
(en)
|
2007-03-26 |
2010-11-16 |
Rigel Pharmaceuticals, Inc. |
Compositions and methods for inhibition of the JAK pathway
|
|
US8809273B2
(en)
|
2007-03-28 |
2014-08-19 |
Pharmacyclics, Inc. |
Inhibitors of Bruton's tyrosine kinase
|
|
US20120065201A1
(en)
|
2007-03-28 |
2012-03-15 |
Pharmacyclics, Inc. |
Inhibitors of bruton's tyrosine kinase
|
|
TWI433677B
(zh)
|
2007-06-04 |
2014-04-11 |
Avila Therapeutics Inc |
雜環化合物及其用途
|
|
CA2693594A1
(en)
|
2007-07-17 |
2009-01-22 |
Rigel Pharmaceuticals, Inc. |
Cyclic amine substituted pyrimidinediamines as pkc inhibitors
|
|
WO2009017838A2
(en)
|
2007-08-01 |
2009-02-05 |
Exelixis, Inc. |
Combinations of jak-2 inhibitors and other agents
|
|
AU2008296479A1
(en)
|
2007-08-28 |
2009-03-12 |
Dana Farber Cancer Institute |
Amino substituted pyrimidine, pyrollopyridine and pyrazolopyrimidine derivatives useful as kinase inhibitors and in treating proliferative disorders and diseases associated with angiogenesis
|
|
US20090088371A1
(en)
|
2007-08-28 |
2009-04-02 |
Rigel Pharmaceuticals, Inc. |
Combination therapy with syk kinase inhibitor
|
|
EP2190826A2
(en)
|
2007-08-28 |
2010-06-02 |
Irm Llc |
2-biphenylamino-4-aminopyrimidine derivatives as kinase inhibitors
|
|
JP5600063B2
(ja)
*
|
2007-10-19 |
2014-10-01 |
セルジーン アビロミクス リサーチ, インコーポレイテッド |
ヘテロアリール化合物およびその使用
|
|
US7989465B2
(en)
|
2007-10-19 |
2011-08-02 |
Avila Therapeutics, Inc. |
4,6-disubstituted pyrimidines useful as kinase inhibitors
|
|
US20110028405A1
(en)
|
2007-12-20 |
2011-02-03 |
Richard John Harrison |
Sulfamides as zap-70 inhibitors
|
|
ES2610880T3
(es)
|
2008-02-22 |
2017-05-03 |
Rigel Pharmaceuticals, Inc. |
Uso de 2,4-pirimidinadiaminas para el tratamiento de la aterosclerosis
|
|
EP2276747A1
(en)
|
2008-03-11 |
2011-01-26 |
Cellzome Limited |
Sulfonamides as zap-70 inhibitors
|
|
US8205348B2
(en)
|
2008-03-19 |
2012-06-26 |
Zashiki-Warashi Manufacturing Inc. |
Tile spacer and holder therefor
|
|
CL2009000600A1
(es)
|
2008-03-20 |
2010-05-07 |
Bayer Cropscience Ag |
Uso de compuestos de diaminopirimidina como agentes fitosanitarios; compuestos de diaminopirimidina; su procedimiento de preparacion; agente que los contiene; procedimiento para la preparacion de dicho agente; y procedimiento para combatir plagas de animales y/u hongos dañinos patogenos de plantas.
|
|
WO2009127642A2
(en)
|
2008-04-15 |
2009-10-22 |
Cellzome Limited |
Use of lrrk2 inhibitors for neurodegenerative diseases
|
|
KR20100132550A
(ko)
|
2008-04-16 |
2010-12-17 |
포톨라 파마슈티컬스, 인코포레이티드 |
syk 또는 JAK 키나제 억제제로서의 2,6-디아미노-피리미딘-5-일-카르복스아미드
|
|
US8138339B2
(en)
|
2008-04-16 |
2012-03-20 |
Portola Pharmaceuticals, Inc. |
Inhibitors of protein kinases
|
|
US8871753B2
(en)
|
2008-04-24 |
2014-10-28 |
Incyte Corporation |
Macrocyclic compounds and their use as kinase inhibitors
|
|
PT2300013T
(pt)
|
2008-05-21 |
2017-10-31 |
Ariad Pharma Inc |
Derivados de fósforo como inibidores de cinases
|
|
US8338439B2
(en)
|
2008-06-27 |
2012-12-25 |
Celgene Avilomics Research, Inc. |
2,4-disubstituted pyrimidines useful as kinase inhibitors
|
|
EP2361248B1
(en)
*
|
2008-06-27 |
2018-09-19 |
Celgene CAR LLC |
Heteroaryl compounds and uses thereof
|
|
MX2011000661A
(es)
|
2008-07-16 |
2011-05-25 |
Pharmacyclics Inc |
Inhibidores de tirosina cinasa de bruton para el tratamiento de tumores solidos.
|
|
US20110245284A1
(en)
|
2008-09-03 |
2011-10-06 |
Bayer Cropscience Ag |
Alkoxy- and Alkylthio-Substituted Anilinopyrimidines
|
|
US20110245156A1
(en)
|
2008-12-09 |
2011-10-06 |
Cytokine Pharmasciences, Inc. |
Novel antiviral compounds, compositions, and methods of use
|
|
CA2965031C
(en)
|
2009-01-15 |
2018-12-04 |
F. Hoffmann-La Roche Ag |
Antibodies against phosphorylated tyrosines on erythropoietin receptor (epor)
|
|
US20120270237A9
(en)
|
2009-04-03 |
2012-10-25 |
Cellzone AG |
Methods for the identification of kinase interacting molecules and for the purification of kinase proteins
|
|
JP5918693B2
(ja)
*
|
2009-05-05 |
2016-05-18 |
ダナ ファーバー キャンサー インスティテュート インコーポレイテッド |
Egfr阻害剤及び疾患の治療方法
|
|
EP3009428B1
(en)
|
2009-05-08 |
2018-02-21 |
Astellas Pharma Inc. |
Diamino heterocyclic carboxamide compound
|
|
WO2010146132A1
(en)
|
2009-06-18 |
2010-12-23 |
Cellzome Limited |
Sulfonamides and sulfamides as zap-70 inhibitors
|
|
US7741330B1
(en)
|
2009-10-12 |
2010-06-22 |
Pharmacyclics, Inc. |
Pyrazolo-pyrimidine inhibitors of Bruton's tyrosine kinase
|
|
WO2011079231A1
(en)
|
2009-12-23 |
2011-06-30 |
Gatekeeper Pharmaceutical, Inc. |
Compounds that modulate egfr activity and methods for treating or preventing conditions therewith
|
|
US20130137709A1
(en)
|
2010-05-05 |
2013-05-30 |
Nathanael S. Gray |
Compounds that modulate EGFR activity and methods for treating or preventing conditions therewith
|
|
US20120071497A1
(en)
|
2010-06-03 |
2012-03-22 |
Pharmacyclics, Inc. |
Methods of treating abc-dlbcl using inhibitors of bruton's tyrosine kinase
|
|
NZ604040A
(en)
|
2010-06-03 |
2015-02-27 |
Pharmacyclics Inc |
The use of inhibitors of bruton’s tyrosine kinase (btk)
|
|
WO2011153553A2
(en)
|
2010-06-04 |
2011-12-08 |
The Regents Of The University Of California |
Methods and compositions for kinase inhibition
|
|
NZ607845A
(en)
|
2010-08-10 |
2015-03-27 |
Celgene Avilomics Res Inc |
Besylate salt of a btk inhibitor
|
|
US20130317029A1
(en)
|
2010-11-01 |
2013-11-28 |
Portola Pharmaceuticals, Inc. |
Oxypyrimidines as syk modulators
|
|
WO2012061299A1
(en)
|
2010-11-01 |
2012-05-10 |
Avila Therapeutics, Inc. |
Heterocyclic compounds and uses thereof
|
|
EP2635285B1
(en)
|
2010-11-01 |
2017-05-03 |
Celgene Avilomics Research, Inc. |
Heteroaryl compounds and uses thereof
|
|
US8796255B2
(en)
|
2010-11-10 |
2014-08-05 |
Celgene Avilomics Research, Inc |
Mutant-selective EGFR inhibitors and uses thereof
|
|
CN102558149A
(zh)
|
2010-12-29 |
2012-07-11 |
中国医学科学院药物研究所 |
嘧啶衍生物、及其制法和药物组合物与用途
|
|
EP2704572B1
(en)
|
2011-05-04 |
2015-12-30 |
Ariad Pharmaceuticals, Inc. |
Compounds for inhibiting cell proliferation in egfr-driven cancers
|
|
DK2710007T3
(da)
|
2011-05-17 |
2020-01-27 |
Principia Biopharma Inc |
Kinasehæmmere
|
|
EP2771010A4
(en)
|
2011-10-19 |
2015-04-01 |
Pharmacyclics Inc |
USE OF BRUTON TYROSINE KINASE (BTK) INHIBITORS
|
|
CN103159742B
(zh)
|
2011-12-16 |
2015-08-12 |
北京韩美药品有限公司 |
5-氯嘧啶类化合物及其作为egfr酪氨酸激酶抑制剂的应用
|
|
MX356753B
(es)
|
2012-03-15 |
2018-06-12 |
Celgene Avilomics Res Inc |
Formas solidas de un inhibidor de cinasa del receptor del factor de crecimiento epidermico.
|
|
PT2825042T
(pt)
*
|
2012-03-15 |
2018-11-16 |
Celgene Car Llc |
Sais de um inibidor de cinases do recetor do fator de crescimento epidérmico
|
|
EA201590822A1
(ru)
|
2012-11-02 |
2016-01-29 |
Фармасайкликс, Инк. |
Адъювантная терапия ингибитором киназы семейства tec
|
|
JP6800750B2
(ja)
|
2013-08-02 |
2020-12-16 |
ファーマサイクリックス エルエルシー |
固形腫瘍の処置方法
|