JP2013541503A5 - - Google Patents
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- Publication number
- JP2013541503A5 JP2013541503A5 JP2013523380A JP2013523380A JP2013541503A5 JP 2013541503 A5 JP2013541503 A5 JP 2013541503A5 JP 2013523380 A JP2013523380 A JP 2013523380A JP 2013523380 A JP2013523380 A JP 2013523380A JP 2013541503 A5 JP2013541503 A5 JP 2013541503A5
- Authority
- JP
- Japan
- Prior art keywords
- aryl
- alkyl
- pharmaceutical composition
- heterocycle
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003118 aryl group Chemical group 0.000 claims 46
- 239000008194 pharmaceutical composition Substances 0.000 claims 42
- 125000000217 alkyl group Chemical group 0.000 claims 35
- 125000000623 heterocyclic group Chemical group 0.000 claims 34
- 125000004450 alkenylene group Chemical group 0.000 claims 16
- 125000004419 alkynylene group Chemical group 0.000 claims 16
- 229910052736 halogen Inorganic materials 0.000 claims 16
- 150000002367 halogens Chemical group 0.000 claims 16
- 125000006832 (C1-C10) alkylene group Chemical group 0.000 claims 15
- 229910052739 hydrogen Inorganic materials 0.000 claims 13
- 239000001257 hydrogen Substances 0.000 claims 11
- 229910052731 fluorine Inorganic materials 0.000 claims 10
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 9
- 229910052801 chlorine Inorganic materials 0.000 claims 9
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims 8
- 125000005865 C2-C10alkynyl group Chemical group 0.000 claims 8
- 229910052794 bromium Inorganic materials 0.000 claims 7
- 150000008267 fucoses Chemical class 0.000 claims 7
- 229910052740 iodine Inorganic materials 0.000 claims 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 6
- 241000124008 Mammalia Species 0.000 claims 5
- 150000001323 aldoses Chemical class 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 239000012453 solvate Substances 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 125000006575 electron-withdrawing group Chemical group 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- -1 benzyloxymethyl Chemical group 0.000 claims 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 230000033581 fucosylation Effects 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 125000005103 alkyl silyl group Chemical group 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 230000000890 antigenic effect Effects 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 150000001540 azides Chemical class 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 230000002163 immunogen Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- ARYZCSRUUPFYMY-UHFFFAOYSA-N methoxysilane Chemical compound CO[SiH3] ARYZCSRUUPFYMY-UHFFFAOYSA-N 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 0 *C1[C@@](*)C(*)O[C@@](*)C1* Chemical compound *C1[C@@](*)C(*)O[C@@](*)C1* 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37111610P | 2010-08-05 | 2010-08-05 | |
| US61/371,116 | 2010-08-05 | ||
| PCT/US2011/046857 WO2012019165A2 (en) | 2010-08-05 | 2011-08-05 | Methods of inhibition of protein fucosylation in vivo using fucose analogs |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016076930A Division JP6113887B2 (ja) | 2010-08-05 | 2016-04-07 | フコースアナログを用いるイン・ビボでのタンパク質フコシル化の阻害方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013541503A JP2013541503A (ja) | 2013-11-14 |
| JP2013541503A5 true JP2013541503A5 (cg-RX-API-DMAC7.html) | 2014-09-25 |
| JP5918235B2 JP5918235B2 (ja) | 2016-05-18 |
Family
ID=45560106
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013523380A Active JP5918235B2 (ja) | 2010-08-05 | 2011-08-05 | フコースアナログを用いるイン・ビボでのタンパク質フコシル化の阻害方法 |
| JP2016076930A Expired - Fee Related JP6113887B2 (ja) | 2010-08-05 | 2016-04-07 | フコースアナログを用いるイン・ビボでのタンパク質フコシル化の阻害方法 |
| JP2017049534A Active JP6622238B2 (ja) | 2010-08-05 | 2017-03-15 | フコースアナログを用いるイン・ビボでのタンパク質フコシル化の阻害方法 |
| JP2019210313A Pending JP2020040974A (ja) | 2010-08-05 | 2019-11-21 | フコースアナログを用いるイン・ビボでのタンパク質フコシル化の阻害方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016076930A Expired - Fee Related JP6113887B2 (ja) | 2010-08-05 | 2016-04-07 | フコースアナログを用いるイン・ビボでのタンパク質フコシル化の阻害方法 |
| JP2017049534A Active JP6622238B2 (ja) | 2010-08-05 | 2017-03-15 | フコースアナログを用いるイン・ビボでのタンパク質フコシル化の阻害方法 |
| JP2019210313A Pending JP2020040974A (ja) | 2010-08-05 | 2019-11-21 | フコースアナログを用いるイン・ビボでのタンパク質フコシル化の阻害方法 |
Country Status (21)
| Country | Link |
|---|---|
| US (4) | US9504702B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP3513794A3 (cg-RX-API-DMAC7.html) |
| JP (4) | JP5918235B2 (cg-RX-API-DMAC7.html) |
| KR (2) | KR101950520B1 (cg-RX-API-DMAC7.html) |
| CN (2) | CN103402525B (cg-RX-API-DMAC7.html) |
| AU (3) | AU2011285490B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2803388C (cg-RX-API-DMAC7.html) |
| CY (1) | CY1121419T1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK2608796T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2711622T3 (cg-RX-API-DMAC7.html) |
| HU (1) | HUE043370T2 (cg-RX-API-DMAC7.html) |
| IL (2) | IL224487A (cg-RX-API-DMAC7.html) |
| MX (1) | MX356671B (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ606250A (cg-RX-API-DMAC7.html) |
| PL (1) | PL2608796T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT2608796T (cg-RX-API-DMAC7.html) |
| RU (2) | RU2017122482A (cg-RX-API-DMAC7.html) |
| SI (1) | SI2608796T1 (cg-RX-API-DMAC7.html) |
| TR (1) | TR201902439T4 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2012019165A2 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA201300653B (cg-RX-API-DMAC7.html) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2282773B2 (en) | 2008-05-02 | 2025-03-05 | Seagen Inc. | Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation |
| US9504702B2 (en) | 2010-08-05 | 2016-11-29 | Seattle Genetics, Inc. | Methods of inhibition of protein fucosylation in vivo using fucose analogs |
| CA2882725C (en) | 2012-08-23 | 2021-03-09 | Regents Of The University Of Minnesota | Treatment of sickle cell disease and inflammatory conditions |
| US9328134B2 (en) | 2013-02-22 | 2016-05-03 | Amgen Inc. | Carbohydrate phosphonate derivatives as modulators of glycosylation |
| CN106699886A (zh) * | 2015-07-13 | 2017-05-24 | 西藏海思科药业集团股份有限公司 | 抗体依赖性细胞介导的细胞毒性(adcc)增强的奥法木抗体 |
| JP6906520B2 (ja) * | 2015-12-04 | 2021-07-21 | シージェン インコーポレイテッド | チェックポイント阻害剤と組みわせて２−デオキシ−２−フルオロ−ｌ−フコースを用いる癌治療 |
| ES2908067T3 (es) | 2016-05-10 | 2022-04-27 | Ares Trading Sa | Métodos para modular los perfiles de galactosilación proteicos de proteínas recombinantes empleando peracetil galactosa |
| JP2018002666A (ja) * | 2016-07-04 | 2018-01-11 | 国立研究開発法人理化学研究所 | フコース類似体と糖を検出する方法 |
| JP7245177B2 (ja) * | 2017-06-07 | 2023-03-23 | シージェン インコーポレイテッド | 低減した表面フコシル化を有するｔ細胞、及びそれを作製及び使用する方法 |
| MX2020005662A (es) | 2017-12-01 | 2020-08-20 | Pfizer | Anticuerpos anti-cxcr5 y composiciones y usos de los mismos. |
| PE20211235A1 (es) | 2018-03-29 | 2021-07-08 | Univ California | Variantes de lfa3 y composiciones y usos de las mismas |
| US11401339B2 (en) | 2018-08-23 | 2022-08-02 | Seagen Inc. | Anti-TIGIT antibodies |
| WO2020138447A1 (ja) * | 2018-12-27 | 2020-07-02 | 学校法人慶應義塾 | 抗ヒトノロウイルス剤 |
| KR20220115998A (ko) * | 2019-12-19 | 2022-08-19 | 메르크 파텐트 게엠베하 | 단백질의 글리코실화 프로파일을 조절하기 위한 방법 및 조성물 |
| TWI877278B (zh) * | 2019-12-30 | 2025-03-21 | 美商思進公司 | 以非海藻糖苷化抗－ｃｄ７０抗體治療癌症之方法 |
| IL272389A (en) | 2020-01-30 | 2021-08-31 | Yeda Res & Dev | Kits containing antibodies to PD-L1 and their uses in therapy |
| CN116194089A (zh) * | 2020-06-03 | 2023-05-30 | 西蒙弗雷泽大学 | 蛋白质岩藻糖基化抑制剂及其用途 |
| WO2022198231A1 (en) | 2021-03-18 | 2022-09-22 | Seagen Inc. | Selective drug release from internalized conjugates of biologically active compounds |
| AU2022289365A1 (en) | 2021-06-07 | 2023-12-14 | Amgen Inc. | Using fucosidase to control afucosylation level of glycosylated proteins |
| CN113413465B (zh) * | 2021-06-15 | 2022-06-03 | 北京大学 | 岩藻糖基化抑制剂在抗癌导致炎症中的应用 |
| WO2024118503A1 (en) | 2022-11-28 | 2024-06-06 | Hongene Biotech Corporation | Functionalized n-acetylgalactosamine analogs |
| WO2024191807A1 (en) | 2023-03-10 | 2024-09-19 | Seagen Inc. | Methods of treating cancer with anti-tigit antibodies |
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| KR100211417B1 (ko) | 1990-11-30 | 1999-10-01 | 유충식 | L-탈로피라노시드 유도체 및 그의 제조방법 |
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-
2011
- 2011-08-05 US US13/814,083 patent/US9504702B2/en active Active
- 2011-08-05 EP EP18206850.2A patent/EP3513794A3/en not_active Withdrawn
- 2011-08-05 EP EP11815404.6A patent/EP2608796B1/en active Active
- 2011-08-05 SI SI201131673T patent/SI2608796T1/sl unknown
- 2011-08-05 NZ NZ606250A patent/NZ606250A/en unknown
- 2011-08-05 WO PCT/US2011/046857 patent/WO2012019165A2/en not_active Ceased
- 2011-08-05 KR KR1020137005545A patent/KR101950520B1/ko not_active Expired - Fee Related
- 2011-08-05 RU RU2017122482A patent/RU2017122482A/ru not_active Application Discontinuation
- 2011-08-05 CN CN201180038334.2A patent/CN103402525B/zh active Active
- 2011-08-05 HU HUE11815404A patent/HUE043370T2/hu unknown
- 2011-08-05 CA CA2803388A patent/CA2803388C/en active Active
- 2011-08-05 RU RU2013109415A patent/RU2625768C2/ru active
- 2011-08-05 KR KR1020197004266A patent/KR20190022884A/ko not_active Ceased
- 2011-08-05 CN CN201710076003.7A patent/CN107007615A/zh active Pending
- 2011-08-05 PT PT11815404T patent/PT2608796T/pt unknown
- 2011-08-05 ES ES11815404T patent/ES2711622T3/es active Active
- 2011-08-05 DK DK11815404.6T patent/DK2608796T3/en active
- 2011-08-05 TR TR2019/02439T patent/TR201902439T4/tr unknown
- 2011-08-05 JP JP2013523380A patent/JP5918235B2/ja active Active
- 2011-08-05 AU AU2011285490A patent/AU2011285490B2/en active Active
- 2011-08-05 PL PL11815404T patent/PL2608796T3/pl unknown
- 2011-08-05 MX MX2013001303A patent/MX356671B/es active IP Right Grant
-
2013
- 2013-01-24 ZA ZA2013/00653A patent/ZA201300653B/en unknown
- 2013-01-30 IL IL224487A patent/IL224487A/en active IP Right Grant
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2016
- 2016-02-08 IL IL244019A patent/IL244019B/en active IP Right Grant
- 2016-04-07 JP JP2016076930A patent/JP6113887B2/ja not_active Expired - Fee Related
- 2016-06-29 AU AU2016204495A patent/AU2016204495A1/en not_active Abandoned
- 2016-10-21 US US15/299,894 patent/US10342811B2/en active Active
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2017
- 2017-03-15 JP JP2017049534A patent/JP6622238B2/ja active Active
- 2017-12-20 AU AU2017279653A patent/AU2017279653A1/en not_active Abandoned
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2019
- 2019-02-20 CY CY20191100218T patent/CY1121419T1/el unknown
- 2019-06-25 US US16/452,160 patent/US11033561B2/en active Active
- 2019-11-21 JP JP2019210313A patent/JP2020040974A/ja active Pending
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2021
- 2021-05-07 US US17/315,144 patent/US20210260086A1/en not_active Abandoned