JP2013539015A5 - - Google Patents
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- JP2013539015A5 JP2013539015A5 JP2013520854A JP2013520854A JP2013539015A5 JP 2013539015 A5 JP2013539015 A5 JP 2013539015A5 JP 2013520854 A JP2013520854 A JP 2013520854A JP 2013520854 A JP2013520854 A JP 2013520854A JP 2013539015 A5 JP2013539015 A5 JP 2013539015A5
- Authority
- JP
- Japan
- Prior art keywords
- complex
- compound
- alkyl
- carbons
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 30
- -1 acyl azide Chemical class 0.000 claims 20
- 125000000217 alkyl group Chemical group 0.000 claims 16
- 125000003118 aryl group Chemical group 0.000 claims 13
- 125000001072 heteroaryl group Chemical group 0.000 claims 12
- 229910052736 halogen Inorganic materials 0.000 claims 10
- 150000002367 halogens Chemical class 0.000 claims 9
- 229910052739 hydrogen Inorganic materials 0.000 claims 9
- 239000001257 hydrogen Substances 0.000 claims 9
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 9
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims 8
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 8
- 229920001222 biopolymer Polymers 0.000 claims 7
- 230000009870 specific binding Effects 0.000 claims 7
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical group OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 claims 6
- 125000003545 alkoxy group Chemical group 0.000 claims 6
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims 6
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 5
- 125000003710 aryl alkyl group Chemical group 0.000 claims 5
- 125000005382 boronyl group Chemical group 0.000 claims 5
- 125000000753 cycloalkyl group Chemical group 0.000 claims 5
- 125000000623 heterocyclic group Chemical group 0.000 claims 5
- 125000005499 phosphonyl group Chemical group 0.000 claims 5
- 150000003573 thiols Chemical class 0.000 claims 5
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 5
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 claims 4
- PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 claims 4
- 239000002202 Polyethylene glycol Substances 0.000 claims 4
- 150000001412 amines Chemical class 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 150000002148 esters Chemical class 0.000 claims 4
- 150000002540 isothiocyanates Chemical class 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 229920001223 polyethylene glycol Polymers 0.000 claims 4
- 125000004429 atom Chemical group 0.000 claims 3
- 230000003915 cell function Effects 0.000 claims 3
- 230000000295 complement effect Effects 0.000 claims 3
- 108091034117 Oligonucleotide Proteins 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- 150000004676 glycans Chemical class 0.000 claims 2
- 238000012544 monitoring process Methods 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 229920001282 polysaccharide Polymers 0.000 claims 2
- 239000005017 polysaccharide Substances 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 150000003461 sulfonyl halides Chemical class 0.000 claims 2
- QGKMIGUHVLGJBR-UHFFFAOYSA-M (4z)-1-(3-methylbutyl)-4-[[1-(3-methylbutyl)quinolin-1-ium-4-yl]methylidene]quinoline;iodide Chemical group [I-].C12=CC=CC=C2N(CCC(C)C)C=CC1=CC1=CC=[N+](CCC(C)C)C2=CC=CC=C12 QGKMIGUHVLGJBR-UHFFFAOYSA-M 0.000 claims 1
- BCHZICNRHXRCHY-UHFFFAOYSA-N 2h-oxazine Chemical compound N1OC=CC=C1 BCHZICNRHXRCHY-UHFFFAOYSA-N 0.000 claims 1
- DWAOUXYZOSPAOH-UHFFFAOYSA-N 4-[2-(diethylamino)ethoxy]furo[3,2-g]chromen-7-one;hydrochloride Chemical compound [Cl-].O1C(=O)C=CC2=C1C=C1OC=CC1=C2OCC[NH+](CC)CC DWAOUXYZOSPAOH-UHFFFAOYSA-N 0.000 claims 1
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical group NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims 1
- 108090001008 Avidin Proteins 0.000 claims 1
- NOWKCMXCCJGMRR-UHFFFAOYSA-N Aziridine Chemical compound C1CN1 NOWKCMXCCJGMRR-UHFFFAOYSA-N 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 102000004856 Lectins Human genes 0.000 claims 1
- 108090001090 Lectins Proteins 0.000 claims 1
- 102000004895 Lipoproteins Human genes 0.000 claims 1
- 108090001030 Lipoproteins Proteins 0.000 claims 1
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 claims 1
- 239000004698 Polyethylene Substances 0.000 claims 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
- 108010090804 Streptavidin Proteins 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 150000001299 aldehydes Chemical class 0.000 claims 1
- 150000001350 alkyl halides Chemical class 0.000 claims 1
- 150000008064 anhydrides Chemical class 0.000 claims 1
- 210000004102 animal cell Anatomy 0.000 claims 1
- 150000001502 aryl halides Chemical class 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 150000001540 azides Chemical class 0.000 claims 1
- 239000012620 biological material Substances 0.000 claims 1
- ZADPBFCGQRWHPN-UHFFFAOYSA-N boronic acid Chemical compound OBO ZADPBFCGQRWHPN-UHFFFAOYSA-N 0.000 claims 1
- 238000000423 cell based assay Methods 0.000 claims 1
- 239000002131 composite material Substances 0.000 claims 1
- 150000004696 coordination complex Chemical class 0.000 claims 1
- 239000002158 endotoxin Substances 0.000 claims 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 1
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 claims 1
- 125000003827 glycol group Chemical group 0.000 claims 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 1
- 230000001678 irradiating effect Effects 0.000 claims 1
- 239000012948 isocyanate Substances 0.000 claims 1
- 150000002513 isocyanates Chemical class 0.000 claims 1
- 239000002523 lectin Substances 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 229920006008 lipopolysaccharide Polymers 0.000 claims 1
- 239000002502 liposome Substances 0.000 claims 1
- 239000011859 microparticle Substances 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 150000003904 phospholipids Chemical class 0.000 claims 1
- IEQIEDJGQAUEQZ-UHFFFAOYSA-N phthalocyanine Chemical compound N1C(N=C2C3=CC=CC=C3C(N=C3C4=CC=CC=C4C(=N4)N3)=N2)=C(C=CC=C2)C2=C1N=C1C2=CC=CC=C2C4=N1 IEQIEDJGQAUEQZ-UHFFFAOYSA-N 0.000 claims 1
- 229910052697 platinum Inorganic materials 0.000 claims 1
- 229920000573 polyethylene Polymers 0.000 claims 1
- 230000009257 reactivity Effects 0.000 claims 1
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 claims 1
- 229910052711 selenium Inorganic materials 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 claims 1
- 125000001273 sulfonato group Chemical group [O-]S(*)(=O)=O 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39999510P | 2010-07-21 | 2010-07-21 | |
| US61/399,995 | 2010-07-21 | ||
| US13/181,107 | 2011-07-12 | ||
| US13/181,107 US8623324B2 (en) | 2010-07-21 | 2011-07-12 | Luminescent dyes with a water-soluble intramolecular bridge and their biological conjugates |
| PCT/US2011/044776 WO2012012595A2 (en) | 2010-07-21 | 2011-07-21 | Luminescent dyes with a water-soluble intramolecular bridge and their biological conjugates |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013539015A JP2013539015A (ja) | 2013-10-17 |
| JP2013539015A5 true JP2013539015A5 (cg-RX-API-DMAC7.html) | 2014-09-04 |
| JP5819426B2 JP5819426B2 (ja) | 2015-11-24 |
Family
ID=44629873
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013520854A Active JP5819426B2 (ja) | 2010-07-21 | 2011-07-21 | 水溶性の分子内橋を持つ発光性色素およびそれらの生物学的複合体 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8623324B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2596065B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5819426B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2806025C (cg-RX-API-DMAC7.html) |
| ES (1) | ES2667858T3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2012012595A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX345403B (es) | 2009-05-13 | 2017-01-30 | Sio2 Medical Products Inc | Revestimiento por pecvd utilizando un precursor organosilícico. |
| US9545360B2 (en) | 2009-05-13 | 2017-01-17 | Sio2 Medical Products, Inc. | Saccharide protective coating for pharmaceutical package |
| US9458536B2 (en) | 2009-07-02 | 2016-10-04 | Sio2 Medical Products, Inc. | PECVD coating methods for capped syringes, cartridges and other articles |
| US11624115B2 (en) | 2010-05-12 | 2023-04-11 | Sio2 Medical Products, Inc. | Syringe with PECVD lubrication |
| US9878101B2 (en) | 2010-11-12 | 2018-01-30 | Sio2 Medical Products, Inc. | Cyclic olefin polymer vessels and vessel coating methods |
| US9272095B2 (en) | 2011-04-01 | 2016-03-01 | Sio2 Medical Products, Inc. | Vessels, contact surfaces, and coating and inspection apparatus and methods |
| US11116695B2 (en) | 2011-11-11 | 2021-09-14 | Sio2 Medical Products, Inc. | Blood sample collection tube |
| CN103930595A (zh) | 2011-11-11 | 2014-07-16 | Sio2医药产品公司 | 用于药物包装的钝化、pH保护性或润滑性涂层、涂布方法以及设备 |
| CA2867144C (en) | 2012-03-27 | 2019-07-02 | Ventana Medical Systems, Inc. | Signaling conjugates and methods of use |
| US20150297800A1 (en) | 2012-07-03 | 2015-10-22 | Sio2 Medical Products, Inc. | SiOx BARRIER FOR PHARMACEUTICAL PACKAGE AND COATING PROCESS |
| CN104736561B (zh) | 2012-08-21 | 2018-06-12 | 詹森药业有限公司 | 帕潘立酮的抗体及其用途 |
| AU2013305901B2 (en) | 2012-08-21 | 2017-10-26 | Saladax Biomedical Inc. | Antibodies to olanzapine and use thereof |
| ES2822004T3 (es) | 2012-08-21 | 2021-04-28 | Janssen Pharmaceutica Nv | Anticuerpos contra quetiapina y uso de los mismos |
| ES2739383T3 (es) | 2012-08-21 | 2020-01-30 | Janssen Pharmaceutica Nv | Haptenos de paliperidona |
| CA2882454C (en) | 2012-08-21 | 2020-08-11 | Matthew Garrett DONAHUE | Haptens of olanzapine |
| PT3305784T (pt) | 2012-08-21 | 2020-10-23 | Janssen Pharmaceutica Nv | Haptenos de quetiapina para utilização em ensaios imunológicos |
| JP6389176B2 (ja) | 2012-08-21 | 2018-09-12 | ヤンセン ファーマシューティカ エヌ．ベー． | アリピプラゾールハプテンに対する抗体及びその使用 |
| JP2015529199A (ja) | 2012-08-21 | 2015-10-05 | オルソ−クリニカル ダイアグノスティクス，インコーポレイティド | パリペリドンハプテンに対する抗体及びその使用 |
| JP6450314B2 (ja) | 2012-08-21 | 2019-01-09 | ヤンセン ファーマシューティカ エヌ．ベー． | クエチアピンハプテンに対する抗体及びその使用 |
| CN108517014A (zh) | 2012-08-21 | 2018-09-11 | 詹森药业有限公司 | 利培酮半抗原的抗体及其用途 |
| JP6389177B2 (ja) | 2012-08-21 | 2018-09-12 | ヤンセン ファーマシューティカ エヌ．ベー． | オランザピンハプテンに対する抗体及びその使用 |
| CN107043424B (zh) | 2012-08-21 | 2021-03-16 | 詹森药业有限公司 | 利培酮的抗体及其用途 |
| EP3415516B1 (en) | 2012-08-21 | 2021-12-15 | Janssen Pharmaceutica NV | Haptens of risperidone and paliperidone |
| WO2014031584A1 (en) | 2012-08-21 | 2014-02-27 | Janssen Pharmaceutica Nv | Haptens of aripiprazole and their use in immunoassays |
| AU2013305879B2 (en) | 2012-08-21 | 2017-10-12 | Saladax Biomedical Inc. | Antibodies to aripiprazole and use thereof |
| AU2013334635B2 (en) | 2012-10-24 | 2018-12-06 | Becton, Dickinson And Company | Hydroxamate substituted azaindoline-cyanine dyes and bioconjugates of the same |
| WO2014071061A1 (en) | 2012-11-01 | 2014-05-08 | Sio2 Medical Products, Inc. | Coating inspection method |
| US9903782B2 (en) | 2012-11-16 | 2018-02-27 | Sio2 Medical Products, Inc. | Method and apparatus for detecting rapid barrier coating integrity characteristics |
| CA2892294C (en) | 2012-11-30 | 2021-07-27 | Sio2 Medical Products, Inc. | Controlling the uniformity of pecvd deposition on medical syringes, cartridges, and the like |
| US9764093B2 (en) | 2012-11-30 | 2017-09-19 | Sio2 Medical Products, Inc. | Controlling the uniformity of PECVD deposition |
| US20160015898A1 (en) | 2013-03-01 | 2016-01-21 | Sio2 Medical Products, Inc. | Plasma or cvd pre-treatment for lubricated pharmaceutical package, coating process and apparatus |
| JP6453841B2 (ja) | 2013-03-11 | 2019-01-16 | エスアイオーツー・メディカル・プロダクツ・インコーポレイテッド | 被覆包装 |
| US9937099B2 (en) | 2013-03-11 | 2018-04-10 | Sio2 Medical Products, Inc. | Trilayer coated pharmaceutical packaging with low oxygen transmission rate |
| US9863042B2 (en) | 2013-03-15 | 2018-01-09 | Sio2 Medical Products, Inc. | PECVD lubricity vessel coating, coating process and apparatus providing different power levels in two phases |
| CN103288673B (zh) * | 2013-05-28 | 2015-05-06 | 广东药学院 | 一种铂配体及其配合物 |
| WO2015148471A1 (en) | 2014-03-28 | 2015-10-01 | Sio2 Medical Products, Inc. | Antistatic coatings for plastic vessels |
| US20150017658A1 (en) * | 2014-05-19 | 2015-01-15 | National Institute Of Standards And Technology | Stain, process for staining and acquiring normalized signal |
| US11077233B2 (en) | 2015-08-18 | 2021-08-03 | Sio2 Medical Products, Inc. | Pharmaceutical and other packaging with low oxygen transmission rate |
| ES2911298T3 (es) | 2015-12-16 | 2022-05-18 | Becton Dickinson Co | Colorantes poliméricos en tándem fluorescentes fotoestables que incluyen complejos de metales luminiscentes |
| WO2017106508A1 (en) | 2015-12-17 | 2017-06-22 | Janssen Pharmaceutica Nv | Antibodies to quetiapine and use thereof |
| CA3008809A1 (en) | 2015-12-17 | 2017-06-22 | Janssen Pharmaceutica Nv | Antibodies to risperidone and use thereof |
| CN108884030B (zh) * | 2016-02-26 | 2022-06-28 | 安捷伦科技有限公司 | 使用双吡啶改善亲核物质的标记 |
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| DE102016012162A1 (de) * | 2016-10-11 | 2018-04-12 | Rijksuniversiteit Groningen | Synthese und Struktur chemisch schaltbarer Fluoreszenzsonden auf der Basis von Aminosäuren |
| CN107857788B (zh) * | 2017-07-06 | 2021-04-13 | 江南大学 | 糖基化氟硼二吡咯衍生物、表面糖修饰的纳米胶束及其制备方法和应用 |
| CN108982447B (zh) * | 2018-07-19 | 2020-12-01 | 曲阜师范大学 | 一种用于检测肼的比率式荧光探针的制备方法及应用 |
| CA3107113A1 (en) * | 2018-08-07 | 2020-02-13 | Becton, Dickinson And Company | Polymeric tandem dyes having pendant narrow emission acceptor |
| KR102403979B1 (ko) * | 2019-03-14 | 2022-06-02 | 고려대학교 산학협력단 | 카라지난 유도체, 대식세포 표지용 프로브 및 이의 제조방법 |
| CN111454715B (zh) * | 2020-03-30 | 2023-03-21 | 西南大学 | 一种耐水室温磷光材料的制备方法和应用 |
| EP4190795A4 (en) * | 2020-07-30 | 2024-08-28 | FUJIFILM Corporation | Compound, and labeled biological substance in which same is used |
| GB2605404A (en) * | 2021-03-30 | 2022-10-05 | Sumitomo Chemical Co | Sequencing method |
| EP4634306A1 (en) * | 2022-12-13 | 2025-10-22 | Becton, Dickinson and Company | Sulfonate-containing water-solubilizing peptides |
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2011
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- 2011-07-21 EP EP11741365.8A patent/EP2596065B1/en active Active
- 2011-07-21 WO PCT/US2011/044776 patent/WO2012012595A2/en not_active Ceased
- 2011-07-21 JP JP2013520854A patent/JP5819426B2/ja active Active
- 2011-07-21 CA CA2806025A patent/CA2806025C/en active Active
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