JP2013538230A - 抗ウイルス治療用の2’−フルオロ置換カルバヌクレオシド類似体 - Google Patents
抗ウイルス治療用の2’−フルオロ置換カルバヌクレオシド類似体 Download PDFInfo
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- JP2013538230A JP2013538230A JP2013529139A JP2013529139A JP2013538230A JP 2013538230 A JP2013538230 A JP 2013538230A JP 2013529139 A JP2013529139 A JP 2013529139A JP 2013529139 A JP2013529139 A JP 2013529139A JP 2013538230 A JP2013538230 A JP 2013538230A
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- 0 *C(*)([C@](*1)([C@]1(C(N1N=C(*)N=C(*)C1=I)=**)O1)F)[C@]1(CO*)S Chemical compound *C(*)([C@](*1)([C@]1(C(N1N=C(*)N=C(*)C1=I)=**)O1)F)[C@]1(CO*)S 0.000 description 24
- WSNWHSYQUNVAGB-DXLKZPDWSA-N C[C@@]1([C@@](c2ccc3[n]2ncnc3N)(C#N)O[C@H](COP(O)(O)=O)[C@H]1O)F Chemical compound C[C@@]1([C@@](c2ccc3[n]2ncnc3N)(C#N)O[C@H](COP(O)(O)=O)[C@H]1O)F WSNWHSYQUNVAGB-DXLKZPDWSA-N 0.000 description 2
- JLTWKDTWEKYNOG-ZCKHLOCKSA-N CC(C)NP(OC[C@H]1O[C@H]2c3cnc4[n]3ncnc4N)(O[C@H]1[C@@]2(C)F)=O Chemical compound CC(C)NP(OC[C@H]1O[C@H]2c3cnc4[n]3ncnc4N)(O[C@H]1[C@@]2(C)F)=O JLTWKDTWEKYNOG-ZCKHLOCKSA-N 0.000 description 1
- HIYGPRPXQYIGJV-ZDZLMVPKSA-N CC(C)OC(OCOP(OC[C@H]([C@H]([C@@]1(C)F)O)O[C@]1(c1ccc2[n]1ncnc2N)C#N)(OCOC(OC(C)C)=O)=O)=O Chemical compound CC(C)OC(OCOP(OC[C@H]([C@H]([C@@]1(C)F)O)O[C@]1(c1ccc2[n]1ncnc2N)C#N)(OCOC(OC(C)C)=O)=O)=O HIYGPRPXQYIGJV-ZDZLMVPKSA-N 0.000 description 1
- FILMSNVIFXMGLK-ZCKHLOCKSA-N CC(C)OP(OC[C@H]1O[C@H]2c3cnc4[n]3ncnc4N)(O[C@H]1[C@@]2(C)F)=O Chemical compound CC(C)OP(OC[C@H]1O[C@H]2c3cnc4[n]3ncnc4N)(O[C@H]1[C@@]2(C)F)=O FILMSNVIFXMGLK-ZCKHLOCKSA-N 0.000 description 1
- IHHYVNLKTGGVQQ-LTRIDOHMSA-N CC(C)OP(OC[C@H]1O[C@]2(c3ccc4[n]3ncnc4N)C#N)(O[C@H]1[C@@]2(C)F)=O Chemical compound CC(C)OP(OC[C@H]1O[C@]2(c3ccc4[n]3ncnc4N)C#N)(O[C@H]1[C@@]2(C)F)=O IHHYVNLKTGGVQQ-LTRIDOHMSA-N 0.000 description 1
- HBBQNAOQGVDSCS-XPYFYPHYSA-N CCC(CC)COC(C(C)(C)NP(OC[C@H]([C@H]([C@@]1(C)F)O)O[C@]1(c1ccc2[n]1ncnc2N)C#N)(Oc1ccccc1)=O)=O Chemical compound CCC(CC)COC(C(C)(C)NP(OC[C@H]([C@H]([C@@]1(C)F)O)O[C@]1(c1ccc2[n]1ncnc2N)C#N)(Oc1ccccc1)=O)=O HBBQNAOQGVDSCS-XPYFYPHYSA-N 0.000 description 1
- YZGBNRQYEMDESW-MWZJXMJLSA-N CCOC(CNP(OCC(C)([C@H]([C@@H]1C)O)O[C@@]1(C)c1ccc2[n]1ncnc2N)(Oc1ccccc1)=O)=O Chemical compound CCOC(CNP(OCC(C)([C@H]([C@@H]1C)O)O[C@@]1(C)c1ccc2[n]1ncnc2N)(Oc1ccccc1)=O)=O YZGBNRQYEMDESW-MWZJXMJLSA-N 0.000 description 1
- LQROMCOLFKIOJF-TZOLMFNISA-N CCOC([C@H](CCC1)N1P(OC[C@H]([C@H]([C@@H]1C)O)O[C@@]1(C)c1ccc2[n]1ncnc2N)(Oc1ccccc1)=O)=O Chemical compound CCOC([C@H](CCC1)N1P(OC[C@H]([C@H]([C@@H]1C)O)O[C@@]1(C)c1ccc2[n]1ncnc2N)(Oc1ccccc1)=O)=O LQROMCOLFKIOJF-TZOLMFNISA-N 0.000 description 1
- DGCHYEPETMXRQA-HSZMQJMCSA-N CC[C@@H]1[C@](C)(c2ccc3[n]2ncnc3N)OC(COP(NCCc2c[N](C)(C)c3c2cccc3)(O)=O)[C@H]1O Chemical compound CC[C@@H]1[C@](C)(c2ccc3[n]2ncnc3N)OC(COP(NCCc2c[N](C)(C)c3c2cccc3)(O)=O)[C@H]1O DGCHYEPETMXRQA-HSZMQJMCSA-N 0.000 description 1
- HZGJEERNMNIQDV-UHFFFAOYSA-N CNCCCOC(COC)=O Chemical compound CNCCCOC(COC)=O HZGJEERNMNIQDV-UHFFFAOYSA-N 0.000 description 1
- QFJJGVDPVAQMDP-CZLJTSCOSA-N C[C@@H](C(OC1CCCC1)=O)NP(OC[C@H](C[C@@]1(C)F)O[C@H]1c1cnc2[n]1ncnc2N)([O]=C)=O Chemical compound C[C@@H](C(OC1CCCC1)=O)NP(OC[C@H](C[C@@]1(C)F)O[C@H]1c1cnc2[n]1ncnc2N)([O]=C)=O QFJJGVDPVAQMDP-CZLJTSCOSA-N 0.000 description 1
- YRGVZEKWHSBGBS-OSOWUJPXSA-N C[C@@H](C(OCC(C)(C)C)=O)NP(OC[C@H](C[C@@]1(C)F)O[C@H]1c1cnc2[n]1ncnc2N)([O]=C)=O Chemical compound C[C@@H](C(OCC(C)(C)C)=O)NP(OC[C@H](C[C@@]1(C)F)O[C@H]1c1cnc2[n]1ncnc2N)([O]=C)=O YRGVZEKWHSBGBS-OSOWUJPXSA-N 0.000 description 1
- QZXXSGXTXAPPIQ-QLYKKUTRSA-N C[C@@H](COC(C(C)(C)C)=O)NP(OC[C@H]([C@H]([C@@]1(C)F)O)O[C@H]1c1cnc2[n]1ncnc2N)(Oc1ccccc1)=O Chemical compound C[C@@H](COC(C(C)(C)C)=O)NP(OC[C@H]([C@H]([C@@]1(C)F)O)O[C@H]1c1cnc2[n]1ncnc2N)(Oc1ccccc1)=O QZXXSGXTXAPPIQ-QLYKKUTRSA-N 0.000 description 1
- OTFCNCSHNRUJMP-WWKIVAJVSA-N C[C@@H]1[C@@](c2ccc3[n]2ncnc3N)(C#N)O[C@H](COP(NCCc2c[nH]c3ccccc23)(OCc2ccccc2)=O)[C@H]1O Chemical compound C[C@@H]1[C@@](c2ccc3[n]2ncnc3N)(C#N)O[C@H](COP(NCCc2c[nH]c3ccccc23)(OCc2ccccc2)=O)[C@H]1O OTFCNCSHNRUJMP-WWKIVAJVSA-N 0.000 description 1
- DLXZOHMKNJEPMB-DXLKZPDWSA-N C[C@@]1([C@@](c2ccc3[n]2ncnc3N)(C#N)O[C@H](CO)[C@H]1O)F Chemical compound C[C@@]1([C@@](c2ccc3[n]2ncnc3N)(C#N)O[C@H](CO)[C@H]1O)F DLXZOHMKNJEPMB-DXLKZPDWSA-N 0.000 description 1
- LLRZIXIPJMUEMH-DXLKZPDWSA-N C[C@@]1([C@@](c2ccc3[n]2ncnc3N)(C#N)O[C@H](CO2)[C@H]1OP2(O)=O)F Chemical compound C[C@@]1([C@@](c2ccc3[n]2ncnc3N)(C#N)O[C@H](CO2)[C@H]1OP2(O)=O)F LLRZIXIPJMUEMH-DXLKZPDWSA-N 0.000 description 1
- JJMRWZGUOHWNNW-HZLHGAJGSA-N C[C@@]1([C@H](c2cnc(c(N)n3)[n]2nc3SC)O[C@H](CO)[C@H]1O)F Chemical compound C[C@@]1([C@H](c2cnc(c(N)n3)[n]2nc3SC)O[C@H](CO)[C@H]1O)F JJMRWZGUOHWNNW-HZLHGAJGSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/885,917 US7973013B2 (en) | 2009-09-21 | 2010-09-20 | 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment |
US12/885,917 | 2010-09-20 | ||
US13/050,820 US8455451B2 (en) | 2009-09-21 | 2011-03-17 | 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment |
US13/050,820 | 2011-03-17 | ||
PCT/US2011/029441 WO2012039791A1 (en) | 2010-09-20 | 2011-03-22 | 2' -fluoro substituted carba-nucleoside analogs for antiviral treatment |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2016006833A Division JP2016074732A (ja) | 2010-09-20 | 2016-01-18 | 抗ウイルス治療用の2’−フルオロ置換カルバヌクレオシド類似体 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2013538230A true JP2013538230A (ja) | 2013-10-10 |
JP2013538230A5 JP2013538230A5 (es) | 2014-05-08 |
Family
ID=47748238
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2013529139A Withdrawn JP2013538230A (ja) | 2010-09-20 | 2011-03-22 | 抗ウイルス治療用の2’−フルオロ置換カルバヌクレオシド類似体 |
JP2016006833A Withdrawn JP2016074732A (ja) | 2010-09-20 | 2016-01-18 | 抗ウイルス治療用の2’−フルオロ置換カルバヌクレオシド類似体 |
JP2017077366A Active JP6475280B2 (ja) | 2010-09-20 | 2017-04-10 | 抗ウイルス治療用の2’−フルオロ置換カルバヌクレオシド類似体 |
JP2018173758A Withdrawn JP2019014726A (ja) | 2010-09-20 | 2018-09-18 | 抗ウイルス治療用の2’−フルオロ置換カルバヌクレオシド類似体 |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2016006833A Withdrawn JP2016074732A (ja) | 2010-09-20 | 2016-01-18 | 抗ウイルス治療用の2’−フルオロ置換カルバヌクレオシド類似体 |
JP2017077366A Active JP6475280B2 (ja) | 2010-09-20 | 2017-04-10 | 抗ウイルス治療用の2’−フルオロ置換カルバヌクレオシド類似体 |
JP2018173758A Withdrawn JP2019014726A (ja) | 2010-09-20 | 2018-09-18 | 抗ウイルス治療用の2’−フルオロ置換カルバヌクレオシド類似体 |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP2619206A1 (es) |
JP (4) | JP2013538230A (es) |
KR (1) | KR101879887B1 (es) |
CN (1) | CN103108876A (es) |
AP (1) | AP3699A (es) |
AU (1) | AU2011306066B2 (es) |
BR (1) | BR112013008017A2 (es) |
CA (1) | CA2807496C (es) |
CL (1) | CL2013000727A1 (es) |
CO (1) | CO6680669A2 (es) |
CR (1) | CR20130172A (es) |
EA (1) | EA026523B1 (es) |
EC (1) | ECSP13012560A (es) |
IL (1) | IL225221A0 (es) |
MA (1) | MA34593B1 (es) |
MX (1) | MX2013003179A (es) |
NZ (1) | NZ608070A (es) |
PE (3) | PE20131165A1 (es) |
SG (1) | SG188223A1 (es) |
WO (1) | WO2012039791A1 (es) |
ZA (1) | ZA201301042B (es) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2017523169A (ja) * | 2014-07-28 | 2017-08-17 | ギリアード サイエンシーズ, インコーポレイテッド | 呼吸器合胞体ウイルス感染の処置のために有用な、チエノ[3,2−d]ピリミジン、フロ[3,2−d]ピリミジン、およびピロロ[3,2−d]ピリミジン |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101645742B1 (ko) | 2008-04-23 | 2016-08-04 | 길리애드 사이언시즈, 인코포레이티드 | 항바이러스 치료를 위한 카바-뉴클레오사이드 유사체 |
SI2480559T1 (sl) | 2009-09-21 | 2013-10-30 | Gilead Sciences, Inc. | Postopki in intermediati za pripravo 1'-ciano-karbanukleozidnih analogov |
ES2524398T3 (es) | 2010-07-19 | 2014-12-09 | Gilead Sciences, Inc. | Métodos para la preparación de profármacos de fosforoamidato diastereoméricamente puros |
WO2012012776A1 (en) | 2010-07-22 | 2012-01-26 | Gilead Sciences, Inc. | Methods and compounds for treating paramyxoviridae virus infections |
JP5891241B2 (ja) | 2010-12-20 | 2016-03-22 | ギリアード サイエンシーズ, インコーポレイテッド | Hcvを処置するための組合せ |
TW201329096A (zh) | 2011-09-12 | 2013-07-16 | Idenix Pharmaceuticals Inc | 經取代羰氧基甲基磷酸醯胺化合物及用於治療病毒感染之藥學組成物 |
DE202012013074U1 (de) | 2011-09-16 | 2014-10-29 | Gilead Pharmasset Lcc | Zusammensetzungen zur Behandlung von HCV |
SG10201706949VA (en) | 2013-01-31 | 2017-09-28 | Gilead Pharmasset Llc | Combination formulation of two antiviral compounds |
UA119050C2 (uk) * | 2013-11-11 | 2019-04-25 | Ґілеад Саєнсиз, Інк. | ПІРОЛО[1.2-f][1.2.4]ТРИАЗИНИ, ЯКІ ВИКОРИСТОВУЮТЬСЯ ДЛЯ ЛІКУВАННЯ РЕСПІРАТОРНО-СИНЦИТІАЛЬНИХ ВІРУСНИХ ІНФЕКЦІЙ |
CN104230985B (zh) * | 2014-09-01 | 2017-01-18 | 北京天弘天达医药科技有限公司 | (s)‑2‑[(s)‑(4‑硝基‑苯氧基)‑苯氧基‑磷酰基氨基]丙酸异丙酯的制备方法 |
TWI767201B (zh) | 2014-10-29 | 2022-06-11 | 美商基利科學股份有限公司 | 絲狀病毒科病毒感染之治療 |
HUE056470T2 (hu) | 2014-12-26 | 2022-02-28 | Univ Emory | Vírusellenes N4-Hidroxicitidin származékok |
CN114366745A (zh) | 2015-09-16 | 2022-04-19 | 吉利德科学公司 | 治疗沙粒病毒科和冠状病毒科病毒感染的方法 |
KR102460968B1 (ko) | 2017-03-14 | 2022-11-01 | 길리애드 사이언시즈, 인코포레이티드 | 고양이 코로나바이러스 감염의 치료 방법 |
ES2938859T3 (es) | 2017-05-01 | 2023-04-17 | Gilead Sciences Inc | Una forma cristalina de (S)-2-etilbutilo 2-(((S)-(((2R,3S,4R,5R)-5-(4-aminopirrolo[2,1-f][1,2,4]triazin-7-il)-5-ciano-3,4-dihidroxitetrahidrofuran-2-il)metoxi)(fenoxi)fosforil)amino)propanoato |
TW201919648A (zh) | 2017-07-11 | 2019-06-01 | 美商基利科學股份有限公司 | 用於治療病毒感染之含rna聚合酶抑制劑與環糊精的組合物 |
GB2590198B (en) | 2017-12-07 | 2022-02-23 | Univ Emory | N4-hydroxycytidine derivatives and anti-viral uses related thereto |
TW202313067A (zh) | 2020-01-27 | 2023-04-01 | 美商基利科學股份有限公司 | 治療sars cov-2感染之方法 |
JP2023516087A (ja) | 2020-03-12 | 2023-04-17 | ギリアード サイエンシーズ, インコーポレイテッド | 1’-シアノヌクレオシドを調製する方法 |
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JP2017523169A (ja) * | 2014-07-28 | 2017-08-17 | ギリアード サイエンシーズ, インコーポレイテッド | 呼吸器合胞体ウイルス感染の処置のために有用な、チエノ[3,2−d]ピリミジン、フロ[3,2−d]ピリミジン、およびピロロ[3,2−d]ピリミジン |
JP2020023590A (ja) * | 2014-07-28 | 2020-02-13 | ギリアード サイエンシーズ, インコーポレイテッド | 呼吸器合胞体ウイルス感染の処置のために有用な、チエノ[3,2−d]ピリミジン、フロ[3,2−d]ピリミジン、およびピロロ[3,2−d]ピリミジン |
JP6991188B2 (ja) | 2014-07-28 | 2022-01-12 | ギリアード サイエンシーズ, インコーポレイテッド | 呼吸器合胞体ウイルス感染の処置のために有用な、チエノ[3,2-d]ピリミジン、フロ[3,2-d]ピリミジン、およびピロロ[3,2-d]ピリミジン |
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CO6680669A2 (es) | 2013-05-31 |
EA026523B1 (ru) | 2017-04-28 |
AP2013006767A0 (en) | 2013-03-31 |
AP3699A (en) | 2016-05-31 |
CL2013000727A1 (es) | 2013-08-23 |
KR20130110168A (ko) | 2013-10-08 |
JP2017119726A (ja) | 2017-07-06 |
SG188223A1 (en) | 2013-04-30 |
PE20230684A1 (es) | 2023-04-21 |
MX2013003179A (es) | 2013-04-24 |
MA34593B1 (fr) | 2013-10-02 |
AU2011306066A1 (en) | 2013-02-28 |
PE20131165A1 (es) | 2013-10-14 |
CR20130172A (es) | 2013-05-29 |
CA2807496C (en) | 2019-01-22 |
KR101879887B1 (ko) | 2018-07-18 |
JP2019014726A (ja) | 2019-01-31 |
CA2807496A1 (en) | 2012-03-29 |
ZA201301042B (en) | 2014-07-30 |
EA201390141A1 (ru) | 2013-09-30 |
CN103108876A (zh) | 2013-05-15 |
JP6475280B2 (ja) | 2019-02-27 |
JP2016074732A (ja) | 2016-05-12 |
IL225221A0 (en) | 2013-06-27 |
AU2011306066B2 (en) | 2015-01-29 |
EP2619206A1 (en) | 2013-07-31 |
WO2012039791A1 (en) | 2012-03-29 |
ECSP13012560A (es) | 2013-06-28 |
BR112013008017A2 (pt) | 2016-06-14 |
PE20171624A1 (es) | 2017-11-02 |
NZ608070A (en) | 2015-11-27 |
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