IL225221A0 - 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment - Google Patents
2'-fluoro substituted carba-nucleoside analogs for antiviral treatmentInfo
- Publication number
- IL225221A0 IL225221A0 IL225221A IL22522113A IL225221A0 IL 225221 A0 IL225221 A0 IL 225221A0 IL 225221 A IL225221 A IL 225221A IL 22522113 A IL22522113 A IL 22522113A IL 225221 A0 IL225221 A0 IL 225221A0
- Authority
- IL
- Israel
- Prior art keywords
- nucleoside analogs
- fluoro substituted
- antiviral treatment
- substituted carba
- carba
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/885,917 US7973013B2 (en) | 2009-09-21 | 2010-09-20 | 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment |
US13/050,820 US8455451B2 (en) | 2009-09-21 | 2011-03-17 | 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment |
PCT/US2011/029441 WO2012039791A1 (en) | 2010-09-20 | 2011-03-22 | 2' -fluoro substituted carba-nucleoside analogs for antiviral treatment |
Publications (1)
Publication Number | Publication Date |
---|---|
IL225221A0 true IL225221A0 (en) | 2013-06-27 |
Family
ID=47748238
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL225221A IL225221A0 (en) | 2010-09-20 | 2013-03-14 | 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP2619206A1 (en) |
JP (4) | JP2013538230A (en) |
KR (1) | KR101879887B1 (en) |
CN (1) | CN103108876A (en) |
AP (1) | AP3699A (en) |
AU (1) | AU2011306066B2 (en) |
BR (1) | BR112013008017A2 (en) |
CA (1) | CA2807496C (en) |
CL (1) | CL2013000727A1 (en) |
CO (1) | CO6680669A2 (en) |
CR (1) | CR20130172A (en) |
EA (1) | EA026523B1 (en) |
EC (1) | ECSP13012560A (en) |
IL (1) | IL225221A0 (en) |
MA (1) | MA34593B1 (en) |
MX (1) | MX2013003179A (en) |
NZ (1) | NZ608070A (en) |
PE (3) | PE20171624A1 (en) |
SG (1) | SG188223A1 (en) |
WO (1) | WO2012039791A1 (en) |
ZA (1) | ZA201301042B (en) |
Families Citing this family (26)
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HUE038946T2 (en) | 2008-04-23 | 2018-12-28 | Gilead Sciences Inc | 1' -substituted carba-nucleoside analogs for antiviral treatment |
AU2010295392B2 (en) | 2009-09-21 | 2015-10-22 | Gilead Sciences, Inc. | Processes and intermediates for the preparation of 1'-substituted carba-nucleoside analogs |
EP2805960A1 (en) | 2010-07-19 | 2014-11-26 | Gilead Sciences, Inc. | Methods for the preparation of diasteromerically pure phosphoramidate prodrugs |
BR122020020745B8 (en) | 2010-07-22 | 2023-10-31 | Gilead Sciences Inc | Antiviral compound for the treatment of paramyxoviridae infections and pharmaceutical composition comprising it |
TW201306841A (en) | 2010-12-20 | 2013-02-16 | Gilead Sciences Inc | Methods for treating HCV |
WO2013039920A1 (en) | 2011-09-12 | 2013-03-21 | Idenix Pharmaceuticals, Inc. | Substituted carbonyloxymethylphosphoramidate compounds and pharmaceutical compositions for the treatment of viral infections |
ES2659216T5 (en) | 2011-09-16 | 2021-06-09 | Gilead Pharmasset Llc | Methods for treating HCV |
PE20151778A1 (en) | 2013-01-31 | 2015-12-16 | Gilead Pharmasset Llc | COMBINED FORMULATION OF TWO ANTIVIRAL COMPOUNDS |
UA119050C2 (en) * | 2013-11-11 | 2019-04-25 | Ґілеад Саєнсиз, Інк. | Pyrrolo [1,2,f] [1,2,4] triazines useful for treating respiratory syncitial virus infections |
TWI678369B (en) | 2014-07-28 | 2019-12-01 | 美商基利科學股份有限公司 | Thieno[3,2-d]pyrimidine, furo[3,2-d]pyrimidine, and pyrrolo[3,2-d]pyrimidines useful for treating respiratory syncitial virus infections |
CN104230985B (en) * | 2014-09-01 | 2017-01-18 | 北京天弘天达医药科技有限公司 | Preparation method of (s)-2-[(s)-(4-nitro-phenoxy)-phenoxy-phosphoryl amino] isopropyl propionate |
TWI687432B (en) | 2014-10-29 | 2020-03-11 | 美商基利科學股份有限公司 | Methods for treating filoviridae virus infections |
BR112017013858A2 (en) | 2014-12-26 | 2018-02-27 | Univ Emory | n4-hydroxycytidine and related antiviral derivatives and uses |
JP6742403B2 (en) | 2015-09-16 | 2020-08-19 | ギリアード サイエンシーズ, インコーポレイテッド | Methods for treating arenaviridae and coronaviridae viral infections |
KR102460968B1 (en) | 2017-03-14 | 2022-11-01 | 길리애드 사이언시즈, 인코포레이티드 | Methods of treating feline coronavirus infections |
AR111490A1 (en) | 2017-05-01 | 2019-07-17 | Gilead Sciences Inc | CRYSTALLINE FORMS OF PROPANOATE OF (S) -2-ETILBUTIL 2 - (((S) - (((2R, 3S, 4R, 5R) -5- (4-AMINOPIRROLO [2,1-F] [1,2, 4] TRIAZIN-7-IL) -5-CIANO-3,4-DIHYDROXITETRAHIDROFURAN-2-IL) METOXI) (FENOXI) FOSFORIL) AMINO) |
EP3651734A1 (en) | 2017-07-11 | 2020-05-20 | Gilead Sciences, Inc. | Compositions comprising an rna polymerase inhibitor and cyclodextrin for treating viral infections |
BR112020010581A2 (en) | 2017-12-07 | 2020-11-10 | Emory University | pharmaceutical composition, pressurized container, and, methods to treat or prevent a viral infection and to treat or prevent human coronavirus, sars, coronavirus mers, eastern equine encephalitis virus, western equine encephalitis virus, Venezuelan equine encephalitis virus, chikungunya virus and infection by ross river infection, orthomyxoviridae virus or paramyxoviridae virus or rsv virus, or infection by influenza a virus and influenza b virus or filoviridae virus or ebola virus. |
TW202313067A (en) | 2020-01-27 | 2023-04-01 | 美商基利科學股份有限公司 | Methods for treating sars cov-2 infections |
EP4118085A2 (en) | 2020-03-12 | 2023-01-18 | Gilead Sciences, Inc. | Methods of preparing 1'-cyano nucleosides |
KR20220164784A (en) | 2020-04-06 | 2022-12-13 | 길리애드 사이언시즈, 인코포레이티드 | Inhalation Formulations of 1′-Cyano Substituted Carbanucleoside Analogues |
TW202203941A (en) | 2020-05-29 | 2022-02-01 | 美商基利科學股份有限公司 | Remdesivir treatment methods |
AU2021296841A1 (en) | 2020-06-24 | 2023-02-16 | Gilead Sciences, Inc. | 1'-cyano nucleoside analogs and uses thereof |
DK4204421T3 (en) | 2020-08-27 | 2024-05-27 | Gilead Sciences Inc | Compounds and methods for treating viral infections |
TW202400185A (en) | 2022-03-02 | 2024-01-01 | 美商基利科學股份有限公司 | Compounds and methods for treatment of viral infections |
WO2023207942A1 (en) * | 2022-04-25 | 2023-11-02 | 北京沐华生物科技有限责任公司 | Nucleoside drug for treating or preventing coronavirus infection, and use thereof |
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US4816570A (en) | 1982-11-30 | 1989-03-28 | The Board Of Regents Of The University Of Texas System | Biologically reversible phosphate and phosphonate protective groups |
US4968788A (en) | 1986-04-04 | 1990-11-06 | Board Of Regents, The University Of Texas System | Biologically reversible phosphate and phosphonate protective gruops |
CA2083386C (en) | 1990-06-13 | 1999-02-16 | Arnold Glazier | Phosphorous prodrugs |
ATE167679T1 (en) | 1990-09-14 | 1998-07-15 | Acad Of Science Czech Republic | PHOSPHONATE PRECURSORS |
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NZ526703A (en) | 2001-01-22 | 2004-12-24 | Merck & Co Inc | Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase |
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DK1576138T3 (en) | 2002-11-15 | 2017-05-01 | Idenix Pharmaceuticals Llc | 2'-METHYL NUCLEOSIDES IN COMBINATION WITH INTERFERON AND FLAVIVIRIDAE MUTATION |
CN100503628C (en) * | 2003-05-30 | 2009-06-24 | 法莫赛特股份有限公司 | Modified fluorinated nucleoside analogues |
EP3109244B1 (en) | 2004-09-14 | 2019-03-06 | Gilead Pharmasset LLC | Preparation of 2'fluoro-2'-alkyl-substituted or other optionally substituted ribofuranosyl pyrimidines and purines and their derivatives |
WO2006065335A2 (en) * | 2004-10-21 | 2006-06-22 | Merck & Co., Inc. | Fluorinated pyrrolo[2,3-d]pyrimidine nucleosides for the treatment of rna-dependent rna viral infection |
CN101043893A (en) * | 2004-10-21 | 2007-09-26 | 默克公司 | Fluorinated pyrrolo[2,3-d]pyrimidine nucleosides for the treatment of rna-dependent rna viral infection |
WO2006121820A1 (en) | 2005-05-05 | 2006-11-16 | Valeant Research & Development | Phosphoramidate prodrugs for treatment of viral infection |
WO2007027248A2 (en) | 2005-05-16 | 2007-03-08 | Valeant Research & Development | 3', 5' - cyclic nucleoside analogues for treatment of hcv |
WO2007056170A2 (en) | 2005-11-02 | 2007-05-18 | Bayer Healthcare Ag | Pyrrolo[2,1-f] [1,2,4] triazin-4-ylamines igf-1r kinase inhibitors for the treatment of cancer and other hyperproliferative diseases |
US7951789B2 (en) | 2006-12-28 | 2011-05-31 | Idenix Pharmaceuticals, Inc. | Compounds and pharmaceutical compositions for the treatment of viral infections |
CA2673649A1 (en) | 2007-01-05 | 2008-07-17 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Nucleoside aryl phosphoramidates for the treatment of rna-dependent rna viral infection |
SG177974A1 (en) | 2007-01-12 | 2012-02-28 | Biocryst Pharm Inc | Antiviral nucleoside analogs |
JP2010522241A (en) | 2007-03-21 | 2010-07-01 | ブリストル−マイヤーズ スクイブ カンパニー | Condensed heterocyclic compounds useful as proliferative diseases, allergic diseases, autoimmune diseases or inflammatory diseases |
PL2155758T3 (en) | 2007-05-10 | 2013-06-28 | Biocryst Pharm Inc | Tetrahydrofuro[3,4-d]dioxolane compounds for use in the treatment of viral infections and cancer |
HUE038946T2 (en) * | 2008-04-23 | 2018-12-28 | Gilead Sciences Inc | 1' -substituted carba-nucleoside analogs for antiviral treatment |
WO2010036407A2 (en) * | 2008-05-15 | 2010-04-01 | Biocryst Pharmaceuticals, Inc. | Antiviral nucleoside analogs |
WO2010002877A2 (en) * | 2008-07-03 | 2010-01-07 | Biota Scientific Management | Bycyclic nucleosides and nucleotides as therapeutic agents |
UA112140C2 (en) * | 2009-02-10 | 2016-07-25 | Гіліад Сайєнсіз, Інк. | NUCLEID OXIDES (OPTIONS), PHARMACEUTICAL COMPOSITION ON THEIR BASES, METHOD OF TREATMENT OF VIRAL INFECTION AND USE OF LOW MEDICINAL PRODUCTS |
RS55699B1 (en) * | 2009-09-21 | 2017-07-31 | Gilead Sciences | 2' -fluoro substituted carba-nucleoside analogs for antiviral treatment |
-
2011
- 2011-03-22 PE PE2017001530A patent/PE20171624A1/en unknown
- 2011-03-22 MX MX2013003179A patent/MX2013003179A/en not_active Application Discontinuation
- 2011-03-22 PE PE2022003082A patent/PE20230684A1/en unknown
- 2011-03-22 WO PCT/US2011/029441 patent/WO2012039791A1/en active Application Filing
- 2011-03-22 BR BR112013008017A patent/BR112013008017A2/en not_active Application Discontinuation
- 2011-03-22 EP EP11715792.5A patent/EP2619206A1/en not_active Withdrawn
- 2011-03-22 CA CA2807496A patent/CA2807496C/en active Active
- 2011-03-22 AP AP2013006767A patent/AP3699A/en active
- 2011-03-22 EA EA201390141A patent/EA026523B1/en unknown
- 2011-03-22 CN CN2011800449231A patent/CN103108876A/en active Pending
- 2011-03-22 NZ NZ608070A patent/NZ608070A/en unknown
- 2011-03-22 SG SG2013011325A patent/SG188223A1/en unknown
- 2011-03-22 KR KR1020137010012A patent/KR101879887B1/en active IP Right Grant
- 2011-03-22 PE PE2013000530A patent/PE20131165A1/en active IP Right Grant
- 2011-03-22 AU AU2011306066A patent/AU2011306066B2/en active Active
- 2011-03-22 JP JP2013529139A patent/JP2013538230A/en not_active Withdrawn
-
2013
- 2013-02-07 ZA ZA2013/01042A patent/ZA201301042B/en unknown
- 2013-02-26 CO CO13038918A patent/CO6680669A2/en not_active Application Discontinuation
- 2013-03-14 IL IL225221A patent/IL225221A0/en unknown
- 2013-03-18 CL CL2013000727A patent/CL2013000727A1/en unknown
- 2013-04-04 MA MA35795A patent/MA34593B1/en unknown
- 2013-04-17 CR CR20130172A patent/CR20130172A/en unknown
- 2013-04-18 EC ECSP13012560 patent/ECSP13012560A/en unknown
-
2016
- 2016-01-18 JP JP2016006833A patent/JP2016074732A/en not_active Withdrawn
-
2017
- 2017-04-10 JP JP2017077366A patent/JP6475280B2/en active Active
-
2018
- 2018-09-18 JP JP2018173758A patent/JP2019014726A/en not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
EP2619206A1 (en) | 2013-07-31 |
AU2011306066A1 (en) | 2013-02-28 |
AP3699A (en) | 2016-05-31 |
JP2019014726A (en) | 2019-01-31 |
PE20230684A1 (en) | 2023-04-21 |
CA2807496C (en) | 2019-01-22 |
CR20130172A (en) | 2013-05-29 |
BR112013008017A2 (en) | 2016-06-14 |
PE20131165A1 (en) | 2013-10-14 |
MX2013003179A (en) | 2013-04-24 |
MA34593B1 (en) | 2013-10-02 |
PE20171624A1 (en) | 2017-11-02 |
JP6475280B2 (en) | 2019-02-27 |
ZA201301042B (en) | 2014-07-30 |
CL2013000727A1 (en) | 2013-08-23 |
WO2012039791A1 (en) | 2012-03-29 |
KR20130110168A (en) | 2013-10-08 |
NZ608070A (en) | 2015-11-27 |
CO6680669A2 (en) | 2013-05-31 |
EA201390141A1 (en) | 2013-09-30 |
AP2013006767A0 (en) | 2013-03-31 |
JP2016074732A (en) | 2016-05-12 |
JP2017119726A (en) | 2017-07-06 |
JP2013538230A (en) | 2013-10-10 |
SG188223A1 (en) | 2013-04-30 |
CA2807496A1 (en) | 2012-03-29 |
ECSP13012560A (en) | 2013-06-28 |
KR101879887B1 (en) | 2018-07-18 |
EA026523B1 (en) | 2017-04-28 |
AU2011306066B2 (en) | 2015-01-29 |
CN103108876A (en) | 2013-05-15 |
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