JP2013535987A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013535987A5 JP2013535987A5 JP2013526178A JP2013526178A JP2013535987A5 JP 2013535987 A5 JP2013535987 A5 JP 2013535987A5 JP 2013526178 A JP2013526178 A JP 2013526178A JP 2013526178 A JP2013526178 A JP 2013526178A JP 2013535987 A5 JP2013535987 A5 JP 2013535987A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- host cell
- polypeptide
- oil
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37724810P | 2010-08-26 | 2010-08-26 | |
| US61/377,248 | 2010-08-26 | ||
| US201061428277P | 2010-12-30 | 2010-12-30 | |
| US61/428,277 | 2010-12-30 | ||
| US201161479921P | 2011-04-28 | 2011-04-28 | |
| US61/479,921 | 2011-04-28 | ||
| PCT/US2011/049384 WO2012027689A1 (en) | 2010-08-26 | 2011-08-26 | Recombinant microbial host cells for high eicosapentaenoic acid production |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013535987A JP2013535987A (ja) | 2013-09-19 |
| JP2013535987A5 true JP2013535987A5 (cg-RX-API-DMAC7.html) | 2014-10-02 |
Family
ID=45697764
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013526178A Pending JP2013535987A (ja) | 2010-08-26 | 2011-08-26 | 高レベルのエイコサペンタエン酸生産のための組換え微生物宿主細胞 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8703473B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2609203B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2013535987A (cg-RX-API-DMAC7.html) |
| KR (1) | KR20130138760A (cg-RX-API-DMAC7.html) |
| CN (1) | CN103249834B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2011293180B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112013004351A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2807834C (cg-RX-API-DMAC7.html) |
| CL (1) | CL2013000533A1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK2609203T3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2012027689A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2808002A1 (en) * | 2010-08-26 | 2012-03-01 | E. I. Du Pont De Nemours And Company | Mutant hpgg motif and hdash motif delta-5 desaturases and their use in making polyunsaturated fatty acids |
| EP2691518A1 (en) * | 2011-03-31 | 2014-02-05 | E.I. Du Pont De Nemours And Company | Yarrowia diacylglycerol acyltransferase promoter regions for gene expression in yeast |
| US8735094B2 (en) | 2011-04-05 | 2014-05-27 | E I Du Pont De Nemours And Company | Yarrowia n-alkane-hydroxylating cytochrome P450 promoter regions for gene expression in yeast |
| CA2833400A1 (en) | 2011-05-26 | 2012-11-29 | E.I. Dupont De Nemours And Company | Expression of caleosin in recombinant oleaginous microorganisms to increase oil content therein |
| US9416382B2 (en) | 2012-06-19 | 2016-08-16 | E I Du Pont De Nemours And Company | Production of polyunsaturated fatty acids by coexpression of acyl-CoA:lysophosphatidylcholine acyltransferases and phospholipid:diacylglycerol acyltransferases |
| CA2893409A1 (en) * | 2012-12-21 | 2014-06-26 | E. I. Du Pont De Nemours And Company | Recombinant microbial cells that produce at least 28% eicosapentaenoic acid as dry cell weight |
| EP2935591B1 (en) | 2012-12-21 | 2017-07-05 | E. I. du Pont de Nemours and Company | Down-regulation of a polynucleotide encoding a sou2 sorbitol utilization protein to modify lipid production in microbial cells |
| US9074160B2 (en) * | 2013-03-07 | 2015-07-07 | Algisys, Llc | Production of omega-3 fatty acids from pythium species |
| US10513711B2 (en) | 2014-08-13 | 2019-12-24 | Dupont Us Holding, Llc | Genetic targeting in non-conventional yeast using an RNA-guided endonuclease |
| ES2590220B1 (es) * | 2015-05-18 | 2017-12-18 | Neol Biosolutions, S.A. | Producción de aceites microbianos con alto contenido en acido oleico |
| EP4144844B1 (en) | 2015-10-12 | 2025-09-10 | DuPont US Holding, LLC | Protected dna templates for gene modification and increased homologous recombination in cells and methods of use |
| CN108330114B (zh) * | 2018-03-21 | 2020-11-03 | 北京大学 | 一种利用epa的甘油二酯酰基转移酶及其应用 |
| WO2019209241A1 (en) | 2018-04-23 | 2019-10-31 | Dupont Nutrition Biosciences Aps | Increasing export of 2' fucosyllactose from microbial cells through the expression of a heterologous nucleic acid |
| WO2020082221A1 (zh) * | 2018-10-23 | 2020-04-30 | 利时雨 | 重组磷酸胆碱胞苷转移酶的粘红酵母携带外源多肽的活细胞脂质体及其应用 |
| CN116555054B (zh) * | 2023-06-09 | 2024-05-14 | 陕西海斯夫生物工程有限公司 | 一株高产dha的重组裂殖壶菌、其构建方法及应用 |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4880741A (en) | 1983-10-06 | 1989-11-14 | Pfizer Inc. | Process for transformation of Yarrowia lipolytica |
| US5071764A (en) | 1983-10-06 | 1991-12-10 | Pfizer Inc. | Process for integrative transformation of yarrowia lipolytica |
| US4792523A (en) | 1984-08-31 | 1988-12-20 | Cetus Corporation | 3'Expression enhancing fragments and method |
| DE3783396T2 (de) | 1986-07-08 | 1993-07-29 | Suntory Ltd | Verfahren zur herstellung von bishomo-gamma-linolensaeure und eicosapentaensaeure. |
| JP2527340B2 (ja) | 1986-12-15 | 1996-08-21 | アプライド バイオシステムズ インコーポレイテッド | ロ―ダミン染料の５−及び６−スクシニミジルカルボキシレ―ト異性体 |
| US5246841A (en) | 1986-12-26 | 1993-09-21 | Sagami Chemical Research Center | Microbial process for production of eicosapentaenoic acid |
| US5366860A (en) | 1989-09-29 | 1994-11-22 | Applied Biosystems, Inc. | Spectrally resolvable rhodamine dyes for nucleic acid sequence determination |
| US5244921A (en) | 1990-03-21 | 1993-09-14 | Martek Corporation | Eicosapentaenoic acids and methods for their production |
| US5246842A (en) | 1991-10-30 | 1993-09-21 | The United States Of America As Represented By The Secretary Of Agriculture | Production of eicosapentaenoic acid from filamentous fungi utilizing lactose as a primary carbon source |
| US5972664A (en) | 1997-04-11 | 1999-10-26 | Abbott Laboratories | Methods and compositions for synthesis of long chain poly-unsaturated fatty acids |
| GB0107510D0 (en) | 2001-03-26 | 2001-05-16 | Univ Bristol | New elongase gene and a process for the production of -9-polyunsaturated fatty acids |
| ES2310197T3 (es) | 2002-10-18 | 2009-01-01 | Sloning Biotechnology Gmbh | Metodo para la preparacion de moleculas de acido nucleico. |
| CA2510462A1 (en) | 2002-12-19 | 2004-07-08 | University Of Bristol | Method for producing polyunsaturated fatty acids in a transgenic plant or microorganism comprising an introduced delta-9-elongase and a delta-8-desaturase |
| CA2517253C (en) | 2003-02-27 | 2018-07-03 | Basf Plant Science Gmbh | Method for the production of polyunsaturated fatty acids |
| EP1613746B1 (de) | 2003-03-31 | 2013-03-06 | University Of Bristol | Neue pflanzliche acyltransferasen spezifisch für langkettige, mehrfach ungesättigte fettsäuren |
| US8313911B2 (en) | 2003-05-07 | 2012-11-20 | E I Du Pont De Nemours And Company | Production of polyunsaturated fatty acids in oleaginous yeasts |
| US7125672B2 (en) | 2003-05-07 | 2006-10-24 | E. I. Du Pont De Nemours And Company | Codon-optimized genes for the production of polyunsaturated fatty acids in oleaginous yeasts |
| US7238482B2 (en) | 2003-05-07 | 2007-07-03 | E. I. Du Pont De Nemours And Company | Production of polyunsaturated fatty acids in oleaginous yeasts |
| US7259255B2 (en) | 2003-06-25 | 2007-08-21 | E. I. Du Pont De Nemours And Company | Glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate mutase promoters for gene expression in oleaginous yeast |
| US20110059496A1 (en) | 2003-06-25 | 2011-03-10 | E. I. Du Pont De Nemours And Company | Glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate mutase promoters for gene expression in oleaginous yeast |
| US7267976B2 (en) | 2003-07-02 | 2007-09-11 | E.I. Du Pont De Nemours And Company | Acyltransferases for alteration of polyunsaturated fatty acids and oil content in oleaginous yeasts |
| ES2713548T3 (es) | 2003-08-01 | 2019-05-22 | Basf Plant Science Gmbh | Procedimiento para la producción de ácidos grasos poliinsaturados en organismos transgénicos |
| AU2004290051A1 (en) | 2003-11-12 | 2005-05-26 | E.I. Dupont De Nemours And Company | Delta-15 desaturases suitable for altering levels of polyunsaturated fatty acids in oilseed plants and oleaginous yeast |
| US7504259B2 (en) | 2003-11-12 | 2009-03-17 | E. I. Du Pont De Nemours And Company | Δ12 desaturases suitable for altering levels of polyunsaturated fatty acids in oleaginous yeast |
| CA2559360A1 (en) | 2004-02-27 | 2005-09-09 | Basf Plant Science Gmbh | Method for producing c18, c20 and c22 polyunsaturated fatty acids in transgenic plants |
| US7550651B2 (en) | 2004-06-25 | 2009-06-23 | E.I. Du Pont De Nemours And Company | Delta-8 desaturase and its use in making polyunsaturated fatty acids |
| US7550286B2 (en) | 2004-11-04 | 2009-06-23 | E. I. Du Pont De Nemours And Company | Docosahexaenoic acid producing strains of Yarrowia lipolytica |
| US20060094102A1 (en) | 2004-11-04 | 2006-05-04 | Zhixiong Xue | Ammonium transporter promoter for gene expression in oleaginous yeast |
| US7879591B2 (en) * | 2004-11-04 | 2011-02-01 | E.I. Du Pont De Nemours And Company | High eicosapentaenoic acid producing strains of Yarrowia lipolytica |
| DE102004062294A1 (de) | 2004-12-23 | 2006-07-06 | Basf Plant Science Gmbh | Verfahren zur Herstellung von mehrfach ungesättigten langkettigen Fettsäuren in transgenen Organismen |
| CN103589650A (zh) | 2005-03-18 | 2014-02-19 | 米克罗比亚公司 | 产油酵母和真菌中类胡萝卜素的产生 |
| US7470532B2 (en) | 2005-10-19 | 2008-12-30 | E.I. Du Pont De Nemours And Company | Mortierella alpina C16/18 fatty acid elongase |
| DK1951866T3 (da) | 2005-11-23 | 2014-10-27 | Du Pont | Delta-9-elongaser og anvendelse heraf til fremstilling af flerumættede fedtsyrer |
| US7678560B2 (en) | 2006-05-17 | 2010-03-16 | E.I. Du Pont De Nemours And Company | Δ 5 desaturase and its use in making polyunsaturated fatty acids |
| DK2087105T3 (da) | 2006-10-30 | 2015-05-26 | Du Pont | Delta 17-desaturase og anvendelse heraf ved fremstilling af flerumættede fedtsyrer |
| US7709239B2 (en) | 2006-12-07 | 2010-05-04 | E.I. Du Pont De Nemours And Company | Mutant Δ8 desaturase genes engineered by targeted mutagenesis and their use in making polyunsaturated fatty acids |
| US8846374B2 (en) | 2006-12-12 | 2014-09-30 | E I Du Pont De Nemours And Company | Carotenoid production in a recombinant oleaginous yeast |
| ES2559312T3 (es) * | 2007-04-03 | 2016-02-11 | E. I. Du Pont De Nemours And Company | Multienzimas y su uso en la fabricación de ácidos grasos poliinsaturados |
| US7790156B2 (en) | 2007-04-10 | 2010-09-07 | E. I. Du Pont De Nemours And Company | Δ-8 desaturases and their use in making polyunsaturated fatty acids |
| US7794701B2 (en) | 2007-04-16 | 2010-09-14 | E.I. Du Pont De Nemours And Company | Δ-9 elongases and their use in making polyunsaturated fatty acids |
| US8957280B2 (en) | 2007-05-03 | 2015-02-17 | E. I. Du Pont De Nemours And Company | Delta-5 desaturases and their use in making polyunsaturated fatty acids |
| WO2009001315A2 (en) | 2007-06-26 | 2008-12-31 | Staahl Ulf | Use of a class of genes encoding lysophospholipid acyl transferases for application in agriculture, biotechnology, and medicine |
| EP2182071B1 (en) | 2007-07-23 | 2016-12-14 | Suntory Holdings Limited | A method for preparing a fatty acid composition |
| US20090117253A1 (en) | 2007-10-03 | 2009-05-07 | E. I. Du Pont De Nemours And Company | Peroxisome biogenesis factor protein (pex) disruptions for altering polyunsaturated fatty acids and total lipid content in oleaginous eukaryotic organisms |
| AU2009293160B2 (en) | 2008-09-19 | 2013-11-21 | E. I. Du Pont De Nemours And Company | Mutant delta5 desaturases and their use in making polyunsaturated fatty acids |
| CN102257126B (zh) | 2008-12-18 | 2014-07-09 | 纳幕尔杜邦公司 | 减少发酵过程中的丙二酸副产物 |
| US8637298B2 (en) * | 2009-06-16 | 2014-01-28 | E I Du Pont De Nemours And Company | Optimized strains of yarrowia lipolytica for high eicosapentaenoic acid production |
-
2011
- 2011-08-26 EP EP11752426.4A patent/EP2609203B1/en not_active Not-in-force
- 2011-08-26 AU AU2011293180A patent/AU2011293180B2/en not_active Ceased
- 2011-08-26 CA CA2807834A patent/CA2807834C/en not_active Expired - Fee Related
- 2011-08-26 DK DK11752426.4T patent/DK2609203T3/da active
- 2011-08-26 US US13/218,708 patent/US8703473B2/en active Active
- 2011-08-26 JP JP2013526178A patent/JP2013535987A/ja active Pending
- 2011-08-26 CN CN201180041064.0A patent/CN103249834B/zh not_active Expired - Fee Related
- 2011-08-26 KR KR1020137007481A patent/KR20130138760A/ko not_active Withdrawn
- 2011-08-26 BR BR112013004351A patent/BR112013004351A2/pt not_active IP Right Cessation
- 2011-08-26 WO PCT/US2011/049384 patent/WO2012027689A1/en not_active Ceased
-
2013
- 2013-02-25 CL CL2013000533A patent/CL2013000533A1/es unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2013535987A5 (cg-RX-API-DMAC7.html) | ||
| JP5465183B2 (ja) | 光合成微生物による脂肪酸の分泌 | |
| JP5931721B2 (ja) | アシルＣｏＡリゾリン脂質アシルトランスフェラーゼの発現による長鎖オメガ−３及びオメガ−６多価不飽和脂肪酸生合成の改良 | |
| JP2012529912A5 (cg-RX-API-DMAC7.html) | ||
| CN103249834B (zh) | 生产高水平二十碳五烯酸的重组微生物宿主细胞 | |
| JP2010523147A5 (cg-RX-API-DMAC7.html) | ||
| JP2013511972A (ja) | 組換え型Ｙａｒｒｏｗｉａｓｐ．を用いた発酵による超長鎖脂肪酸（ＶＬＣＦＡ）の生産方法 | |
| CN104017786B (zh) | 一种磷脂酶a2突变体及其制备方法 | |
| WO2006052824A2 (en) | A mortierella alpina glycerol-3-phosphate o-acyltransferase for alteration of polyunsaturated fatty acids and oil content in oleaginous organisms | |
| US8785164B2 (en) | Expression of caleosin in recombinant oleaginous microorganisms to increase oil content therein | |
| CN112410357B (zh) | 非从头合成的高产脂卷枝毛霉重组菌的构建方法、该方法构建的重组菌及应用 | |
| JP2012529913A5 (cg-RX-API-DMAC7.html) | ||
| JP2012530182A6 (ja) | 改良されたヤロウイア・リポリティカ（ｙａｒｒｏｗｉａ ｌｉｐｏｌｙｔｉｃａ）最適化株による高エイコサペンタエン酸油 | |
| CN117210508B (zh) | 一种制备高产二十碳五烯酸裂殖壶菌的方法 | |
| JP6351582B2 (ja) | アシルＣｏＡ：リゾホスファチジルコリンアシルトランスフェラーゼおよびリン脂質：ジアシルグリセロールアシルトランスフェラーゼの同時発現による多価不飽和脂肪酸の産生の改善 | |
| CN119753042B (zh) | 一株高产epa的重组裂殖壶菌、其构建方法及应用 | |
| CN105255912B (zh) | 一种具有三脂酰甘油合成功能的基因及其应用 | |
| JP2013541328A5 (cg-RX-API-DMAC7.html) | ||
| JP2013535988A5 (cg-RX-API-DMAC7.html) | ||
| US20140335578A1 (en) | Integrated biodiesel process | |
| CN102559710B (zh) | 等鞭金藻δ4-脂肪酸去饱和酶基因及其克隆方法 | |
| CN102373229B (zh) | 油脂酵母δ12和δ15双功能脂肪酸去饱和酶基因及其克隆方法 | |
| CN121759326A (zh) | 一种产dha的解脂酵母工程菌及其构建方法和应用 | |
| CN116479028A (zh) | 能够以甲醇为唯一碳源产脂肪酸工程菌的构建方法及其应用 | |
| Class et al. | Patent application title: Method for the Production of Very Long Chain Fatty Acids (VLCFA) by Fermentation with a Recombinant Yarrowia SP Inventors: Jean-Denis Faure (Gif-Sur-Yvette, FR) Jean-Marc Nicaud (Trappes, FR) Jean-Marc Nicaud (Trappes, FR) Brice Bourdenx (Fontenay Le Fleury, FR) Ramdane Haddouche (Thiverval-Grignon, FR) |