JP2013535961A5 - - Google Patents
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- JP2013535961A5 JP2013535961A5 JP2013518758A JP2013518758A JP2013535961A5 JP 2013535961 A5 JP2013535961 A5 JP 2013535961A5 JP 2013518758 A JP2013518758 A JP 2013518758A JP 2013518758 A JP2013518758 A JP 2013518758A JP 2013535961 A5 JP2013535961 A5 JP 2013535961A5
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- JP
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- Prior art keywords
- cells
- tissue
- medium
- nacl
- buffer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims 23
- 210000001519 tissue Anatomy 0.000 claims 19
- 210000004027 cell Anatomy 0.000 claims 16
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 14
- 239000002609 medium Substances 0.000 claims 12
- 239000000872 buffer Substances 0.000 claims 8
- 238000004519 manufacturing process Methods 0.000 claims 7
- 239000011780 sodium chloride Substances 0.000 claims 7
- 229940124158 Protease/peptidase inhibitor Drugs 0.000 claims 4
- 239000000137 peptide hydrolase inhibitor Substances 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 210000000130 stem cell Anatomy 0.000 claims 4
- 102000008186 Collagen Human genes 0.000 claims 3
- 108010035532 Collagen Proteins 0.000 claims 3
- 229920001436 collagen Polymers 0.000 claims 3
- 230000007935 neutral effect Effects 0.000 claims 3
- 235000010469 Glycine max Nutrition 0.000 claims 2
- 244000068988 Glycine max Species 0.000 claims 2
- 239000012980 RPMI-1640 medium Substances 0.000 claims 2
- 229940122618 Trypsin inhibitor Drugs 0.000 claims 2
- 101710162629 Trypsin inhibitor Proteins 0.000 claims 2
- 239000007640 basal medium Substances 0.000 claims 2
- 210000000013 bile duct Anatomy 0.000 claims 2
- 238000004113 cell culture Methods 0.000 claims 2
- 239000006143 cell culture medium Substances 0.000 claims 2
- 210000003722 extracellular fluid Anatomy 0.000 claims 2
- 210000004185 liver Anatomy 0.000 claims 2
- 239000011159 matrix material Substances 0.000 claims 2
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 2
- 230000001954 sterilising effect Effects 0.000 claims 2
- 239000002753 trypsin inhibitor Substances 0.000 claims 2
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 102000016911 Deoxyribonucleases Human genes 0.000 claims 1
- 108010053770 Deoxyribonucleases Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 claims 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 claims 1
- 102000004882 Lipase Human genes 0.000 claims 1
- 108090001060 Lipase Proteins 0.000 claims 1
- 239000004367 Lipase Substances 0.000 claims 1
- 102100037611 Lysophospholipase Human genes 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 108010058864 Phospholipases A2 Proteins 0.000 claims 1
- 102000006382 Ribonucleases Human genes 0.000 claims 1
- 108010083644 Ribonucleases Proteins 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 210000004381 amniotic fluid Anatomy 0.000 claims 1
- 210000000941 bile Anatomy 0.000 claims 1
- 210000005068 bladder tissue Anatomy 0.000 claims 1
- 229960003964 deoxycholic acid Drugs 0.000 claims 1
- 239000003599 detergent Substances 0.000 claims 1
- 230000004069 differentiation Effects 0.000 claims 1
- 210000002889 endothelial cell Anatomy 0.000 claims 1
- 210000002744 extracellular matrix Anatomy 0.000 claims 1
- 230000001605 fetal effect Effects 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 239000000122 growth hormone Substances 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
- 210000005003 heart tissue Anatomy 0.000 claims 1
- 210000003494 hepatocyte Anatomy 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 229910052500 inorganic mineral Inorganic materials 0.000 claims 1
- 230000000968 intestinal effect Effects 0.000 claims 1
- 235000019421 lipase Nutrition 0.000 claims 1
- 210000005229 liver cell Anatomy 0.000 claims 1
- 210000005228 liver tissue Anatomy 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 239000011707 mineral Substances 0.000 claims 1
- 238000010899 nucleation Methods 0.000 claims 1
- 210000004923 pancreatic tissue Anatomy 0.000 claims 1
- 210000004738 parenchymal cell Anatomy 0.000 claims 1
- 230000009984 peri-natal effect Effects 0.000 claims 1
- 210000005084 renal tissue Anatomy 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- FHHPUSMSKHSNKW-SMOYURAASA-M sodium deoxycholate Chemical compound [Na+].C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC([O-])=O)C)[C@@]2(C)[C@@H](O)C1 FHHPUSMSKHSNKW-SMOYURAASA-M 0.000 claims 1
- 210000004500 stellate cell Anatomy 0.000 claims 1
- 238000004659 sterilization and disinfection Methods 0.000 claims 1
- 210000001685 thyroid gland Anatomy 0.000 claims 1
- 210000004881 tumor cell Anatomy 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
- 229940088594 vitamin Drugs 0.000 claims 1
- 229930003231 vitamin Natural products 0.000 claims 1
- 235000013343 vitamin Nutrition 0.000 claims 1
- 150000003722 vitamin derivatives Chemical class 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36093910P | 2010-07-02 | 2010-07-02 | |
| US61/360,939 | 2010-07-02 | ||
| PCT/US2011/042805 WO2012003450A2 (en) | 2010-07-02 | 2011-07-01 | Biomatrix scaffolds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016237356A Division JP6612722B2 (ja) | 2010-07-02 | 2016-12-07 | バイオマトリックス足場 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013535961A JP2013535961A (ja) | 2013-09-19 |
| JP2013535961A5 true JP2013535961A5 (https=) | 2014-08-14 |
| JP6308781B2 JP6308781B2 (ja) | 2018-04-11 |
Family
ID=45402468
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013518763A Pending JP2013539960A (ja) | 2010-07-02 | 2011-07-01 | 工業規模の散布のためのバイオマトリックス足場 |
| JP2013518758A Expired - Fee Related JP6308781B2 (ja) | 2010-07-02 | 2011-07-01 | バイオマトリックス足場 |
| JP2016237356A Expired - Fee Related JP6612722B2 (ja) | 2010-07-02 | 2016-12-07 | バイオマトリックス足場 |
| JP2016237355A Pending JP2017055764A (ja) | 2010-07-02 | 2016-12-07 | 工業規模の散布のためのバイオマトリックス足場 |
| JP2018102418A Expired - Fee Related JP6527272B2 (ja) | 2010-07-02 | 2018-05-29 | 工業規模の散布のためのバイオマトリックス足場 |
| JP2018193565A Pending JP2019017393A (ja) | 2010-07-02 | 2018-10-12 | バイオマトリックス足場 |
| JP2018193545A Pending JP2019017392A (ja) | 2010-07-02 | 2018-10-12 | 工業規模の散布のためのバイオマトリックス足場 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013518763A Pending JP2013539960A (ja) | 2010-07-02 | 2011-07-01 | 工業規模の散布のためのバイオマトリックス足場 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016237356A Expired - Fee Related JP6612722B2 (ja) | 2010-07-02 | 2016-12-07 | バイオマトリックス足場 |
| JP2016237355A Pending JP2017055764A (ja) | 2010-07-02 | 2016-12-07 | 工業規模の散布のためのバイオマトリックス足場 |
| JP2018102418A Expired - Fee Related JP6527272B2 (ja) | 2010-07-02 | 2018-05-29 | 工業規模の散布のためのバイオマトリックス足場 |
| JP2018193565A Pending JP2019017393A (ja) | 2010-07-02 | 2018-10-12 | バイオマトリックス足場 |
| JP2018193545A Pending JP2019017392A (ja) | 2010-07-02 | 2018-10-12 | 工業規模の散布のためのバイオマトリックス足場 |
Country Status (11)
| Country | Link |
|---|---|
| US (7) | US9102913B2 (https=) |
| EP (6) | EP3192862B1 (https=) |
| JP (7) | JP2013539960A (https=) |
| CN (4) | CN103491898B (https=) |
| DK (2) | DK2588027T3 (https=) |
| ES (6) | ES2946590T3 (https=) |
| HU (2) | HUE032730T2 (https=) |
| LT (2) | LT2588083T (https=) |
| PL (2) | PL2588027T3 (https=) |
| PT (2) | PT2588027T (https=) |
| WO (2) | WO2012003450A2 (https=) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2588027T3 (pl) * | 2010-07-02 | 2017-09-29 | The University Of North Carolina At Chapel Hill | Rusztowania biomacierzowe do rozpraszania na skalę przemysłową |
| NL2009145C2 (en) * | 2012-07-06 | 2014-01-07 | Xeltis B V | Implant. |
| CN103536967B (zh) * | 2012-07-10 | 2016-04-13 | 上海微创医疗器械（集团）有限公司 | 一种制备细胞外基质支架材料的脱细胞方法 |
| US9533013B2 (en) | 2013-03-13 | 2017-01-03 | University Of North Carolina At Chapel Hill | Method of treating pancreatic and liver conditions by endoscopic-mediated (or laparoscopic-mediated) transplantation of stem cells into/onto bile duct walls of particular regions of the biliary tree |
| JP2016513465A (ja) * | 2013-03-15 | 2016-05-16 | ミロマトリックス メディカル インコーポレイティド | 膵島細胞の再細胞化のための灌流型脱細胞化肝臓の使用 |
| AU2014228022B9 (en) * | 2013-03-15 | 2016-11-03 | NuTech Medical, Inc. | Preparations derived from placental materials of making and using same |
| ES2703785T3 (es) * | 2013-04-08 | 2019-03-12 | Regentys Corp | Método y composición para tratar una enfermedad inflamatoria intestinal sin colectomía |
| US20150037436A1 (en) | 2013-07-30 | 2015-02-05 | Musculoskeletal Transplant Foundation | Acellular soft tissue-derived matrices and methods for preparing same |
| CN103432627B (zh) * | 2013-08-26 | 2015-03-25 | 北京瑞健高科生物科技有限公司 | 一种制备动物脱细胞组织基质材料的方法及其制备的组织基质材料 |
| EP3122872B1 (en) | 2014-03-27 | 2019-07-03 | The Salk Institute for Biological Studies | Compositions and methods for treating type 1 and type 2 diabetes and related disorders |
| GB201409858D0 (en) * | 2014-06-03 | 2014-07-16 | Ucl Business Plc | Human liver scaffolds |
| CN104288837B (zh) * | 2014-09-11 | 2016-04-13 | 杨淑珍 | 一种脱细胞真皮基质及其制备方法和用途 |
| AU2016225076B2 (en) | 2015-02-27 | 2018-09-13 | Salk Institute For Biological Studies | Reprogramming progenitor compositions and methods of use therefore |
| CN104928241B (zh) * | 2015-03-27 | 2018-04-13 | 北京康爱瑞浩生物科技股份有限公司 | 一种增强型nk细胞的活化方法及细胞制备方法 |
| WO2016200340A1 (en) | 2015-06-12 | 2016-12-15 | Agency For Science, Technology And Research | Derivation of hepatic stem cells and mature liver cell types and uses thereof |
| US10912864B2 (en) | 2015-07-24 | 2021-02-09 | Musculoskeletal Transplant Foundation | Acellular soft tissue-derived matrices and methods for preparing same |
| US11052175B2 (en) | 2015-08-19 | 2021-07-06 | Musculoskeletal Transplant Foundation | Cartilage-derived implants and methods of making and using same |
| US12551509B2 (en) | 2015-11-18 | 2026-02-17 | Lucina Patent Holdco, Llc | Acellular regenerative products and methods of their manufacture |
| CN106884002B (zh) * | 2015-12-15 | 2021-03-19 | 上海市针灸经络研究所 | 一种稳定的结肠上皮细胞培养方法 |
| CN105833353B (zh) * | 2016-05-09 | 2018-04-20 | 拜欧迪赛尔（北京）生物科技有限公司 | 一种生物工程脱细胞真皮基质的制备及用途 |
| US20170369849A1 (en) * | 2016-05-11 | 2017-12-28 | The University Of North Carolina At Chapel Hill | Compositions and methods for bioengineered tissues |
| US11760977B2 (en) | 2016-05-25 | 2023-09-19 | Salk Institute For Biological Studies | Compositions and methods for organoid generation and disease modeling |
| KR20190028726A (ko) * | 2016-07-12 | 2019-03-19 | 더 유니버시티 오브 노스캐롤라이나 앳 채플 힐 | 암 진단 및 모델링에 사용하기 위한 바이오매트릭스 스캐폴드 |
| CN106362212A (zh) * | 2016-10-21 | 2017-02-01 | 华中科技大学同济医学院附属协和医院 | 一种用于去除组织细胞的亲脂性去细胞溶液、试剂盒和方法 |
| GB2555787A (en) * | 2016-11-07 | 2018-05-16 | Landberg Goran | Diagnostic methods |
| CN116243006A (zh) * | 2016-11-30 | 2023-06-09 | 布鲁克·道尔顿有限及两合公司 | 制备活的微生物样品和微生物用于随后的质谱测量和评估 |
| WO2018144469A1 (en) * | 2017-01-31 | 2018-08-09 | University Of Vermont And State Agricultural College | Avian based lung assist device |
| CN111032090A (zh) * | 2017-06-12 | 2020-04-17 | 北卡罗来纳大学教堂山分校 | 用于细胞植入的补片植入物组合物 |
| ES2938458T3 (es) * | 2017-07-31 | 2023-04-11 | Canto Zago Alexandre Do | Dispositivo y método para promover la cobertura rápida de malla estructural y la cobertura endotelial vascular |
| EP3470096A1 (en) * | 2017-10-13 | 2019-04-17 | Erasmus University Medical Center Rotterdam | Elastin reduction allowing recellularization of cartilage implants |
| WO2019129646A1 (en) * | 2017-12-29 | 2019-07-04 | F. Hoffmann-La Roche Ag | Tissue sample preparation system |
| EP3813896B1 (en) * | 2018-05-14 | 2025-10-01 | Roosterbio, Inc. | Methods and compositions related to extracellular material derived from hypertonic cell solutions |
| WO2019241499A1 (en) | 2018-06-13 | 2019-12-19 | Miromatrix Medical Inc. | Fistula filler and deployment system |
| CN108753687B (zh) * | 2018-06-22 | 2021-04-16 | 中国人民解放军军事科学院军事医学研究院 | 微肝组织培养模型、其构建方法及其应用 |
| CN108753686B (zh) * | 2018-06-22 | 2021-06-22 | 中国人民解放军军事科学院军事医学研究院 | 组织工程肝脏模型、其构建方法及其应用 |
| CN109735490A (zh) * | 2019-03-06 | 2019-05-10 | 福建省海西细胞生物工程有限公司 | 一种脂肪干细胞提取方法 |
| CN110257335B (zh) * | 2019-04-10 | 2020-09-29 | 首都医科大学附属北京天坛医院 | 单层或多层的3d脑胶质瘤细胞培养模型及其构建方法和应用 |
| EP4712098A2 (en) | 2019-05-16 | 2026-03-18 | ResMed Pty Ltd | Two-way communication in a medical device |
| KR102360023B1 (ko) * | 2019-09-04 | 2022-02-09 | 한국생명공학연구원 | 증식 가능한 간 오가노이드 |
| CN110559485B (zh) * | 2019-09-25 | 2021-02-02 | 北京大清生物技术股份有限公司 | 一种生物组织基质材料及其制备方法与应用 |
| DE102019130568A1 (de) | 2019-11-13 | 2021-05-20 | Aesculap Ag | Chirurgischer Fräser mit verbesserter Spanabfuhr |
| CN118846235A (zh) * | 2019-12-30 | 2024-10-29 | 广东泓志生物科技有限公司 | 大网膜脱细胞基质材料的制备方法及软骨组织的构建方法 |
| EP4098739A4 (en) | 2020-02-14 | 2024-03-20 | Cellartgen Inc. | SCAFFOLD FROM DECELLULARIZED ORGANIC TISSUE, FOR THE CULTURE AND TRANSPLANTATION OF ORGANOIDS, AND ASSOCIATED PRODUCTION METHOD |
| CN111760072B (zh) * | 2020-08-24 | 2022-09-23 | 鲁峰 | 脂肪来源的真皮内填充物及其制备和应用 |
| GB202102232D0 (en) * | 2021-02-17 | 2021-03-31 | Cambridge Entpr Ltd | Methods of Expanding Cholangiocytes |
| CN114748208B (zh) * | 2022-04-15 | 2024-01-12 | 柔脉医疗(深圳)有限公司 | 一种可原位检测多种化学、生物成分的组织工程支架 |
| CN115948331B (zh) * | 2022-10-17 | 2024-10-22 | 中国人民解放军西部战区总医院 | 一种从小鼠胆囊中分离获取间充质干细胞的方法 |
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| DE19569C (de) | ANNA ERBER in Brieg | Neuerungen an der unter Nr. 17581 patentirten Handlaterne | ||
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| WO2004076631A2 (en) * | 2003-02-21 | 2004-09-10 | The Uab Research Foundation | Biologically active native biomatrix composition |
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| WO2005001080A2 (en) | 2003-06-27 | 2005-01-06 | Ethicon, Incorporated | Postpartum-derived cells for use in treatment of disease of the heart and circulatory system |
| BRPI0611739A2 (pt) * | 2005-06-10 | 2011-12-20 | Celgene Corp | colágeno de atelopeptìdeo, composição, método e kit para aumentar, avolumar ou substituir tecido de um mamìfero, e, processos para preparar e para reticular colágeno de atelopeptìdeo, e para reduzir a quantidade de partìculas virais em uma composição de colágeno |
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| US8241908B2 (en) * | 2006-05-16 | 2012-08-14 | Becton, Dickinson And Company | Extracellular matrix coated surface for culturing cells |
| US8685107B2 (en) * | 2007-07-03 | 2014-04-01 | Histogenics Corporation | Double-structured tissue implant and a method for preparation and use thereof |
| ES2628100T3 (es) * | 2008-09-30 | 2017-08-01 | The Regents Of The University Of California | Composiciones que comprenden matriz extracelular descelularizada obtenida a partir de tejido cardíaco |
| US20120064050A1 (en) * | 2009-02-04 | 2012-03-15 | Yale University | Tissue Engineering of Lung |
| WO2010099463A2 (en) * | 2009-02-27 | 2010-09-02 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Joint bioscaffolds |
| EP2588592B1 (en) | 2010-06-30 | 2017-09-06 | Miromatrix Medical Inc. | Use of perfusion decellularized organs for matched recellularization |
| PL2588027T3 (pl) * | 2010-07-02 | 2017-09-29 | The University Of North Carolina At Chapel Hill | Rusztowania biomacierzowe do rozpraszania na skalę przemysłową |
-
2011
- 2011-07-01 PL PL11801504T patent/PL2588027T3/pl unknown
- 2011-07-01 PL PL11801493T patent/PL2588083T3/pl unknown
- 2011-07-01 ES ES19199017T patent/ES2946590T3/es active Active
- 2011-07-01 ES ES16191506T patent/ES2791312T3/es active Active
- 2011-07-01 PT PT118015049T patent/PT2588027T/pt unknown
- 2011-07-01 US US13/807,260 patent/US9102913B2/en active Active
- 2011-07-01 EP EP16191501.2A patent/EP3192862B1/en active Active
- 2011-07-01 LT LTEP11801493.5T patent/LT2588083T/lt unknown
- 2011-07-01 EP EP19199017.5A patent/EP3603622B1/en active Active
- 2011-07-01 ES ES16191501T patent/ES2879246T3/es active Active
- 2011-07-01 US US13/807,253 patent/US8802081B2/en active Active
- 2011-07-01 CN CN201180042690.1A patent/CN103491898B/zh not_active Expired - Fee Related
- 2011-07-01 JP JP2013518763A patent/JP2013539960A/ja active Pending
- 2011-07-01 CN CN201610286180.3A patent/CN106362211A/zh active Pending
- 2011-07-01 HU HUE11801493A patent/HUE032730T2/en unknown
- 2011-07-01 EP EP19174054.7A patent/EP3581171B1/en not_active Not-in-force
- 2011-07-01 EP EP11801493.5A patent/EP2588083B1/en not_active Not-in-force
- 2011-07-01 WO PCT/US2011/042805 patent/WO2012003450A2/en not_active Ceased
- 2011-07-01 WO PCT/US2011/042825 patent/WO2012003463A1/en not_active Ceased
- 2011-07-01 HU HUE11801504A patent/HUE032727T2/en unknown
- 2011-07-01 ES ES11801493.5T patent/ES2624742T3/es active Active
- 2011-07-01 CN CN2011800426899A patent/CN103249404A/zh active Pending
- 2011-07-01 ES ES11801504.9T patent/ES2626145T3/es active Active
- 2011-07-01 LT LTEP11801504.9T patent/LT2588027T/lt unknown
- 2011-07-01 DK DK11801504.9T patent/DK2588027T3/en active
- 2011-07-01 DK DK11801493.5T patent/DK2588083T3/en active
- 2011-07-01 PT PT118014935T patent/PT2588083T/pt unknown
- 2011-07-01 EP EP16191506.1A patent/EP3216444B1/en active Active
- 2011-07-01 JP JP2013518758A patent/JP6308781B2/ja not_active Expired - Fee Related
- 2011-07-01 ES ES19174054T patent/ES2916580T3/es active Active
- 2011-07-01 EP EP11801504.9A patent/EP2588027B8/en not_active Not-in-force
- 2011-07-01 CN CN201510751844.4A patent/CN105713868A/zh active Pending
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2014
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2015
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2016
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- 2016-12-07 JP JP2016237356A patent/JP6612722B2/ja not_active Expired - Fee Related
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2018
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- 2018-05-29 JP JP2018102418A patent/JP6527272B2/ja not_active Expired - Fee Related
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2019
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