JP2013534536A5 - - Google Patents
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- Publication number
- JP2013534536A5 JP2013534536A5 JP2013519726A JP2013519726A JP2013534536A5 JP 2013534536 A5 JP2013534536 A5 JP 2013534536A5 JP 2013519726 A JP2013519726 A JP 2013519726A JP 2013519726 A JP2013519726 A JP 2013519726A JP 2013534536 A5 JP2013534536 A5 JP 2013534536A5
- Authority
- JP
- Japan
- Prior art keywords
- batch
- laquinimod
- pharmaceutically acceptable
- ethylaniline
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- OJGMBLNIHDZDGS-UHFFFAOYSA-N N-Ethylaniline Chemical compound CCNC1=CC=CC=C1 OJGMBLNIHDZDGS-UHFFFAOYSA-N 0.000 claims description 40
- GKWPCEFFIHSJOE-UHFFFAOYSA-N laquinimod Chemical compound OC=1C2=C(Cl)C=CC=C2N(C)C(=O)C=1C(=O)N(CC)C1=CC=CC=C1 GKWPCEFFIHSJOE-UHFFFAOYSA-N 0.000 claims description 31
- 229960004577 laquinimod Drugs 0.000 claims description 31
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 claims description 20
- 150000003839 salts Chemical class 0.000 claims description 20
- 239000008194 pharmaceutical composition Substances 0.000 claims description 16
- 238000004519 manufacturing process Methods 0.000 claims description 15
- 150000001875 compounds Chemical class 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 12
- BZKCTVZVKAXVFH-UHFFFAOYSA-N 5-chloro-4-hydroxy-1-methyl-2-oxo-n-phenylquinoline-3-carboxamide Chemical compound O=C1N(C)C2=CC=CC(Cl)=C2C(O)=C1C(=O)NC1=CC=CC=C1 BZKCTVZVKAXVFH-UHFFFAOYSA-N 0.000 claims description 11
- 239000000203 mixture Substances 0.000 claims description 11
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 claims description 4
- 239000003937 drug carrier Substances 0.000 claims description 4
- FTBWKSJUFWRKGL-UHFFFAOYSA-N 5-chloro-4-hydroxy-1-methyl-2-oxoquinoline-3-carboxylic acid Chemical compound C1=CC(Cl)=C2C(O)=C(C(O)=O)C(=O)N(C)C2=C1 FTBWKSJUFWRKGL-UHFFFAOYSA-N 0.000 claims description 2
- 150000003857 carboxamides Chemical class 0.000 claims description 2
- 150000004702 methyl esters Chemical class 0.000 claims description 2
- TVMXDCGIABBOFY-UHFFFAOYSA-N octane Chemical compound CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 claims description 2
- 239000008247 solid mixture Substances 0.000 claims 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 4
- 239000008186 active pharmaceutical agent Substances 0.000 description 3
- 229940088679 drug related substance Drugs 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39926410P | 2010-07-09 | 2010-07-09 | |
| US61/399,264 | 2010-07-09 | ||
| PCT/US2011/043391 WO2012006544A1 (en) | 2010-07-09 | 2011-07-08 | 5-chloro-4-hydroxy-1-methyl-2-oxo-n-phenyl-1,2-dihydroquinoline-3-carboxamide, salts and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015204932A Division JP2016053049A (ja) | 2010-07-09 | 2015-10-16 | ５−クロロ−４−ヒドロキシ−１−メチル−２−オキソ−ｎ−フェニル−１，２−ジヒドロキノリン−３−カルボキサミドと、その塩及びその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013534536A JP2013534536A (ja) | 2013-09-05 |
| JP2013534536A5 true JP2013534536A5 (enExample) | 2014-08-21 |
| JP5934202B2 JP5934202B2 (ja) | 2016-06-15 |
Family
ID=45439027
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013519726A Expired - Fee Related JP5934202B2 (ja) | 2010-07-09 | 2011-07-08 | ５−クロロ−４−ヒドロキシ−１−メチル−２−オキソ−ｎ−フェニル−１，２−ジヒドロキノリン−３−カルボキサミドと、その塩及びその使用 |
| JP2015204932A Pending JP2016053049A (ja) | 2010-07-09 | 2015-10-16 | ５−クロロ−４−ヒドロキシ−１−メチル−２−オキソ−ｎ−フェニル−１，２−ジヒドロキノリン−３−カルボキサミドと、その塩及びその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015204932A Pending JP2016053049A (ja) | 2010-07-09 | 2015-10-16 | ５−クロロ−４−ヒドロキシ−１−メチル−２−オキソ−ｎ−フェニル−１，２−ジヒドロキノリン−３−カルボキサミドと、その塩及びその使用 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US20120010239A1 (enExample) |
| EP (2) | EP3056205A1 (enExample) |
| JP (2) | JP5934202B2 (enExample) |
| KR (1) | KR20130041193A (enExample) |
| CN (1) | CN102985090B (enExample) |
| AU (2) | AU2011274502A1 (enExample) |
| BR (1) | BR112013000607A2 (enExample) |
| CA (1) | CA2804989A1 (enExample) |
| EA (1) | EA201390074A1 (enExample) |
| HK (1) | HK1225308A1 (enExample) |
| MX (1) | MX2013000332A (enExample) |
| NZ (1) | NZ606589A (enExample) |
| WO (1) | WO2012006544A1 (enExample) |
| ZA (1) | ZA201300957B (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1937642T3 (en) * | 2005-10-19 | 2014-12-15 | Teva Pharma | Crystals of sodium laquinimod and the process for its preparation |
| EA018031B1 (ru) | 2006-06-12 | 2013-05-30 | Тева Фармасьютикал Индастриз, Лтд. | Стабильные препараты лаквинимода |
| PT2682120T (pt) | 2007-12-20 | 2016-11-07 | Teva Pharma | Preparações de laquinimod estáveis |
| BR112012000568A2 (pt) * | 2009-06-19 | 2015-10-06 | Teva Pharma | tratamento da esclerose múltipla com laquinimod |
| JP5882208B2 (ja) * | 2009-07-30 | 2016-03-09 | テバ ファーマシューティカル インダストリーズ リミティド | ラキニモドによるクローン病の治療 |
| AU2010282948C1 (en) | 2009-08-10 | 2017-03-02 | Active Biotech, Ab | Treatment of BDNF-related disorders using laquinimod |
| SI2542079T1 (sl) * | 2010-03-03 | 2014-08-29 | Teva Pharmaceutical Industries Ltd. | Zdravljenje revmatoidnega artritisa s kombinacijo lakvinimoda in metotreksata |
| EA201290837A1 (ru) | 2010-03-03 | 2013-05-30 | Тева Фармасьютикал Индастриз Лтд. | Лечение волчаночного нефрита с применением лаквинимода |
| KR20130092558A (ko) | 2010-07-09 | 2013-08-20 | 테바 파마슈티컬 인더스트리즈 리미티드 | 중수소화된 n-에틸-n-페닐-1,2-다이하이드로-4-하이드록시-5-클로로-1-메틸-2-옥소퀴놀린-3-카복스아마이드, 그의 염 및 용도 |
| JP2014530821A (ja) | 2011-10-12 | 2014-11-20 | テバ ファーマシューティカル インダストリーズ リミティド | ラキニモドおよびフィンゴリモドを組み合わせた多発性硬化症の治療 |
| WO2013116657A1 (en) | 2012-02-03 | 2013-08-08 | Teva Pharmaceutical Industries Ltd. | USE OF LAQUINIMOD FOR TREATING CROHN'S DISEASE PATIENTS WHO FAILED FIRST-LINE ANTI-TNFα THERAPY |
| JP6215238B2 (ja) | 2012-02-16 | 2017-10-18 | テバ ファーマシューティカル インダストリーズ リミティド | Ｎ−エチル−ｎ−フェニル−１，２−ジヒドロ−４，５−ジ−ヒドロキシ−１−メチル−２−オキソ−３−キノリンカルボキサミド、その製剤、および使用 |
| TW201350467A (zh) | 2012-05-08 | 2013-12-16 | Teva Pharma | Ｎ－乙基－４－羥基－１－甲基－５－（甲基（２，３，４，５，６－五羥基己基）胺基）－２－側氧－ｎ－苯基－１，２－二氫喹啉－３－甲醯胺 |
| TW201400117A (zh) | 2012-06-05 | 2014-01-01 | Teva Pharma | 使用拉喹莫德治療眼發炎疾病 |
| TW201410244A (zh) | 2012-08-13 | 2014-03-16 | Teva Pharma | 用於治療ｇａｂａ媒介之疾病之拉喹莫德（ｌａｑｕｉｎｉｍｏｄ） |
| CN103626701A (zh) * | 2012-08-28 | 2014-03-12 | 天津药物研究院 | 一种制备喹啉衍生物的方法 |
| CN103626702A (zh) * | 2012-08-30 | 2014-03-12 | 天津药物研究院 | 一种制备喹啉酮衍生物的方法 |
| MX2015005632A (es) | 2012-11-07 | 2016-02-05 | Teva Pharma | Sales de amina de laquinimod. |
| JP2016513665A (ja) | 2013-03-14 | 2016-05-16 | テバ ファーマシューティカル インダストリーズ リミティド | ラキニモドの経皮製剤 |
| WO2014153145A2 (en) * | 2013-03-14 | 2014-09-25 | Teva Pharmaceutical Industries Ltd. | Crystals of laquinimod sodium and improved process for the manufacture thereof |
| SG11201608674UA (en) | 2014-04-29 | 2016-11-29 | Teva Pharma | Laquinimod for the treatment of relapsing-remitting multiple sclerosis (rrms) patients with a high disability status |
| US20190090046A1 (en) * | 2017-09-21 | 2019-03-21 | Bragi GmbH | Tactile Feedback for Audio Defined Menu System and Method |
| GB202006390D0 (en) * | 2020-04-30 | 2020-06-17 | Aqilion Ab | Novel treatments |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2380420A (en) * | 1940-12-16 | 1945-07-31 | William S Emerson | Production of secondary and tertiary amines from nitrogen compounds |
| IE52670B1 (en) * | 1981-03-03 | 1988-01-20 | Leo Ab | Heterocyclic carboxamides,compositions containing such compounds,and processes for their preparation |
| DE3724018A1 (de) * | 1987-07-21 | 1989-02-02 | Bayer Ag | Verfahren zur trennung von anilin-derivaten |
| SE9801474D0 (sv) * | 1998-04-27 | 1998-04-27 | Active Biotech Ab | Quinoline Derivatives |
| US6077851A (en) | 1998-04-27 | 2000-06-20 | Active Biotech Ab | Quinoline derivatives |
| SE0201778D0 (sv) * | 2002-06-12 | 2002-06-12 | Active Biotech Ab | Process for the manufacture of quinoline derivatives |
| US6875869B2 (en) | 2002-06-12 | 2005-04-05 | Active Biotech Ab | Process for the manufacture of quinoline derivatives |
| US7560557B2 (en) * | 2002-06-12 | 2009-07-14 | Active Biotech Ag | Process for the manufacture of quinoline derivatives |
| SE0400235D0 (sv) | 2004-02-06 | 2004-02-06 | Active Biotech Ab | New composition containing quinoline compounds |
| DK1937642T3 (en) | 2005-10-19 | 2014-12-15 | Teva Pharma | Crystals of sodium laquinimod and the process for its preparation |
| EA018031B1 (ru) * | 2006-06-12 | 2013-05-30 | Тева Фармасьютикал Индастриз, Лтд. | Стабильные препараты лаквинимода |
| PT2682120T (pt) * | 2007-12-20 | 2016-11-07 | Teva Pharma | Preparações de laquinimod estáveis |
| EP2318371A2 (en) * | 2008-07-01 | 2011-05-11 | Actavis Group PTC EHF | Novel solid state forms of laquinimod and its sodium salt |
| WO2010070449A2 (en) * | 2008-12-17 | 2010-06-24 | Actavis Group Ptc Ehf | Highly pure laquinimod or a pharmaceutically acceptable salt thereof |
-
2011
- 2011-07-08 KR KR1020137003331A patent/KR20130041193A/ko not_active Ceased
- 2011-07-08 WO PCT/US2011/043391 patent/WO2012006544A1/en not_active Ceased
- 2011-07-08 EA EA201390074A patent/EA201390074A1/ru unknown
- 2011-07-08 EP EP16159268.8A patent/EP3056205A1/en not_active Withdrawn
- 2011-07-08 EP EP11804416.3A patent/EP2590653A4/en not_active Withdrawn
- 2011-07-08 AU AU2011274502A patent/AU2011274502A1/en not_active Abandoned
- 2011-07-08 BR BR112013000607A patent/BR112013000607A2/pt not_active IP Right Cessation
- 2011-07-08 MX MX2013000332A patent/MX2013000332A/es unknown
- 2011-07-08 US US13/178,865 patent/US20120010239A1/en not_active Abandoned
- 2011-07-08 CN CN201180034077.5A patent/CN102985090B/zh not_active Expired - Fee Related
- 2011-07-08 CA CA2804989A patent/CA2804989A1/en not_active Abandoned
- 2011-07-08 NZ NZ606589A patent/NZ606589A/en not_active IP Right Cessation
- 2011-07-08 JP JP2013519726A patent/JP5934202B2/ja not_active Expired - Fee Related
-
2013
- 2013-02-05 ZA ZA2013/00957A patent/ZA201300957B/en unknown
- 2013-05-20 HK HK16113723.9A patent/HK1225308A1/en unknown
-
2015
- 2015-10-16 JP JP2015204932A patent/JP2016053049A/ja active Pending
-
2016
- 2016-06-13 US US15/180,727 patent/US20160279121A1/en not_active Abandoned
-
2017
- 2017-11-17 AU AU2017261621A patent/AU2017261621A1/en not_active Abandoned
-
2018
- 2018-01-04 US US15/861,952 patent/US20180140592A1/en not_active Abandoned
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