JP2013526577A5 - - Google Patents
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- Publication number
- JP2013526577A5 JP2013526577A5 JP2013511354A JP2013511354A JP2013526577A5 JP 2013526577 A5 JP2013526577 A5 JP 2013526577A5 JP 2013511354 A JP2013511354 A JP 2013511354A JP 2013511354 A JP2013511354 A JP 2013511354A JP 2013526577 A5 JP2013526577 A5 JP 2013526577A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound represented
- reaction mixture
- buffer
- acylating agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000000034 method Methods 0.000 claims description 31
- 150000001875 compounds Chemical class 0.000 claims description 23
- KUZYSQSABONDME-QRLOMCMNSA-N vintafolide Chemical compound C([C@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)NNC(=O)OCCSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)CC[C@H](NC(=O)C=4C=CC(NCC=5N=C6C(=O)NC(N)=NC6=NC=5)=CC=4)C(O)=O)C(O)=O)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 KUZYSQSABONDME-QRLOMCMNSA-N 0.000 claims description 12
- 239000011541 reaction mixture Substances 0.000 claims description 11
- 239000000872 buffer Substances 0.000 claims description 10
- 239000003795 chemical substances by application Substances 0.000 claims description 10
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims description 6
- 125000004391 aryl sulfonyl group Chemical group 0.000 claims description 6
- 125000005110 aryl thio group Chemical group 0.000 claims description 6
- PPRGGNQLPSVURC-ZVTSDNJWSA-N deacetylvinblastine hydrazide Chemical compound C([C@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)NN)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 PPRGGNQLPSVURC-ZVTSDNJWSA-N 0.000 claims description 6
- 125000005368 heteroarylthio group Chemical group 0.000 claims description 6
- 239000002253 acid Substances 0.000 claims description 5
- 150000003839 salts Chemical class 0.000 claims description 5
- 239000012062 aqueous buffer Substances 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 9
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 4
- 239000000243 solution Substances 0.000 claims 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 2
- 239000012458 free base Substances 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- 239000012064 sodium phosphate buffer Substances 0.000 claims 2
- 239000007864 aqueous solution Substances 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 238000007865 diluting Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000008363 phosphate buffer Substances 0.000 claims 1
- 239000002952 polymeric resin Substances 0.000 claims 1
- 229920003053 polystyrene-divinylbenzene Polymers 0.000 claims 1
- 239000000047 product Substances 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 239000012264 purified product Substances 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 229920003002 synthetic resin Polymers 0.000 claims 1
- 238000000108 ultra-filtration Methods 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 0 C*C[C@@](C(N[C@@](CC(O)=O)C(N[C@](*)CS)=O)=O)NC(CNC([C@](C)NC(CC[C@@](C(O)=O)NC(c(cc1)ccc1NCc1nc(*=O)c(N*)nc1)=O)=O)=O)=O Chemical compound C*C[C@@](C(N[C@@](CC(O)=O)C(N[C@](*)CS)=O)=O)NC(CNC([C@](C)NC(CC[C@@](C(O)=O)NC(c(cc1)ccc1NCc1nc(*=O)c(N*)nc1)=O)=O)=O)=O 0.000 description 35
- KRPACOYLOTZHII-UHFFFAOYSA-N O=C(OCCSSc1ccccn1)O[n]1nnc2c1cccc2 Chemical compound O=C(OCCSSc1ccccn1)O[n]1nnc2c1cccc2 KRPACOYLOTZHII-UHFFFAOYSA-N 0.000 description 2
- BPCWEXKVIAISEV-UHFFFAOYSA-N Cc(cc1)ccc1NCc1nc(C(NN2)=O)c2nc1 Chemical compound Cc(cc1)ccc1NCc1nc(C(NN2)=O)c2nc1 BPCWEXKVIAISEV-UHFFFAOYSA-N 0.000 description 1
- FCWZGVQTBMHYKD-UHFFFAOYSA-N Cc(cc1)ccc1NCc1nc(CNN2)c2nc1 Chemical compound Cc(cc1)ccc1NCc1nc(CNN2)c2nc1 FCWZGVQTBMHYKD-UHFFFAOYSA-N 0.000 description 1
- ADEUBFAWQRMQQZ-UHFFFAOYSA-N N=C(OCCSSc1ncccc1)O[n]1nnc2ccccc12 Chemical compound N=C(OCCSSc1ncccc1)O[n]1nnc2ccccc12 ADEUBFAWQRMQQZ-UHFFFAOYSA-N 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34644410P | 2010-05-19 | 2010-05-19 | |
| US61/346,444 | 2010-05-19 | ||
| US35102210P | 2010-06-03 | 2010-06-03 | |
| US61/351,022 | 2010-06-03 | ||
| PCT/US2011/037134 WO2011146707A1 (en) | 2010-05-19 | 2011-05-19 | Improved process for a folate-targeted agent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013526577A JP2013526577A (ja) | 2013-06-24 |
| JP2013526577A5 true JP2013526577A5 (enExample) | 2014-07-10 |
Family
ID=44992057
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013511354A Withdrawn JP2013526577A (ja) | 2010-05-19 | 2011-05-19 | 葉酸を標的にする薬剤用の改善されたプロセス |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20130065841A1 (enExample) |
| JP (1) | JP2013526577A (enExample) |
| KR (1) | KR20130079431A (enExample) |
| CN (1) | CN102984943B (enExample) |
| BR (1) | BR112012029458A2 (enExample) |
| CA (1) | CA2799391A1 (enExample) |
| IL (1) | IL222964A0 (enExample) |
| MX (1) | MX2012013250A (enExample) |
| RU (1) | RU2012154914A (enExample) |
| SG (1) | SG185592A1 (enExample) |
| WO (1) | WO2011146707A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6676650B2 (ja) | 2015-03-13 | 2020-04-08 | エンドサイト・インコーポレイテッドＥｎｄｏｃｙｔｅ， Ｉｎｃ． | 疾患を処置するためのコンジュゲート |
| WO2017172930A1 (en) * | 2016-03-29 | 2017-10-05 | Endocyte, Inc. | Pbd conjugates for treating diseases |
| WO2019196999A1 (en) | 2018-04-11 | 2019-10-17 | Radisurf Aps | Compositions for forming polymer brushes |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100381177C (zh) * | 2003-01-27 | 2008-04-16 | 恩多塞特公司 | 维生素受体结合递药缀合物 |
| CN100423778C (zh) * | 2003-11-25 | 2008-10-08 | 上海复旦张江生物医药股份有限公司 | 用于上载抗肿瘤药物的脂质体载体及其制备方法和应用 |
| JP2009504783A (ja) * | 2005-08-19 | 2009-02-05 | エンドサイト，インコーポレイテッド | ビンカアルカロイド、類似体および誘導体のリガンド結合体 |
-
2011
- 2011-05-19 US US13/698,215 patent/US20130065841A1/en not_active Abandoned
- 2011-05-19 WO PCT/US2011/037134 patent/WO2011146707A1/en not_active Ceased
- 2011-05-19 CN CN201180035630.7A patent/CN102984943B/zh not_active Expired - Fee Related
- 2011-05-19 SG SG2012084190A patent/SG185592A1/en unknown
- 2011-05-19 RU RU2012154914/13A patent/RU2012154914A/ru not_active Application Discontinuation
- 2011-05-19 BR BR112012029458A patent/BR112012029458A2/pt not_active IP Right Cessation
- 2011-05-19 KR KR1020127032401A patent/KR20130079431A/ko not_active Withdrawn
- 2011-05-19 CA CA2799391A patent/CA2799391A1/en not_active Abandoned
- 2011-05-19 MX MX2012013250A patent/MX2012013250A/es not_active Application Discontinuation
- 2011-05-19 JP JP2013511354A patent/JP2013526577A/ja not_active Withdrawn
-
2012
- 2012-11-11 IL IL222964A patent/IL222964A0/en unknown
-
2013
- 2013-03-14 US US13/803,150 patent/US20140066593A1/en not_active Abandoned
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