JP2013533213A5 - - Google Patents
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- JP2013533213A5 JP2013533213A5 JP2013510362A JP2013510362A JP2013533213A5 JP 2013533213 A5 JP2013533213 A5 JP 2013533213A5 JP 2013510362 A JP2013510362 A JP 2013510362A JP 2013510362 A JP2013510362 A JP 2013510362A JP 2013533213 A5 JP2013533213 A5 JP 2013533213A5
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- leukemia
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- 206010024324 Leukaemias Diseases 0.000 claims 17
- 239000008194 pharmaceutical composition Substances 0.000 claims 17
- 210000004027 cells Anatomy 0.000 claims 15
- 239000003795 chemical substances by application Substances 0.000 claims 15
- 101700009767 BRD4 Proteins 0.000 claims 8
- 230000002401 inhibitory effect Effects 0.000 claims 6
- 206010000880 Acute myeloid leukaemia Diseases 0.000 claims 5
- 208000007046 Leukemia, Myeloid, Acute Diseases 0.000 claims 5
- 206010008958 Chronic lymphocytic leukaemia Diseases 0.000 claims 4
- 208000000429 Leukemia, Lymphocytic, Chronic, B-Cell Diseases 0.000 claims 4
- 208000008456 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Diseases 0.000 claims 4
- 210000002540 Macrophages Anatomy 0.000 claims 4
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 4
- 201000005510 acute lymphocytic leukemia Diseases 0.000 claims 4
- 201000006934 chronic myeloid leukemia Diseases 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- 230000004069 differentiation Effects 0.000 claims 4
- 230000000694 effects Effects 0.000 claims 4
- 239000003550 marker Substances 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 102100015500 BRD4 Human genes 0.000 claims 2
- 210000003979 Eosinophils Anatomy 0.000 claims 2
- 206010020243 Hodgkin's disease Diseases 0.000 claims 2
- 201000006743 Hodgkin's lymphoma Diseases 0.000 claims 2
- 206010028576 Myeloproliferative disease Diseases 0.000 claims 2
- 206010029592 Non-Hodgkin's lymphomas Diseases 0.000 claims 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- 230000012010 growth Effects 0.000 claims 2
- 210000002768 hair cell Anatomy 0.000 claims 2
- 201000009251 multiple myeloma Diseases 0.000 claims 2
- 201000003793 myelodysplastic syndrome Diseases 0.000 claims 2
- 230000004043 responsiveness Effects 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 230000004083 survival Effects 0.000 claims 2
- 208000000214 Leukemia, Myelomonocytic, Chronic Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 108020004459 Small Interfering RNA Proteins 0.000 claims 1
- 229920001891 Small hairpin RNA Polymers 0.000 claims 1
- 230000001058 adult Effects 0.000 claims 1
- 230000000692 anti-sense Effects 0.000 claims 1
- 230000030833 cell death Effects 0.000 claims 1
- 230000011712 cell development Effects 0.000 claims 1
- 230000010261 cell growth Effects 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 230000001684 chronic Effects 0.000 claims 1
- 201000010902 chronic myelomonocytic leukemia Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 239000002924 silencing RNA Substances 0.000 claims 1
- 239000004055 small Interfering RNA Substances 0.000 claims 1
Claims (22)
- Ｂｒｄ４を阻害する作用物質またはその誘導体を含んでなる、白血病または関連障害を治療するための医薬組成物。
- 前記作用物質が、式Ｉ〜ＸＸＩＩのいずれかの化合物、または本明細書で開示されるいずれかの化合物、またはその誘導体である、請求項１に記載の医薬組成物。
- 前記白血病が、急性骨髄性白血病（ＡＭＬ）、慢性リンパ球性白血病（ＣＬＬ）、急性リンパ球性白血病（ＡＬＬ）、慢性骨髄性白血病（ＣＭＬ）、慢性骨髄単核白血病（ＣＭＭＬ）、好酸球性白血病、有毛細胞白血病、ホジキンリンパ腫、多発性骨髄腫、非ホジキンリンパ腫、骨髄増殖性障害または骨髄異形成症候群である、請求項１に記載の医薬組成物。
- Ｂｒｄ４を阻害する作用物質またはその誘導体を含んでなる、白血病細胞の成長、増殖または生存を低下させるための医薬組成物。
- Ｂｒｄ４を阻害する作用物質またはその誘導体を含んでなる、白血病細胞における細胞死または最終分化を誘導するための医薬組成物。
- 細胞が対象中にある、請求項１〜４のいずれか一項に記載の医薬組成物。
- 細胞が、急性骨髄性白血病（ＡＭＬ）、慢性リンパ球性白血病（ＣＬＬ）、急性リンパ球性白血病（ＡＬＬ）、慢性骨髄性白血病（ＣＭＬ）、慢性骨髄単核白血病（ＣＭＭＬ）、好酸球性白血病、有毛細胞白血病、ホジキンリンパ腫、多発性骨髄腫、非ホジキンリンパ腫、脊髄形成異常症または骨髄増殖性障害に由来する、請求項１〜４のいずれか一項に記載の医薬組成物。
- Ｂｒｄ４を阻害する作用物質を含んでなる、対象において急性骨髄性白血病を治療するための医薬組成物。
- 前記作用物質が、小型化合物または阻害性核酸分子である、請求項１〜８のいずれか一項に記載の医薬組成物。
- 前記小型化合物が、ＪＱ１またはその誘導体である、請求項９に記載の医薬組成物。
- 前記阻害性核酸分子が、ｓｉＲＮＡ、ｓｈＲＮＡまたはアンチセンス核酸分子である、請求項９に記載の医薬組成物。
- 前記対象が哺乳類である、請求項８に記載の医薬組成物。
- 前記対象がヒト患者である、請求項１２に記載の医薬組成物。
- 前記ヒト患者が成人である、請求項１３に記載の医薬組成物。
- 前記ヒト患者が小児である、請求項１３に記載の医薬組成物。
- 前記作用物質が、対象中で白血病細胞の成長、増殖または生存を低下させる、請求項８に記載の医薬組成物。
- 治療効果のある賦形剤中に、Ｂｒｄ４を阻害する作用物質またはその誘導体を含んでなる医薬組成物。
- Ｂｒｄ４を阻害する作用物質、および
請求項８に規定の用途における作用物質の投与のための指示書
を含んでなる、白血病を治療するためのキット。 - 白血病細胞をＢｒｄ４阻害性作用物質またはその誘導体に接触させるステップと、前記細胞中でマクロファージ特異的分化マーカーの発現を検出するステップを含んでなり、前記マクロファージ特異的分化マーカーの発現増大が、前記細胞が前記作用物質に対して応答性であることを示す、白血病細胞の臨床応答性を検出する方法。
- 対象の白血病細胞をＢｒｄ４阻害性作用物質またはその誘導体に接触させるステップと、前記細胞中でマクロファージ特異的分化マーカーの発現を検出するステップを含んでなり、前記マクロファージ特異的分化マーカーの発現増大が、その作用物質を含む治療計画を前記対象のために選択すべきであることを示す、白血病を有すると同定された対象のために、治療計画を選択する方法。
- 白血病細胞をＢｒｄ４阻害性作用物質またはその誘導体に接触させるステップと、前記細胞中のｍｙｃの発現または生物学的活性を検出するステップを含んでなり、ｍｙｃの発現または生物学的活性の低下が、前記細胞が前記作用物質に応答性であることを示す、白血病細胞の臨床応答性を検出する方法。
- 白血病細胞をＢｒｄ４阻害性作用物質またはその誘導体に接触させるステップと、ｍｙｃの発現または生物学的活性を検出するステップを含んでなり、ｍｙｃの発現または生物学的活性の低下が、前記作用物質を含む治療計画を対象のために選択すべきことを示す、前記対象のために治療計画を選択する方法。
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33499110P | 2010-05-14 | 2010-05-14 | |
| US61/334,991 | 2010-05-14 | ||
| US37074510P | 2010-08-04 | 2010-08-04 | |
| US61/370,745 | 2010-08-04 | ||
| US37586310P | 2010-08-22 | 2010-08-22 | |
| US61/375,863 | 2010-08-22 | ||
| US201161467376P | 2011-03-24 | 2011-03-24 | |
| US201161467342P | 2011-03-24 | 2011-03-24 | |
| US61/467,376 | 2011-03-24 | ||
| US61/467,342 | 2011-03-24 | ||
| PCT/US2011/036672 WO2011143660A2 (en) | 2010-05-14 | 2011-05-16 | Compositions and methods for treating leukemia |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015208118A Division JP2016102105A (ja) | 2010-05-14 | 2015-10-22 | 白血病を治療するための組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013533213A JP2013533213A (ja) | 2013-08-22 |
| JP2013533213A5 true JP2013533213A5 (ja) | 2014-07-03 |
| JP5935030B2 JP5935030B2 (ja) | 2016-06-15 |
Family
ID=44915025
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013510362A Active JP5935030B2 (ja) | 2010-05-14 | 2011-05-16 | 白血病を治療するための組成物および方法 |
| JP2015208118A Pending JP2016102105A (ja) | 2010-05-14 | 2015-10-22 | 白血病を治療するための組成物および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015208118A Pending JP2016102105A (ja) | 2010-05-14 | 2015-10-22 | 白血病を治療するための組成物および方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US9815849B2 (ja) |
| EP (1) | EP2569434B1 (ja) |
| JP (2) | JP5935030B2 (ja) |
| CN (2) | CN105582014B (ja) |
| AU (1) | AU2011252799B2 (ja) |
| BR (1) | BR112012029057A2 (ja) |
| CA (1) | CA2799403C (ja) |
| MX (1) | MX354217B (ja) |
| WO (1) | WO2011143660A2 (ja) |
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| JP2017504650A (ja) | 2014-01-31 | 2017-02-09 | ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド | ジアゼパン誘導体およびその使用 |
| WO2015131113A1 (en) | 2014-02-28 | 2015-09-03 | Tensha Therapeutics, Inc. | Treatment of conditions associated with hyperinsulinaemia |
| BR112017008714A2 (pt) | 2014-10-27 | 2017-12-19 | Tensha Therapeutics Inc | inibidores de bromodomínio |
| AU2015358334A1 (en) | 2014-12-05 | 2017-06-08 | Dana-Farber Cancer Institute, Inc. | Bromodomain inhibitor as adjuvant in cancer immunotherapy |
| KR20180035785A (ko) | 2015-06-26 | 2018-04-06 | 텐샤 세러퓨틱스 인코포레이티드 | Nut 중간선 암종의 치료 |
| MX2018003824A (es) | 2015-10-02 | 2019-04-01 | Dana Farber Cancer Inst Inc | Terapia de combinación de inhibidores de bromodominios y bloqueo de puntos de control. |
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