JP2013532636A5 - - Google Patents

Download PDF

Info

Publication number
JP2013532636A5
JP2013532636A5 JP2013519865A JP2013519865A JP2013532636A5 JP 2013532636 A5 JP2013532636 A5 JP 2013532636A5 JP 2013519865 A JP2013519865 A JP 2013519865A JP 2013519865 A JP2013519865 A JP 2013519865A JP 2013532636 A5 JP2013532636 A5 JP 2013532636A5
Authority
JP
Japan
Prior art keywords
alkyl
compound
group
tetramethyl
alkenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2013519865A
Other languages
English (en)
Japanese (ja)
Other versions
JP5819959B2 (ja
JP2013532636A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2011/044283 external-priority patent/WO2012009699A2/en
Publication of JP2013532636A publication Critical patent/JP2013532636A/ja
Publication of JP2013532636A5 publication Critical patent/JP2013532636A5/ja
Application granted granted Critical
Publication of JP5819959B2 publication Critical patent/JP5819959B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2013519865A 2010-07-16 2011-07-15 抗ウイルス性化合物を調製するための方法 Expired - Fee Related JP5819959B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US36529310P 2010-07-16 2010-07-16
US61/365,293 2010-07-16
US201161444475P 2011-02-18 2011-02-18
US61/444,475 2011-02-18
PCT/US2011/044283 WO2012009699A2 (en) 2010-07-16 2011-07-15 Process for preparing antiviral compounds

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015191211A Division JP6162191B2 (ja) 2010-07-16 2015-09-29 抗ウイルス性化合物を調製するための方法

Publications (3)

Publication Number Publication Date
JP2013532636A JP2013532636A (ja) 2013-08-19
JP2013532636A5 true JP2013532636A5 (enExample) 2015-09-10
JP5819959B2 JP5819959B2 (ja) 2015-11-24

Family

ID=45467152

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2013519865A Expired - Fee Related JP5819959B2 (ja) 2010-07-16 2011-07-15 抗ウイルス性化合物を調製するための方法
JP2015191211A Expired - Fee Related JP6162191B2 (ja) 2010-07-16 2015-09-29 抗ウイルス性化合物を調製するための方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2015191211A Expired - Fee Related JP6162191B2 (ja) 2010-07-16 2015-09-29 抗ウイルス性化合物を調製するための方法

Country Status (24)

Country Link
US (1) US8895737B2 (enExample)
EP (3) EP3056486B1 (enExample)
JP (2) JP5819959B2 (enExample)
KR (1) KR101893751B1 (enExample)
CN (2) CN105622525B (enExample)
AU (1) AU2011278927B2 (enExample)
BR (1) BR112013001132A2 (enExample)
CA (1) CA2805748A1 (enExample)
CL (2) CL2013000159A1 (enExample)
CO (1) CO6670583A2 (enExample)
CR (2) CR20180412A (enExample)
DO (1) DOP2013000017A (enExample)
EA (2) EA028082B1 (enExample)
EC (1) ECSP13012438A (enExample)
GT (1) GT201300021A (enExample)
IL (1) IL224222A (enExample)
MX (2) MX344148B (enExample)
MY (1) MY167881A (enExample)
NZ (2) NZ705225A (enExample)
PE (1) PE20131086A1 (enExample)
PH (1) PH12013500105A1 (enExample)
SG (2) SG187102A1 (enExample)
UA (1) UA115025C2 (enExample)
WO (1) WO2012009699A2 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9255074B2 (en) 2010-07-16 2016-02-09 Abbvie Inc. Process for preparing antiviral compounds
US8975443B2 (en) 2010-07-16 2015-03-10 Abbvie Inc. Phosphine ligands for catalytic reactions
US8841487B2 (en) 2010-07-16 2014-09-23 Abbvie Inc. Phosphine ligands for catalytic reactions
NZ705225A (en) * 2010-07-16 2016-11-25 Abbvie Bahamas Ltd Process for preparing antiviral compounds
SG10201602384VA (en) * 2011-03-31 2016-05-30 Konstanze Schäfer Perfluorinated compounds for the non-viral transfer of nucleic acids
WO2014031791A1 (en) * 2012-08-21 2014-02-27 Abbvie Inc. Process for preparing antiviral compounds
TW201542581A (zh) 2013-09-11 2015-11-16 艾默理大學 核苷酸與核苷治療組成物及其相關用途
WO2016054240A1 (en) 2014-09-30 2016-04-07 Sean Dalziel Fixed dose combinations for the treatment of viral diseases
WO2016105547A1 (en) 2014-12-24 2016-06-30 Concert Pharmaceuticals, Inc. Deuterated dasabuvir
JP7129703B2 (ja) 2016-04-28 2022-09-02 エモリー ユニバーシティー アルキン含有ヌクレオチド及びヌクレオシド治療組成物並びにそれらに関連した使用
WO2017202207A1 (zh) * 2016-05-27 2017-11-30 深圳市塔吉瑞生物医药有限公司 一种取代的萘环化合物及药物组合物及其应用
CN110201714B (zh) * 2019-07-04 2022-07-29 蚌埠学院 二氢嘧啶酮类化合物合成方法及催化剂
CN110669006A (zh) * 2019-10-22 2020-01-10 中国科学技术大学 茚并异喹啉类化合物及其制备方法
CN112735799B (zh) * 2020-12-10 2022-12-20 华东理工大学 一种新型磁性材料及其制备方法

Family Cites Families (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4239888A (en) 1974-11-04 1980-12-16 Pfizer Inc. 1-Phenyluracils
JPS60243017A (ja) 1984-05-16 1985-12-03 Kyowa Hakko Kogyo Co Ltd 抗けいれん組成物
US4731472A (en) 1986-03-03 1988-03-15 Merck & Co., Inc. (5,6-dichloro-3-oxo-9A-propyl-2,3,9,9A-tetrahydrofluoren-7-yl)alkanoic acids and alkanimidamides
US4873238A (en) 1988-09-19 1989-10-10 American Home Products Corporation 2-Pyridinecarbothioamides and pharmaceutical compositions comprising the same
US4958023A (en) 1988-09-19 1990-09-18 American Home Products Corporation 2-pyridinecarbothioamides, processes for preparation thereof and pharmaceutical compositions comprising the same
US5084084A (en) 1989-07-14 1992-01-28 Nissan Chemical Industries Ltd. Uracil derivatives and herbicides containing the same as active ingredient
AU627906B2 (en) 1989-07-14 1992-09-03 Nissan Chemical Industries Ltd. Uracil derivatives and herbicides containing the same as active ingredient
DE69129998T2 (de) 1990-02-15 1998-12-24 Takeda Chemical Industries, Ltd., Osaka Pyrimidindionderivate, deren Herstellung und Verwendung
NL9001075A (enExample) 1990-05-04 1991-12-02 Duphar Int Res
US5489682A (en) 1990-11-21 1996-02-06 Massachusetts Institute Of Technology Catalytic asymmetric reduction of enamines
WO1992009545A2 (en) 1990-11-21 1992-06-11 Massachusetts Institute Of Technology New methods for the catalytic reduction of organic substrates
WO1993015089A1 (de) 1992-01-31 1993-08-05 F. Hoffmann-La Roche Ag Diphosphinliganden
JPH05213755A (ja) 1992-02-07 1993-08-24 Nikko Kyodo Co Ltd 肝臓障害治療薬
JP3345476B2 (ja) 1993-05-18 2002-11-18 株式会社東芝 有機非線形光学材料
IT1264813B1 (it) 1993-07-28 1996-10-10 Oxon Italia Spa Procedimento per la preparazione di alcansolfonammidi
DE59407903D1 (de) 1993-10-08 1999-04-15 Hoffmann La Roche Optisch aktive phosphorverbindungen
DE19528305A1 (de) 1995-08-02 1997-02-06 Bayer Ag Substituierte Phenyluracile
WO1997018179A1 (en) 1995-11-14 1997-05-22 Massachusetts Institute Of Technology Replacement solvents for use in chemical synthesis
US6031105A (en) 1996-04-09 2000-02-29 Pfizer Inc Substituted pyridines
US5847166A (en) 1996-10-10 1998-12-08 Massachusetts Institute Of Technology Synthesis of aryl ethers
US20050065353A1 (en) 1996-12-03 2005-03-24 Smith Amos B. Synthetic techniques and intermediates for polyhydroxy dienyl lactones and mimics thereof
US6242616B1 (en) 1996-12-03 2001-06-05 The Trustees Of The University Of Pennsylvania Synthetic techniques and intermediates for polyhydroxy, dienyl lactone derivatives
US6096904A (en) 1996-12-03 2000-08-01 The Trustees Of The University Of Pennsylvania Synthetic techniques and intermediates for polyhydroxy, dienyl lactone derivatives
US5789605A (en) 1996-12-03 1998-08-04 Trustees Of The University Of Pennsylvania Synthetic techniques and intermediates for polyhydroxy, dienyl lactones and mimics thereof
US6870058B2 (en) 1996-12-03 2005-03-22 The Trustees Of The University Of Pennsylvania Compounds which mimic the chemical and biological properties of discodermolide
US6323366B1 (en) 1997-07-29 2001-11-27 Massachusetts Institute Of Technology Arylamine synthesis
WO1999018057A1 (en) 1997-10-06 1999-04-15 Massachusetts Institute Of Technology Preparation of diaryl ether by condensation reactions
US6867310B1 (en) 1997-11-20 2005-03-15 Massachusetts Institute Of Technology Arylation and vinylation of activated carbons
WO1999028290A1 (en) 1997-12-03 1999-06-10 Massachusetts Institute Of Technology Synthesis of oligoarylamines, and uses and reagents related thereto
EP1058678B1 (en) 1998-02-26 2002-12-11 Massachusetts Institute of Technology Metal-catalyzed arylations and vinylations of hydrazines, hydrazones, hydroxylamines and oximes
US6307087B1 (en) 1998-07-10 2001-10-23 Massachusetts Institute Of Technology Ligands for metals and improved metal-catalyzed processes based thereon
US7223879B2 (en) 1998-07-10 2007-05-29 Massachusetts Institute Of Technology Ligands for metals and improved metal-catalyzed processes based thereon
US6395916B1 (en) 1998-07-10 2002-05-28 Massachusetts Institute Of Technology Ligands for metals and improved metal-catalyzed processes based thereon
JP5035813B2 (ja) 1998-07-10 2012-09-26 マサチューセッツ インスティテュート オブ テクノロジー 金属用のリガンドおよびそれらに基づいて改善された金属触媒法
DE19920847A1 (de) 1999-05-06 2000-11-09 Clariant Gmbh Pd- und Ni-Komplexe von Biphenyl-2-yl-phosphanen und ihre Anwendung in katalytischen C,C-,N- und C,O-Kupplungen
WO2001019761A2 (en) 1999-09-15 2001-03-22 Massachusetts Institute Of Technology Asymmetric 1,4-reductions of and 1,4-additions to enoates and related systems
CA2391966A1 (en) 1999-11-24 2001-05-31 Massachusetts Institute Of Technology Protecting groups useful in the synthesis of polysaccharides, natural products, and combinatorial libraries
DE60034061T2 (de) 1999-12-06 2007-12-13 F. Hoffmann-La Roche Ag 4-pyrimidinyl-n-acyl-l-phenylanine
US6380387B1 (en) 1999-12-06 2002-04-30 Hoffmann-La Roche Inc. 4-Pyrimidinyl-n-acyl-l phenylalanines
IL167957A (en) 2000-02-04 2009-07-20 Sumitomo Chemical Co Hydroxypyridine compounds
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
US6624159B2 (en) 2000-07-12 2003-09-23 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
KR20030092107A (ko) 2001-04-24 2003-12-03 메사추세츠 인스티튜트 오브 테크놀로지 탄소-헤테로원자 및 탄소-탄소 결합을 형성하는 구리-촉매방법
CA2446716A1 (en) * 2001-06-05 2002-12-12 Eli Lilly And Company Sulfonamide derivatives
US7652031B2 (en) 2001-08-07 2010-01-26 The Trustees Of The University Of Pennsylvania Compounds which mimic the chemical and biological properties of discodermolide
DE10162700A1 (de) * 2001-12-19 2003-07-03 Merck Patent Gmbh Dioxathianone
JP2005530681A (ja) 2001-12-20 2005-10-13 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー ピリドキノキサリン抗ウイルス剤
AU2003217232A1 (en) 2002-02-04 2003-09-02 Massachusetts Institute Of Technology Transition-metal-catalyzed carbon-nitrogen bond-forming methods using carbene ligands
ITMI20020415A1 (it) 2002-03-01 2003-09-01 Chemi Spa Catalizzatori metallici per reazione chemo- regio- stereo-selettive erelativi precursori
US6888032B2 (en) 2002-08-02 2005-05-03 Massachusetts Institute Of Technology Copper-catalyzed formation of carbon-heteroatom and carbon-carbon bonds
US20050113450A1 (en) 2002-08-23 2005-05-26 Atli Thorarensen Antibacterial agents
US20040110802A1 (en) 2002-08-23 2004-06-10 Atli Thorarensen Antibacterial benzoic acid derivatives
US20040142981A1 (en) 2002-08-23 2004-07-22 Atli Thorarensen Antibacterial benzoic acid derivatives
US7208490B2 (en) 2002-10-07 2007-04-24 Pharmacia & Upjohn Company Llc Tricyclic tetrahydroquinoline antibacterial agents
US20040097492A1 (en) * 2002-11-01 2004-05-20 Pratt John K Anti-infective agents
EP2583958B1 (en) 2002-12-09 2016-08-10 Massachusetts Institute of Technology (MIT) Ligands for metals and improved metal-catalyzed processes based thereon
US7163937B2 (en) 2003-08-21 2007-01-16 Bristol-Myers Squibb Company Cyclic derivatives as modulators of chemokine receptor activity
CA2548518A1 (en) 2003-12-04 2005-07-07 Wyeth Biaryl sulfonamides as mmp inhibitors
US7507832B2 (en) 2003-12-22 2009-03-24 Eli Lilly And Company Triazole PPAR modulators
DE602005009017D1 (de) 2004-11-10 2008-09-25 Pfizer Substituierte n-sulfonylaminobenzyl-2-phenoxyacetamidverbindungen
SE0403006D0 (sv) 2004-12-09 2004-12-09 Biovitrum Ab New compounds
GB0427403D0 (en) 2004-12-15 2005-01-19 Astrazeneca Ab Novel compounds I
ATE446962T1 (de) 2004-12-17 2009-11-15 Lilly Co Eli Thiazolopyridinon-derivate als mch- rezeptorantagonisten
EP1833605B1 (en) 2005-01-10 2018-08-15 Massachusetts Institute Of Technology Palladium-catalyzed carbon-nitrogen and carbon-carbon bond-forming reactions
EP1858865B1 (en) 2005-03-10 2009-09-16 Pfizer Inc. Substituted n-sulfonylaminophenylethyl-2-phenoxy acetamide compounds
EA200701745A1 (ru) 2005-03-17 2008-06-30 Пфайзер, Инк. Циклопропанкарбоксамидные производные
JP2009536657A (ja) 2006-05-10 2009-10-15 レノビス, インコーポレイテッド イオンチャンネルリガンドとしてのアミド誘導体およびそれを用いる医薬組成物および方法
GB0713686D0 (en) 2007-07-13 2007-08-22 Addex Pharmaceuticals Sa New compounds 2
US8258131B2 (en) 2007-08-01 2012-09-04 Mitsubishi Tanabe Pharma Corporation Fused bicyclic compound
WO2009039134A1 (en) * 2007-09-17 2009-03-26 Abbott Laboratories Anti-infective pyrimidines and uses thereof
HRP20110632T1 (hr) 2007-09-17 2011-10-31 Abbott Laboratories N-fenil-diokso-hidropirimidini korisni kao inhibitori virusa hepatitisa c (hcv)
AR070027A1 (es) 2007-09-17 2010-03-10 Abbott Lab Agentes anti-infecciosos contra el virus hcv
CN101952298B (zh) 2007-12-12 2015-06-17 麻省理工学院 用于过渡金属催化的交联偶合反应的配体及其使用方法
MX2011000656A (es) 2008-07-23 2011-02-23 Hoffmann La Roche Compuestos heterociclicos antiviricos.
EP2184273A1 (de) 2008-11-05 2010-05-12 Bayer CropScience AG Halogen-substituierte Verbindungen als Pestizide
JP5326510B2 (ja) 2008-11-11 2013-10-30 セントラル硝子株式会社 α−置換エステル類の製造方法
ES2488821T3 (es) 2009-03-24 2014-08-29 Abbvie Bahamas Ltd. Proceso de preparación de un compuesto antiviral
CN102803212A (zh) 2009-06-24 2012-11-28 弗·哈夫曼-拉罗切有限公司 抗病毒的杂环化合物
US20110005533A1 (en) 2009-07-07 2011-01-13 Evans Douglas J Mold For a Smoking Device
US20110015401A1 (en) 2009-07-13 2011-01-20 Massachusetts Institute Of Technology Metal-Catalyzed Carbon-Fluorine Bond Formation
WO2011008618A1 (en) 2009-07-13 2011-01-20 National University Of Singapore Metal-catalyzed carbon-fluorine bond formation
AR079170A1 (es) 2009-12-10 2011-12-28 Lilly Co Eli Compuesto de ciclopropil-benzamida-imidazo-benzazepina inhibidor de diacil-glicerol aciltransferasa, sal del mismo, composicion farmaceutica que lo comprende, su uso para preparar un medicamento util para el tratamiento de obesidad o para mejorar la sensibilidad a insulina y compuesto intermedio par
JP5848712B2 (ja) 2009-12-11 2016-01-27 ノノ インコーポレイテッド 虚血性疾患および他の疾患を治療するための薬剤および方法
US20130022629A1 (en) 2010-01-04 2013-01-24 Sharpe Arlene H Modulators of Immunoinhibitory Receptor PD-1, and Methods of Use Thereof
FR2958289B1 (fr) 2010-03-30 2012-06-15 Sanofi Aventis Procede de preparation de derives de 3-ceto-benzofurane
WO2011133795A2 (en) 2010-04-22 2011-10-27 The Brigham And Women's Hospital, Inc. Beta-carbolines as inhibitors of haspin and dyrk kinases
WO2011146358A1 (en) 2010-05-21 2011-11-24 Merck Sharp & Dohme Corp. Substituted seven-membered heterocyclic compounds as dipeptidyl peptidase-iv inhibitors for the treatment of diabetes
NZ705225A (en) * 2010-07-16 2016-11-25 Abbvie Bahamas Ltd Process for preparing antiviral compounds
US8841487B2 (en) 2010-07-16 2014-09-23 Abbvie Inc. Phosphine ligands for catalytic reactions

Similar Documents

Publication Publication Date Title
Fu et al. Palladium-catalyzed air-based oxidative coupling of arylboronic acids with H-phosphine oxides leading to aryl phosphine oxides
KR101893751B1 (ko) 항바이러스성 화합물의 제조 방법
JP6800334B2 (ja) Btk阻害剤を調製するプロセス
TWI663155B (zh) 製造嘧啶磺醯胺衍生物之方法
JP5803042B2 (ja) クロスカップリング反応におけるモノリン配位子及びそれらの使用
CN105073716B (zh) 嘧啶中间物的制备
KR20070092307A (ko) 로수바스타틴 제조 방법
JP2018525391A (ja) 芳香族またはビニル系化合物をホウ素含有化合物にカップリングさせるための方法
KR102472711B1 (ko) 트리아진, 피리미딘 및 피리딘 유도체의 신규한 제조방법
CN107250141A (zh) 磷配体及使用方法
CN103443111B (zh) 钌配合物以及以该配合物作为催化剂的光学活性醇化合物的制备方法
CN104884440A (zh) 用于制备抗病毒化合物的方法
JP2017531635A (ja) フルオロスルホネート化合物をアミン化合物にカップリングさせるための方法
JP2017105717A (ja) カップリング反応副生物の低減方法
CN108586519A (zh) 一种有机硅烷或有机锗烷衍生物的制备方法
TWI618729B (zh) 聚芳基聚合物之形成方法及由此形成之聚合物
CN105294573B (zh) 一种合成4,6-二氯-2-(丙硫基)-5-氨基嘧啶的方法
JP7117796B2 (ja) 化合物並びにブリバラセタム(Brivaracetam)の中間体及び原薬の合成におけるその用途
EP3484842B1 (en) Halogen-containing metathesis catalysts and methods thereof
CN103242378A (zh) 二茂铁基嘧啶钳形配体及其制备方法
JP2021066737A (ja) カップリング化合物の製造方法
CN105061387A (zh) 二芳基醚类稠环类化合物、制备方法和用途
CN103242372A (zh) 苯并喹啉三苯基膦环铱氢加合物及其制备方法和用途
EP3237383B1 (en) One-step process for the synthesis of alkylated metyrapone analogs
CN104619683A (zh) 用于制备任选地取代的苯基和吡啶基吡咯烷类的方法