JP2013530950A5 - - Google Patents
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- Publication number
- JP2013530950A5 JP2013530950A5 JP2013511591A JP2013511591A JP2013530950A5 JP 2013530950 A5 JP2013530950 A5 JP 2013530950A5 JP 2013511591 A JP2013511591 A JP 2013511591A JP 2013511591 A JP2013511591 A JP 2013511591A JP 2013530950 A5 JP2013530950 A5 JP 2013530950A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody preparation
- process according
- igm
- solution
- immunoglobulin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 23
- 238000002360 preparation method Methods 0.000 claims 19
- 108060003951 Immunoglobulin Proteins 0.000 claims 15
- 102000018358 immunoglobulin Human genes 0.000 claims 15
- 239000000243 solution Substances 0.000 claims 14
- 239000000203 mixture Substances 0.000 claims 6
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 4
- 238000011534 incubation Methods 0.000 claims 4
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 3
- 239000000706 filtrate Substances 0.000 claims 3
- 239000011259 mixed solution Substances 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- BFSVOASYOCHEOV-UHFFFAOYSA-N 2-diethylaminoethanol Chemical compound CCN(CC)CCO BFSVOASYOCHEOV-UHFFFAOYSA-N 0.000 claims 2
- 239000004471 Glycine Substances 0.000 claims 2
- 108091005804 Peptidases Proteins 0.000 claims 2
- 239000004365 Protease Substances 0.000 claims 2
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 2
- 229920005654 Sephadex Polymers 0.000 claims 2
- 239000012507 Sephadex™ Substances 0.000 claims 2
- 238000011118 depth filtration Methods 0.000 claims 2
- 208000026278 immune system disease Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000001728 nano-filtration Methods 0.000 claims 2
- 244000309711 non-enveloped viruses Species 0.000 claims 2
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims 2
- 239000011148 porous material Substances 0.000 claims 2
- 230000002797 proteolythic effect Effects 0.000 claims 2
- 239000003381 stabilizer Substances 0.000 claims 2
- 208000035143 Bacterial infection Diseases 0.000 claims 1
- 108010035369 Cohn fraction I Proteins 0.000 claims 1
- 108010044316 Cohn fraction III Proteins 0.000 claims 1
- 102000057297 Pepsin A Human genes 0.000 claims 1
- 108090000284 Pepsin A Proteins 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- OBETXYAYXDNJHR-UHFFFAOYSA-N alpha-ethylcaproic acid Natural products CCCCC(CC)C(O)=O OBETXYAYXDNJHR-UHFFFAOYSA-N 0.000 claims 1
- 230000002391 anti-complement effect Effects 0.000 claims 1
- 108010008730 anticomplement Proteins 0.000 claims 1
- 208000022362 bacterial infectious disease Diseases 0.000 claims 1
- VEZXCJBBBCKRPI-UHFFFAOYSA-N beta-propiolactone Chemical compound O=C1CCO1 VEZXCJBBBCKRPI-UHFFFAOYSA-N 0.000 claims 1
- 230000007812 deficiency Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 238000011049 filling Methods 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 210000002196 fr. b Anatomy 0.000 claims 1
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims 1
- 229940072221 immunoglobulins Drugs 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 238000002156 mixing Methods 0.000 claims 1
- 229940111202 pepsin Drugs 0.000 claims 1
- 239000002244 precipitate Substances 0.000 claims 1
- 229960000380 propiolactone Drugs 0.000 claims 1
- 238000000108 ultra-filtration Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1006753.6 | 2010-04-22 | ||
| GBGB1006753.6A GB201006753D0 (en) | 2010-04-22 | 2010-04-22 | Process for preparing an immunolobulin composition |
| PCT/EP2011/056486 WO2011131786A2 (en) | 2010-04-22 | 2011-04-21 | Process for preparing an immunoglobulin composition |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016110121A Division JP6612182B2 (ja) | 2010-04-22 | 2016-06-01 | 免疫グロブリン組成物を調製するためのプロセス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013530950A JP2013530950A (ja) | 2013-08-01 |
| JP2013530950A5 true JP2013530950A5 (cg-RX-API-DMAC7.html) | 2014-06-05 |
| JP6118248B2 JP6118248B2 (ja) | 2017-04-19 |
Family
ID=42270688
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013511591A Active JP6118248B2 (ja) | 2010-04-22 | 2011-04-21 | 免疫グロブリン組成物を調製するためのプロセス |
| JP2013511592A Active JP6283517B2 (ja) | 2010-04-22 | 2011-04-21 | 抗体調製物 |
| JP2016110121A Active JP6612182B2 (ja) | 2010-04-22 | 2016-06-01 | 免疫グロブリン組成物を調製するためのプロセス |
| JP2016118887A Active JP6612186B2 (ja) | 2010-04-22 | 2016-06-15 | 抗体調製物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013511592A Active JP6283517B2 (ja) | 2010-04-22 | 2011-04-21 | 抗体調製物 |
| JP2016110121A Active JP6612182B2 (ja) | 2010-04-22 | 2016-06-01 | 免疫グロブリン組成物を調製するためのプロセス |
| JP2016118887A Active JP6612186B2 (ja) | 2010-04-22 | 2016-06-15 | 抗体調製物 |
Country Status (18)
| Country | Link |
|---|---|
| US (6) | US9243056B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP2560691B1 (cg-RX-API-DMAC7.html) |
| JP (4) | JP6118248B2 (cg-RX-API-DMAC7.html) |
| KR (2) | KR101860459B1 (cg-RX-API-DMAC7.html) |
| CN (3) | CN107080842A (cg-RX-API-DMAC7.html) |
| AU (2) | AU2011244241B2 (cg-RX-API-DMAC7.html) |
| CA (2) | CA2796409A1 (cg-RX-API-DMAC7.html) |
| CO (2) | CO6640238A2 (cg-RX-API-DMAC7.html) |
| ES (2) | ES2553385T3 (cg-RX-API-DMAC7.html) |
| GB (1) | GB201006753D0 (cg-RX-API-DMAC7.html) |
| HU (2) | HUE025853T2 (cg-RX-API-DMAC7.html) |
| IL (2) | IL222374A (cg-RX-API-DMAC7.html) |
| MX (2) | MX338195B (cg-RX-API-DMAC7.html) |
| PL (2) | PL2560682T5 (cg-RX-API-DMAC7.html) |
| RU (4) | RU2617532C2 (cg-RX-API-DMAC7.html) |
| SG (2) | SG184844A1 (cg-RX-API-DMAC7.html) |
| WO (2) | WO2011131787A2 (cg-RX-API-DMAC7.html) |
| ZA (2) | ZA201208541B (cg-RX-API-DMAC7.html) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201006753D0 (en) | 2010-04-22 | 2010-06-09 | Biotest Ag | Process for preparing an immunolobulin composition |
| FR2959821B1 (fr) * | 2010-05-05 | 2012-07-06 | Lab Francais Du Fractionnement | Procede de mesure de l'activation du complement par des igg |
| FR2974301B1 (fr) | 2011-04-20 | 2013-08-23 | Lab Francais Du Fractionnement | Procede de preparation d'un produit plasmatique deplete en un ou plusieurs facteurs thrombogenes |
| FR2977893B1 (fr) * | 2011-07-11 | 2015-02-20 | Lab Francais Du Fractionnement | Procede de preparation d'un concentre d'immunoglobulines polyvalentes |
| PL2822967T3 (pl) | 2012-03-09 | 2020-01-31 | Csl Behring Ag | Kompozycje zawierające immunoglobuliny typu wydzielniczego |
| EP2636681A1 (en) | 2012-03-09 | 2013-09-11 | CSL Behring AG | Process for enriching IgA |
| EP2636684A1 (en) | 2012-03-09 | 2013-09-11 | CSL Behring AG | Prevention of infection |
| KR20150115639A (ko) * | 2014-04-04 | 2015-10-14 | 전숙영 | 치료용 면역글로불린 제제 제조에 사용되는 산성 완충액, 이를 이용한 치료용 면역글로불린 제제 제조방법 및 이 제조방법으로 제조된 치료용 면역글로불린 제제 |
| WO2016011054A2 (en) * | 2014-07-15 | 2016-01-21 | The Regents Of The University Of California | Novel treatment for polycystic kidney disease |
| WO2017027861A1 (en) | 2015-08-13 | 2017-02-16 | Amgen Inc. | Charged depth filtration of antigen-binding proteins |
| ES2881201T3 (es) | 2016-03-14 | 2021-11-29 | Biotest Ag | Tratamiento de la neumonía grave adquirida en la comunidad |
| EP3275897A1 (en) * | 2016-07-27 | 2018-01-31 | Biotest AG | Process for preparing immunoglobulin compositions |
| RU2660584C1 (ru) * | 2017-06-06 | 2018-07-06 | Федеральное государственное бюджетное учреждение науки "Кировский научно-исследовательский институт гематологии и переливания крови Федерального медико-биологического агентства" | Способ определения FC-функции препаратов иммуноглобулина человека |
| EP3717916B1 (en) * | 2017-11-29 | 2025-01-01 | F. Hoffmann-La Roche AG | Target interference suppressed anti-drug antibody assay |
| EP3747903A1 (en) | 2019-06-07 | 2020-12-09 | Biotest AG | Method and kit for testing potency of immunoglobulin compositions |
| BR112022020211A2 (pt) * | 2020-04-10 | 2022-11-22 | Vanudis GmbH | Anticorpos naturais em profilaxia e terapia |
| JP2023527864A (ja) * | 2020-06-03 | 2023-06-30 | グリフォルス・ワールドワイド・オペレーションズ・リミテッド | 過免疫ｉｇｇ及び／又はｉｇｍ組成物及びその調製方法及び過免疫ヒト血漿をドナーから得る方法 |
| US20240010710A1 (en) * | 2020-07-10 | 2024-01-11 | Grifols Worldwide Operations Limited | Method for obtaining a composition comprising human plasma-derived immunoglobulin m |
| CN111944043B (zh) * | 2020-09-01 | 2023-05-09 | 华兰生物工程重庆有限公司 | 一种从血浆废弃物中提取IgM的方法 |
| EP4193155A1 (en) | 2020-11-19 | 2023-06-14 | Biotest AG | Method and kit for testing immunomodulatory potency of immunoglobulin compositions, e.g., for treatment of covid-19 |
| MX2024001187A (es) | 2021-07-29 | 2024-02-27 | Csl Behring Ag | Metodo para purificar inmunoglobulina g y usos de la misma. |
| KR20250161658A (ko) | 2023-03-29 | 2025-11-17 | 체에스엘 베링 아게 | 부작용과 관련된 면역글로불린을 식별하는 방법 |
| WO2025008781A1 (en) | 2023-07-04 | 2025-01-09 | Csl Behring Ag | Method of purification |
| WO2025229607A1 (en) | 2024-05-03 | 2025-11-06 | Csl Behring Ag | Systems and methods for solid-liquid separation |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US136556A (en) | 1873-03-04 | Improvements in button-fastenings | ||
| DE2901822A1 (de) * | 1979-01-18 | 1980-07-31 | Biotest Serum Institut Gmbh | Verfahren zur herstellung einer fuer die intravenoese applikation geeigneten immunglobulinloesung, die igm in ankonzentrierter form enthaelt |
| US4371520A (en) * | 1981-10-28 | 1983-02-01 | The Green Cross Corporation | Process for preparing immunoglobulin suitable for intravenous injection |
| DE3310150A1 (de) * | 1983-03-21 | 1984-09-27 | Lentia GmbH Chem. u. pharm. Erzeugnisse - Industriebedarf, 8000 München | Verfahren zur herstellung einer nebenwirkungsfreien igg-immunglobulinloesung fuer die intravenoese applikation |
| IL90281A (en) | 1988-06-06 | 1994-10-07 | Miles Inc | Preparations containing MGI antibodies |
| DE3825429C2 (de) | 1988-07-27 | 1994-02-10 | Biotest Pharma Gmbh | Verfahren zur Herstellung eines intravenös verabreichbaren polyklonalen Immunglobulin-Präparates mit hohem IgM-Gehalt |
| US4939176A (en) | 1988-12-20 | 1990-07-03 | Miles Inc. | Viral inactivation process |
| DE3927111C3 (de) * | 1989-08-17 | 1994-09-01 | Biotest Pharma Gmbh | Verfahren zur Herstellung nicht modifizierter intravenös verabreichbarer IgM- und/oderIgA-haltiger Immunglobulinpräparate |
| DE3927112C1 (cg-RX-API-DMAC7.html) * | 1989-08-17 | 1990-10-25 | Biotest Pharma Gmbh, 6072 Dreieich, De | |
| US5256771A (en) | 1990-04-03 | 1993-10-26 | Miles Inc. | Heat treatment of IgM-containing immunoglobulins to eliminate non-specific complement activation |
| US5367054A (en) * | 1993-04-12 | 1994-11-22 | Stolle Research & Development Corp. | Large-scale purification of egg immunoglobulin |
| ATE367830T1 (de) | 1995-07-14 | 2007-08-15 | Caf Dcf Cvba Scrl | Vorrichtung zur inaktivierung von viralen kontaminationen in blutprodukten |
| DK0764658T3 (da) | 1995-09-22 | 2002-04-22 | Zlb Bioplasma Ag | Fremgangsmåde til fremstilling af immunoglobuliner ud fra fraktioner, som opstår ved fraktionering af blodplasma fra mennesker |
| EP0835880A1 (de) | 1996-10-14 | 1998-04-15 | Rotkreuzstiftung Zentrallaboratorium Blutspendedienst Srk | Verfahren zur Herstellung eines IgM Präparates für die intravenöse Applikation |
| JP3987599B2 (ja) * | 1996-12-05 | 2007-10-10 | 日本製薬株式会社 | 筋ジストロフィー治療剤 |
| JPH10167894A (ja) * | 1996-12-11 | 1998-06-23 | Mitsubishi Gas Chem Co Inc | ビスマス置換希土類鉄ガーネット単結晶膜の製造法 |
| US6955917B2 (en) * | 1997-06-20 | 2005-10-18 | Bayer Healthcare Llc | Chromatographic method for high yield purification and viral inactivation of antibodies |
| US5886154A (en) | 1997-06-20 | 1999-03-23 | Lebing; Wytold R. | Chromatographic method for high yield purification and viral inactivation of antibodies |
| EP2272870B1 (en) | 1998-06-09 | 2013-05-08 | CSL Behring AG | Process for manufacturing immunoglobulins for intravenous administration and other immunoglobulin-like products |
| RU2178309C2 (ru) * | 2000-01-12 | 2002-01-20 | Российский научно-исследовательский институт геронтологии | Антитимоцитарный глобулин для внутривенного введения и способ его получения |
| RU2192279C2 (ru) * | 2000-09-07 | 2002-11-10 | Нижегородское государственное предприятие по производству бактерийных препаратов | Способ получения иммуноглобулинового препарата |
| WO2002038191A2 (en) | 2000-11-13 | 2002-05-16 | Bayer Aktiengesellschaft | Method of inactivating microorganisms in a fluid using ultraviolet radiation |
| FR2824568B1 (fr) | 2001-05-11 | 2004-04-09 | Lab Francais Du Fractionnement | Procede de preparation de concentres d'immunoglobulines humaines a usage therapeutique |
| US7727974B2 (en) | 2001-08-10 | 2010-06-01 | Eisai R & D Management Co., Ltd. | Methods of reducing the severity of mucositis |
| WO2003037504A1 (en) | 2001-11-02 | 2003-05-08 | Japan Techno Co., Ltd. | Vibratory stirrer for sterilization and sterilizer and sterilization method employing vibratory stirrer |
| RU2255766C2 (ru) * | 2003-03-05 | 2005-07-10 | Государственное учреждение "Московский научно-исследовательский институт эпидемиологии и микробиологии им. Г.Н. Габрического Министерства здравоохранения Российской Федерации" | Способ получения иммуноглобулинового препарата для профилактики и терапии бактериальных и вирусных инфекций, иммуноглобулиновый препарат для профилактики и терапии бактериальных и вирусных инфекций (варианты) и суппозитории на основе иммуноглобулинового препарата |
| WO2004087735A2 (en) | 2003-03-26 | 2004-10-14 | The University Of Texas | Proteolytic and covalent antibodies |
| DK2336172T3 (en) | 2003-10-27 | 2015-01-26 | Wyeth Llc | The removal of aggregates of high molecular weight by hydroxylapatite chromatography |
| EP1532983A1 (en) | 2003-11-18 | 2005-05-25 | ZLB Bioplasma AG | Immunoglobulin preparations having increased stability |
| EP1709077A1 (en) | 2004-01-30 | 2006-10-11 | Suomen Punainen Risti Veripalvelu | Process for the manufacture of virus safe immunoglobulin |
| EP1718675B2 (en) | 2004-02-27 | 2017-01-25 | Octapharma AG | A method of providing a purified, virus safe antibody preparation |
| DE602005021694D1 (de) | 2004-12-10 | 2010-07-15 | Novimmune Sa | Kombinationstherapien gegen multiple toll-like-rezeptoren und ihre verwendung |
| WO2006064373A2 (en) | 2004-12-16 | 2006-06-22 | Genzyme Polyclonals S.A.S. | Methods of purifying immunologlobulins |
| KR101157174B1 (ko) | 2005-11-24 | 2012-06-20 | 삼성전자주식회사 | 세포 또는 바이러스의 신속한 파괴 방법 및 장치 |
| DE102005062634A1 (de) | 2005-12-23 | 2007-06-28 | Blutspendedienst der Landesverbände des Deutschen Roten Kreuzes Niedersachsen, Sachsen-Anhalt, Thüringen, Oldenburg und Bremen gGmbH | Verfahren zur Inaktivierung von Pathogenen in Spenderblut, Blutplasma oder Erythrozytenkonzentraten in flexiblen Behältnissen unter Bewegung |
| FR2899111B1 (fr) | 2006-03-31 | 2010-09-03 | Lab Francais Du Fractionnement | Concentre d'immunoglobulines specifiques du chikungunya en tant que medicament. |
| FR2899112B1 (fr) * | 2006-03-31 | 2010-09-03 | Lab Francais Du Fractionnement | Concentre d'immunoglobulines et de fragments f (ab)'2 et/ou fab specifiques d'un arbovirus en tant que medicament. |
| US8354076B2 (en) | 2006-10-02 | 2013-01-15 | Palo Alto Research Center Incorporated | Fluid stirring mechanism |
| EP1950225A1 (de) | 2007-01-25 | 2008-07-30 | Octapharma AG | Verfahren zur Steigerung von Proteinausbeuten |
| CA2760493A1 (en) | 2008-05-12 | 2009-11-19 | Strox Biopharmaceuticals, Llc | Staphylococcus aureus-specific antibody preparations |
| RU2457863C2 (ru) * | 2008-08-05 | 2012-08-10 | Виктор Владимирович Чалов | Композиция, обладающая противовирусным и антимикробным действием, содержащая консорциум иммуноглобулинов |
| RU2457861C2 (ru) * | 2008-08-05 | 2012-08-10 | Виктор Владимирович Чалов | Композиция, обладающая противовирусным и антимикробным действием, содержащая консорциум иммуноглобулинов |
| GB201006753D0 (en) | 2010-04-22 | 2010-06-09 | Biotest Ag | Process for preparing an immunolobulin composition |
| NZ591514A (en) | 2011-03-03 | 2013-11-29 | Kode Biotech Ltd | Assay method |
-
2010
- 2010-04-22 GB GBGB1006753.6A patent/GB201006753D0/en not_active Ceased
-
2011
- 2011-04-21 RU RU2012149741A patent/RU2617532C2/ru active
- 2011-04-21 JP JP2013511591A patent/JP6118248B2/ja active Active
- 2011-04-21 WO PCT/EP2011/056487 patent/WO2011131787A2/en not_active Ceased
- 2011-04-21 HU HUE11715567A patent/HUE025853T2/en unknown
- 2011-04-21 PL PL11715567.1T patent/PL2560682T5/pl unknown
- 2011-04-21 WO PCT/EP2011/056486 patent/WO2011131786A2/en not_active Ceased
- 2011-04-21 RU RU2017111820A patent/RU2749732C2/ru active
- 2011-04-21 EP EP11715928.5A patent/EP2560691B1/en active Active
- 2011-04-21 CA CA2796409A patent/CA2796409A1/en not_active Abandoned
- 2011-04-21 CN CN201611045494.0A patent/CN107080842A/zh active Pending
- 2011-04-21 ES ES11715928.5T patent/ES2553385T3/es active Active
- 2011-04-21 MX MX2012012263A patent/MX338195B/es active IP Right Grant
- 2011-04-21 ES ES11715567T patent/ES2551605T5/es active Active
- 2011-04-21 RU RU2016140455A patent/RU2765738C2/ru active
- 2011-04-21 JP JP2013511592A patent/JP6283517B2/ja active Active
- 2011-04-21 KR KR1020127030528A patent/KR101860459B1/ko active Active
- 2011-04-21 CA CA2796263A patent/CA2796263C/en active Active
- 2011-04-21 SG SG2012076063A patent/SG184844A1/en unknown
- 2011-04-21 PL PL11715928T patent/PL2560691T3/pl unknown
- 2011-04-21 HU HUE11715928A patent/HUE028581T2/en unknown
- 2011-04-21 RU RU2012149743A patent/RU2612899C2/ru active
- 2011-04-21 MX MX2012012262A patent/MX337060B/es active IP Right Grant
- 2011-04-21 EP EP11715567.1A patent/EP2560682B2/en active Active
- 2011-04-21 AU AU2011244241A patent/AU2011244241B2/en active Active
- 2011-04-21 AU AU2011244240A patent/AU2011244240B2/en active Active
- 2011-04-21 CN CN201180029337.XA patent/CN102939107B/zh active Active
- 2011-04-21 SG SG2012076055A patent/SG184843A1/en unknown
- 2011-04-21 KR KR1020127030527A patent/KR101872747B1/ko active Active
- 2011-04-21 CN CN201180029338.4A patent/CN102939111B/zh active Active
-
2012
- 2012-10-11 IL IL222374A patent/IL222374A/en active IP Right Grant
- 2012-10-11 IL IL222373A patent/IL222373A/en active IP Right Grant
- 2012-10-19 US US13/655,649 patent/US9243056B2/en active Active
- 2012-10-19 US US13/655,686 patent/US8900806B2/en active Active
- 2012-11-13 ZA ZA2012/08541A patent/ZA201208541B/en unknown
- 2012-11-13 ZA ZA2012/08540A patent/ZA201208540B/en unknown
- 2012-11-22 CO CO12211854A patent/CO6640238A2/es not_active Application Discontinuation
- 2012-11-22 CO CO12211856A patent/CO6640239A2/es unknown
-
2014
- 2014-10-31 US US14/529,400 patent/US9518110B2/en active Active
-
2016
- 2016-06-01 JP JP2016110121A patent/JP6612182B2/ja active Active
- 2016-06-15 JP JP2016118887A patent/JP6612186B2/ja active Active
- 2016-11-10 US US15/348,121 patent/US10059759B2/en active Active
-
2018
- 2018-07-09 US US16/029,781 patent/US10954290B2/en active Active
-
2021
- 2021-02-05 US US17/168,848 patent/US11780909B2/en active Active
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