JP2013529064A5 - - Google Patents
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- Publication number
- JP2013529064A5 JP2013529064A5 JP2013502705A JP2013502705A JP2013529064A5 JP 2013529064 A5 JP2013529064 A5 JP 2013529064A5 JP 2013502705 A JP2013502705 A JP 2013502705A JP 2013502705 A JP2013502705 A JP 2013502705A JP 2013529064 A5 JP2013529064 A5 JP 2013529064A5
- Authority
- JP
- Japan
- Prior art keywords
- toxin protein
- host cell
- recombinant
- fused
- recombinant toxin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31915210P | 2010-03-30 | 2010-03-30 | |
| US61/319,152 | 2010-03-30 | ||
| USPCT/US2010/030573 | 2010-04-09 | ||
| PCT/US2010/030573 WO2011123139A1 (en) | 2010-03-30 | 2010-04-09 | High level expression of recombinant crm197 |
| US32523510P | 2010-04-16 | 2010-04-16 | |
| US61/325,235 | 2010-04-16 | ||
| PCT/US2011/030227 WO2011126811A2 (en) | 2010-03-30 | 2011-03-28 | High level expression of recombinant toxin proteins |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013529064A JP2013529064A (ja) | 2013-07-18 |
| JP2013529064A5 true JP2013529064A5 (https=) | 2014-04-17 |
| JP5839411B2 JP5839411B2 (ja) | 2016-01-06 |
Family
ID=44763483
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013502705A Active JP5839411B2 (ja) | 2010-03-30 | 2011-03-28 | 組み換え型毒素タンパク質の高レベルの発現 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US8530171B2 (https=) |
| EP (1) | EP2553102B1 (https=) |
| JP (1) | JP5839411B2 (https=) |
| KR (1) | KR20130072201A (https=) |
| CN (1) | CN102869778B (https=) |
| AU (1) | AU2011238711B2 (https=) |
| CA (1) | CA2793978C (https=) |
| MX (1) | MX343356B (https=) |
| NZ (1) | NZ602958A (https=) |
| WO (1) | WO2011126811A2 (https=) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7527797B1 (en) | 2000-09-01 | 2009-05-05 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Vibrio cholerae 0139 conjugate vaccines |
| GB0917647D0 (en) | 2009-10-08 | 2009-11-25 | Glaxosmithkline Biolog Sa | Expression system |
| KR20130072201A (ko) | 2010-03-30 | 2013-07-01 | 피페넥스 인크. | 재조합 독소 단백질의 고수준 발현 |
| TWI815599B (zh) | 2011-04-22 | 2023-09-11 | 美商惠氏有限責任公司 | 與難養芽胞梭菌(Clostridium difficile)之突變毒素有關之組成物及彼之方法 |
| WO2013084071A2 (en) | 2011-12-08 | 2013-06-13 | Novartis Ag | Clostridium difficile toxin-based vaccine |
| US9169304B2 (en) | 2012-05-01 | 2015-10-27 | Pfenex Inc. | Process for purifying recombinant Plasmodium falciparum circumsporozoite protein |
| US10722569B2 (en) * | 2012-07-05 | 2020-07-28 | Children's Medical Center Corporation | Bacterial biofilm matrix as a platform for protein delivery |
| BR122016023101B1 (pt) | 2012-10-21 | 2022-03-22 | Pfizer Inc | Polipeptídeo, composição imunogênica que o compreende, bem como célula recombinante derivada de clostridium difficile |
| CN104140972B (zh) * | 2013-05-07 | 2018-01-23 | 上海惠盾生物技术有限公司 | 白喉毒素突变体crm197的制备方法 |
| US9321834B2 (en) | 2013-12-05 | 2016-04-26 | Leidos, Inc. | Anti-malarial compositions |
| DK3099800T3 (da) | 2014-01-31 | 2021-01-11 | Fina Biosolutions Llc | Ekspression og oprensning af crm197 og beslægtede proteiner |
| US12104161B2 (en) | 2014-01-31 | 2024-10-01 | Fina Biosolutions Llc | Production of soluble recombinant proteins without N-terminal methionine in E-coli |
| US11060123B2 (en) | 2014-01-31 | 2021-07-13 | Fina Biosolutions, Llc | Production of soluble recombinant protein without n-terminal methionine |
| US10597664B2 (en) * | 2014-01-31 | 2020-03-24 | Fina Biosolutions, Llc | Expression and purification of CRM proteins and related proteins, and protein domains |
| CA2968491C (en) | 2014-11-20 | 2023-09-26 | Biological E Limited | Codon optimized polynucleotide for high level expression of crm197 |
| US11371011B2 (en) | 2016-04-06 | 2022-06-28 | Plant Health Care, Inc. | Beneficial microbes for delivery of effector peptides or proteins and use thereof |
| WO2017219004A2 (en) | 2016-06-17 | 2017-12-21 | Children's Medical Center Corporation | Biofilm matrix-boosted vaccine |
| RU2636346C1 (ru) * | 2016-07-01 | 2017-11-22 | Федеральное бюджетное учреждение науки Государственный научный центр прикладной микробиологии и биотехнологии (ФБУН ГНЦ ПМБ) | Способ получения рекомбинантного экзопротеина А Pseudomonas aeruginosa |
| KR101908590B1 (ko) | 2017-02-01 | 2018-10-16 | (주)포바이오코리아 | Crm197의 용해성 단백질 발현 및 정제 방법 |
| EP3444269A1 (en) | 2017-08-17 | 2019-02-20 | National Research Council of Canada | Systems and methods for the production of diphtheria toxin polypeptides |
| CA3077393A1 (en) | 2017-10-27 | 2019-05-02 | Pfenex Inc. | Bacterial leader sequences for periplasmic protein expression |
| EP3701036A4 (en) * | 2017-10-27 | 2021-09-01 | Pfenex Inc. | PROCESS FOR PRODUCING ASPARAGINASE OF E. COLI |
| JP7784804B2 (ja) * | 2017-10-27 | 2025-12-12 | フェネックス インク. | 組み換えerwiniaアスパラギナーゼの製造のための方法 |
| KR102905809B1 (ko) * | 2018-01-19 | 2025-12-30 | 오비아이 파머 인코퍼레이티드 | Crm197 단백질 발현 |
| US10829731B2 (en) * | 2018-01-25 | 2020-11-10 | Alliance For Sustainable Energy, Llc | Biocatalysts for conversion of thermochemical waste streams |
| KR102475419B1 (ko) * | 2018-07-16 | 2022-12-07 | 주식회사 유바이오로직스 | Crm197을 고농도로 발현하는 코리네박테리움 균주 |
| EP3632465A1 (en) * | 2018-10-03 | 2020-04-08 | Sanofi Pasteur Inc. | Combined immunization against meningococcal disease and human papillomavirus |
| CN113453677A (zh) | 2018-12-13 | 2021-09-28 | 沪亚生物国际有限责任公司 | 用于治疗急性心房颤动的舒卡定施用 |
| NL2023863B1 (en) * | 2019-09-20 | 2021-05-25 | Univ Griffith | Protein particles and uses thereof |
| CN114514320B (zh) * | 2019-10-14 | 2025-04-01 | 先正达农作物保护股份公司 | 杀昆虫蛋白 |
| WO2021255690A2 (en) | 2020-06-19 | 2021-12-23 | Pfizer Inc. | Immunogenic compositions against clostridioides (clostridium) difficile and methods thereof |
| BE1029145B1 (fr) * | 2021-02-26 | 2022-09-27 | Curavac Europe | Methode de production d'une forme periplasmique de la proteine crm197 |
| WO2022211829A1 (en) | 2021-03-30 | 2022-10-06 | Jazz Pharmaceuticals Ireland Ltd. | Dosing of recombinant l-asparaginase |
| CN113201473B (zh) * | 2021-04-22 | 2022-06-07 | 广东省科学院微生物研究所(广东省微生物分析检测中心) | 香茅醇在制备促进铜绿假单胞菌毒力基因toxA表达的制剂中的应用 |
| EP4689147A2 (en) | 2023-04-05 | 2026-02-11 | Primrose Bio, Inc. | Methods and compositions for nucleic acid synthesis |
| CN119662671B (zh) * | 2024-11-26 | 2025-11-25 | 吉林大学 | 一种来源于谷氨酸棒杆菌耐热元件及其应用 |
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| GB8517071D0 (en) | 1985-07-05 | 1985-08-14 | Hoffmann La Roche | Gram-positive expression control sequence |
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| US5128130A (en) | 1988-01-22 | 1992-07-07 | Mycogen Corporation | Hybrid Bacillus thuringiensis gene, plasmid and transformed Pseudomonas fluorescens |
| US5055294A (en) | 1988-03-03 | 1991-10-08 | Mycogen Corporation | Chimeric bacillus thuringiensis crystal protein gene comprising hd-73 and berliner 1715 toxin genes, transformed and expressed in pseudomonas fluorescens |
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| US9580719B2 (en) | 2007-04-27 | 2017-02-28 | Pfenex, Inc. | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins |
| US9394571B2 (en) * | 2007-04-27 | 2016-07-19 | Pfenex Inc. | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins |
| WO2010008764A1 (en) * | 2008-06-23 | 2010-01-21 | Dow Global Technologies Inc. | Pseudomonas fluorescens strains for production of extracellular recombinant protein |
| GB0917647D0 (en) * | 2009-10-08 | 2009-11-25 | Glaxosmithkline Biolog Sa | Expression system |
| KR20130072201A (ko) | 2010-03-30 | 2013-07-01 | 피페넥스 인크. | 재조합 독소 단백질의 고수준 발현 |
-
2011
- 2011-03-28 KR KR1020127027780A patent/KR20130072201A/ko not_active Ceased
- 2011-03-28 JP JP2013502705A patent/JP5839411B2/ja active Active
- 2011-03-28 WO PCT/US2011/030227 patent/WO2011126811A2/en not_active Ceased
- 2011-03-28 US US13/073,955 patent/US8530171B2/en active Active
- 2011-03-28 AU AU2011238711A patent/AU2011238711B2/en active Active
- 2011-03-28 MX MX2012011103A patent/MX343356B/es active IP Right Grant
- 2011-03-28 CA CA2793978A patent/CA2793978C/en active Active
- 2011-03-28 NZ NZ602958A patent/NZ602958A/en unknown
- 2011-03-28 EP EP11766437.5A patent/EP2553102B1/en active Active
- 2011-03-28 CN CN201180018149.7A patent/CN102869778B/zh active Active
-
2013
- 2013-07-26 US US13/952,484 patent/US8906636B2/en active Active
-
2014
- 2014-11-03 US US14/531,833 patent/US20150361405A1/en not_active Abandoned
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