JP2013525331A5 - - Google Patents
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- JP2013525331A5 JP2013525331A5 JP2013505467A JP2013505467A JP2013525331A5 JP 2013525331 A5 JP2013525331 A5 JP 2013525331A5 JP 2013505467 A JP2013505467 A JP 2013505467A JP 2013505467 A JP2013505467 A JP 2013505467A JP 2013525331 A5 JP2013525331 A5 JP 2013525331A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- trans
- pharmaceutical composition
- compound according
- haloalkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000000217 alkyl group Chemical group 0.000 claims 34
- 150000001875 compounds Chemical class 0.000 claims 31
- 239000008194 pharmaceutical composition Substances 0.000 claims 21
- 125000003545 alkoxy group Chemical group 0.000 claims 17
- 125000004438 haloalkoxy group Chemical group 0.000 claims 17
- 125000001188 haloalkyl group Chemical group 0.000 claims 17
- 125000001475 halogen functional group Chemical group 0.000 claims 17
- 125000001424 substituent group Chemical group 0.000 claims 17
- 125000004093 cyano group Chemical group *C#N 0.000 claims 15
- -1 -CH 2 C (= O) NH 2 Chemical group 0.000 claims 14
- 150000001408 amides Chemical class 0.000 claims 11
- 125000002102 aryl alkyloxo group Chemical group 0.000 claims 11
- 125000003118 aryl group Chemical group 0.000 claims 11
- 238000011282 treatment Methods 0.000 claims 8
- 101001050886 Homo sapiens Lysine-specific histone demethylase 1A Proteins 0.000 claims 7
- 102100024985 Lysine-specific histone demethylase 1A Human genes 0.000 claims 7
- 125000000753 cycloalkyl group Chemical group 0.000 claims 7
- 125000001072 heteroaryl group Chemical group 0.000 claims 7
- 230000002265 prevention Effects 0.000 claims 7
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 6
- 125000003710 aryl alkyl group Chemical group 0.000 claims 5
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 5
- 108010062431 Monoamine oxidase Proteins 0.000 claims 4
- 229940124639 Selective inhibitor Drugs 0.000 claims 4
- 208000036142 Viral infection Diseases 0.000 claims 4
- 125000001931 aliphatic group Chemical group 0.000 claims 4
- 125000004104 aryloxy group Chemical group 0.000 claims 4
- 125000002837 carbocyclic group Chemical group 0.000 claims 4
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 4
- 125000000623 heterocyclic group Chemical group 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 claims 4
- 230000009385 viral infection Effects 0.000 claims 4
- 125000004442 acylamino group Chemical group 0.000 claims 3
- 125000003282 alkyl amino group Chemical group 0.000 claims 3
- 125000000304 alkynyl group Chemical group 0.000 claims 3
- 125000005018 aryl alkenyl group Chemical group 0.000 claims 3
- 125000005015 aryl alkynyl group Chemical group 0.000 claims 3
- 125000005110 aryl thio group Chemical group 0.000 claims 3
- 125000004452 carbocyclyl group Chemical group 0.000 claims 3
- 125000001651 cyanato group Chemical group [*]OC#N 0.000 claims 3
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 3
- 125000005366 cycloalkylthio group Chemical group 0.000 claims 3
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 3
- 125000003106 haloaryl group Chemical group 0.000 claims 3
- 125000005553 heteroaryloxy group Chemical group 0.000 claims 3
- 125000005368 heteroarylthio group Chemical group 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 239000012453 solvate Substances 0.000 claims 3
- 125000000858 thiocyanato group Chemical group *SC#N 0.000 claims 3
- 241001529453 unidentified herpesvirus Species 0.000 claims 3
- 102100028661 Amine oxidase [flavin-containing] A Human genes 0.000 claims 2
- 102100028116 Amine oxidase [flavin-containing] B Human genes 0.000 claims 2
- 208000003174 Brain Neoplasms Diseases 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 2
- 208000029433 Herpesviridae infectious disease Diseases 0.000 claims 2
- 241000700588 Human alphaherpesvirus 1 Species 0.000 claims 2
- 241000701074 Human alphaherpesvirus 2 Species 0.000 claims 2
- 241000701044 Human gammaherpesvirus 4 Species 0.000 claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 208000000453 Skin Neoplasms Diseases 0.000 claims 2
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 2
- 206010057644 Testis cancer Diseases 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- 125000004423 acyloxy group Chemical group 0.000 claims 2
- 125000004414 alkyl thio group Chemical group 0.000 claims 2
- 125000003368 amide group Chemical group 0.000 claims 2
- 125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 201000005787 hematologic cancer Diseases 0.000 claims 2
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims 2
- 125000005114 heteroarylalkoxy group Chemical group 0.000 claims 2
- 238000011534 incubation Methods 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 230000007420 reactivation Effects 0.000 claims 2
- 201000000849 skin cancer Diseases 0.000 claims 2
- 201000003120 testicular cancer Diseases 0.000 claims 2
- 125000005423 trihalomethanesulfonamido group Chemical group 0.000 claims 2
- 230000007419 viral reactivation Effects 0.000 claims 2
- JWZZKOKVBUJMES-UHFFFAOYSA-N (+-)-Isoprenaline Chemical compound CC(C)NCC(O)C1=CC=C(O)C(O)=C1 JWZZKOKVBUJMES-UHFFFAOYSA-N 0.000 claims 1
- JXFCSNCFHXWKCF-XZOQPEGZSA-N (1r,2s)-2-[4-(3-chlorophenyl)phenyl]-n-(2-cyclohexylethyl)cyclopropan-1-amine Chemical compound ClC1=CC=CC(C=2C=CC(=CC=2)[C@H]2[C@@H](C2)NCCC2CCCCC2)=C1 JXFCSNCFHXWKCF-XZOQPEGZSA-N 0.000 claims 1
- DKXFGPJMRWQEJZ-XZOQPEGZSA-N (1r,2s)-2-[4-(4-chlorophenyl)phenyl]-n-(2-cyclohexylethyl)cyclopropan-1-amine Chemical compound C1=CC(Cl)=CC=C1C1=CC=C([C@H]2[C@@H](C2)NCCC2CCCCC2)C=C1 DKXFGPJMRWQEJZ-XZOQPEGZSA-N 0.000 claims 1
- OMLUSVPZLJACMT-BJKOFHAPSA-N (1r,2s)-2-[4-[(3-bromophenyl)methoxy]phenyl]-n-(2-cyclohexylethyl)cyclopropan-1-amine Chemical compound BrC1=CC=CC(COC=2C=CC(=CC=2)[C@H]2[C@@H](C2)NCCC2CCCCC2)=C1 OMLUSVPZLJACMT-BJKOFHAPSA-N 0.000 claims 1
- BGTYDVHTSKDFPF-ZWKOTPCHSA-N (1r,2s)-n-(2-cycloheptylethyl)-2-phenylcyclopropan-1-amine Chemical compound N([C@H]1[C@@H](C1)C=1C=CC=CC=1)CCC1CCCCCC1 BGTYDVHTSKDFPF-ZWKOTPCHSA-N 0.000 claims 1
- KHTQKTORDGNBRF-BJKOFHAPSA-N (1r,2s)-n-(2-cyclohexylethyl)-2-[4-(3-methoxyphenyl)phenyl]cyclopropan-1-amine Chemical compound COC1=CC=CC(C=2C=CC(=CC=2)[C@H]2[C@@H](C2)NCCC2CCCCC2)=C1 KHTQKTORDGNBRF-BJKOFHAPSA-N 0.000 claims 1
- CUUAZVAEZZVJPO-ZWKOTPCHSA-N (1r,2s)-n-(3-cyclohexylpropyl)-2-phenylcyclopropan-1-amine Chemical compound C1([C@@H]2C[C@H]2NCCCC2CCCCC2)=CC=CC=C1 CUUAZVAEZZVJPO-ZWKOTPCHSA-N 0.000 claims 1
- YHNQRLPXWDLVDN-QNRWSGHRSA-N 4,5-dimethoxy-n-[(1r,2s)-2-(4-phenylmethoxyphenyl)cyclopropyl]-2,3-dihydro-1h-inden-1-amine Chemical compound C1=CC([C@@H]2C[C@H]2NC2C3=CC=C(C(=C3CC2)OC)OC)=CC=C1OCC1=CC=CC=C1 YHNQRLPXWDLVDN-QNRWSGHRSA-N 0.000 claims 1
- UPLFFRCQYPKTOS-DEWJTGPOSA-N 5,6-dimethoxy-n-[(1r,2s)-2-(4-phenylmethoxyphenyl)cyclopropyl]-2,3-dihydro-1h-inden-1-amine Chemical compound C1=CC([C@@H]2C[C@H]2NC2CCC=3C=C(C(=CC=32)OC)OC)=CC=C1OCC1=CC=CC=C1 UPLFFRCQYPKTOS-DEWJTGPOSA-N 0.000 claims 1
- XYCRGAPMMXRAJL-PXKIYYGHSA-N 6-chloro-n-[(1r,2s)-2-phenylcyclopropyl]-2,3-dihydro-1h-inden-1-amine Chemical compound C1([C@@H]2C[C@H]2NC2CCC3=CC=C(C=C32)Cl)=CC=CC=C1 XYCRGAPMMXRAJL-PXKIYYGHSA-N 0.000 claims 1
- GTUTWJPRKOCKAP-KCIKGWAESA-N 6-methoxy-n-[(1r,2s)-2-(4-phenylmethoxyphenyl)cyclopropyl]-2,3-dihydro-1h-inden-1-amine Chemical compound C1=CC([C@@H]2C[C@H]2NC2CCC3=CC=C(C=C32)OC)=CC=C1OCC1=CC=CC=C1 GTUTWJPRKOCKAP-KCIKGWAESA-N 0.000 claims 1
- YEZIEPBYZJECGY-KCIKGWAESA-N 6-methoxy-n-[(1r,2s)-2-[4-(3-methoxyphenyl)phenyl]cyclopropyl]-2,3-dihydro-1h-inden-1-amine Chemical compound C1=CC([C@@H]2C[C@H]2NC2CCC3=CC=C(C=C32)OC)=CC=C1C1=CC=CC(OC)=C1 YEZIEPBYZJECGY-KCIKGWAESA-N 0.000 claims 1
- NEABQLUIWQPBNJ-LJJQOFDWSA-N 6-methoxy-n-[(1r,2s)-2-phenylcyclopropyl]-2,3-dihydro-1h-inden-1-amine Chemical compound C1([C@@H]2C[C@H]2NC2CCC3=CC=C(C=C32)OC)=CC=CC=C1 NEABQLUIWQPBNJ-LJJQOFDWSA-N 0.000 claims 1
- HEJHLIFIPMUHJZ-DRXLFZDCSA-N 7-methoxy-n-[(1r,2s)-2-(4-phenylmethoxyphenyl)cyclopropyl]-1,2,3,4-tetrahydronaphthalen-1-amine Chemical compound C1=CC([C@@H]2C[C@H]2NC2CCCC3=CC=C(C=C32)OC)=CC=C1OCC1=CC=CC=C1 HEJHLIFIPMUHJZ-DRXLFZDCSA-N 0.000 claims 1
- BWWMRSAGHGFIDQ-SJBAFXMYSA-N 7-methoxy-n-[(1r,2s)-2-phenylcyclopropyl]-1,2,3,4-tetrahydronaphthalen-1-amine Chemical compound C1([C@@H]2C[C@H]2NC2CCCC3=CC=C(C=C32)OC)=CC=CC=C1 BWWMRSAGHGFIDQ-SJBAFXMYSA-N 0.000 claims 1
- 230000001028 anti-proliverative effect Effects 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- AIMMVWOEOZMVMS-UHFFFAOYSA-N cyclopropanecarboxamide Chemical compound NC(=O)C1CC1 AIMMVWOEOZMVMS-UHFFFAOYSA-N 0.000 claims 1
- 125000006317 cyclopropyl amino group Chemical group 0.000 claims 1
- 239000000824 cytostatic agent Substances 0.000 claims 1
- 239000002254 cytotoxic agent Substances 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 231100000599 cytotoxic agent Toxicity 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 125000001261 isocyanato group Chemical group *N=C=O 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- IWZGJIQMVRUHPI-UHFFFAOYSA-N n-(2-phenylcyclopropyl)-6,11-dihydro-5h-dibenzo[1,2-a:1',2'-e][7]annulen-11-amine Chemical compound C1C(NC2C3=CC=CC=C3CCC3=CC=CC=C32)C1C1=CC=CC=C1 IWZGJIQMVRUHPI-UHFFFAOYSA-N 0.000 claims 1
- PLYANGBAOXRROA-UHFFFAOYSA-N n-(2-phenylcyclopropyl)cyclopentanamine Chemical compound C=1C=CC=CC=1C1CC1NC1CCCC1 PLYANGBAOXRROA-UHFFFAOYSA-N 0.000 claims 1
- DHZITQRRQYOFRP-QNRWSGHRSA-N n-[(1r,2s)-2-[4-(3-chlorophenyl)phenyl]cyclopropyl]-6-methoxy-2,3-dihydro-1h-inden-1-amine Chemical compound C1=CC([C@@H]2C[C@H]2NC2CCC3=CC=C(C=C32)OC)=CC=C1C1=CC=CC(Cl)=C1 DHZITQRRQYOFRP-QNRWSGHRSA-N 0.000 claims 1
- LTCCTDWUXLBMOZ-QNRWSGHRSA-N n-[(1r,2s)-2-[4-(4-chlorophenyl)phenyl]cyclopropyl]-6-methoxy-2,3-dihydro-1h-inden-1-amine Chemical compound C1=CC([C@@H]2C[C@H]2NC2CCC3=CC=C(C=C32)OC)=CC=C1C1=CC=C(Cl)C=C1 LTCCTDWUXLBMOZ-QNRWSGHRSA-N 0.000 claims 1
- FIHPHWRNHZMRQA-KCIKGWAESA-N n-[(1r,2s)-2-[4-[(3-bromophenyl)methoxy]phenyl]cyclopropyl]-6-methoxy-2,3-dihydro-1h-inden-1-amine Chemical compound C1=CC([C@@H]2C[C@H]2NC2CCC3=CC=C(C=C32)OC)=CC=C1OCC1=CC=CC(Br)=C1 FIHPHWRNHZMRQA-KCIKGWAESA-N 0.000 claims 1
- YPFUZAOHQYLSHW-PXKIYYGHSA-N n-[(1r,2s)-2-phenylcyclopropyl]-2,3-dihydro-1h-inden-1-amine Chemical compound C1([C@H]2[C@H](NC3C4=CC=CC=C4CC3)C2)=CC=CC=C1 YPFUZAOHQYLSHW-PXKIYYGHSA-N 0.000 claims 1
- ISBBCWJDLSIJAX-PXKIYYGHSA-N n-[(1r,2s)-2-phenylcyclopropyl]-6-(trifluoromethyl)-2,3-dihydro-1h-inden-1-amine Chemical compound C1([C@@H]2C[C@H]2NC2CCC3=CC=C(C=C32)C(F)(F)F)=CC=CC=C1 ISBBCWJDLSIJAX-PXKIYYGHSA-N 0.000 claims 1
- YPEIHBUSSOFCJK-LSDHHAIUSA-N n-[(1r,2s)-2-phenylcyclopropyl]cyclohexanamine Chemical compound N([C@@H]1C[C@H]1C=1C=CC=CC=1)C1CCCCC1 YPEIHBUSSOFCJK-LSDHHAIUSA-N 0.000 claims 1
- 238000011321 prophylaxis Methods 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
- 229940124530 sulfonamide Drugs 0.000 claims 1
- 150000003456 sulfonamides Chemical class 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
- 125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10160315 | 2010-04-19 | ||
| EP10160315.7 | 2010-04-19 | ||
| PCT/EP2011/056279 WO2011131697A1 (en) | 2010-04-19 | 2011-04-19 | Lysine specific demethylase-1 inhibitors and their use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013525331A JP2013525331A (ja) | 2013-06-20 |
| JP2013525331A5 true JP2013525331A5 (enExample) | 2014-06-05 |
| JP5868948B2 JP5868948B2 (ja) | 2016-02-24 |
Family
ID=44280905
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013505467A Expired - Fee Related JP5868948B2 (ja) | 2010-04-19 | 2011-04-19 | リジン特異的脱メチル化酵素１阻害薬およびその使用 |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US8722743B2 (enExample) |
| EP (2) | EP2560947B1 (enExample) |
| JP (1) | JP5868948B2 (enExample) |
| KR (1) | KR101794020B1 (enExample) |
| CN (1) | CN102947265B (enExample) |
| AU (1) | AU2011244325B2 (enExample) |
| BR (2) | BR122019020471B1 (enExample) |
| CA (1) | CA2796726C (enExample) |
| CY (1) | CY1118344T1 (enExample) |
| DK (1) | DK2560947T3 (enExample) |
| ES (1) | ES2607081T3 (enExample) |
| HR (1) | HRP20161748T1 (enExample) |
| HU (1) | HUE030938T2 (enExample) |
| IL (1) | IL222361A (enExample) |
| LT (1) | LT2560947T (enExample) |
| MX (1) | MX2012012111A (enExample) |
| PL (1) | PL2560947T3 (enExample) |
| PT (1) | PT2560947T (enExample) |
| RS (1) | RS55348B1 (enExample) |
| RU (1) | RU2599248C2 (enExample) |
| SI (1) | SI2560947T1 (enExample) |
| WO (1) | WO2011131697A1 (enExample) |
Families Citing this family (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2361242B1 (en) | 2008-10-17 | 2018-08-01 | Oryzon Genomics, S.A. | Oxidase inhibitors and their use |
| US8993808B2 (en) | 2009-01-21 | 2015-03-31 | Oryzon Genomics, S.A. | Phenylcyclopropylamine derivatives and their medical use |
| AU2010297557C1 (en) | 2009-09-25 | 2017-04-06 | Oryzon Genomics S.A. | Lysine specific demethylase-1 inhibitors and their use |
| US8946296B2 (en) | 2009-10-09 | 2015-02-03 | Oryzon Genomics S.A. | Substituted heteroaryl- and aryl-cyclopropylamine acetamides and their use |
| US9616058B2 (en) | 2010-02-24 | 2017-04-11 | Oryzon Genomics, S.A. | Potent selective LSD1 inhibitors and dual LSD1/MAO-B inhibitors for antiviral use |
| WO2011106573A2 (en) | 2010-02-24 | 2011-09-01 | Oryzon Genomics, S.A. | Lysine demethylase inhibitors for diseases and disorders associated with hepadnaviridae |
| JP5868948B2 (ja) | 2010-04-19 | 2016-02-24 | オリゾン・ジェノミックス・ソシエダッド・アノニマＯｒｙｚｏｎ Ｇｅｎｏｍｉｃｓ Ｓ．Ａ． | リジン特異的脱メチル化酵素１阻害薬およびその使用 |
| EP2598480B1 (en) | 2010-07-29 | 2019-04-24 | Oryzon Genomics, S.A. | Cyclopropylamine derivatives useful as lsd1 inhibitors |
| BR112013002164B1 (pt) | 2010-07-29 | 2021-11-09 | Oryzon Genomics S.A. | Inibidores de desmetilase à base de arilciclopropilamina de lsd1, seus usos, e composição farmacêutica |
| US20130303545A1 (en) * | 2010-09-30 | 2013-11-14 | Tamara Maes | Cyclopropylamine derivatives useful as lsd1 inhibitors |
| WO2012045883A1 (en) * | 2010-10-08 | 2012-04-12 | Oryzon Genomics S.A. | Cyclopropylamine inhibitors of oxidases |
| WO2012072713A2 (en) | 2010-11-30 | 2012-06-07 | Oryzon Genomics, S.A. | Lysine demethylase inhibitors for diseases and disorders associated with flaviviridae |
| EP2712316A1 (en) | 2011-02-08 | 2014-04-02 | Oryzon Genomics, S.A. | Lysine demethylase inhibitors for myeloproliferative or lymphoproliferative diseases or disorders |
| EP3981395A1 (en) | 2011-02-08 | 2022-04-13 | Oryzon Genomics, S.A. | Lysine demethylase inhibitors for myeloproliferative disorders |
| BR112013024502B1 (pt) | 2011-03-25 | 2021-09-08 | Glaxosmithkline Intellectual Property (No.2) Limited | Compostos de ciclopropilaminas como inibidores lsd1 e composições farmacêuticas compreendendo ditos compostos |
| EP2750671A2 (en) | 2011-05-19 | 2014-07-09 | Oryzon Genomics, S.A. | Lysine demethylase inhibitors for thrombosis and cardiovascular diseases |
| WO2012156531A2 (en) | 2011-05-19 | 2012-11-22 | Oryzon Genomics, S.A. | Lysine demethylase inhibitors for inflammatory diseases or conditions |
| CN107417549A (zh) * | 2011-10-20 | 2017-12-01 | 奥莱松基因组股份有限公司 | 作为lsd1抑制剂的（杂）芳基环丙基胺化合物 |
| EP2768805B1 (en) * | 2011-10-20 | 2020-03-25 | Oryzon Genomics, S.A. | (hetero)aryl cyclopropylamine compounds as lsd1 inhibitors |
| CA2887598A1 (en) * | 2012-10-12 | 2014-04-17 | Takeda Pharmaceutical Company Limited | Cyclopropanamine compound and use thereof |
| CN103242171A (zh) * | 2013-05-09 | 2013-08-14 | 苏州明锐医药科技有限公司 | 反式-(1r,2s)-2-(3,4-二氟苯基)环丙胺的制备方法 |
| EP3030323B1 (en) | 2013-08-06 | 2019-04-24 | Imago Biosciences Inc. | Kdm1a inhibitors for the treatment of disease |
| WO2015120281A1 (en) | 2014-02-07 | 2015-08-13 | Musc Foundation For Research Development | Aminotriazole- and aminotetrazole-based kdm1a inhibitors as epigenetic modulators |
| LT3105226T (lt) | 2014-02-13 | 2019-11-11 | Incyte Corp | Ciklopropilaminai, kaip lsd1 inhibitoriai |
| TW201613860A (en) | 2014-02-13 | 2016-04-16 | Incyte Corp | Cyclopropylamines as LSD1 inhibitors |
| US9527835B2 (en) | 2014-02-13 | 2016-12-27 | Incyte Corporation | Cyclopropylamines as LSD1 inhibitors |
| PL3105218T3 (pl) | 2014-02-13 | 2020-03-31 | Incyte Corporation | Cyklopropyloaminy jako inhibitory lsd1 |
| CA2945085C (en) | 2014-04-11 | 2022-05-10 | Takeda Pharmaceutical Company Limited | Cyclopropanamine compound and use thereof |
| US9758523B2 (en) | 2014-07-10 | 2017-09-12 | Incyte Corporation | Triazolopyridines and triazolopyrazines as LSD1 inhibitors |
| TWI687419B (zh) | 2014-07-10 | 2020-03-11 | 美商英塞特公司 | 作為ｌｓｄ１抑制劑之咪唑并吡啶及咪唑并吡嗪 |
| WO2016007722A1 (en) | 2014-07-10 | 2016-01-14 | Incyte Corporation | Triazolopyridines and triazolopyrazines as lsd1 inhibitors |
| US9695180B2 (en) | 2014-07-10 | 2017-07-04 | Incyte Corporation | Substituted imidazo[1,2-a]pyrazines as LSD1 inhibitors |
| CA2958704A1 (en) | 2014-08-25 | 2016-03-03 | University Of Canberra | Compositions for modulating cancer stem cells and uses therefor |
| CN107427699B (zh) | 2015-02-12 | 2021-10-19 | 伊美格生物科学公司 | 用于治疗疾病的kdm1a抑制剂 |
| EP3277689B1 (en) | 2015-04-03 | 2019-09-04 | Incyte Corporation | Heterocyclic compounds as lsd1 inhibitors |
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| WO2012001531A2 (en) | 2010-06-30 | 2012-01-05 | Actavis Group Ptc Ehf | Novel processes for the preparation of phenylcyclopropylamine derivatives and use thereof for preparing ticagrelor |
| BR112013002164B1 (pt) | 2010-07-29 | 2021-11-09 | Oryzon Genomics S.A. | Inibidores de desmetilase à base de arilciclopropilamina de lsd1, seus usos, e composição farmacêutica |
| EP2598480B1 (en) | 2010-07-29 | 2019-04-24 | Oryzon Genomics, S.A. | Cyclopropylamine derivatives useful as lsd1 inhibitors |
| WO2012034116A2 (en) | 2010-09-10 | 2012-03-15 | The Johns Hopkins University | Small molecules as epigenetic modulators of lysine-specific demethylase 1 and methods of treating disorders |
| US20130303545A1 (en) | 2010-09-30 | 2013-11-14 | Tamara Maes | Cyclopropylamine derivatives useful as lsd1 inhibitors |
| WO2012045883A1 (en) | 2010-10-08 | 2012-04-12 | Oryzon Genomics S.A. | Cyclopropylamine inhibitors of oxidases |
| WO2012072713A2 (en) | 2010-11-30 | 2012-06-07 | Oryzon Genomics, S.A. | Lysine demethylase inhibitors for diseases and disorders associated with flaviviridae |
| EP2712316A1 (en) | 2011-02-08 | 2014-04-02 | Oryzon Genomics, S.A. | Lysine demethylase inhibitors for myeloproliferative or lymphoproliferative diseases or disorders |
| EP3981395A1 (en) | 2011-02-08 | 2022-04-13 | Oryzon Genomics, S.A. | Lysine demethylase inhibitors for myeloproliferative disorders |
| BR112013024502B1 (pt) | 2011-03-25 | 2021-09-08 | Glaxosmithkline Intellectual Property (No.2) Limited | Compostos de ciclopropilaminas como inibidores lsd1 e composições farmacêuticas compreendendo ditos compostos |
| EP2750671A2 (en) | 2011-05-19 | 2014-07-09 | Oryzon Genomics, S.A. | Lysine demethylase inhibitors for thrombosis and cardiovascular diseases |
| WO2012156531A2 (en) | 2011-05-19 | 2012-11-22 | Oryzon Genomics, S.A. | Lysine demethylase inhibitors for inflammatory diseases or conditions |
| CN107417549A (zh) | 2011-10-20 | 2017-12-01 | 奥莱松基因组股份有限公司 | 作为lsd1抑制剂的（杂）芳基环丙基胺化合物 |
| EP2768805B1 (en) | 2011-10-20 | 2020-03-25 | Oryzon Genomics, S.A. | (hetero)aryl cyclopropylamine compounds as lsd1 inhibitors |
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