JP2013523739A5

JP2013523739A5 -

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Publication number: JP2013523739A5
Authority: JP; Japan
Prior art keywords: formula; compound; pharmaceutically acceptable; acceptable salt; hydroxy
Prior art date: 2011-03-25
Legal status : Pending

Application number

JP2013502678A

Other languages

English (en)

Japanese (ja)

Other versions

JP2013523739A (ja

Filing date

2011-03-25

Publication date

2014-05-08

2011-03-25 Application filed filed Critical

2011-03-25 Priority claimed from PCT/US2011/030009 external-priority patent/WO2011119969A1/en

2013-06-17 Publication of JP2013523739A publication Critical patent/JP2013523739A/ja

2014-05-08 Publication of JP2013523739A5 publication Critical patent/JP2013523739A5/ja

Status Pending legal-status Critical Current

Links

150000003839 salts Chemical class 0.000 claims 18
LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 16
125000004356 hydroxy functional group Chemical group O* 0.000 claims 14
150000001875 compounds Chemical class 0.000 claims 8
125000001475 halogen functional group Chemical group 0.000 claims 8
238000010276 construction Methods 0.000 claims 7
125000003118 aryl group Chemical group 0.000 claims 4
125000000623 heterocyclic group Chemical group 0.000 claims 4
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
125000001931 aliphatic group Chemical group 0.000 claims 3
125000000753 cycloalkyl group Chemical group 0.000 claims 3
230000004410 intraocular pressure Effects 0.000 claims 3
125000000217 alkyl group Chemical group 0.000 claims 2
201000010099 disease Diseases 0.000 claims 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
239000008194 pharmaceutical composition Substances 0.000 claims 2
125000000640 cyclooctyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
239000003814 drug Substances 0.000 claims 1
230000004406 elevated intraocular pressure Effects 0.000 claims 1
239000000546 pharmaceutical excipient Substances 0.000 claims 1

JP2013502678A 2010-03-26 2011-03-25 Ｎ６−シクロペンチルアデノシン（ｃｐａ）、ｃｐａ誘導体またはそれらのプロドラッグを用いてヒトにおける眼内圧を低下させる方法 Pending JP2013523739A (ja)