JP2013523739A5 - - Google Patents

Info

Publication number

JP2013523739A5

JP2013523739A5 JP2013502678A JP2013502678A JP2013523739A5 JP 2013523739 A5 JP2013523739 A5 JP 2013523739A5 JP 2013502678 A JP2013502678 A JP 2013502678A JP 2013502678 A JP2013502678 A JP 2013502678A JP 2013523739 A5 JP2013523739 A5 JP 2013523739A5

Authority

JP

Japan

Prior art keywords

formula

compound

pharmaceutically acceptable

acceptable salt

hydroxy

Prior art date

2011-03-25

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 150000003839 salts Chemical class 0.000 claims 18
• LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 16
• 125000004356 hydroxy functional group Chemical group O* 0.000 claims 14
• 150000001875 compounds Chemical class 0.000 claims 8
• 125000001475 halogen functional group Chemical group 0.000 claims 8
• 238000010276 construction Methods 0.000 claims 7
• 125000003118 aryl group Chemical group 0.000 claims 4
• 125000000623 heterocyclic group Chemical group 0.000 claims 4
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
• 125000001931 aliphatic group Chemical group 0.000 claims 3
• 125000000753 cycloalkyl group Chemical group 0.000 claims 3
• 230000004410 intraocular pressure Effects 0.000 claims 3
• 125000000217 alkyl group Chemical group 0.000 claims 2
• 201000010099 disease Diseases 0.000 claims 2
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• 125000000640 cyclooctyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 230000004406 elevated intraocular pressure Effects 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1