MX2012010724A - Metodo para reducir la presion intraocular en seres humanos empleando n6-ciclopentiladenosina (cpa), derivados de cpa o profarmacos de los mismos. - Google Patents
Metodo para reducir la presion intraocular en seres humanos empleando n6-ciclopentiladenosina (cpa), derivados de cpa o profarmacos de los mismos.Info
- Publication number
- MX2012010724A MX2012010724A MX2012010724A MX2012010724A MX2012010724A MX 2012010724 A MX2012010724 A MX 2012010724A MX 2012010724 A MX2012010724 A MX 2012010724A MX 2012010724 A MX2012010724 A MX 2012010724A MX 2012010724 A MX2012010724 A MX 2012010724A
- Authority
- MX
- Mexico
- Prior art keywords
- compound
- formula
- iop
- hydroxy
- pharmaceutically acceptable
- Prior art date
Links
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- 230000003389 potentiating effect Effects 0.000 description 1
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- 238000002953 preparative HPLC Methods 0.000 description 1
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- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/167—Purine radicals with ribosyl as the saccharide radical
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Organic Chemistry (AREA)
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- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
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- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Ophthalmology & Optometry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31810510P | 2010-03-26 | 2010-03-26 | |
| PCT/US2011/030009 WO2011119969A1 (en) | 2010-03-26 | 2011-03-25 | Method of reducing intraocular pressure in humans using n6 -cyclopentyladenosine (cpa), cpa derivatives or prodrugs thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2012010724A true MX2012010724A (es) | 2012-11-12 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2012010724A MX2012010724A (es) | 2010-03-26 | 2011-03-25 | Metodo para reducir la presion intraocular en seres humanos empleando n6-ciclopentiladenosina (cpa), derivados de cpa o profarmacos de los mismos. |
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| JP (2) | JP2013523739A (enExample) |
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| CN (1) | CN102933593A (enExample) |
| AU (1) | AU2011230580A1 (enExample) |
| BR (1) | BR112012023749A2 (enExample) |
| CA (1) | CA2792266A1 (enExample) |
| CL (1) | CL2012002613A1 (enExample) |
| CO (1) | CO6630141A2 (enExample) |
| EA (1) | EA201290958A1 (enExample) |
| MX (1) | MX2012010724A (enExample) |
| PH (1) | PH12012501906A1 (enExample) |
| SG (1) | SG184221A1 (enExample) |
| WO (1) | WO2011119969A1 (enExample) |
| ZA (1) | ZA201207090B (enExample) |
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|---|---|---|---|---|
| BR112012017106A2 (pt) * | 2010-01-11 | 2018-05-29 | Inotek Pharmaceuticals Corp | combinação, kit e método de redução de pressão intraocular. |
| JP2013523739A (ja) * | 2010-03-26 | 2013-06-17 | イノテック ファーマシューティカルズ コーポレイション | Ｎ６−シクロペンチルアデノシン（ｃｐａ）、ｃｐａ誘導体またはそれらのプロドラッグを用いてヒトにおける眼内圧を低下させる方法 |
| NZ627778A (en) * | 2012-01-26 | 2017-01-27 | Inotek Pharmaceuticals Corp | Anhydrous polymorphs of (2r,3s,4r,5r)-5-(6-(cyclopentylamino)-9h-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)} methyl nitrate and processes of preparation thereof |
| AU2014239222A1 (en) | 2013-03-15 | 2015-10-01 | Inotek Pharmaceuticals Corporation | Ophthalmic formulations |
| JP2018501219A (ja) * | 2014-12-03 | 2018-01-18 | イノテック ファーマシューティカルズ コーポレイション | 黄斑変性の予防、軽減または治療方法 |
| KR20250025414A (ko) * | 2022-06-17 | 2025-02-21 | 상하이 센후이 메디슨 컴퍼니 리미티드 | 시클로펜틸아데노신 유도체 및 이의 약학적 용도 |
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-
2011
- 2011-03-25 JP JP2013502678A patent/JP2013523739A/ja active Pending
- 2011-03-25 MX MX2012010724A patent/MX2012010724A/es not_active Application Discontinuation
- 2011-03-25 KR KR1020127023971A patent/KR20130029050A/ko not_active Withdrawn
- 2011-03-25 US US13/072,349 patent/US8476247B2/en not_active Expired - Fee Related
- 2011-03-25 PH PH1/2012/501906A patent/PH12012501906A1/en unknown
- 2011-03-25 BR BR112012023749A patent/BR112012023749A2/pt not_active IP Right Cessation
- 2011-03-25 EP EP11760319.1A patent/EP2569325A4/en not_active Withdrawn
- 2011-03-25 EA EA201290958A patent/EA201290958A1/ru unknown
- 2011-03-25 AU AU2011230580A patent/AU2011230580A1/en not_active Abandoned
- 2011-03-25 CA CA2792266A patent/CA2792266A1/en not_active Abandoned
- 2011-03-25 CN CN2011800163075A patent/CN102933593A/zh active Pending
- 2011-03-25 SG SG2012070587A patent/SG184221A1/en unknown
- 2011-03-25 WO PCT/US2011/030009 patent/WO2011119969A1/en not_active Ceased
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2012
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- 2012-09-21 CL CL2012002613A patent/CL2012002613A1/es unknown
- 2012-10-17 CO CO12183283A patent/CO6630141A2/es not_active Application Discontinuation
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2013
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2014
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- 2016-05-26 JP JP2016105169A patent/JP2016147918A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20150080330A1 (en) | 2015-03-19 |
| EA201290958A1 (ru) | 2013-04-30 |
| AU2011230580A1 (en) | 2012-10-11 |
| US8476247B2 (en) | 2013-07-02 |
| SG184221A1 (en) | 2012-10-30 |
| CA2792266A1 (en) | 2011-09-29 |
| WO2011119969A1 (en) | 2011-09-29 |
| US20140018314A1 (en) | 2014-01-16 |
| JP2013523739A (ja) | 2013-06-17 |
| BR112012023749A2 (pt) | 2016-08-23 |
| KR20130029050A (ko) | 2013-03-21 |
| CN102933593A (zh) | 2013-02-13 |
| US20160158268A1 (en) | 2016-06-09 |
| US8895530B2 (en) | 2014-11-25 |
| US20110245195A1 (en) | 2011-10-06 |
| EP2569325A4 (en) | 2013-10-09 |
| CL2012002613A1 (es) | 2012-12-21 |
| ZA201207090B (en) | 2014-03-26 |
| US9289383B2 (en) | 2016-03-22 |
| EP2569325A1 (en) | 2013-03-20 |
| PH12012501906A1 (en) | 2013-01-14 |
| CO6630141A2 (es) | 2013-03-01 |
| JP2016147918A (ja) | 2016-08-18 |
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