MX2012010724A - Metodo para reducir la presion intraocular en seres humanos empleando n6-ciclopentiladenosina (cpa), derivados de cpa o profarmacos de los mismos. - Google Patents
Metodo para reducir la presion intraocular en seres humanos empleando n6-ciclopentiladenosina (cpa), derivados de cpa o profarmacos de los mismos.Info
- Publication number
- MX2012010724A MX2012010724A MX2012010724A MX2012010724A MX2012010724A MX 2012010724 A MX2012010724 A MX 2012010724A MX 2012010724 A MX2012010724 A MX 2012010724A MX 2012010724 A MX2012010724 A MX 2012010724A MX 2012010724 A MX2012010724 A MX 2012010724A
- Authority
- MX
- Mexico
- Prior art keywords
- compound
- formula
- iop
- hydroxy
- pharmaceutically acceptable
- Prior art date
Links
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- 235000011152 sodium sulphate Nutrition 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/167—Purine radicals with ribosyl as the saccharide radical
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Ophthalmology & Optometry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31810510P | 2010-03-26 | 2010-03-26 | |
| PCT/US2011/030009 WO2011119969A1 (en) | 2010-03-26 | 2011-03-25 | Method of reducing intraocular pressure in humans using n6 -cyclopentyladenosine (cpa), cpa derivatives or prodrugs thereof |
Publications (1)
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| MX2012010724A true MX2012010724A (es) | 2012-11-12 |
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| MX2012010724A MX2012010724A (es) | 2010-03-26 | 2011-03-25 | Metodo para reducir la presion intraocular en seres humanos empleando n6-ciclopentiladenosina (cpa), derivados de cpa o profarmacos de los mismos. |
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| Country | Link |
|---|---|
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| JP (2) | JP2013523739A (enExample) |
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| AU (1) | AU2011230580A1 (enExample) |
| BR (1) | BR112012023749A2 (enExample) |
| CA (1) | CA2792266A1 (enExample) |
| CL (1) | CL2012002613A1 (enExample) |
| CO (1) | CO6630141A2 (enExample) |
| EA (1) | EA201290958A1 (enExample) |
| MX (1) | MX2012010724A (enExample) |
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| SG (1) | SG184221A1 (enExample) |
| WO (1) | WO2011119969A1 (enExample) |
| ZA (1) | ZA201207090B (enExample) |
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| MX2012007661A (es) * | 2010-01-11 | 2012-08-01 | Inotek Pharmaceuticals Corp | Combinacion, kit y metodo para reducir la presion intraocular. |
| US8476247B2 (en) * | 2010-03-26 | 2013-07-02 | Inotek Pharmaceuticals Corporation | Method of reducing intraocular pressure in humans |
| CA2861009A1 (en) | 2012-01-26 | 2013-08-01 | Inotek Pharmaceuticals Corporation | Anhydrous polymorphs of [(2r,3s,4r,5r)-5-(6-(cyclopentylamino)-9h-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)} methyl nitrate and processes of preparation thereof |
| AU2014239222A1 (en) | 2013-03-15 | 2015-10-01 | Inotek Pharmaceuticals Corporation | Ophthalmic formulations |
| WO2016090005A1 (en) * | 2014-12-03 | 2016-06-09 | Inotek Pharmaceuticals Corporation | Methods of preventing, reducing or treating macular degeneration |
| JP2025520300A (ja) * | 2022-06-17 | 2025-07-03 | 上海森輝医薬有限公司 | シクロペンチルアデノシン誘導体及びその医薬的使用 |
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2011
- 2011-03-25 US US13/072,349 patent/US8476247B2/en not_active Expired - Fee Related
- 2011-03-25 KR KR1020127023971A patent/KR20130029050A/ko not_active Withdrawn
- 2011-03-25 CN CN2011800163075A patent/CN102933593A/zh active Pending
- 2011-03-25 EA EA201290958A patent/EA201290958A1/ru unknown
- 2011-03-25 BR BR112012023749A patent/BR112012023749A2/pt not_active IP Right Cessation
- 2011-03-25 EP EP11760319.1A patent/EP2569325A4/en not_active Withdrawn
- 2011-03-25 AU AU2011230580A patent/AU2011230580A1/en not_active Abandoned
- 2011-03-25 MX MX2012010724A patent/MX2012010724A/es not_active Application Discontinuation
- 2011-03-25 JP JP2013502678A patent/JP2013523739A/ja active Pending
- 2011-03-25 CA CA2792266A patent/CA2792266A1/en not_active Abandoned
- 2011-03-25 WO PCT/US2011/030009 patent/WO2011119969A1/en not_active Ceased
- 2011-03-25 PH PH1/2012/501906A patent/PH12012501906A1/en unknown
- 2011-03-25 SG SG2012070587A patent/SG184221A1/en unknown
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2012
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2014
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2016
- 2016-02-16 US US15/044,705 patent/US20160158268A1/en not_active Abandoned
- 2016-05-26 JP JP2016105169A patent/JP2016147918A/ja active Pending
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| Publication number | Publication date |
|---|---|
| EA201290958A1 (ru) | 2013-04-30 |
| ZA201207090B (en) | 2014-03-26 |
| JP2016147918A (ja) | 2016-08-18 |
| US9289383B2 (en) | 2016-03-22 |
| KR20130029050A (ko) | 2013-03-21 |
| CO6630141A2 (es) | 2013-03-01 |
| EP2569325A4 (en) | 2013-10-09 |
| SG184221A1 (en) | 2012-10-30 |
| PH12012501906A1 (en) | 2013-01-14 |
| WO2011119969A1 (en) | 2011-09-29 |
| CN102933593A (zh) | 2013-02-13 |
| JP2013523739A (ja) | 2013-06-17 |
| BR112012023749A2 (pt) | 2016-08-23 |
| US20150080330A1 (en) | 2015-03-19 |
| US20140018314A1 (en) | 2014-01-16 |
| CA2792266A1 (en) | 2011-09-29 |
| EP2569325A1 (en) | 2013-03-20 |
| US8895530B2 (en) | 2014-11-25 |
| US20160158268A1 (en) | 2016-06-09 |
| AU2011230580A1 (en) | 2012-10-11 |
| US8476247B2 (en) | 2013-07-02 |
| CL2012002613A1 (es) | 2012-12-21 |
| US20110245195A1 (en) | 2011-10-06 |
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