JP2013521285A5 - - Google Patents
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- Publication number
- JP2013521285A5 JP2013521285A5 JP2012556121A JP2012556121A JP2013521285A5 JP 2013521285 A5 JP2013521285 A5 JP 2013521285A5 JP 2012556121 A JP2012556121 A JP 2012556121A JP 2012556121 A JP2012556121 A JP 2012556121A JP 2013521285 A5 JP2013521285 A5 JP 2013521285A5
- Authority
- JP
- Japan
- Prior art keywords
- aryl
- pyridine
- heterocyclyl
- alkyl
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31041010P | 2010-03-04 | 2010-03-04 | |
| US61/310,410 | 2010-03-04 | ||
| PCT/US2011/026399 WO2011109254A1 (en) | 2010-03-04 | 2011-02-28 | Inhibitors of catechol o-methyl transferase and their use in the treatment of psychotic disorders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013521285A JP2013521285A (ja) | 2013-06-10 |
| JP2013521285A5 true JP2013521285A5 (cg-RX-API-DMAC7.html) | 2014-04-17 |
| JP5995728B2 JP5995728B2 (ja) | 2016-09-21 |
Family
ID=44542511
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012556121A Expired - Fee Related JP5995728B2 (ja) | 2010-03-04 | 2011-02-28 | カテコールｏ−メチルトランスフェラーゼの阻害剤および精神障害の治療におけるその使用 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US9024032B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2542076B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5995728B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR101720824B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN102869256B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2011223969B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112012021652A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2789471C (cg-RX-API-DMAC7.html) |
| ES (1) | ES2862931T3 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2012010187A (cg-RX-API-DMAC7.html) |
| RU (1) | RU2586974C2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2011109254A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112012021652A2 (pt) * | 2010-03-04 | 2016-06-21 | Merck Sharp & Dohme | composto, uso do mesmo, e, composição farmacêutica |
| GB201111705D0 (en) | 2011-07-07 | 2011-08-24 | Takeda Pharmaceutical | Compounds and their use |
| GB201111704D0 (en) | 2011-07-07 | 2011-08-24 | Takeda Pharmaceutical | Novel compounds |
| JO3115B1 (ar) | 2011-08-22 | 2017-09-20 | Takeda Pharmaceuticals Co | مركبات بيريدازينون واستخدامها كمثبطات daao |
| PE20141361A1 (es) | 2011-11-15 | 2014-10-13 | Takeda Pharmaceutical | Compuesto heterociclico dihidroxi aromatico |
| TWI638802B (zh) | 2012-05-24 | 2018-10-21 | 芬蘭商奧利安公司 | 兒茶酚ｏ－甲基轉移酶活性抑制化合物 |
| CN103845317B (zh) * | 2012-11-28 | 2018-05-08 | 北京生命科学研究所 | 恩他卡朋在预防或治疗肥胖等代谢综合征中的应用 |
| GB201222711D0 (en) | 2012-12-17 | 2013-01-30 | Takeda Pharmaceutical | Novel compounds |
| CA2886139A1 (en) | 2012-12-27 | 2014-07-03 | F. Hoffmann-La Roche Ag | Comt inhibitors |
| WO2014151367A1 (en) | 2013-03-15 | 2014-09-25 | Janssen Pharmaceutica Nv | 1,2,5-substituted benzimidazoles as flap modulators |
| WO2014151380A1 (en) | 2013-03-15 | 2014-09-25 | Janssen Pharmaceutica Nv | 1,2,6-substituted benzimidazoles as flap modulators |
| CN103588702B (zh) * | 2013-10-26 | 2016-01-06 | 浙江大学 | N-取代苯基吡啶-4-酮衍生物及其制备和应用 |
| US9988373B2 (en) | 2013-12-26 | 2018-06-05 | Shionogi & Co., Ltd. | Nitrogen-containing six-membered cyclic derivatives and pharmaceutical composition comprising the same |
| JP6858712B2 (ja) | 2015-01-30 | 2021-04-14 | リーバー インスティテュート フォー ブレイン ディベロップメントＬｉｅｂｅｒ Ｉｎｓｔｉｔｕｔｅ Ｆｏｒ Ｂｒａｉｎ Ｄｅｖｅｌｏｐｍｅｎｔ | Ｃｏｍｔ阻害方法及び組成物 |
| AU2016252686B2 (en) | 2015-04-24 | 2019-03-14 | Shionogi & Co., Ltd. | 6-membered heterocyclic derivative and pharmaceutical composition comprising same |
| WO2017070089A1 (en) | 2015-10-19 | 2017-04-27 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| US20170145025A1 (en) | 2015-11-19 | 2017-05-25 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| PL3380471T3 (pl) | 2015-11-25 | 2021-12-20 | Lieber Institute Inc. Dba Lieber Institute For Brain Development | Tetrahydro-8h-pirydo[1,2-a]pirazyn-8-ony jako inhibitory comt do leczenia chorób i zaburzeń neurodegeneracyjnych |
| CN105481812B (zh) * | 2015-11-30 | 2020-04-21 | 重庆天奕恒化科技有限公司 | 一种5-苄氧基-4-氧代-4h-吡喃-2-羧酸的制备方法 |
| LT3394033T (lt) | 2015-12-22 | 2021-03-10 | Incyte Corporation | Heterocikliniai junginiai, kaip imunomoduliatoriai |
| US20170320875A1 (en) | 2016-05-06 | 2017-11-09 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| US20170342060A1 (en) | 2016-05-26 | 2017-11-30 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| HRP20221030T1 (hr) | 2016-06-20 | 2022-11-11 | Incyte Corporation | Heterociklički spojevi kao imunomodulatori |
| WO2018013789A1 (en) | 2016-07-14 | 2018-01-18 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| MA46045A (fr) | 2016-08-29 | 2021-04-28 | Incyte Corp | Composés hétérocycliques utilisés comme immunomodulateurs |
| CA3039458A1 (en) | 2016-10-17 | 2018-04-26 | Shionogi & Co., Ltd. | Bicyclic nitrogen-containing heterocyclic derivatives and pharmaceutical composition comprising the same |
| WO2018119221A1 (en) | 2016-12-22 | 2018-06-28 | Incyte Corporation | Pyridine derivatives as immunomodulators |
| EP3558963B1 (en) | 2016-12-22 | 2022-03-23 | Incyte Corporation | Bicyclic heteroaromatic compounds as immunomodulators |
| WO2018119236A1 (en) | 2016-12-22 | 2018-06-28 | Incyte Corporation | Triazolo[1,5-a]pyridine derivatives as immunomodulators |
| BR112019012993A2 (pt) | 2016-12-22 | 2019-12-03 | Incyte Corporation | derivados de benzo-oxazol como imunomoduladores |
| JP7149276B2 (ja) | 2016-12-22 | 2022-10-06 | インサイト・コーポレイション | Ｐｄ－ｌ１内在化誘導物質としてのテトラヒドロイミダゾ［４，５－ｃ］ピリジン誘導体 |
| MX2019011762A (es) | 2017-03-31 | 2019-12-02 | Fujifilm Corp | Compuesto de 4-piridona o su sal, y composicion y formulacion farmaceutica que incluye el mismo. |
| CN108191746B (zh) * | 2018-02-02 | 2020-06-16 | 暨南大学 | 一种羟基吡啶酮类化合物及其制备方法与应用 |
| MY210070A (en) | 2018-03-30 | 2025-08-25 | Incyte Corp | Heterocyclic compounds as immunomodulators |
| PT3790877T (pt) | 2018-05-11 | 2023-05-10 | Incyte Corp | Derivados de tetrahidro-imidazo[4,5-c]piridina como imunomoduladores pd-l1 |
| WO2020097398A1 (en) | 2018-11-07 | 2020-05-14 | Dana-Farber Cancer Institute, Inc. | Benzothiazole derivatives and 7-aza-benzothiazole derivatives as janus kinase 2 inhibitors and uses thereof |
| TW202115059A (zh) | 2019-08-09 | 2021-04-16 | 美商英塞特公司 | Ｐｄ—１／ｐｄ—ｌ１抑制劑之鹽 |
| BR112022005826A2 (pt) | 2019-09-30 | 2022-06-21 | Incyte Corp | Compostos de pirido[3,2-d]pirimidina como imunomoduladores |
| BR112022009031A2 (pt) | 2019-11-11 | 2022-10-11 | Incyte Corp | Sais e formas cristalinas de um inibidor de pd-1/pd-l1 |
| CN111170936B (zh) | 2020-01-19 | 2021-01-01 | 杭州泽德医药科技有限公司 | 3,4-二羟基-n-(1’-苄基-2’-羟乙基)-2-甲基吡啶氯化物及制备和应用 |
| WO2021226261A1 (en) | 2020-05-06 | 2021-11-11 | Ajax Therapeutics, Inc. | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors |
| KR102377058B1 (ko) | 2020-11-04 | 2022-03-22 | 경북대학교 산학협력단 | 니아스텔라 코리엔시스에서 유래한 카테콜 o-메틸 트렌스퍼라제 및 이의 변이체 |
| MX2023005362A (es) | 2020-11-06 | 2023-06-22 | Incyte Corp | Proceso para hacer un inhibidor de proteina de muerte programada 1 (pd-1)/ligando de muerte programada 1 (pd-l1) y sales y formas cristalinas del mismo. |
| WO2022099018A1 (en) | 2020-11-06 | 2022-05-12 | Incyte Corporation | Process of preparing a pd-1/pd-l1 inhibitor |
| TW202233615A (zh) | 2020-11-06 | 2022-09-01 | 美商英塞特公司 | Ｐｄ—１／ｐｄ—ｌ１抑制劑之結晶形式 |
| EP4267574B1 (en) | 2020-12-23 | 2025-04-23 | Ajax Therapeutics, Inc. | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors |
| EP4373487A4 (en) * | 2021-07-19 | 2025-10-29 | Baylor College Medicine | CORONAVIRUS MAJOR PROTEASE INHIBITORS AND THEIR METHODS OF USE |
| US12162881B2 (en) | 2021-11-09 | 2024-12-10 | Ajax Therapeutics, Inc. | Forms and compositions of inhibitors of JAK2 |
| CA3234638A1 (en) | 2021-11-09 | 2023-05-19 | Ajax Therapeutics, Inc. | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors |
| CN114716366B (zh) * | 2022-04-13 | 2023-12-26 | 浙江大学 | 3-羟基吡啶-4-酮类衍生物及在抑制肾细胞铁死亡中的应用 |
| CN116947812B (zh) * | 2023-06-30 | 2025-09-02 | 南京红太阳医药研究院有限公司 | 一种艾司奥美拉唑镁降解杂质的制备方法 |
| WO2025257687A1 (en) * | 2024-06-11 | 2025-12-18 | Universidade Do Porto | Hydroxypyridinone compounds as inhibitors of catechol-o-methyltransferase |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8811055D0 (en) * | 1988-05-10 | 1988-06-15 | Ici Plc | Antibiotic compounds |
| US5336482A (en) * | 1991-12-05 | 1994-08-09 | The Du Pont Merck Pharmaceutical Company | Technetium-99m complexes with N-substituted 3-hydroxy-4-pyridinones |
| FR2687674B1 (fr) * | 1992-02-07 | 1995-05-19 | Roussel Uclaf | Nouveaux derives de la pyridone, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant. |
| JP2001319486A (ja) * | 2000-05-12 | 2001-11-16 | Mitsubishi Electric Corp | 不揮発性半導体記憶装置 |
| SE0004053D0 (sv) | 2000-11-06 | 2000-11-06 | Astrazeneca Ab | N-type calcium channel antagonists for the treatment of pain |
| DE122008000016I1 (de) * | 2001-10-26 | 2011-12-01 | Angeletti P Ist Richerche Bio | N-substituierte hydroxypyrimidinoncarboxamidhemmerder HIV-integrase. |
| WO2005047268A2 (en) * | 2003-11-10 | 2005-05-26 | X-Ceptor Therapeutics, Inc. | Substituted pyrimidine compositions and methods of use |
| JP2007126716A (ja) * | 2005-11-04 | 2007-05-24 | Miyazaki Tlo:Kk | カドミウムに対する亜鉛の高選択的抽出剤及び亜鉛の回収 |
| US7834050B2 (en) * | 2006-03-29 | 2010-11-16 | Duke University | Small molecule insulin mimetics absent quinones |
| JP2009234959A (ja) * | 2008-03-26 | 2009-10-15 | Pias Arise Kk | ３−ヒドロキシ−２−メチル−１−フェニル−４−ピリジノン又はその誘導体からなる美白剤、並びにその美白剤を含有する美白用皮膚外用剤、化粧料 |
| BR112012021652A2 (pt) * | 2010-03-04 | 2016-06-21 | Merck Sharp & Dohme | composto, uso do mesmo, e, composição farmacêutica |
-
2011
- 2011-02-28 BR BR112012021652A patent/BR112012021652A2/pt not_active IP Right Cessation
- 2011-02-28 WO PCT/US2011/026399 patent/WO2011109254A1/en not_active Ceased
- 2011-02-28 MX MX2012010187A patent/MX2012010187A/es unknown
- 2011-02-28 CA CA2789471A patent/CA2789471C/en active Active
- 2011-02-28 ES ES11751121T patent/ES2862931T3/es active Active
- 2011-02-28 AU AU2011223969A patent/AU2011223969B2/en not_active Ceased
- 2011-02-28 EP EP11751121.2A patent/EP2542076B1/en active Active
- 2011-02-28 CN CN201180012426.3A patent/CN102869256B/zh not_active Expired - Fee Related
- 2011-02-28 US US13/582,601 patent/US9024032B2/en active Active
- 2011-02-28 KR KR1020127023048A patent/KR101720824B1/ko not_active Expired - Fee Related
- 2011-02-28 RU RU2012142194/04A patent/RU2586974C2/ru not_active IP Right Cessation
- 2011-02-28 JP JP2012556121A patent/JP5995728B2/ja not_active Expired - Fee Related
-
2015
- 2015-03-27 US US14/671,452 patent/US9399651B2/en active Active - Reinstated
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