JP2013519699A - 因子viii融合タンパク質 - Google Patents

因子viii融合タンパク質 Download PDF

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Publication number
JP2013519699A
JP2013519699A JP2012553267A JP2012553267A JP2013519699A JP 2013519699 A JP2013519699 A JP 2013519699A JP 2012553267 A JP2012553267 A JP 2012553267A JP 2012553267 A JP2012553267 A JP 2012553267A JP 2013519699 A JP2013519699 A JP 2013519699A
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fviii
molecule
domain
factor viii
fusion
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Japanese (ja)
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JP2013519699A5 (cg-RX-API-DMAC7.html
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ゲルト・ボルト
クリスティアン・ケアゴー
ペダー・リスビー・ノービー
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ノヴォ ノルディスク アー/エス
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Publication of JP2013519699A5 publication Critical patent/JP2013519699A5/ja
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745Blood coagulation or fibrinolysis factors
    • C07K14/755Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/70535Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76Albumins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/31Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2012553267A 2010-02-16 2011-02-10 因子viii融合タンパク質 Withdrawn JP2013519699A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP10153715 2010-02-16
EP10153715.7 2010-02-16
US30617710P 2010-02-19 2010-02-19
US61/306,177 2010-02-19
PCT/EP2011/051959 WO2011101284A1 (en) 2010-02-16 2011-02-10 Factor viii fusion protein

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016021624A Division JP6185097B2 (ja) 2010-02-16 2016-02-08 因子viii融合タンパク質

Publications (2)

Publication Number Publication Date
JP2013519699A true JP2013519699A (ja) 2013-05-30
JP2013519699A5 JP2013519699A5 (cg-RX-API-DMAC7.html) 2015-07-02

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JP2012553267A Withdrawn JP2013519699A (ja) 2010-02-16 2011-02-10 因子viii融合タンパク質
JP2016021624A Expired - Fee Related JP6185097B2 (ja) 2010-02-16 2016-02-08 因子viii融合タンパク質
JP2017144266A Withdrawn JP2017190342A (ja) 2010-02-16 2017-07-26 因子viii融合タンパク質

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2016021624A Expired - Fee Related JP6185097B2 (ja) 2010-02-16 2016-02-08 因子viii融合タンパク質
JP2017144266A Withdrawn JP2017190342A (ja) 2010-02-16 2017-07-26 因子viii融合タンパク質

Country Status (5)

Country Link
US (2) US9493543B2 (cg-RX-API-DMAC7.html)
EP (2) EP2977055A1 (cg-RX-API-DMAC7.html)
JP (3) JP2013519699A (cg-RX-API-DMAC7.html)
CN (2) CN102770450B (cg-RX-API-DMAC7.html)
WO (1) WO2011101284A1 (cg-RX-API-DMAC7.html)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017536105A (ja) * 2014-10-17 2017-12-07 コディアック サイエンシーズ インコーポレイテッドKodiak Sciences Inc. ブチリルコリンエステラーゼ両性イオン性ポリマーコンジュゲート
JP2019502361A (ja) * 2015-11-13 2019-01-31 アステリオン・リミテッド 成長ホルモン受容体の細胞外結合ドメインを含む融合ポリペプチド
US11066465B2 (en) 2015-12-30 2021-07-20 Kodiak Sciences Inc. Antibodies and conjugates thereof
US11155610B2 (en) 2014-06-28 2021-10-26 Kodiak Sciences Inc. Dual PDGF/VEGF antagonists
JP2021530437A (ja) * 2018-05-18 2021-11-11 鄭州晟斯生物科技有限公司Zhengzhou Gensciences Inc 改良されたfviii融合タンパク質及びその応用
JP2023511871A (ja) * 2020-01-20 2023-03-23 ウーシー バイオロジクス アイルランド リミテッド アフィニティークロマトグラフィー用の新規な洗浄緩衝液
JP2023542389A (ja) * 2020-09-23 2023-10-06 アブレヴィア バイオテック ゲーエムベーハー 自己抗体で媒介される状態の予防又は治療のための化合物
US11912784B2 (en) 2019-10-10 2024-02-27 Kodiak Sciences Inc. Methods of treating an eye disorder
US12071476B2 (en) 2018-03-02 2024-08-27 Kodiak Sciences Inc. IL-6 antibodies and fusion constructs and conjugates thereof

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CN102741422B (zh) 2009-08-24 2016-06-08 阿穆尼克斯运营公司 凝血因子ⅶ组合物及其制备和使用方法
WO2011075185A1 (en) 2009-12-18 2011-06-23 Oligasis Targeted drug phosphorylcholine polymer conjugates
CN102770449B (zh) * 2010-02-16 2016-02-24 诺沃—诺迪斯克有限公司 具有降低的vwf结合的因子viii分子
EP2804623B1 (en) * 2012-01-12 2019-08-07 Bioverativ Therapeutics Inc. Chimeric factor viii polypeptides and uses thereof
JP6383666B2 (ja) 2012-02-15 2018-08-29 バイオベラティブ セラピューティクス インコーポレイテッド 組換え第viii因子タンパク質
EP2814840B1 (en) 2012-02-15 2019-11-13 Bioverativ Therapeutics Inc. Factor viii compositions and methods of making and using same
CN104411716B (zh) * 2012-04-24 2018-09-07 诺和诺德股份有限公司 适用于治疗血友病的化合物
EP2841091A1 (en) 2012-04-24 2015-03-04 Novo Nordisk A/S Pharmaceutical composition suitable for treatment of haemophilia
SG10201701037WA (en) 2012-07-11 2017-03-30 Amunix Operating Inc Factor viii complex with xten and von willebrand factor protein, and uses thereof
EP2989122B1 (en) 2013-04-23 2019-04-03 President and Fellows of Harvard College Genetic reprogramming of bacterial biofilms
EP3033097B1 (en) 2013-08-14 2021-03-10 Bioverativ Therapeutics Inc. Factor viii-xten fusions and uses thereof
LT3041513T (lt) 2013-09-08 2020-11-25 Kodiak Sciences Inc. Viii faktoriaus cviterioninių polimerų konjugatai
HRP20220960T1 (hr) 2014-01-10 2022-10-28 Bioverativ Therapeutics Inc. Kimerni proteini faktora viii i njihova upotreba
WO2015132724A1 (en) * 2014-03-05 2015-09-11 Pfizer Inc. Improved muteins of clotting factor viii
DK3177317T3 (en) 2014-08-04 2020-06-15 Csl Ltd Factor viii formulation
AU2016231327B2 (en) 2015-03-06 2018-08-09 CSL Behring Lengnau AG Modified von Willebrand factor having improved half-life
EP3280397A4 (en) * 2015-04-06 2018-08-22 President and Fellows of Harvard College Biosynthetic amyloid-based materials displaying functional protein sequences
WO2016198521A1 (en) * 2015-06-10 2016-12-15 Novo Nordisk A/S Fviii fusion proteins
CN104926946B (zh) * 2015-07-13 2021-09-17 中国科学院广州生物医药与健康研究院 具有延长体内半衰期的adamts13-mdtcs融合蛋白及其应用
WO2017024060A1 (en) 2015-08-03 2017-02-09 Biogen Ma Inc. Factor ix fusion proteins and methods of making and using same
KR20180031775A (ko) 2015-08-12 2018-03-28 셀 머신스, 인크. 긴 반감기 응집 복합체와 관련된 방법 및 조성물
WO2017201428A1 (en) 2016-05-19 2017-11-23 President And Fellows Of Harvard College Methods of making gels and film using curli nanofibers
WO2018032638A1 (zh) 2016-08-19 2018-02-22 安源医药科技(上海)有限公司 用于构建融合蛋白的连接肽
CN106279437B (zh) * 2016-08-19 2017-10-31 安源医药科技(上海)有限公司 高糖基化人凝血因子viii融合蛋白及其制备方法与用途
CN106317226B (zh) 2016-08-19 2017-09-05 安源医药科技(上海)有限公司 用于构建融合蛋白的连接肽
IL266972B2 (en) 2016-12-02 2024-04-01 Bioverativ Therapeutics Inc Methods of treating hemophilic arthropathy using chimeric clotting factors
CN108623695B (zh) * 2017-03-24 2022-03-15 中国科学院过程工程研究所 一种白蛋白结合肽-人睫状神经营养因子融合蛋白及其制备方法和应用
WO2018191548A2 (en) 2017-04-14 2018-10-18 Kodiak Sciences Inc. Complement factor d antagonist antibodies and conjugates thereof
GB201706781D0 (en) 2017-04-28 2017-06-14 Univ Sheffield Parathyroid hormone fusion polypeptide
CA3099049A1 (en) 2018-05-18 2019-11-21 Bioverativ Therapeutics Inc. Methods of treating hemophilia a
WO2019219048A1 (zh) * 2018-05-18 2019-11-21 北京辅仁瑞辉生物医药研究院有限公司 具有延长半衰期的融合多肽缀合物
CN110950964B (zh) * 2018-09-26 2021-06-18 安源医药科技(上海)有限公司 突变型单链人凝血因子viii融合蛋白及其制备方法与用途
JP7780341B2 (ja) 2019-07-04 2025-12-04 ツェー・エス・エル・ベーリング・レングナウ・アクチエンゲゼルシャフト 第VIII凝固因子のin vitroでの安定性を向上させるための切断型フォン・ヴィレブランド因子(VWF)
EP3785726A1 (en) 2019-09-02 2021-03-03 Biotest AG Factor viii protein with increased half-life
CA3150442A1 (en) * 2019-09-02 2021-03-11 Biotest Ag Factor viii protein with increased half-life
JP7680442B2 (ja) 2019-11-11 2025-05-20 ツェー・エス・エル・ベーリング・レングナウ・アクチエンゲゼルシャフト 第viii因子に対する寛容を誘導するためのポリペプチド
US11981718B2 (en) 2020-05-27 2024-05-14 Ampsource Biopharma Shanghai Inc. Dual-function protein for lipid and blood glucose regulation
KR20250013211A (ko) * 2022-05-25 2025-01-31 지앙수 젠사이언시스 아이엔씨. 연장된 반감기를 갖는 fviii 융합 단백질 접합체 및 이의 용도

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WO2008025856A2 (en) * 2006-09-01 2008-03-06 Novo Nordisk Health Care Ag Modified glycoproteins
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Cited By (14)

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Publication number Priority date Publication date Assignee Title
US11155610B2 (en) 2014-06-28 2021-10-26 Kodiak Sciences Inc. Dual PDGF/VEGF antagonists
US10363290B2 (en) 2014-10-17 2019-07-30 Kodiak Sciences Inc. Butyrylcholinesterase zwitterionic polymer conjugates
US11071771B2 (en) 2014-10-17 2021-07-27 Kodiak Sciences Inc. Butyrylcholinesterase zwitterionic polymer conjugates
JP2017536105A (ja) * 2014-10-17 2017-12-07 コディアック サイエンシーズ インコーポレイテッドKodiak Sciences Inc. ブチリルコリンエステラーゼ両性イオン性ポリマーコンジュゲート
JP2019502361A (ja) * 2015-11-13 2019-01-31 アステリオン・リミテッド 成長ホルモン受容体の細胞外結合ドメインを含む融合ポリペプチド
US11066465B2 (en) 2015-12-30 2021-07-20 Kodiak Sciences Inc. Antibodies and conjugates thereof
US12071476B2 (en) 2018-03-02 2024-08-27 Kodiak Sciences Inc. IL-6 antibodies and fusion constructs and conjugates thereof
JP2021530437A (ja) * 2018-05-18 2021-11-11 鄭州晟斯生物科技有限公司Zhengzhou Gensciences Inc 改良されたfviii融合タンパク質及びその応用
JP2023093634A (ja) * 2018-05-18 2023-07-04 鄭州晟斯生物科技有限公司 改良されたfviii融合タンパク質及びその応用
JP7492780B2 (ja) 2018-05-18 2024-05-30 鄭州晟斯生物科技有限公司 改良されたfviii融合タンパク質及びその応用
US11912784B2 (en) 2019-10-10 2024-02-27 Kodiak Sciences Inc. Methods of treating an eye disorder
JP7462762B2 (ja) 2020-01-20 2024-04-05 ウーシー バイオロジクス アイルランド リミテッド アフィニティークロマトグラフィー用の新規な洗浄緩衝液
JP2023511871A (ja) * 2020-01-20 2023-03-23 ウーシー バイオロジクス アイルランド リミテッド アフィニティークロマトグラフィー用の新規な洗浄緩衝液
JP2023542389A (ja) * 2020-09-23 2023-10-06 アブレヴィア バイオテック ゲーエムベーハー 自己抗体で媒介される状態の予防又は治療のための化合物

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US20170015729A1 (en) 2017-01-19
EP2977055A1 (en) 2016-01-27
JP2016084365A (ja) 2016-05-19
US20130040889A1 (en) 2013-02-14
EP2536754A1 (en) 2012-12-26
CN102770450B (zh) 2015-12-02
CN105153313A (zh) 2015-12-16
WO2011101284A1 (en) 2011-08-25
CN102770450A (zh) 2012-11-07
JP2017190342A (ja) 2017-10-19
JP6185097B2 (ja) 2017-08-23
US9493543B2 (en) 2016-11-15

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