JP2013518902A5 - - Google Patents
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- JP2013518902A5 JP2013518902A5 JP2012552115A JP2012552115A JP2013518902A5 JP 2013518902 A5 JP2013518902 A5 JP 2013518902A5 JP 2012552115 A JP2012552115 A JP 2012552115A JP 2012552115 A JP2012552115 A JP 2012552115A JP 2013518902 A5 JP2013518902 A5 JP 2013518902A5
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- JP
- Japan
- Prior art keywords
- alkyl
- tetrahydro
- trifluoromethyl
- carbazol
- dichloro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 10
- 229910052731 fluorine Inorganic materials 0.000 claims 10
- 239000011737 fluorine Substances 0.000 claims 10
- 229910052801 chlorine Inorganic materials 0.000 claims 8
- 239000000460 chlorine Substances 0.000 claims 8
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 7
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 7
- 239000000178 monomer Substances 0.000 claims 7
- 125000001424 substituent group Chemical group 0.000 claims 7
- 125000001188 haloalkyl group Chemical group 0.000 claims 6
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 5
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- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 5
- 229910052794 bromium Inorganic materials 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
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- GLOACQUUNCBWQT-GFCCVEGCSA-N (1r)-6,8-dichloro-1-(trifluoromethyl)-2,3,4,9-tetrahydrocarbazol-1-ol Chemical compound N1C2=C(Cl)C=C(Cl)C=C2C2=C1[C@@](O)(C(F)(F)F)CCC2 GLOACQUUNCBWQT-GFCCVEGCSA-N 0.000 claims 1
- OZXBEIHRSWLQHT-LBPRGKRZSA-N (1s)-6,7-dichloro-1-(trifluoromethyl)-2,3,4,9-tetrahydrocarbazol-1-ol Chemical compound N1C2=CC(Cl)=C(Cl)C=C2C2=C1[C@](O)(C(F)(F)F)CCC2 OZXBEIHRSWLQHT-LBPRGKRZSA-N 0.000 claims 1
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- DZMHVXDYRBLHFR-UHFFFAOYSA-N 8-hydroxy-8-(trifluoromethyl)-5,6,7,9-tetrahydrocarbazole-3-carbonitrile Chemical compound N1C2=CC=C(C#N)C=C2C2=C1C(O)(C(F)(F)F)CCC2 DZMHVXDYRBLHFR-UHFFFAOYSA-N 0.000 claims 1
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30149210P | 2010-02-04 | 2010-02-04 | |
| US61/301,492 | 2010-02-04 | ||
| PCT/US2011/023768 WO2011097496A1 (en) | 2010-02-04 | 2011-02-04 | Selective androgen receptor modulators |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016035296A Division JP2016138118A (ja) | 2010-02-04 | 2016-02-26 | 選択的アンドロゲン受容体モジュレーター |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013518902A JP2013518902A (ja) | 2013-05-23 |
| JP2013518902A5 true JP2013518902A5 (enExample) | 2015-05-28 |
| JP5964756B2 JP5964756B2 (ja) | 2016-08-03 |
Family
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| DK2187965T3 (da) | 2007-08-17 | 2020-01-20 | Purdue Research Foundation | Psma-bindingsligand-linker-konjugater og fremgangsmåder til anvendelse |
| JP5964756B2 (ja) | 2010-02-04 | 2016-08-03 | ラジウス ヘルス，インコーポレイテッド | 選択的アンドロゲン受容体モジュレーター |
| US9951324B2 (en) | 2010-02-25 | 2018-04-24 | Purdue Research Foundation | PSMA binding ligand-linker conjugates and methods for using |
| PL2568806T3 (pl) | 2010-05-12 | 2017-03-31 | Radius Health, Inc. | Schematy lecznicze |
| AU2011312490B2 (en) | 2010-09-28 | 2015-06-25 | Radius Pharmaceuticals, Inc. | Selective androgen receptor modulators |
| CN103172643B (zh) * | 2011-12-26 | 2016-03-02 | 中国医学科学院药物研究所 | 黄皮咔唑生物碱及其制备方法和其药物组合物与用途 |
| KR102318999B1 (ko) | 2012-11-15 | 2021-10-29 | 엔도사이트, 인코포레이티드 | Psma 발현 세포에 의해 야기되는 질병을 치료하기 위한 컨쥬게이트 |
| AU2014336638C1 (en) | 2013-10-18 | 2020-09-17 | Novartis Ag | Labeled inhibitors of prostate specific membrane antigen (PSMA), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer |
| WO2015073678A1 (en) | 2013-11-14 | 2015-05-21 | Endocyte, Inc. | Compounds for positron emission tomography |
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| US9421264B2 (en) | 2014-03-28 | 2016-08-23 | Duke University | Method of treating cancer using selective estrogen receptor modulators |
| US10188759B2 (en) | 2015-01-07 | 2019-01-29 | Endocyte, Inc. | Conjugates for imaging |
| JP6757037B2 (ja) * | 2016-02-15 | 2020-09-16 | 学校法人近畿大学 | ストレス評価方法 |
| WO2017223115A1 (en) | 2016-06-22 | 2017-12-28 | Radius Health, Inc. | Ar+ breast cancer treatment methods |
| EP3565542B1 (en) | 2017-01-05 | 2024-04-10 | Radius Pharmaceuticals, Inc. | Polymorphic forms of rad1901-2hcl |
| MX2020010813A (es) | 2018-04-17 | 2021-01-08 | Endocyte Inc | Metodos de tratamiento de cancer. |
| SG11202013177WA (en) | 2018-07-04 | 2021-01-28 | Radius Pharmaceuticals Inc | Polymorphic forms of rad 1901-2hcl |
| CN109239214B (zh) * | 2018-09-19 | 2020-01-31 | 珠海润都制药股份有限公司 | 一种沙库比曲钠中沙库比曲异构体检验方法 |
| US12441745B2 (en) | 2019-02-12 | 2025-10-14 | Radius Pharmaceuticals, Inc. | Processes and compounds |
| EP3972627A4 (en) | 2019-05-20 | 2023-06-21 | Endocyte, Inc. | Methods for preparing psma conjugates |
| WO2022106629A1 (en) | 2020-11-19 | 2022-05-27 | Novartis Ag | Synthesis of prostate specific membrane antigen (psma) ligands |
| US20250034089A1 (en) * | 2021-11-19 | 2025-01-30 | Nain Biotech (Hangzhou) Co., Ltd. | Tetrahydrocarbazole compound, and pharmaceutical composition and use thereof |
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2011
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- 2011-02-04 AU AU2011212813A patent/AU2011212813B2/en not_active Ceased
- 2011-02-04 BR BR112012019551A patent/BR112012019551A2/pt not_active IP Right Cessation
- 2011-02-04 WO PCT/US2011/023768 patent/WO2011097496A1/en not_active Ceased
- 2011-02-04 US US13/576,754 patent/US8987319B2/en not_active Expired - Fee Related
- 2011-02-04 CA CA2788907A patent/CA2788907A1/en not_active Abandoned
- 2011-02-04 MX MX2012008995A patent/MX338831B/es active IP Right Grant
- 2011-02-04 EP EP11740437.6A patent/EP2531029B1/en not_active Not-in-force
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2015
- 2015-03-23 US US14/665,849 patent/US20150266821A1/en not_active Abandoned
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2016
- 2016-02-26 JP JP2016035296A patent/JP2016138118A/ja active Pending
- 2016-11-07 US US15/330,845 patent/US20170121285A1/en not_active Abandoned
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