JP2013516633A5 - - Google Patents
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- JP2013516633A5 JP2013516633A5 JP2012548227A JP2012548227A JP2013516633A5 JP 2013516633 A5 JP2013516633 A5 JP 2013516633A5 JP 2012548227 A JP2012548227 A JP 2012548227A JP 2012548227 A JP2012548227 A JP 2012548227A JP 2013516633 A5 JP2013516633 A5 JP 2013516633A5
- Authority
- JP
- Japan
- Prior art keywords
- subject
- hpvlp
- sample
- jcv antibody
- level
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims description 82
- 239000000523 sample Substances 0.000 claims description 47
- 241000701460 JC polyomavirus Species 0.000 claims description 41
- 239000002955 immunomodulating agent Substances 0.000 claims description 28
- 229940121354 immunomodulator Drugs 0.000 claims description 28
- 230000002584 immunomodulator Effects 0.000 claims description 28
- 239000012472 biological sample Substances 0.000 claims description 17
- 238000001514 detection method Methods 0.000 claims description 16
- 239000002245 particle Substances 0.000 claims description 15
- 238000003556 assay Methods 0.000 claims description 10
- 230000002411 adverse Effects 0.000 claims description 6
- 238000012544 monitoring process Methods 0.000 claims description 6
- 229920001184 polypeptide Polymers 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 6
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 6
- 208000024891 symptom Diseases 0.000 claims description 6
- 229960005027 natalizumab Drugs 0.000 claims description 4
- 239000007787 solid Substances 0.000 claims description 4
- 239000000758 substrate Substances 0.000 claims description 4
- 239000006228 supernatant Substances 0.000 claims description 4
- 238000012286 ELISA Assay Methods 0.000 claims description 3
- 208000014644 Brain disease Diseases 0.000 claims description 2
- 208000011231 Crohn disease Diseases 0.000 claims description 2
- 208000032274 Encephalopathy Diseases 0.000 claims description 2
- 101710163270 Nuclease Proteins 0.000 claims description 2
- 239000013592 cell lysate Substances 0.000 claims description 2
- 230000002490 cerebral effect Effects 0.000 claims description 2
- 239000003153 chemical reaction reagent Substances 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims description 2
- 238000011026 diafiltration Methods 0.000 claims description 2
- 238000011534 incubation Methods 0.000 claims description 2
- 238000005342 ion exchange Methods 0.000 claims description 2
- 239000006166 lysate Substances 0.000 claims description 2
- 230000002934 lysing effect Effects 0.000 claims description 2
- 201000006417 multiple sclerosis Diseases 0.000 claims description 2
- 102000039446 nucleic acids Human genes 0.000 claims description 2
- 108020004707 nucleic acids Proteins 0.000 claims description 2
- 150000007523 nucleic acids Chemical class 0.000 claims description 2
- 230000001376 precipitating effect Effects 0.000 claims description 2
- 238000001556 precipitation Methods 0.000 claims description 2
- 230000000750 progressive effect Effects 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 238000000746 purification Methods 0.000 claims description 2
- 238000005185 salting out Methods 0.000 claims description 2
- 210000002966 serum Anatomy 0.000 claims description 2
- 238000007689 inspection Methods 0.000 claims 1
- 230000002787 reinforcement Effects 0.000 claims 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 239000013068 control sample Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29404810P | 2010-01-11 | 2010-01-11 | |
| US61/294,048 | 2010-01-11 | ||
| US31619310P | 2010-03-22 | 2010-03-22 | |
| US61/316,193 | 2010-03-22 | ||
| PCT/US2011/020832 WO2011085369A1 (en) | 2010-01-11 | 2011-01-11 | Assay for jc virus antibodies |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015246985A Division JP2016040557A (ja) | 2010-01-11 | 2015-12-18 | Ｊｃウイルス抗体に対するアッセイ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013516633A JP2013516633A (ja) | 2013-05-13 |
| JP2013516633A5 true JP2013516633A5 (en:Method) | 2014-02-27 |
| JP5946218B2 JP5946218B2 (ja) | 2016-07-05 |
Family
ID=44305841
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012548227A Active JP5946218B2 (ja) | 2010-01-11 | 2011-01-11 | Ｊｃウイルス抗体に対するアッセイ |
| JP2015246985A Withdrawn JP2016040557A (ja) | 2010-01-11 | 2015-12-18 | Ｊｃウイルス抗体に対するアッセイ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015246985A Withdrawn JP2016040557A (ja) | 2010-01-11 | 2015-12-18 | Ｊｃウイルス抗体に対するアッセイ |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US9316641B2 (en:Method) |
| EP (4) | EP4524571A3 (en:Method) |
| JP (2) | JP5946218B2 (en:Method) |
| KR (1) | KR101877576B1 (en:Method) |
| CN (1) | CN102906278A (en:Method) |
| AU (1) | AU2011203815B2 (en:Method) |
| BR (1) | BR112012017014B1 (en:Method) |
| CA (1) | CA2784137A1 (en:Method) |
| CY (2) | CY1119972T1 (en:Method) |
| DK (3) | DK2524060T3 (en:Method) |
| ES (3) | ES2930469T3 (en:Method) |
| FI (2) | FI3339865T5 (en:Method) |
| HR (3) | HRP20221390T1 (en:Method) |
| HU (3) | HUE060312T2 (en:Method) |
| IN (1) | IN2012DN06139A (en:Method) |
| LT (3) | LT3339865T (en:Method) |
| ME (1) | ME03026B (en:Method) |
| MX (1) | MX341991B (en:Method) |
| NO (1) | NO2524060T3 (en:Method) |
| NZ (1) | NZ600681A (en:Method) |
| PL (3) | PL2524060T3 (en:Method) |
| PT (3) | PT2524060T (en:Method) |
| RS (3) | RS63744B1 (en:Method) |
| SG (2) | SG181653A1 (en:Method) |
| SI (3) | SI3339865T1 (en:Method) |
| SM (3) | SMT202500065T1 (en:Method) |
| WO (1) | WO2011085369A1 (en:Method) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE052412T2 (hu) | 2005-04-04 | 2021-04-28 | Biogen Ma Inc | Módszerek egy gyógyászati hatóanyagra adott immunválasz kiértékelésére |
| PL2676967T3 (pl) | 2006-02-28 | 2019-12-31 | Biogen Ma Inc. | Metody leczenia chorób zapalnych i autoimmunologicznych za pomocą natalizumabu |
| KR20080104343A (ko) | 2006-03-03 | 2008-12-02 | 엘란 파마슈티칼스, 인크. | 나탈리주마브로 염증 및 자가면역 질환을 치료하는 방법 |
| EP2485762B1 (en) | 2009-10-11 | 2017-12-13 | Biogen MA Inc. | Anti-vla-4 related assays |
| NO2524060T3 (en:Method) | 2010-01-11 | 2018-04-28 | ||
| US11287423B2 (en) * | 2010-01-11 | 2022-03-29 | Biogen Ma Inc. | Assay for JC virus antibodies |
| PT2715352T (pt) * | 2011-05-31 | 2019-06-12 | Biogen Ma Inc | Método de avaliação do risco de lmp |
| EP2791162A2 (en) * | 2011-12-12 | 2014-10-22 | Janssen Diagnostics BVBA | Polyomavirus peptide sequences |
| EP2839032A4 (en) * | 2012-04-16 | 2015-11-18 | Univ Texas | PROOF OF EXCELLULAR JCV MIRNA |
| US9631243B2 (en) | 2012-06-18 | 2017-04-25 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods and compositions for identifying JC virus |
| EP3517545A1 (en) * | 2012-12-31 | 2019-07-31 | Neurimmune Holding AG | Recombinant human antibodies for therapy and prevention of polyomavirus-related diseases |
| US9949671B2 (en) | 2013-03-13 | 2018-04-24 | Orthoaccel Technologies, Inc. | Diagnostic mouthpieces |
| US10119976B2 (en) | 2013-05-28 | 2018-11-06 | Biogen Ma Inc. | Method of assessing risk of PML |
| EP3110976B1 (en) * | 2014-02-27 | 2020-05-13 | Biogen MA Inc. | Method of assessing risk of pml |
| MA40985A (fr) | 2014-11-17 | 2017-09-26 | Biogen Ma Inc | Méthodes de traitement de la sclérose en plaques |
| IT201600083859A1 (it) * | 2016-08-09 | 2018-02-09 | Univ Degli Studi Di Ferrara | Immunosaggio per l’identificazione di anticorpi contro il virus Polioma JC (JCPyV) mediante l’uso di peptidi sintetici. |
| WO2019169317A1 (en) * | 2018-03-02 | 2019-09-06 | Stueve Olaf | Methods and compositions for treating natalizumab-associated progressive multifocal encephalopathy |
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| NO2524060T3 (en:Method) | 2010-01-11 | 2018-04-28 | ||
| PT2715352T (pt) | 2011-05-31 | 2019-06-12 | Biogen Ma Inc | Método de avaliação do risco de lmp |
-
2011
- 2011-01-11 NO NO11732315A patent/NO2524060T3/no unknown
- 2011-01-11 HR HRP20221390TT patent/HRP20221390T1/hr unknown
- 2011-01-11 MX MX2012007660A patent/MX341991B/es active IP Right Grant
- 2011-01-11 RS RS20221053A patent/RS63744B1/sr unknown
- 2011-01-11 FI FIEP17203178.3T patent/FI3339865T5/fi active
- 2011-01-11 KR KR1020127019171A patent/KR101877576B1/ko active Active
- 2011-01-11 ME MEP-2018-60A patent/ME03026B/me unknown
- 2011-01-11 PT PT117323154T patent/PT2524060T/pt unknown
- 2011-01-11 SI SI201132069T patent/SI3339865T1/sl unknown
- 2011-01-11 NZ NZ600681A patent/NZ600681A/en unknown
- 2011-01-11 HU HUE17203178A patent/HUE060312T2/hu unknown
- 2011-01-11 EP EP24213770.1A patent/EP4524571A3/en active Pending
- 2011-01-11 SI SI201131438T patent/SI2524060T1/en unknown
- 2011-01-11 HU HUE11732315A patent/HUE036183T2/hu unknown
- 2011-01-11 AU AU2011203815A patent/AU2011203815B2/en active Active
- 2011-01-11 DK DK11732315.4T patent/DK2524060T3/en active
- 2011-01-11 ES ES17203178T patent/ES2930469T3/es active Active
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