JP2013516619A5 - - Google Patents
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- Publication number
- JP2013516619A5 JP2013516619A5 JP2012547511A JP2012547511A JP2013516619A5 JP 2013516619 A5 JP2013516619 A5 JP 2013516619A5 JP 2012547511 A JP2012547511 A JP 2012547511A JP 2012547511 A JP2012547511 A JP 2012547511A JP 2013516619 A5 JP2013516619 A5 JP 2013516619A5
- Authority
- JP
- Japan
- Prior art keywords
- biomarker
- fatal
- subject
- cardiovascular event
- nidogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000090 biomarker Substances 0.000 claims description 19
- 230000007211 cardiovascular event Effects 0.000 claims description 11
- 102000012192 Cystatin C Human genes 0.000 claims description 8
- 108010061642 Cystatin C Proteins 0.000 claims description 8
- 101000946889 Homo sapiens Monocyte differentiation antigen CD14 Proteins 0.000 claims description 8
- 102100035877 Monocyte differentiation antigen CD14 Human genes 0.000 claims description 8
- 102100037371 Nidogen-2 Human genes 0.000 claims description 8
- 101710091705 Nidogen-2 Proteins 0.000 claims description 8
- 102000013566 Plasminogen Human genes 0.000 claims description 8
- 108010051456 Plasminogen Proteins 0.000 claims description 8
- 102100035140 Vitronectin Human genes 0.000 claims description 8
- 108010031318 Vitronectin Proteins 0.000 claims description 8
- 102000003801 alpha-2-Antiplasmin Human genes 0.000 claims description 8
- 108090000183 alpha-2-Antiplasmin Proteins 0.000 claims description 8
- 210000001808 exosome Anatomy 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 7
- 102000004169 proteins and genes Human genes 0.000 claims description 7
- 108090000623 proteins and genes Proteins 0.000 claims description 7
- 208000032109 Transient ischaemic attack Diseases 0.000 claims description 4
- 208000002223 abdominal aortic aneurysm Diseases 0.000 claims description 4
- 208000007474 aortic aneurysm Diseases 0.000 claims description 4
- 210000002966 serum Anatomy 0.000 claims description 4
- 201000010875 transient cerebral ischemia Diseases 0.000 claims description 4
- 230000002792 vascular Effects 0.000 claims description 4
- 208000004476 Acute Coronary Syndrome Diseases 0.000 claims description 2
- 206010007556 Cardiac failure acute Diseases 0.000 claims description 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims description 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims description 2
- 206010025538 Malignant ascites Diseases 0.000 claims description 2
- 206010042434 Sudden death Diseases 0.000 claims description 2
- 210000004381 amniotic fluid Anatomy 0.000 claims description 2
- 210000001124 body fluid Anatomy 0.000 claims description 2
- 239000010839 body fluid Substances 0.000 claims description 2
- 210000001715 carotid artery Anatomy 0.000 claims description 2
- 239000003153 chemical reaction reagent Substances 0.000 claims description 2
- 208000029078 coronary artery disease Diseases 0.000 claims description 2
- 210000004351 coronary vessel Anatomy 0.000 claims description 2
- 210000001105 femoral artery Anatomy 0.000 claims description 2
- 239000012530 fluid Substances 0.000 claims description 2
- 210000004251 human milk Anatomy 0.000 claims description 2
- 235000020256 human milk Nutrition 0.000 claims description 2
- 238000002350 laparotomy Methods 0.000 claims description 2
- 208000010125 myocardial infarction Diseases 0.000 claims description 2
- 210000002381 plasma Anatomy 0.000 claims description 2
- 238000004393 prognosis Methods 0.000 claims description 2
- 210000003296 saliva Anatomy 0.000 claims description 2
- 210000001179 synovial fluid Anatomy 0.000 claims description 2
- 210000002700 urine Anatomy 0.000 claims description 2
- 206010007687 Carotid artery stenosis Diseases 0.000 claims 1
- 201000000057 Coronary Stenosis Diseases 0.000 claims 1
- 206010011089 Coronary artery stenosis Diseases 0.000 claims 1
- 210000001367 artery Anatomy 0.000 claims 1
- 208000006170 carotid stenosis Diseases 0.000 claims 1
- 208000030613 peripheral artery disease Diseases 0.000 claims 1
- 208000037803 restenosis Diseases 0.000 claims 1
- 206010051113 Arterial restenosis Diseases 0.000 description 1
- 208000005764 Peripheral Arterial Disease Diseases 0.000 description 1
- 208000030831 Peripheral arterial occlusive disease Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10150340.7 | 2010-01-08 | ||
| EP10150340 | 2010-01-08 | ||
| PCT/EP2011/050171 WO2011083145A1 (en) | 2010-01-08 | 2011-01-07 | Determination of exosomel biomarkers for predicting cardiovascular events |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013516619A JP2013516619A (ja) | 2013-05-13 |
| JP2013516619A5 true JP2013516619A5 (https=) | 2014-02-27 |
| JP5732474B2 JP5732474B2 (ja) | 2015-06-10 |
Family
ID=43533349
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012547511A Expired - Fee Related JP5732474B2 (ja) | 2010-01-08 | 2011-01-07 | 心血管系イベントを予測するためのエキソソームバイオマーカーの決定 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20120309041A1 (https=) |
| EP (1) | EP2521918B1 (https=) |
| JP (1) | JP5732474B2 (https=) |
| CN (1) | CN102812362B (https=) |
| AU (1) | AU2011204625B2 (https=) |
| CA (1) | CA2785592A1 (https=) |
| DK (1) | DK2521918T3 (https=) |
| SG (1) | SG181963A1 (https=) |
| WO (1) | WO2011083145A1 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2012304635B2 (en) * | 2011-09-06 | 2017-08-31 | Translational Sciences Inc. | SerpinF2-binding molecules and methods of use |
| TWI420106B (zh) * | 2011-12-01 | 2013-12-21 | Univ Kaohsiung Medical | Soluble CD14 as a biomarker for detection of coronary artery disease |
| WO2013120995A1 (en) | 2012-02-17 | 2013-08-22 | Cavadis B.V. | Exosomal biomarker for cardiovascular events in females |
| CN103376313A (zh) * | 2012-04-12 | 2013-10-30 | 梁春 | 一种基于血清外来体检测急性冠脉综合征的液相芯片试剂盒及其制备方法 |
| WO2014059336A1 (en) | 2012-10-12 | 2014-04-17 | University Of Notre Dame Du Lac | Exosomes and diagnostic biomarkers |
| CA2893639C (en) * | 2012-12-04 | 2021-01-05 | F. Hoffmann-La Roche Ag | Biomarkers in the selection of therapy of heart failure |
| WO2014159662A1 (en) | 2013-03-13 | 2014-10-02 | University Of Miami | Method for isolation and purification of microvesicles from cell culture supernatants and biological fluids |
| US12558316B2 (en) | 2013-03-13 | 2026-02-24 | University Of Miami | Methods and compositions for the treatment of epidermolysis bullosa |
| JP6547625B2 (ja) | 2013-10-25 | 2019-07-24 | 凸版印刷株式会社 | 膜小胞回収デバイス、膜小胞回収方法、及び膜小胞分析方法 |
| CN106573220B (zh) | 2014-07-24 | 2019-08-16 | 凸版印刷株式会社 | 脂质膜结构体、脂质膜结构体固定化载体、及胞体的融合方法 |
| WO2016048388A1 (en) | 2014-09-26 | 2016-03-31 | Somalogic, Inc. | Cardiovascular risk event prediction and uses thereof |
| WO2016140388A1 (ko) * | 2015-03-05 | 2016-09-09 | 경북대학교 산학협력단 | 엑소좀 또는 이의 단백질을 포함하는 장기 독성 진단용 바이오마커 조성물 및 이를 이용한 진단 방법 |
| ES2957217T3 (es) * | 2015-12-08 | 2024-01-15 | Umc Utrecht Holding Bv | Marcadores de vesículas extracelulares para angina estable y angina inestable |
| WO2020004436A1 (ja) * | 2018-06-27 | 2020-01-02 | 日立化成ダイアグノスティックス・システムズ株式会社 | 試料中のエクソソームの破壊方法及び破壊用試薬 |
| CN109055489A (zh) * | 2018-08-25 | 2018-12-21 | 上海浦美医学科技有限公司 | 一种基于细胞外囊泡dna检测egfr-tki敏感突变的方法 |
| CN113970640B (zh) * | 2020-07-24 | 2022-07-08 | 首都医科大学附属北京天坛医院 | 用于ich预后评估的生物标记物及其应用 |
| CN114150057B (zh) * | 2021-12-21 | 2024-04-26 | 贾龙飞 | 一种诊断阿尔茨海默病的外泌体蛋白及其用途 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60031512T2 (de) * | 1999-02-19 | 2007-08-23 | University Of Iowa Research Foundation | Diagnostika und therapeutika für maculare degeneration |
| CA2384295A1 (en) * | 1999-04-28 | 2000-11-02 | Yahia Gawad | Method for determining plasminogen activator inhibitor |
| US7972802B2 (en) * | 2005-10-31 | 2011-07-05 | University Of Washington | Lipoprotein-associated markers for cardiovascular disease |
| CN101371144A (zh) * | 2006-01-25 | 2009-02-18 | 霍夫曼-拉罗奇有限公司 | 抗肌钙蛋白抗体和心血管风险 |
| JP5357746B2 (ja) * | 2006-03-11 | 2013-12-04 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 末梢性の動脈疾患のためのバイオマーカーとしてのβ−２ミクログロブリン |
| DE102006050497A1 (de) * | 2006-10-26 | 2008-04-30 | Brahms Aktiengesellschaft | Risikostratifizierung des akuten Koronarsyndroms mittels Fragmenten / Teilpeptiden des proVasopressins, insbesondere Copeptin oder Neurophysin II |
| DE102006058266A1 (de) * | 2006-12-08 | 2008-06-12 | Brahms Aktiengesellschaft | Diagnose und Risikostratifizierung von Herzinsuffizienz mittels Neurophysin |
| DE102006060112A1 (de) * | 2006-12-20 | 2008-06-26 | Brahms Aktiengesellschaft | Diagnose und Risikostratifizierung mittels dem neuen Marker CT-proADM |
| WO2009019215A1 (en) * | 2007-08-03 | 2009-02-12 | Dkfz Deutsches Krebsforschungszentrum | Method for prenatal diagnosis using exosomes and cd24 as a marker |
| CN101377492B (zh) * | 2007-08-29 | 2014-04-23 | 北京九强生物技术股份有限公司 | 胱抑素c测定试剂盒 |
| KR100970651B1 (ko) * | 2007-11-01 | 2010-07-15 | 남명진 | 난소암 진단용 키트 |
| WO2010056337A2 (en) * | 2008-11-12 | 2010-05-20 | Caris Mpi, Inc. | Methods and systems of using exosomes for determining phenotypes |
-
2011
- 2011-01-07 JP JP2012547511A patent/JP5732474B2/ja not_active Expired - Fee Related
- 2011-01-07 CA CA2785592A patent/CA2785592A1/en not_active Abandoned
- 2011-01-07 CN CN201180005605.4A patent/CN102812362B/zh not_active Expired - Fee Related
- 2011-01-07 EP EP11700025.7A patent/EP2521918B1/en not_active Not-in-force
- 2011-01-07 AU AU2011204625A patent/AU2011204625B2/en not_active Ceased
- 2011-01-07 WO PCT/EP2011/050171 patent/WO2011083145A1/en not_active Ceased
- 2011-01-07 DK DK11700025.7T patent/DK2521918T3/en active
- 2011-01-07 US US13/516,417 patent/US20120309041A1/en not_active Abandoned
- 2011-01-07 SG SG2012047627A patent/SG181963A1/en unknown
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