CN102812362B - 用于预测心血管事件的外来体生物标志物的确定 - Google Patents

用于预测心血管事件的外来体生物标志物的确定 Download PDF

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Publication number
CN102812362B
CN102812362B CN201180005605.4A CN201180005605A CN102812362B CN 102812362 B CN102812362 B CN 102812362B CN 201180005605 A CN201180005605 A CN 201180005605A CN 102812362 B CN102812362 B CN 102812362B
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proteins
fatal
risk
biomarker
protein
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Chinese (zh)
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CN102812362A (zh
Inventor
莱昂纳德斯·蒂默尔斯
司肖宽
多米尼克斯·帕夏利斯·维克托·德·克莱杰恩
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CAVADIS BV
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CAVADIS BV
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81—Protease inhibitors
    • G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • G01N2333/811—Serine protease (E.C. 3.4.21) inhibitors
    • G01N2333/8121—Serpins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81—Protease inhibitors
    • G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • G01N2333/8139—Cysteine protease (E.C. 3.4.22) inhibitors, e.g. cystatin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/50—Determining the risk of developing a disease

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN201180005605.4A 2010-01-08 2011-01-07 用于预测心血管事件的外来体生物标志物的确定 Expired - Fee Related CN102812362B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10150340.7 2010-01-08
EP10150340 2010-01-08
PCT/EP2011/050171 WO2011083145A1 (en) 2010-01-08 2011-01-07 Determination of exosomel biomarkers for predicting cardiovascular events

Publications (2)

Publication Number Publication Date
CN102812362A CN102812362A (zh) 2012-12-05
CN102812362B true CN102812362B (zh) 2015-02-11

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CN201180005605.4A Expired - Fee Related CN102812362B (zh) 2010-01-08 2011-01-07 用于预测心血管事件的外来体生物标志物的确定

Country Status (9)

Country Link
US (1) US20120309041A1 (https=)
EP (1) EP2521918B1 (https=)
JP (1) JP5732474B2 (https=)
CN (1) CN102812362B (https=)
AU (1) AU2011204625B2 (https=)
CA (1) CA2785592A1 (https=)
DK (1) DK2521918T3 (https=)
SG (1) SG181963A1 (https=)
WO (1) WO2011083145A1 (https=)

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JP6184410B2 (ja) * 2011-09-06 2017-08-23 トランスレーショナル サイエンシィズ インコーポレイテッド Ｓｅｒｐｉｎｆ２結合分子および使用方法
TWI420106B (zh) * 2011-12-01 2013-12-21 Univ Kaohsiung Medical Soluble CD14 as a biomarker for detection of coronary artery disease
WO2013120995A1 (en) 2012-02-17 2013-08-22 Cavadis B.V. Exosomal biomarker for cardiovascular events in females
CN103376313A (zh) * 2012-04-12 2013-10-30 梁春 一种基于血清外来体检测急性冠脉综合征的液相芯片试剂盒及其制备方法
WO2014059336A1 (en) 2012-10-12 2014-04-17 University Of Notre Dame Du Lac Exosomes and diagnostic biomarkers
ES2672255T3 (es) * 2012-12-04 2018-06-13 F. Hoffmann-La Roche Ag Biomarcadores en la selección de tratamiento para la insuficiencia cardíaca
CN105209881B (zh) 2013-03-13 2021-01-22 迈阿密大学 从细胞培养上清液和生物流体分离并纯化微泡的方法
US12558316B2 (en) 2013-03-13 2026-02-24 University Of Miami Methods and compositions for the treatment of epidermolysis bullosa
WO2015060446A1 (ja) 2013-10-25 2015-04-30 凸版印刷株式会社 膜小胞回収デバイス、膜小胞回収方法、及び膜小胞分析方法
SG11201700557RA (en) 2014-07-24 2017-02-27 Toppan Printing Co Ltd Lipid membrane structure, lipid-membrane-structure-immobilization carrier, and method for fusing cells
ES2792227T3 (es) 2014-09-26 2020-11-10 Somalogic Inc Predicción de evento de riesgo cardiovascular y usos de la misma
WO2016140388A1 (ko) * 2015-03-05 2016-09-09 경북대학교 산학협력단 엑소좀 또는 이의 단백질을 포함하는 장기 독성 진단용 바이오마커 조성물 및 이를 이용한 진단 방법
EP3387444B1 (en) * 2015-12-08 2023-07-05 UMC Utrecht Holding B.V. Extracellular vesicle markers for stable angina and unstable angina
WO2020004436A1 (ja) * 2018-06-27 2020-01-02 日立化成ダイアグノスティックス・システムズ株式会社 試料中のエクソソームの破壊方法及び破壊用試薬
CN109055489A (zh) * 2018-08-25 2018-12-21 上海浦美医学科技有限公司 一种基于细胞外囊泡dna检测egfr-tki敏感突变的方法
CN113970640B (zh) * 2020-07-24 2022-07-08 首都医科大学附属北京天坛医院 用于ich预后评估的生物标记物及其应用
CN114150057B (zh) * 2021-12-21 2024-04-26 贾龙飞 一种诊断阿尔茨海默病的外泌体蛋白及其用途

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WO2000065349A2 (en) * 1999-04-28 2000-11-02 Cardiogenics Inc. Method for determining plasminogen activator inhibitor
CN101371144A (zh) * 2006-01-25 2009-02-18 霍夫曼-拉罗奇有限公司 抗肌钙蛋白抗体和心血管风险
CN101583874A (zh) * 2006-12-08 2009-11-18 布拉姆斯股份公司 利用后叶激素运载蛋白对心功能不全进行诊断和危险分层
CN101600967A (zh) * 2006-10-26 2009-12-09 布拉姆斯股份公司 使用抗利尿激素原的片段/部分肽、特别是和肽素或后叶激素运载蛋白ⅱ对急性冠状动脉综合征进行危险性分级
CN101611314A (zh) * 2006-12-20 2009-12-23 布拉姆斯股份公司 利用新颖标志物CT-proADM进行诊断和危险分层
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WO2000065349A2 (en) * 1999-04-28 2000-11-02 Cardiogenics Inc. Method for determining plasminogen activator inhibitor
CN101371144A (zh) * 2006-01-25 2009-02-18 霍夫曼-拉罗奇有限公司 抗肌钙蛋白抗体和心血管风险
CN101600967A (zh) * 2006-10-26 2009-12-09 布拉姆斯股份公司 使用抗利尿激素原的片段/部分肽、特别是和肽素或后叶激素运载蛋白ⅱ对急性冠状动脉综合征进行危险性分级
CN101583874A (zh) * 2006-12-08 2009-11-18 布拉姆斯股份公司 利用后叶激素运载蛋白对心功能不全进行诊断和危险分层
CN101611314A (zh) * 2006-12-20 2009-12-23 布拉姆斯股份公司 利用新颖标志物CT-proADM进行诊断和危险分层
EP2191276B1 (en) * 2007-08-03 2013-11-20 DKFZ Deutsches Krebsforschungszentrum Method for prenatal diagnosis using exosomes and cd24 as a marker

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Also Published As

Publication number Publication date
DK2521918T3 (en) 2015-06-29
EP2521918A1 (en) 2012-11-14
CN102812362A (zh) 2012-12-05
WO2011083145A1 (en) 2011-07-14
JP5732474B2 (ja) 2015-06-10
SG181963A1 (en) 2012-08-30
CA2785592A1 (en) 2011-07-14
US20120309041A1 (en) 2012-12-06
JP2013516619A (ja) 2013-05-13
EP2521918B1 (en) 2015-03-25
AU2011204625A1 (en) 2012-07-12
AU2011204625B2 (en) 2014-05-22

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