JP2013512281A5 - - Google Patents
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- Publication number
- JP2013512281A5 JP2013512281A5 JP2012542165A JP2012542165A JP2013512281A5 JP 2013512281 A5 JP2013512281 A5 JP 2013512281A5 JP 2012542165 A JP2012542165 A JP 2012542165A JP 2012542165 A JP2012542165 A JP 2012542165A JP 2013512281 A5 JP2013512281 A5 JP 2013512281A5
- Authority
- JP
- Japan
- Prior art keywords
- fluoro
- ylamino
- methyl
- tetrazol
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26564809P | 2009-12-01 | 2009-12-01 | |
| US61/265,648 | 2009-12-01 | ||
| US36646910P | 2010-07-21 | 2010-07-21 | |
| US61/366,469 | 2010-07-21 | ||
| US40596810P | 2010-10-22 | 2010-10-22 | |
| US61/405,968 | 2010-10-22 | ||
| PCT/US2010/058597 WO2011068898A1 (en) | 2009-12-01 | 2010-12-01 | Protein kinase c inhibitors and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013512281A JP2013512281A (ja) | 2013-04-11 |
| JP2013512281A5 true JP2013512281A5 (https=) | 2014-01-23 |
| JP5802677B2 JP5802677B2 (ja) | 2015-10-28 |
Family
ID=43902714
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012542165A Expired - Fee Related JP5802677B2 (ja) | 2009-12-01 | 2010-12-01 | プロテインキナーゼｃ阻害剤およびその使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20110130415A1 (https=) |
| EP (1) | EP2507227B1 (https=) |
| JP (1) | JP5802677B2 (https=) |
| CA (1) | CA2780759A1 (https=) |
| WO (1) | WO2011068898A1 (https=) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE506953T1 (de) * | 2003-08-07 | 2011-05-15 | Rigel Pharmaceuticals Inc | 2,4-pyrimidindiamin-verbindungen und verwendungen als antiproliferative mittel |
| JP6035238B2 (ja) | 2010-07-21 | 2016-11-30 | ライジェル ファーマシューティカルズ， インコーポレイテッド | プロテインキナーゼｃ阻害剤およびその使用 |
| WO2012075316A2 (en) | 2010-12-01 | 2012-06-07 | Rigel Pharmaceuticals, Inc. | Cyclopropyl mida boronate |
| US9139534B2 (en) | 2011-04-22 | 2015-09-22 | Signal Pharmaceuticals, Llc | Substituted diaminocarboxamide and diaminocarbonitrile pyrimidines, compositions thereof, and methods of treatment therewith |
| EP2720705A4 (en) * | 2011-06-16 | 2015-02-18 | Jolla Inst Allergy Immunolog | COMPOSITIONS, APPLICATIONS AND METHODS OF TREATING PKC-THETA PATHOLOGIES, UNWANTED IMMUNE REACTIONS AND DISEASES |
| US9839671B2 (en) | 2012-01-13 | 2017-12-12 | The University Of Birmingham | Peptide and uses therefor |
| GB201200555D0 (en) * | 2012-01-13 | 2012-02-29 | Univ Birmingham | Peptide |
| ES2658395T3 (es) | 2012-04-04 | 2018-03-09 | Rigel Pharmaceuticals, Inc. | Inhibidores de proteína cinasa C y usos de los mismos |
| US8754251B2 (en) | 2012-06-06 | 2014-06-17 | Rigel Pharmaceuticals, Inc. | Cyclopropyl PIDA boronate |
| EP2928891B1 (en) | 2012-12-04 | 2019-02-20 | Rigel Pharmaceuticals, Inc. | Protein kinase c inhibitors and uses thereof |
| CA2904610A1 (en) | 2013-03-14 | 2014-09-25 | Rigel Pharmaceuticals, Inc. | Protein kinase c inhibitors and uses thereof |
| CN105473558B (zh) | 2013-06-20 | 2019-04-19 | 拜耳作物科学股份公司 | 作为杀螨剂和杀昆虫剂的芳基硫化物衍生物和芳基硫氧化物衍生物 |
| US10091998B2 (en) | 2013-10-28 | 2018-10-09 | Sumitomo Chemical Company, Limited | Tetrazolinone compound and use thereof |
| NZ715903A (en) | 2014-01-30 | 2017-06-30 | Signal Pharm Llc | Solid forms of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide, compositions thereof and methods of their use |
| US9822085B2 (en) | 2014-03-20 | 2017-11-21 | Sumitomo Chemical Company, Limited | Method for producing tetrazolinone compound |
| WO2015148867A1 (en) | 2014-03-28 | 2015-10-01 | Calitor Sciences, Llc | Substituted heteroaryl compounds and methods of use |
| JO3589B1 (ar) * | 2014-08-06 | 2020-07-05 | Novartis Ag | مثبطات كيناز البروتين c وطرق استخداماتها |
| WO2016060963A1 (en) | 2014-10-14 | 2016-04-21 | Sunshine Lake Pharma Co., Ltd. | Substituted heteroaryl compounds and methods of use |
| CN107108524A (zh) | 2014-12-16 | 2017-08-29 | 西格诺药品有限公司 | 2‑(叔丁基氨基)‑4‑((1r,3r,4r)‑3‑羟基‑4‑甲基环己基氨基)‑嘧啶‑5‑甲酰胺的配制物 |
| US9513297B2 (en) | 2014-12-16 | 2016-12-06 | Signal Pharmaceuticals, Llc | Methods for measurement of inhibition of c-Jun N-terminal kinase in skin |
| JP6662885B2 (ja) * | 2015-01-26 | 2020-03-11 | ライジェル ファーマシューティカルズ， インコーポレイテッド | カルボン酸生物学的等価体としてのテトラゾロン |
| EP3250557B1 (en) | 2015-01-29 | 2024-11-20 | Signal Pharmaceuticals, LLC | Isotopologues of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide |
| CN107922287B (zh) | 2015-07-24 | 2021-04-09 | 细胞基因公司 | 合成(1r,2r,5r)-5-氨基-2-甲基环己醇盐酸盐的方法和其中可用的中间体 |
| JP2018527362A (ja) | 2015-09-11 | 2018-09-20 | サンシャイン・レイク・ファーマ・カンパニー・リミテッドＳｕｎｓｈｉｎｅ Ｌａｋｅ Ｐｈａｒｍａ Ｃｏ．，Ｌｔｄ． | 置換されたヘテロアリール化合物および使用方法 |
| US10736895B2 (en) | 2015-12-04 | 2020-08-11 | Portola Pharmaceuticals, Inc. | Cerdulatinib for treating hematological cancers |
| CN106316864A (zh) * | 2016-08-22 | 2017-01-11 | 苏州天马精细化学品股份有限公司 | 4‑甲基‑3‑三氟甲基苯胺的制备方法 |
| JP7035047B2 (ja) * | 2016-11-28 | 2022-03-14 | 住友化学株式会社 | テトラゾリノン化合物及びその用途 |
| WO2019099311A1 (en) | 2017-11-19 | 2019-05-23 | Sunshine Lake Pharma Co., Ltd. | Substituted heteroaryl compounds and methods of use |
| EP3560913A1 (en) | 2018-04-25 | 2019-10-30 | Dynamit Nobel GmbH Explosivstoff- und Systemtechnik | Process for the production of tetrazolinones |
| WO2019213606A2 (en) | 2018-05-04 | 2019-11-07 | Portola Pharmaceuticals, Inc. | Solid forms of cerdulatinib |
| TWI805751B (zh) * | 2018-05-04 | 2023-06-21 | 美商普托拉製藥有限公司 | 賽度替尼(cerdulatinib)之合成 |
| EP3616725A1 (en) | 2018-08-27 | 2020-03-04 | SmartDyeLivery GmbH | Pkc inhibitors for the treatment of septic cholestasis with polymethine dye targeting |
| EP3616724A1 (en) | 2018-08-27 | 2020-03-04 | SmartDyeLivery GmbH | Pkc inhibitors for the treatment of septic cholestasis with ctm targeting |
| WO2025097025A1 (en) * | 2023-11-03 | 2025-05-08 | Evommune, Inc. | Protein kinase c (pkc) theta inhibitor compounds |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5136868A (en) * | 1983-11-04 | 1992-08-11 | Fmc Corporation | Herbicidal 1-aryl-4-substituted-1,4-dihydro-5h-tetrazol-5-ones and sulfur analogs thereof |
| JPH0782258A (ja) | 1993-09-14 | 1995-03-28 | Nippon Bayeragrochem Kk | １−置換−テトラゾール−５−オン類の製造方法 |
| GB9523675D0 (en) | 1995-11-20 | 1996-01-24 | Celltech Therapeutics Ltd | Chemical compounds |
| DE69926914T2 (de) | 1999-01-13 | 2006-06-29 | Warner-Lambert Co. Llc | 1-heterozyklus-substituierte diarylaminen |
| ATE407678T1 (de) | 2001-10-17 | 2008-09-15 | Boehringer Ingelheim Pharma | Pyrimidinderivate, arzneimittel enthaltend diese verbindungen, deren verwendung und verfahren zu ihrer herstellung |
| TWI329105B (en) * | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| HRP20050089B1 (hr) * | 2002-07-29 | 2015-06-19 | Rigel Pharmaceuticals | Upotreba 2,4 pirimidindiaminskog spoja za proizvodnju lijeka za lijeäśenje ili sprjeäśavanje autoimunosne bolesti |
| WO2004043386A2 (en) | 2002-11-08 | 2004-05-27 | Tolerrx, Inc. | Molecules preferentially associated with effector t cells and methods of their use |
| WO2005012294A1 (en) * | 2003-07-30 | 2005-02-10 | Rigel Pharmaceuticals, Inc. | 2,4-pyrimidinediamine compounds for use in the treatment or prevention of autoimmune diseases |
| ATE506953T1 (de) * | 2003-08-07 | 2011-05-15 | Rigel Pharmaceuticals Inc | 2,4-pyrimidindiamin-verbindungen und verwendungen als antiproliferative mittel |
| EP1663204B1 (en) * | 2003-08-29 | 2014-05-07 | Exelixis, Inc. | C-kit modulators and methods of use |
| US20050164323A1 (en) | 2003-12-24 | 2005-07-28 | Wyeth | Methods of treating asthma |
| EP1883302A4 (en) * | 2005-05-03 | 2009-05-20 | Rigel Pharmaceuticals Inc | JAK KINASE HEMMER AND ITS USE |
| RU2008152195A (ru) * | 2006-06-15 | 2010-07-20 | БЕРИНГЕР ИНГЕЛЬХАЙМ ИНТЕРНАЦИОНАЛЬ ГмбХ (DE) | 2-анилино-4-(гетероциклил)аминопиримидины, как ингибиторы протеинкиназы с-альфа |
| CN101903357A (zh) | 2007-07-17 | 2010-12-01 | 里格尔药品股份有限公司 | 作为pkc抑制剂的环状胺取代的嘧啶二胺 |
| NZ603525A (en) * | 2008-06-27 | 2015-02-27 | Celgene Avilomics Res Inc | Pyrimidine based compound and uses thereof |
| JP5781943B2 (ja) * | 2009-01-21 | 2015-09-24 | ライジェル ファーマシューティカルズ， インコーポレイテッド | 炎症性疾患、自己免疫疾患または増殖性疾患の治療に有用なｎ２−（３−ピリジルまたはフェニル）−ｎ４−（４−ピペリジル）−２，４−ピリミジンジアミン誘導体 |
-
2010
- 2010-12-01 EP EP10796518.8A patent/EP2507227B1/en not_active Not-in-force
- 2010-12-01 WO PCT/US2010/058597 patent/WO2011068898A1/en not_active Ceased
- 2010-12-01 US US12/958,284 patent/US20110130415A1/en not_active Abandoned
- 2010-12-01 JP JP2012542165A patent/JP5802677B2/ja not_active Expired - Fee Related
- 2010-12-01 CA CA2780759A patent/CA2780759A1/en not_active Abandoned
-
2016
- 2016-09-09 US US15/261,294 patent/US9732070B2/en not_active Expired - Fee Related
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