JP2022533260A5 - - Google Patents
Info
- Publication number
- JP2022533260A5 JP2022533260A5 JP2021569449A JP2021569449A JP2022533260A5 JP 2022533260 A5 JP2022533260 A5 JP 2022533260A5 JP 2021569449 A JP2021569449 A JP 2021569449A JP 2021569449 A JP2021569449 A JP 2021569449A JP 2022533260 A5 JP2022533260 A5 JP 2022533260A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- methyl
- dioxopiperidine
- alkyl
- oxoacetamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962852844P | 2019-05-24 | 2019-05-24 | |
| US62/852,844 | 2019-05-24 | ||
| PCT/US2020/034264 WO2020242960A1 (en) | 2019-05-24 | 2020-05-22 | Compounds targeting proteins and pharmaceutical compositions thereof, and their therapeutic applications |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022533260A JP2022533260A (ja) | 2022-07-21 |
| JP2022533260A5 true JP2022533260A5 (https=) | 2023-06-07 |
Family
ID=71092611
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021569449A Pending JP2022533260A (ja) | 2019-05-24 | 2020-05-22 | タンパク質を標的とする化合物及びその医薬組成物並びにそれらの治療的応用 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US11345712B2 (https=) |
| EP (1) | EP3976623A1 (https=) |
| JP (1) | JP2022533260A (https=) |
| KR (1) | KR20220023343A (https=) |
| CN (1) | CN114502543A (https=) |
| AU (1) | AU2020283744A1 (https=) |
| CA (1) | CA3140078C (https=) |
| EA (1) | EA202192910A1 (https=) |
| IL (1) | IL288204A (https=) |
| MX (1) | MX2021014345A (https=) |
| SG (1) | SG11202112355VA (https=) |
| TW (1) | TW202110818A (https=) |
| WO (1) | WO2020242960A1 (https=) |
| ZA (1) | ZA202109124B (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10513515B2 (en) * | 2017-08-25 | 2019-12-24 | Biotheryx, Inc. | Ether compounds and uses thereof |
| MX2022006133A (es) * | 2019-12-06 | 2022-06-17 | Celgene Corp | Procesos para preparar 2-(4-clorofenil)-n-((2-(2,6-dioxopiperidin- 3-il)-1-oxoisoindolin-5-il)metil)-2,2-difluoroacetamida. |
| WO2021119571A1 (en) * | 2019-12-12 | 2021-06-17 | Biotheryx, Inc. | Pde4 inhibitors, pharmaceutical compositions, and therapeutic applications |
| WO2021126973A1 (en) * | 2019-12-17 | 2021-06-24 | Orionis Biosciences, Inc. | Compounds modulating protein recruitment and/or degradation |
| US20240025863A1 (en) | 2020-09-16 | 2024-01-25 | Biotheryx, Inc. | Sos1 protein degraders, pharmaceutical compositions thereof, and their therapeutic applications |
| JP2023545274A (ja) * | 2020-10-07 | 2023-10-27 | クルゲン（シャンハイ），インク． | 癌を処置する化合物および方法 |
| WO2022087335A1 (en) | 2020-10-23 | 2022-04-28 | Biotheryx, Inc. | Kras protein degraders, pharmaceutical compositions thereof, and their therapeutic applications |
| CN117203196A (zh) | 2020-12-14 | 2023-12-08 | 拜欧斯瑞克斯公司 | Pde4降解剂、药物组合物和治疗应用 |
| AU2022207648A1 (en) | 2021-01-13 | 2023-07-27 | Monte Rosa Therapeutics Ag | Isoindolinone compounds |
| AU2022253450A1 (en) * | 2021-04-05 | 2023-11-16 | Bristol-Myers Squibb Company | Pyridinyl substituted oxoisoindoline compounds for the treatment of cancer |
| CA3221549A1 (en) * | 2021-06-08 | 2022-12-15 | Liqiang Fu | Isoindolinone compounds, and uses thereof |
| US20240368113A1 (en) * | 2021-06-28 | 2024-11-07 | Chengdu Fendi Pharmaceutical Co. Ltd. | Amide compound and use thereof |
| JP2024527628A (ja) * | 2021-07-19 | 2024-07-25 | メッドシャイン ディスカバリー インコーポレイテッド | ヘテロアリール－３－ピペリジンジオン化合物その使用 |
| WO2023069731A1 (en) * | 2021-10-22 | 2023-04-27 | Monte Rosa Therapeutics, Inc. | Compounds that mediate protein degradation and methods of use thereof |
| WO2023070120A1 (en) * | 2021-10-22 | 2023-04-27 | Biotheryx, Inc. | Ketoamides for treating malignancy |
| WO2023069708A1 (en) * | 2021-10-22 | 2023-04-27 | Monte Rosa Therapeutics, Inc. | Compounds that mediate protein degradation and uses thereof |
| US12122764B2 (en) | 2021-12-22 | 2024-10-22 | Gilead Sciences, Inc. | IKAROS zinc finger family degraders and uses thereof |
| KR20240123836A (ko) * | 2021-12-22 | 2024-08-14 | 길리애드 사이언시즈, 인코포레이티드 | 이카로스 아연 핑거 패밀리 분해제 및 이의 용도 |
| US12419962B2 (en) | 2022-03-16 | 2025-09-23 | Biotheryx, Inc. | Quinazolines, pharmaceutical compositions, and therapeutic applications |
| WO2023178181A1 (en) | 2022-03-17 | 2023-09-21 | Gilead Sciences, Inc. | Ikaros zinc finger family degraders and uses thereof |
| CN114835680A (zh) * | 2022-04-29 | 2022-08-02 | 成都分迪药业有限公司 | 卤素取代异吲哚啉化合物及其应用 |
| CN115636811A (zh) * | 2022-08-17 | 2023-01-24 | 成都分迪药业有限公司 | 异吲哚啉苄胺衍生物的合成方法 |
| EP4584259A1 (en) * | 2022-09-09 | 2025-07-16 | Innovo Therapeutics, Inc. | Ck1alpha and dual ck1alpha / gspt1 degrading compounds |
| WO2024064358A1 (en) | 2022-09-23 | 2024-03-28 | Ifm Due, Inc. | Compounds and compositions for treating conditions associated with sting activity |
| WO2024167423A1 (en) * | 2023-02-07 | 2024-08-15 | Captor Therapeutics S.A. | Gspt1 degrader compounds |
| WO2024222918A1 (zh) * | 2023-04-28 | 2024-10-31 | 中国药科大学 | 一种苯并六元杂环类gspt1蛋白降解剂及其应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030045552A1 (en) * | 2000-12-27 | 2003-03-06 | Robarge Michael J. | Isoindole-imide compounds, compositions, and uses thereof |
| EP2197552B1 (en) * | 2007-09-19 | 2012-11-21 | 4Sc Ag | Novel tetrahydrofusedpyridines as histone deacetylase inhibitors |
| SG11201805779TA (en) * | 2016-01-08 | 2018-08-30 | Celgene Corp | Antiproliferative compounds, and their pharmaceutical compositions and uses |
| WO2017201069A1 (en) * | 2016-05-18 | 2017-11-23 | Biotheryx, Inc. | Oxoindoline derivatives as protein function modulators |
| KR101825065B1 (ko) * | 2016-05-24 | 2018-02-05 | 한국화학연구원 | Alk 단백질의 분해를 유도하는 약학적 조성물 및 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물 |
| CN108069959A (zh) * | 2016-11-10 | 2018-05-25 | 凯惠科技发展(上海)有限公司 | 一种含氮杂环类化合物、其制备方法、药物组合物及应用 |
| US10040804B2 (en) | 2016-12-21 | 2018-08-07 | Biotheryx, Inc. | Compounds targeting proteins, compositions, methods, and uses thereof |
| US10406165B2 (en) | 2017-03-14 | 2019-09-10 | Biotheryx, Inc. | Compounds targeting proteins, compositions, methods, and uses thereof |
| CN108929307A (zh) * | 2017-05-22 | 2018-12-04 | 苏州偶领生物医药有限公司 | 一类异吲哚酮-酰亚胺环-1,3-二酮-2-烯化合物、其组合物和用途 |
| EP3784665A4 (en) * | 2018-04-26 | 2022-01-26 | Aurigene Discovery Technologies Limited | PYRIDAZINE DERIVATIVES AS SMARCA2/4 DEGRADERS |
| CA3101338A1 (en) | 2018-06-13 | 2019-12-19 | Biotheryx, Inc. | Aminoamide compounds |
| CA3106239A1 (en) * | 2018-07-27 | 2020-01-30 | Biotheryx, Inc. | Bifunctional compounds as cdk modulators |
-
2020
- 2020-05-22 JP JP2021569449A patent/JP2022533260A/ja active Pending
- 2020-05-22 TW TW109117256A patent/TW202110818A/zh unknown
- 2020-05-22 KR KR1020217039259A patent/KR20220023343A/ko not_active Withdrawn
- 2020-05-22 CN CN202080052899.5A patent/CN114502543A/zh active Pending
- 2020-05-22 SG SG11202112355VA patent/SG11202112355VA/en unknown
- 2020-05-22 EP EP20732707.3A patent/EP3976623A1/en not_active Withdrawn
- 2020-05-22 MX MX2021014345A patent/MX2021014345A/es unknown
- 2020-05-22 AU AU2020283744A patent/AU2020283744A1/en not_active Abandoned
- 2020-05-22 WO PCT/US2020/034264 patent/WO2020242960A1/en not_active Ceased
- 2020-05-22 EA EA202192910A patent/EA202192910A1/ru unknown
- 2020-05-22 CA CA3140078A patent/CA3140078C/en active Active
- 2020-05-26 US US16/882,750 patent/US11345712B2/en active Active
-
2021
- 2021-11-16 ZA ZA2021/09124A patent/ZA202109124B/en unknown
- 2021-11-17 IL IL288204A patent/IL288204A/en unknown
-
2022
- 2022-05-30 US US17/804,566 patent/US20220298172A1/en not_active Abandoned
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