JP2024522766A5 - - Google Patents
Info
- Publication number
- JP2024522766A5 JP2024522766A5 JP2023577689A JP2023577689A JP2024522766A5 JP 2024522766 A5 JP2024522766 A5 JP 2024522766A5 JP 2023577689 A JP2023577689 A JP 2023577689A JP 2023577689 A JP2023577689 A JP 2023577689A JP 2024522766 A5 JP2024522766 A5 JP 2024522766A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- cancer
- homologous
- salt
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110687643 | 2021-06-21 | ||
| CN202110687643.8 | 2021-06-21 | ||
| CN202110880105 | 2021-08-02 | ||
| CN202110880105.0 | 2021-08-02 | ||
| CN202111073775 | 2021-09-14 | ||
| CN202111073775.8 | 2021-09-14 | ||
| CN202111225928.6 | 2021-10-21 | ||
| CN202111225928 | 2021-10-21 | ||
| PCT/CN2022/100016 WO2022268051A1 (zh) | 2021-06-21 | 2022-06-21 | 稠合四环类化合物、其制备方法及其在医药上的应用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024522766A JP2024522766A (ja) | 2024-06-21 |
| JP2024522766A5 true JP2024522766A5 (https=) | 2025-07-01 |
Family
ID=84544976
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023577689A Pending JP2024522766A (ja) | 2021-06-21 | 2022-06-21 | 縮合四環系化合物、その調製方法及びその医薬的応用 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20240327434A1 (https=) |
| EP (1) | EP4361157A4 (https=) |
| JP (1) | JP2024522766A (https=) |
| KR (1) | KR20240024903A (https=) |
| CN (1) | CN117255793A (https=) |
| AU (1) | AU2022297474A1 (https=) |
| BR (1) | BR112023024646A2 (https=) |
| CA (1) | CA3220929A1 (https=) |
| MX (1) | MX2023015533A (https=) |
| TW (1) | TW202317587A (https=) |
| WO (1) | WO2022268051A1 (https=) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3210167A1 (en) * | 2021-02-09 | 2022-08-18 | Genentech, Inc. | Tetracyclic oxazepine compounds and uses thereof |
| CA3211725A1 (en) * | 2021-03-17 | 2022-09-22 | Tao Jiang | Pyrimidine-fused cyclic compound, preparation method therefor and use thereof |
| AU2022303440A1 (en) * | 2021-07-02 | 2024-02-22 | Shanghai De Novo Pharmatech Co., Ltd. | Kras g12d inhibitor and use thereof |
| WO2023001141A1 (en) * | 2021-07-23 | 2023-01-26 | Shanghai Zion Pharma Co. Limited | Kras g12d inhibitors and uses thereof |
| TW202315626A (zh) * | 2021-08-31 | 2023-04-16 | 大陸商勁方醫藥科技(上海)有限公司 | 嘧啶并環類化合物及其製法和用途 |
| US20250034166A1 (en) * | 2021-09-27 | 2025-01-30 | Jacobio Pharmaceuticals Co., Ltd. | Polycyclic fused ring derivatives and use thereof |
| EP4471037A1 (en) * | 2022-01-30 | 2024-12-04 | Shanghai Pharmaceuticals Holding Co., Ltd. | Quinoline compound and use thereof |
| CA3243798A1 (en) | 2022-02-09 | 2023-08-17 | Quanta Therapeutics, Inc. | Kras Modulators and Their Uses |
| CR20240508A (es) * | 2022-05-19 | 2024-12-20 | Genentech Inc | Compuestos aza-tetracíclicos de oxazepina y usos de los mismos |
| WO2023230190A1 (en) | 2022-05-25 | 2023-11-30 | Quanta Therapeutics, Inc. | Pyrimidine based modulators and uses thereof |
| CN119790058A (zh) * | 2022-07-09 | 2025-04-08 | 荣山医药股份有限公司 | 用于治疗疾病的稠合环kras抑制剂 |
| WO2024022444A1 (zh) * | 2022-07-27 | 2024-02-01 | 江苏恒瑞医药股份有限公司 | 稠环类化合物、其制备方法及其在医药上的应用 |
| AU2023314335A1 (en) * | 2022-07-29 | 2025-02-27 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Pharmaceutical composition comprising kras g12d inhibitor |
| CN119585278A (zh) * | 2022-08-05 | 2025-03-07 | 杭州中美华东制药有限公司 | 具有KRas G12D抑制作用的化合物 |
| IL318647A (en) | 2022-08-05 | 2025-03-01 | Kumquat Biosciences Inc | Heterocyclic compounds and their uses |
| WO2024041573A1 (en) * | 2022-08-25 | 2024-02-29 | Zai Lab (Shanghai) Co., Ltd. | Fused multi-heterocyclic compounds as kras g12d modulators and uses thereof |
| TW202426459A (zh) * | 2022-09-23 | 2024-07-01 | 大陸商勁方醫藥科技(上海)有限公司 | 嘧啶并環類化合物及其製法和用途 |
| AU2023388747A1 (en) * | 2022-12-07 | 2025-07-10 | Jacobio Pharmaceuticals Co., Ltd. | Fused cyclic compounds and use thereof |
| EP4640689A1 (en) * | 2022-12-20 | 2025-10-29 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Crystal form of kras g12d inhibitor and preparation method therefor |
| WO2024149214A1 (en) * | 2023-01-10 | 2024-07-18 | Nikang Therapeutics, Inc. | Bifunctional compounds for degrading kras-12d via ubiquitin proteasome pathway |
| WO2024234360A1 (en) * | 2023-05-18 | 2024-11-21 | Nikang Therapeutics , Inc. | Tetracyclic derivatives as kras inhibitors |
| WO2024159471A1 (en) * | 2023-02-02 | 2024-08-08 | Nikang Therapeutics , Inc. | Tetracyclic derivatives as kras inhibitors |
| KR20260041941A (ko) | 2023-03-15 | 2026-03-27 | 콴타 테라퓨틱스, 인크. | Kras 조절 인자 및 이의 용도 |
| WO2024208305A1 (zh) * | 2023-04-07 | 2024-10-10 | 江苏恒瑞医药股份有限公司 | 稠合四环类化合物、其制备方法及其在医药上的应用 |
| EP4695262A1 (en) * | 2023-04-10 | 2026-02-18 | Pfizer Inc. | Pyrido[4,3-d]pyrimidine compounds |
| WO2024218686A1 (en) * | 2023-04-20 | 2024-10-24 | Pfizer Inc. | Pyrido[4,3-d]pyrimidine compounds |
| AU2024306338A1 (en) * | 2023-06-30 | 2026-01-08 | Gilead Sciences, Inc. | Kras modulating compounds |
| CN121399088A (zh) | 2023-07-13 | 2026-01-23 | 上海森辉医药有限公司 | Kras g12d中间体的制备方法 |
| TW202517649A (zh) * | 2023-07-18 | 2025-05-01 | 大陸商泰勵生物科技（上海）有限公司 | 具有抗ｋｒａｓ突變腫瘤活性的化合物 |
| WO2025045141A1 (en) * | 2023-08-31 | 2025-03-06 | Suzhou Zanrong Pharma Limited | Kras inhibitors and uses thereof |
| US20250109147A1 (en) | 2023-09-08 | 2025-04-03 | Gilead Sciences, Inc. | Kras g12d modulating compounds |
| US20250114346A1 (en) | 2023-10-09 | 2025-04-10 | Incyte Corporation | Combination therapy using a kras g12d inhibitor and pd-1 inhibitor or pd-l1 inhibitor |
| US20250114339A1 (en) | 2023-10-09 | 2025-04-10 | Incyte Corporation | Combination therapy comprising a kras g12d inhibitor and an egfr inhibitor |
| AU2024374420A1 (en) * | 2023-11-02 | 2026-04-16 | Kumquat Biosciences Inc. | Degraders and uses thereof |
| WO2025108443A2 (en) * | 2023-11-23 | 2025-05-30 | Beigene Switzerland Gmbh | Heterocyclic compounds, compositions thereof, and methods of treatment therewith |
| WO2025146194A1 (en) * | 2024-01-05 | 2025-07-10 | Jacobio Pharmaceuticals Co., Ltd. | Fused tetracyclic compounds and use thereof |
| WO2025153038A1 (en) * | 2024-01-17 | 2025-07-24 | Suzhou Zanrong Pharma Limited | Kras inhibitors and uses thereof |
| CN119684315A (zh) * | 2024-01-26 | 2025-03-25 | 苏州盛迪亚生物医药有限公司 | 一种苯并噻吩取代稠环化合物的结晶形式及其制备方法 |
| WO2025157261A1 (zh) * | 2024-01-26 | 2025-07-31 | 江苏恒瑞医药股份有限公司 | G12d抑制剂化合物晶型及其制备方法 |
| CN119661556B (zh) * | 2024-01-26 | 2025-12-09 | 苏州盛迪亚生物医药有限公司 | 一种稠环类化合物的可药用盐、其结晶形式及用途 |
| CN119490512A (zh) * | 2024-01-26 | 2025-02-21 | 苏州盛迪亚生物医药有限公司 | 一种苯并噻吩取代稠环化合物的可药用盐、其结晶形式及用途 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017172979A1 (en) | 2016-03-30 | 2017-10-05 | Araxes Pharma Llc | Substituted quinazoline compounds and methods of use |
| EP3621968A1 (en) * | 2017-05-11 | 2020-03-18 | Astrazeneca AB | Heteroaryl compounds that inhibit g12c mutant ras proteins |
| US10745385B2 (en) * | 2017-05-25 | 2020-08-18 | Araxes Pharma Llc | Covalent inhibitors of KRAS |
| TW202012415A (zh) * | 2018-05-08 | 2020-04-01 | 瑞典商阿斯特捷利康公司 | 化學化合物 |
| EP3908283A4 (en) | 2019-01-10 | 2022-10-12 | Mirati Therapeutics, Inc. | KRAS G12C INHIBITORS |
| TW202110837A (zh) | 2019-05-24 | 2021-03-16 | 大陸商江蘇恆瑞醫藥股份有限公司 | 氫化吡啶并嘧啶類衍生物、其製備方法及其在醫藥上的應用 |
| WO2021000885A1 (zh) * | 2019-07-01 | 2021-01-07 | 江苏恒瑞医药股份有限公司 | 喹唑啉酮类衍生物、其制备方法及其在医药上的应用 |
| MX2022002465A (es) * | 2019-08-29 | 2022-05-19 | Mirati Therapeutics Inc | Inhibidores de kras g12d. |
| WO2021106231A1 (en) * | 2019-11-29 | 2021-06-03 | Taiho Pharmaceutical Co., Ltd. | A compound having inhibitory activity against kras g12d mutation |
| CA3210167A1 (en) * | 2021-02-09 | 2022-08-18 | Genentech, Inc. | Tetracyclic oxazepine compounds and uses thereof |
| US20240199644A1 (en) * | 2021-03-07 | 2024-06-20 | Jacobio Pharmaceuticals Co., Ltd. | Fused Ring Derivatives Useful as KRAS G12D Inhibitors |
| CA3211725A1 (en) * | 2021-03-17 | 2022-09-22 | Tao Jiang | Pyrimidine-fused cyclic compound, preparation method therefor and use thereof |
| WO2022199587A1 (zh) * | 2021-03-24 | 2022-09-29 | 南京明德新药研发有限公司 | 嘧啶并杂环类化合物及其应用 |
| CN116113632B (zh) * | 2021-03-30 | 2025-08-29 | 浙江海正药业股份有限公司 | 杂环类衍生物、其制备方法及其医药上的用途 |
| AU2022303440A1 (en) * | 2021-07-02 | 2024-02-22 | Shanghai De Novo Pharmatech Co., Ltd. | Kras g12d inhibitor and use thereof |
| WO2023001141A1 (en) * | 2021-07-23 | 2023-01-26 | Shanghai Zion Pharma Co. Limited | Kras g12d inhibitors and uses thereof |
| CN116323625A (zh) * | 2021-08-25 | 2023-06-23 | 浙江海正药业股份有限公司 | 杂环类衍生物、其制备方法及其医药上的用途 |
| TW202315626A (zh) * | 2021-08-31 | 2023-04-16 | 大陸商勁方醫藥科技(上海)有限公司 | 嘧啶并環類化合物及其製法和用途 |
| WO2023103906A1 (zh) * | 2021-12-07 | 2023-06-15 | 贝达药业股份有限公司 | Kras g12d抑制剂及其在医药上的应用 |
| EP4471037A1 (en) * | 2022-01-30 | 2024-12-04 | Shanghai Pharmaceuticals Holding Co., Ltd. | Quinoline compound and use thereof |
| CR20240451A (es) * | 2022-04-21 | 2024-12-04 | Gilead Sciences Inc | Compuestos de modulación de kras g12d |
| CR20240508A (es) * | 2022-05-19 | 2024-12-20 | Genentech Inc | Compuestos aza-tetracíclicos de oxazepina y usos de los mismos |
-
2022
- 2022-06-21 EP EP22827544.2A patent/EP4361157A4/en active Pending
- 2022-06-21 TW TW111123050A patent/TW202317587A/zh unknown
- 2022-06-21 JP JP2023577689A patent/JP2024522766A/ja active Pending
- 2022-06-21 MX MX2023015533A patent/MX2023015533A/es unknown
- 2022-06-21 US US18/571,909 patent/US20240327434A1/en active Pending
- 2022-06-21 BR BR112023024646A patent/BR112023024646A2/pt unknown
- 2022-06-21 CA CA3220929A patent/CA3220929A1/en active Pending
- 2022-06-21 KR KR1020247000906A patent/KR20240024903A/ko active Pending
- 2022-06-21 AU AU2022297474A patent/AU2022297474A1/en active Pending
- 2022-06-21 CN CN202280030759.7A patent/CN117255793A/zh active Pending
- 2022-06-21 WO PCT/CN2022/100016 patent/WO2022268051A1/zh not_active Ceased
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